Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCU3_LEIBR

TriTrypDb:

LbrM.23.0820 , LBRM2903_230017100

Length:

600

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCU3

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.573
CLV_NRD_NRD_1	132	134	PF00675	0.430
CLV_NRD_NRD_1	238	240	PF00675	0.680
CLV_NRD_NRD_1	246	248	PF00675	0.586
CLV_NRD_NRD_1	252	254	PF00675	0.536
CLV_NRD_NRD_1	258	260	PF00675	0.571
CLV_PCSK_FUR_1	236	240	PF00082	0.668
CLV_PCSK_FUR_1	244	248	PF00082	0.587
CLV_PCSK_KEX2_1	132	134	PF00082	0.430
CLV_PCSK_KEX2_1	238	240	PF00082	0.666
CLV_PCSK_KEX2_1	246	248	PF00082	0.678
CLV_PCSK_KEX2_1	252	254	PF00082	0.566
CLV_PCSK_KEX2_1	258	260	PF00082	0.537
CLV_PCSK_SKI1_1	101	105	PF00082	0.577
DEG_ODPH_VHL_1	559	570	PF01847	0.494
DEG_SPOP_SBC_1	315	319	PF00917	0.565
DEG_SPOP_SBC_1	320	324	PF00917	0.614
DEG_SPOP_SBC_1	482	486	PF00917	0.495
DOC_CKS1_1	440	445	PF01111	0.507
DOC_CKS1_1	46	51	PF01111	0.570
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.532
DOC_MAPK_FxFP_2	444	447	PF00069	0.660
DOC_PP2B_LxvP_1	229	232	PF13499	0.670
DOC_PP2B_LxvP_1	278	281	PF13499	0.537
DOC_PP2B_LxvP_1	396	399	PF13499	0.586
DOC_PP4_FxxP_1	444	447	PF00568	0.660
DOC_PP4_FxxP_1	46	49	PF00568	0.551
DOC_USP7_MATH_1	120	124	PF00917	0.561
DOC_USP7_MATH_1	267	271	PF00917	0.525
DOC_USP7_MATH_1	399	403	PF00917	0.557
DOC_USP7_MATH_1	47	51	PF00917	0.636
DOC_USP7_MATH_1	514	518	PF00917	0.689
DOC_USP7_MATH_1	531	535	PF00917	0.485
DOC_USP7_MATH_1	548	552	PF00917	0.589
DOC_USP7_MATH_1	71	75	PF00917	0.541
DOC_USP7_UBL2_3	416	420	PF12436	0.526
DOC_WW_Pin1_4	1	6	PF00397	0.743
DOC_WW_Pin1_4	115	120	PF00397	0.647
DOC_WW_Pin1_4	211	216	PF00397	0.502
DOC_WW_Pin1_4	265	270	PF00397	0.517
DOC_WW_Pin1_4	280	285	PF00397	0.558
DOC_WW_Pin1_4	321	326	PF00397	0.626
DOC_WW_Pin1_4	332	337	PF00397	0.669
DOC_WW_Pin1_4	346	351	PF00397	0.617
DOC_WW_Pin1_4	358	363	PF00397	0.714
DOC_WW_Pin1_4	387	392	PF00397	0.602
DOC_WW_Pin1_4	394	399	PF00397	0.596
DOC_WW_Pin1_4	439	444	PF00397	0.587
DOC_WW_Pin1_4	45	50	PF00397	0.637
DOC_WW_Pin1_4	477	482	PF00397	0.544
DOC_WW_Pin1_4	515	520	PF00397	0.652
DOC_WW_Pin1_4	553	558	PF00397	0.534
LIG_14-3-3_CanoR_1	11	21	PF00244	0.563
LIG_14-3-3_CanoR_1	113	120	PF00244	0.605
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_BIR_III_4	429	433	PF00653	0.675
LIG_BRCT_BRCA1_1	145	149	PF00533	0.475
LIG_BRCT_BRCA1_1	19	23	PF00533	0.641
