G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania braziliensis

UniProt:

A4HCU4_LEIBR

TriTrypDb:

LbrM.23.0830 , LBRM2903_230017200

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCU4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.524
CLV_C14_Caspase3-7	395	399	PF00656	0.657
CLV_C14_Caspase3-7	456	460	PF00656	0.353
CLV_NRD_NRD_1	113	115	PF00675	0.468
CLV_NRD_NRD_1	164	166	PF00675	0.500
CLV_NRD_NRD_1	167	169	PF00675	0.510
CLV_NRD_NRD_1	240	242	PF00675	0.619
CLV_NRD_NRD_1	366	368	PF00675	0.649
CLV_NRD_NRD_1	67	69	PF00675	0.651
CLV_PCSK_FUR_1	364	368	PF00082	0.443
CLV_PCSK_KEX2_1	164	166	PF00082	0.490
CLV_PCSK_KEX2_1	171	173	PF00082	0.530
CLV_PCSK_KEX2_1	239	241	PF00082	0.750
CLV_PCSK_KEX2_1	366	368	PF00082	0.646
CLV_PCSK_KEX2_1	422	424	PF00082	0.334
CLV_PCSK_KEX2_1	67	69	PF00082	0.565
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.565
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.790
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.329
CLV_PCSK_SKI1_1	151	155	PF00082	0.476
CLV_PCSK_SKI1_1	168	172	PF00082	0.511
CLV_PCSK_SKI1_1	21	25	PF00082	0.577
CLV_PCSK_SKI1_1	210	214	PF00082	0.516
CLV_PCSK_SKI1_1	317	321	PF00082	0.225
CLV_PCSK_SKI1_1	419	423	PF00082	0.343
CLV_PCSK_SKI1_1	484	488	PF00082	0.267
CLV_PCSK_SKI1_1	8	12	PF00082	0.584
DEG_APCC_DBOX_1	150	158	PF00400	0.474
DEG_Nend_UBRbox_1	1	4	PF02207	0.459
DEG_SPOP_SBC_1	135	139	PF00917	0.649
DEG_SPOP_SBC_1	45	49	PF00917	0.721
DOC_CKS1_1	295	300	PF01111	0.488
DOC_CKS1_1	332	337	PF01111	0.448
DOC_CKS1_1	372	377	PF01111	0.525
DOC_CYCLIN_RxL_1	314	322	PF00134	0.380
DOC_MAPK_DCC_7	267	276	PF00069	0.545
DOC_MAPK_MEF2A_6	267	276	PF00069	0.442
DOC_PP1_RVXF_1	170	177	PF00149	0.501
DOC_USP7_MATH_1	10	14	PF00917	0.666
DOC_USP7_MATH_1	229	233	PF00917	0.593
DOC_USP7_MATH_1	257	261	PF00917	0.691
DOC_USP7_MATH_1	266	270	PF00917	0.561
DOC_USP7_MATH_1	45	49	PF00917	0.641
DOC_USP7_MATH_1	78	82	PF00917	0.585
DOC_WW_Pin1_4	294	299	PF00397	0.549
DOC_WW_Pin1_4	331	336	PF00397	0.460
DOC_WW_Pin1_4	371	376	PF00397	0.592
DOC_WW_Pin1_4	54	59	PF00397	0.590
LIG_14-3-3_CanoR_1	172	177	PF00244	0.561
LIG_14-3-3_CanoR_1	210	215	PF00244	0.564
LIG_14-3-3_CanoR_1	267	271	PF00244	0.547
LIG_14-3-3_CanoR_1	279	287	PF00244	0.406
LIG_14-3-3_CanoR_1	303	312	PF00244	0.470
LIG_14-3-3_CanoR_1	367	373	PF00244	0.645
LIG_14-3-3_CanoR_1	67	77	PF00244	0.616
LIG_14-3-3_CanoR_1	8	13	PF00244	0.580
LIG_Actin_WH2_2	288	305	PF00022	0.488
LIG_BIR_III_2	459	463	PF00653	0.400
LIG_BRCT_BRCA1_1	307	311	PF00533	0.490
LIG_Clathr_ClatBox_1	318	322	PF01394	0.520
LIG_eIF4E_1	472	478	PF01652	0.417
LIG_FHA_1	184	190	PF00498	0.546
LIG_FHA_1	304	310	PF00498	0.446
LIG_FHA_1	332	338	PF00498	0.424
LIG_FHA_1	450	456	PF00498	0.339
LIG_FHA_1	487	493	PF00498	0.360
LIG_FHA_2	179	185	PF00498	0.516
LIG_FHA_2	454	460	PF00498	0.326
LIG_GBD_Chelix_1	287	295	PF00786	0.338
LIG_LIR_Apic_2	445	450	PF02991	0.492
LIG_LIR_Gen_1	437	447	PF02991	0.375
LIG_LIR_Gen_1	518	525	PF02991	0.409
LIG_LIR_Nem_3	156	161	PF02991	0.477
LIG_LIR_Nem_3	297	302	PF02991	0.492
LIG_LIR_Nem_3	308	314	PF02991	0.443
LIG_LIR_Nem_3	518	524	PF02991	0.438
LIG_MYND_1	262	266	PF01753	0.459
LIG_PCNA_yPIPBox_3	284	296	PF02747	0.446
LIG_PDZ_Class_1	520	525	PF00595	0.455
LIG_SH2_CRK	447	451	PF00017	0.387
LIG_SH2_NCK_1	312	316	PF00017	0.436
LIG_SH2_STAP1	59	63	PF00017	0.432
LIG_SH2_STAT5	158	161	PF00017	0.613
LIG_SH2_STAT5	349	352	PF00017	0.367
LIG_SH2_STAT5	440	443	PF00017	0.315
LIG_SH2_STAT5	472	475	PF00017	0.540
