RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4HCU2_LEIBR

TriTrypDb:

LbrM.23.0810 , LBRM2903_230017000

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCU2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.558
CLV_NRD_NRD_1	176	178	PF00675	0.534
CLV_NRD_NRD_1	302	304	PF00675	0.446
CLV_PCSK_KEX2_1	176	178	PF00082	0.544
CLV_PCSK_KEX2_1	302	304	PF00082	0.440
CLV_PCSK_SKI1_1	207	211	PF00082	0.507
CLV_PCSK_SKI1_1	221	225	PF00082	0.439
DEG_SCF_FBW7_1	126	132	PF00400	0.600
DEG_SCF_FBW7_1	342	348	PF00400	0.528
DEG_SPOP_SBC_1	395	399	PF00917	0.538
DEG_SPOP_SBC_1	483	487	PF00917	0.720
DOC_CKS1_1	126	131	PF01111	0.698
DOC_CKS1_1	150	155	PF01111	0.576
DOC_CKS1_1	342	347	PF01111	0.529
DOC_CKS1_1	377	382	PF01111	0.591
DOC_CKS1_1	503	508	PF01111	0.525
DOC_MAPK_gen_1	267	276	PF00069	0.482
DOC_PP2B_LxvP_1	501	504	PF13499	0.703
DOC_PP4_FxxP_1	377	380	PF00568	0.587
DOC_PP4_MxPP_1	522	525	PF00568	0.606
DOC_USP7_MATH_1	151	155	PF00917	0.585
DOC_USP7_MATH_1	162	166	PF00917	0.612
DOC_USP7_MATH_1	195	199	PF00917	0.518
DOC_USP7_MATH_1	2	6	PF00917	0.573
DOC_USP7_MATH_1	361	365	PF00917	0.530
DOC_USP7_MATH_1	405	409	PF00917	0.611
DOC_USP7_MATH_1	424	428	PF00917	0.610
DOC_USP7_MATH_1	52	56	PF00917	0.647
DOC_USP7_MATH_1	559	563	PF00917	0.640
DOC_USP7_MATH_1	584	588	PF00917	0.595
DOC_WW_Pin1_4	106	111	PF00397	0.692
DOC_WW_Pin1_4	125	130	PF00397	0.700
DOC_WW_Pin1_4	149	154	PF00397	0.573
DOC_WW_Pin1_4	325	330	PF00397	0.625
DOC_WW_Pin1_4	341	346	PF00397	0.637
DOC_WW_Pin1_4	351	356	PF00397	0.696
DOC_WW_Pin1_4	376	381	PF00397	0.589
DOC_WW_Pin1_4	382	387	PF00397	0.594
DOC_WW_Pin1_4	415	420	PF00397	0.608
DOC_WW_Pin1_4	43	48	PF00397	0.626
DOC_WW_Pin1_4	471	476	PF00397	0.680
DOC_WW_Pin1_4	502	507	PF00397	0.561
DOC_WW_Pin1_4	8	13	PF00397	0.549
LIG_14-3-3_CanoR_1	176	185	PF00244	0.546
LIG_14-3-3_CanoR_1	189	194	PF00244	0.666
LIG_14-3-3_CanoR_1	566	575	PF00244	0.564
LIG_APCC_ABBA_1	273	278	PF00400	0.482
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_BRCT_BRCA1_1	588	592	PF00533	0.665
LIG_BRCT_BRCA1_1	77	81	PF00533	0.566
LIG_EVH1_2	373	377	PF00568	0.524
LIG_FHA_1	121	127	PF00498	0.619
LIG_FHA_1	296	302	PF00498	0.546
LIG_FHA_1	337	343	PF00498	0.557
LIG_FHA_1	397	403	PF00498	0.558
LIG_FHA_1	416	422	PF00498	0.638
LIG_FHA_1	84	90	PF00498	0.658
LIG_LIR_Apic_2	145	151	PF02991	0.604
LIG_LIR_Apic_2	28	34	PF02991	0.506
LIG_LIR_Apic_2	376	380	PF02991	0.586