LIG_Clathr_ClatBox_1	51	55	PF01394	0.527
LIG_FHA_1	316	322	PF00498	0.644
LIG_FHA_1	416	422	PF00498	0.555
LIG_FHA_1	46	52	PF00498	0.683
LIG_FHA_1	482	488	PF00498	0.527
LIG_FHA_1	554	560	PF00498	0.495
LIG_FHA_1	57	63	PF00498	0.579
LIG_LIR_Apic_2	43	49	PF02991	0.580
LIG_LIR_Apic_2	442	447	PF02991	0.659
LIG_LIR_Apic_2	511	516	PF02991	0.508
LIG_LIR_Gen_1	576	586	PF02991	0.484
LIG_LIR_Nem_3	146	152	PF02991	0.475
LIG_LIR_Nem_3	486	492	PF02991	0.565
LIG_LIR_Nem_3	494	500	PF02991	0.565
LIG_LIR_Nem_3	576	581	PF02991	0.565
LIG_MYND_1	387	391	PF01753	0.521
LIG_MYND_1	557	561	PF01753	0.642
LIG_Pex14_2	19	23	PF04695	0.696
LIG_Pex14_2	444	448	PF04695	0.662
LIG_PTAP_UEV_1	563	568	PF05743	0.623
LIG_SH2_SRC	562	565	PF00017	0.656
LIG_SH2_STAT5	136	139	PF00017	0.475
LIG_SH2_STAT5	304	307	PF00017	0.654
LIG_SH2_STAT5	541	544	PF00017	0.593
LIG_SH2_STAT5	562	565	PF00017	0.777
LIG_SH3_1	513	519	PF00018	0.501
LIG_SH3_3	266	272	PF00018	0.566
LIG_SH3_3	278	284	PF00018	0.670
LIG_SH3_3	437	443	PF00018	0.668
LIG_SH3_3	485	491	PF00018	0.552
LIG_SH3_3	513	519	PF00018	0.572
LIG_SH3_3	558	564	PF00018	0.578
LIG_SH3_4	125	132	PF00018	0.446
LIG_SUMO_SIM_par_1	50	55	PF11976	0.527
LIG_SUMO_SIM_par_1	565	571	PF11976	0.495
LIG_TYR_ITIM	487	492	PF00017	0.480
LIG_WW_1	141	144	PF00397	0.475
MOD_CK1_1	183	189	PF00069	0.500
MOD_CK1_1	211	217	PF00069	0.508
MOD_CK1_1	22	28	PF00069	0.623
MOD_CK1_1	245	251	PF00069	0.672
MOD_CK1_1	34	40	PF00069	0.654
MOD_CK1_1	349	355	PF00069	0.585
MOD_CK1_1	390	396	PF00069	0.621
MOD_CK1_1	4	10	PF00069	0.637
MOD_CK1_1	402	408	PF00069	0.648
MOD_CK1_1	411	417	PF00069	0.622
MOD_CK1_1	50	56	PF00069	0.654
MOD_CK1_1	517	523	PF00069	0.652
MOD_CK1_1	551	557	PF00069	0.623
MOD_CK1_1	74	80	PF00069	0.570
MOD_CK2_1	27	33	PF00069	0.570
MOD_Cter_Amidation	256	259	PF01082	0.694
MOD_DYRK1A_RPxSP_1	515	519	PF00069	0.501
MOD_GlcNHglycan	122	125	PF01048	0.694
MOD_GlcNHglycan	137	140	PF01048	0.291
MOD_GlcNHglycan	14	17	PF01048	0.651
MOD_GlcNHglycan	184	188	PF01048	0.302
MOD_GlcNHglycan	247	250	PF01048	0.635
MOD_GlcNHglycan	27	30	PF01048	0.645
MOD_GlcNHglycan	33	36	PF01048	0.654
MOD_GlcNHglycan	519	522	PF01048	0.636
MOD_GlcNHglycan	533	536	PF01048	0.555
MOD_GlcNHglycan	553	556	PF01048	0.451
MOD_GlcNHglycan	564	567	PF01048	0.591
MOD_GlcNHglycan	578	581	PF01048	0.492
MOD_GSK3_1	248	255	PF00069	0.739
MOD_GSK3_1	25	32	PF00069	0.591
MOD_GSK3_1	315	322	PF00069	0.647
MOD_GSK3_1	390	397	PF00069	0.625