LIG_SH2_STAT5	480	483	PF00017	0.378
LIG_SH3_2	375	380	PF14604	0.529
LIG_SH3_3	30	36	PF00018	0.610
LIG_SH3_3	318	324	PF00018	0.440
LIG_SH3_3	369	375	PF00018	0.635
LIG_SH3_3	72	78	PF00018	0.468
LIG_SUMO_SIM_par_1	218	223	PF11976	0.469
LIG_SUMO_SIM_par_1	317	322	PF11976	0.401
LIG_SUMO_SIM_par_1	451	456	PF11976	0.329
LIG_WRC_WIRS_1	504	509	PF05994	0.487
MOD_CDK_SPxxK_3	54	61	PF00069	0.556
MOD_CK1_1	136	142	PF00069	0.642
MOD_CK1_1	231	237	PF00069	0.549
MOD_CK1_1	282	288	PF00069	0.272
MOD_CK1_1	331	337	PF00069	0.369
MOD_CK1_1	371	377	PF00069	0.617
MOD_CK1_1	383	389	PF00069	0.628
MOD_CK1_1	44	50	PF00069	0.648
MOD_CK1_1	51	57	PF00069	0.598
MOD_CK2_1	136	142	PF00069	0.642
MOD_CK2_1	78	84	PF00069	0.622
MOD_CMANNOS	176	179	PF00535	0.490
MOD_Cter_Amidation	162	165	PF01082	0.475
MOD_Cter_Amidation	237	240	PF01082	0.739
MOD_GlcNHglycan	12	15	PF01048	0.641
MOD_GlcNHglycan	231	234	PF01048	0.635
MOD_GlcNHglycan	259	262	PF01048	0.561
MOD_GlcNHglycan	281	284	PF01048	0.332
MOD_GlcNHglycan	428	431	PF01048	0.420
MOD_GlcNHglycan	43	46	PF01048	0.671
MOD_GlcNHglycan	70	73	PF01048	0.582
MOD_GlcNHglycan	80	83	PF01048	0.447
MOD_GSK3_1	129	136	PF00069	0.578
MOD_GSK3_1	227	234	PF00069	0.717
MOD_GSK3_1	278	285	PF00069	0.273
MOD_GSK3_1	367	374	PF00069	0.634
MOD_GSK3_1	380	387	PF00069	0.621
MOD_GSK3_1	41	48	PF00069	0.611
MOD_GSK3_1	449	456	PF00069	0.225
MOD_GSK3_1	50	57	PF00069	0.558
MOD_GSK3_1	515	522	PF00069	0.442
MOD_LATS_1	301	307	PF00433	0.345
MOD_LATS_1	365	371	PF00433	0.491
MOD_LATS_1	66	72	PF00433	0.502
MOD_N-GLC_1	227	232	PF02516	0.692
MOD_NEK2_1	16	21	PF00069	0.560
MOD_NEK2_1	190	195	PF00069	0.572
MOD_NEK2_1	302	307	PF00069	0.310
MOD_NEK2_1	426	431	PF00069	0.388
MOD_NEK2_1	487	492	PF00069	0.332
MOD_NEK2_1	503	508	PF00069	0.348
MOD_NEK2_1	52	57	PF00069	0.604
MOD_PIKK_1	472	478	PF00454	0.488
MOD_PKA_1	67	73	PF00069	0.456
MOD_PKA_2	106	112	PF00069	0.487
MOD_PKA_2	129	135	PF00069	0.531
MOD_PKA_2	266	272	PF00069	0.534
MOD_PKA_2	278	284	PF00069	0.246
MOD_PKA_2	302	308	PF00069	0.471
MOD_PKA_2	467	473	PF00069	0.482
MOD_PKA_2	67	73	PF00069	0.559
MOD_Plk_1	519	525	PF00069	0.402
MOD_Plk_4	266	272	PF00069	0.516
MOD_Plk_4	283	289	PF00069	0.204
MOD_ProDKin_1	294	300	PF00069	0.431
MOD_ProDKin_1	331	337	PF00069	0.462
MOD_ProDKin_1	371	377	PF00069	0.593
MOD_ProDKin_1	54	60	PF00069	0.584
MOD_SUMO_rev_2	103	111	PF00179	0.498
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.465
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.195
TRG_DiLeu_BaLyEn_6	409	414	PF01217	0.605
TRG_ENDOCYTIC_2	158	161	PF00928	0.469
TRG_ENDOCYTIC_2	299	302	PF00928	0.272
TRG_ENDOCYTIC_2	329	332	PF00928	0.396
TRG_ENDOCYTIC_2	440	443	PF00928	0.409
TRG_ER_diArg_1	144	147	PF00400	0.527
TRG_ER_diArg_1	164	166	PF00400	0.363
TRG_ER_diArg_1	364	367	PF00400	0.515
TRG_ER_diArg_1	67	69	PF00400	0.682
TRG_NLS_MonoExtN_4	237	243	PF00514	0.527
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	249	254	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	317	322	PF00026	0.195

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I045	Leptomonas seymouri	62%	89%
A0A0S4IVC3	Bodo saltans	43%	100%
A0A1X0NWZ9	Trypanosomatidae	51%	100%
A0A3S7WXN4	Leishmania donovani	83%	78%
A0A422MX57	Trypanosoma rangeli	54%	100%
A4I0C5	Leishmania infantum	83%	78%
C9ZV46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AW89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QB89	Leishmania major	84%	100%
V5ARP5	Trypanosoma cruzi	52%	100%