LIG_LIR_Nem_3	11	17	PF02991	0.558
LIG_LIR_Nem_3	145	150	PF02991	0.594
LIG_LIR_Nem_3	28	33	PF02991	0.588
LIG_LIR_Nem_3	347	353	PF02991	0.583
LIG_LIR_Nem_3	589	595	PF02991	0.602
LIG_LIR_Nem_3	78	83	PF02991	0.657
LIG_MLH1_MIPbox_1	77	81	PF16413	0.656
LIG_Pex14_2	79	83	PF04695	0.658
LIG_PTAP_UEV_1	152	157	PF05743	0.581
LIG_SH2_CRK	148	152	PF00017	0.605
LIG_SH2_CRK	31	35	PF00017	0.505
LIG_SH2_GRB2like	103	106	PF00017	0.692
LIG_SH2_NCK_1	103	107	PF00017	0.520
LIG_SH2_SRC	103	106	PF00017	0.517
LIG_SH2_STAP1	103	107	PF00017	0.695
LIG_SH2_STAP1	512	516	PF00017	0.540
LIG_SH2_STAT3	512	515	PF00017	0.541
LIG_SH2_STAT5	146	149	PF00017	0.567
LIG_SH2_STAT5	578	581	PF00017	0.619
LIG_SH2_STAT5	59	62	PF00017	0.503
LIG_SH2_STAT5	593	596	PF00017	0.583
LIG_SH2_STAT5	80	83	PF00017	0.658
LIG_SH3_1	6	12	PF00018	0.509
LIG_SH3_2	153	158	PF14604	0.589
LIG_SH3_2	525	530	PF14604	0.629
LIG_SH3_3	150	156	PF00018	0.600
LIG_SH3_3	179	185	PF00018	0.675
LIG_SH3_3	309	315	PF00018	0.580
LIG_SH3_3	326	332	PF00018	0.626
LIG_SH3_3	352	358	PF00018	0.574
LIG_SH3_3	452	458	PF00018	0.741
LIG_SH3_3	500	506	PF00018	0.527
LIG_SH3_3	515	521	PF00018	0.616
LIG_SH3_3	522	528	PF00018	0.615
LIG_SH3_3	6	12	PF00018	0.576
LIG_SUMO_SIM_anti_2	208	214	PF11976	0.581
LIG_TRAF2_2	21	26	PF00917	0.482
LIG_WRC_WIRS_1	80	85	PF05994	0.656
MOD_CDK_SPK_2	325	330	PF00069	0.540
MOD_CK1_1	115	121	PF00069	0.673
MOD_CK1_1	125	131	PF00069	0.645
MOD_CK1_1	165	171	PF00069	0.773
MOD_CK1_1	262	268	PF00069	0.596
MOD_CK1_1	281	287	PF00069	0.468
MOD_CK1_1	35	41	PF00069	0.632
MOD_CK1_1	394	400	PF00069	0.663
MOD_CK1_1	408	414	PF00069	0.604
MOD_CK1_1	417	423	PF00069	0.596
MOD_CK1_1	425	431	PF00069	0.600
MOD_CK1_1	460	466	PF00069	0.672
MOD_CK1_1	482	488	PF00069	0.629
MOD_CK1_1	55	61	PF00069	0.701
MOD_CK1_1	558	564	PF00069	0.531
MOD_CK2_1	478	484	PF00069	0.639
MOD_GlcNHglycan	153	156	PF01048	0.568
MOD_GlcNHglycan	164	167	PF01048	0.610
MOD_GlcNHglycan	231	234	PF01048	0.282
MOD_GlcNHglycan	240	243	PF01048	0.282
MOD_GlcNHglycan	280	283	PF01048	0.282
MOD_GlcNHglycan	305	309	PF01048	0.505
MOD_GlcNHglycan	34	37	PF01048	0.628
MOD_GlcNHglycan	370	373	PF01048	0.712
MOD_GlcNHglycan	449	452	PF01048	0.739
MOD_GlcNHglycan	486	489	PF01048	0.734
MOD_GlcNHglycan	492	495	PF01048	0.635
MOD_GlcNHglycan	548	551	PF01048	0.682
MOD_GlcNHglycan	557	560	PF01048	0.604
MOD_GlcNHglycan	561	564	PF01048	0.594
MOD_GlcNHglycan	572	575	PF01048	0.647