MOD_GSK3_1	399	406	PF00069	0.647
MOD_GSK3_1	407	414	PF00069	0.702
MOD_GSK3_1	416	423	PF00069	0.675
MOD_GSK3_1	472	479	PF00069	0.536
MOD_GSK3_1	522	529	PF00069	0.618
MOD_GSK3_1	549	556	PF00069	0.595
MOD_GSK3_1	562	569	PF00069	0.511
MOD_GSK3_1	71	78	PF00069	0.768
MOD_N-GLC_1	12	17	PF02516	0.742
MOD_N-GLC_1	194	199	PF02516	0.275
MOD_N-GLC_1	225	230	PF02516	0.622
MOD_N-GLC_1	242	247	PF02516	0.697
MOD_N-GLC_1	332	337	PF02516	0.665
MOD_N-GLC_1	549	554	PF02516	0.634
MOD_NEK2_1	19	24	PF00069	0.661
MOD_NEK2_1	194	199	PF00069	0.475
MOD_NEK2_1	208	213	PF00069	0.480
MOD_NEK2_1	307	312	PF00069	0.592
MOD_NEK2_1	341	346	PF00069	0.581
MOD_NEK2_1	40	45	PF00069	0.627
MOD_NEK2_1	549	554	PF00069	0.667
MOD_NEK2_1	6	11	PF00069	0.601
MOD_NEK2_1	75	80	PF00069	0.561
MOD_NEK2_2	399	404	PF00069	0.671
MOD_PIKK_1	252	258	PF00454	0.636
MOD_PIKK_1	27	33	PF00454	0.656
MOD_PIKK_1	34	40	PF00454	0.593
MOD_PIKK_1	341	347	PF00454	0.501
MOD_PIKK_1	65	71	PF00454	0.700
MOD_PIKK_1	85	91	PF00454	0.502
MOD_PKA_1	252	258	PF00069	0.688
MOD_PKA_1	93	99	PF00069	0.532
MOD_PKA_2	245	251	PF00069	0.648
MOD_PKA_2	252	258	PF00069	0.587
MOD_PKA_2	514	520	PF00069	0.503
MOD_Plk_1	17	23	PF00069	0.691
MOD_Plk_1	225	231	PF00069	0.600
MOD_Plk_1	71	77	PF00069	0.546
MOD_Plk_4	194	200	PF00069	0.475
MOD_Plk_4	47	53	PF00069	0.629
MOD_Plk_4	483	489	PF00069	0.485
MOD_Plk_4	508	514	PF00069	0.511
MOD_ProDKin_1	1	7	PF00069	0.742
MOD_ProDKin_1	115	121	PF00069	0.648
MOD_ProDKin_1	211	217	PF00069	0.508
MOD_ProDKin_1	265	271	PF00069	0.520
MOD_ProDKin_1	280	286	PF00069	0.558
MOD_ProDKin_1	321	327	PF00069	0.627
MOD_ProDKin_1	332	338	PF00069	0.669
MOD_ProDKin_1	346	352	PF00069	0.617
MOD_ProDKin_1	358	364	PF00069	0.712
MOD_ProDKin_1	387	393	PF00069	0.602
MOD_ProDKin_1	394	400	PF00069	0.599
MOD_ProDKin_1	439	445	PF00069	0.588
MOD_ProDKin_1	45	51	PF00069	0.639
MOD_ProDKin_1	477	483	PF00069	0.541
MOD_ProDKin_1	515	521	PF00069	0.657
MOD_ProDKin_1	553	559	PF00069	0.523
TRG_ENDOCYTIC_2	304	307	PF00928	0.578
TRG_ENDOCYTIC_2	489	492	PF00928	0.594
TRG_ENDOCYTIC_2	497	500	PF00928	0.606
TRG_ENDOCYTIC_2	541	544	PF00928	0.555
TRG_ER_diArg_1	131	133	PF00400	0.448
TRG_ER_diArg_1	244	247	PF00400	0.668
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P747	Leptomonas seymouri	39%	99%
A0A3Q8ICI4	Leishmania donovani	74%	100%
A4I0C4	Leishmania infantum	74%	100%
E9AW88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QB90	Leishmania major	75%	99%