MOD_GlcNHglycan	68	71	PF01048	0.649
MOD_GSK3_1	106	113	PF00069	0.583
MOD_GSK3_1	114	121	PF00069	0.628
MOD_GSK3_1	124	131	PF00069	0.577
MOD_GSK3_1	161	168	PF00069	0.615
MOD_GSK3_1	176	183	PF00069	0.733
MOD_GSK3_1	259	266	PF00069	0.441
MOD_GSK3_1	281	288	PF00069	0.482
MOD_GSK3_1	321	328	PF00069	0.620
MOD_GSK3_1	341	348	PF00069	0.663
MOD_GSK3_1	35	42	PF00069	0.676
MOD_GSK3_1	378	385	PF00069	0.682
MOD_GSK3_1	387	394	PF00069	0.625
MOD_GSK3_1	405	412	PF00069	0.674
MOD_GSK3_1	413	420	PF00069	0.580
MOD_GSK3_1	424	431	PF00069	0.602
MOD_GSK3_1	462	469	PF00069	0.670
MOD_GSK3_1	470	477	PF00069	0.674
MOD_GSK3_1	478	485	PF00069	0.713
MOD_GSK3_1	54	61	PF00069	0.501
MOD_GSK3_1	554	561	PF00069	0.707
MOD_GSK3_1	562	569	PF00069	0.563
MOD_GSK3_1	75	82	PF00069	0.598
MOD_N-GLC_1	115	120	PF02516	0.598
MOD_N-GLC_1	168	173	PF02516	0.607
MOD_N-GLC_1	319	324	PF02516	0.600
MOD_N-GLC_1	405	410	PF02516	0.675
MOD_N-GLC_1	425	430	PF02516	0.463
MOD_N-GLC_1	555	560	PF02516	0.573
MOD_N-GLC_1	570	575	PF02516	0.527
MOD_N-GLC_1	584	589	PF02516	0.662
MOD_N-GLC_1	97	102	PF02516	0.685
MOD_N-GLC_2	283	285	PF02516	0.386
MOD_N-GLC_2	533	535	PF02516	0.520
MOD_NEK2_1	1	6	PF00069	0.580
MOD_NEK2_1	112	117	PF00069	0.634
MOD_NEK2_1	16	21	PF00069	0.514
MOD_NEK2_1	188	193	PF00069	0.522
MOD_NEK2_1	413	418	PF00069	0.609
MOD_NEK2_1	462	467	PF00069	0.739
MOD_NEK2_1	492	497	PF00069	0.690
MOD_NEK2_1	555	560	PF00069	0.597
MOD_NEK2_1	564	569	PF00069	0.592
MOD_NEK2_1	79	84	PF00069	0.657
MOD_NEK2_1	97	102	PF00069	0.752
MOD_NEK2_2	387	392	PF00069	0.562
MOD_NEK2_2	75	80	PF00069	0.659
MOD_PIKK_1	189	195	PF00454	0.550
MOD_PIKK_1	314	320	PF00454	0.592
MOD_PIKK_1	492	498	PF00454	0.605
MOD_PKA_1	176	182	PF00069	0.524
MOD_PKA_2	176	182	PF00069	0.638
MOD_PKA_2	188	194	PF00069	0.556
MOD_PKA_2	238	244	PF00069	0.482
MOD_PKB_1	319	327	PF00069	0.607
MOD_Plk_1	405	411	PF00069	0.567
MOD_Plk_1	425	431	PF00069	0.637
MOD_Plk_4	129	135	PF00069	0.532
MOD_Plk_4	195	201	PF00069	0.510
MOD_Plk_4	26	32	PF00069	0.500
MOD_Plk_4	39	45	PF00069	0.503
MOD_Plk_4	397	403	PF00069	0.586
MOD_Plk_4	417	423	PF00069	0.688
MOD_Plk_4	425	431	PF00069	0.603
MOD_Plk_4	457	463	PF00069	0.712
MOD_Plk_4	55	61	PF00069	0.539
MOD_Plk_4	75	81	PF00069	0.544
MOD_ProDKin_1	106	112	PF00069	0.697
MOD_ProDKin_1	125	131	PF00069	0.699
MOD_ProDKin_1	149	155	PF00069	0.575
MOD_ProDKin_1	325	331	PF00069	0.625
MOD_ProDKin_1	341	347	PF00069	0.636
MOD_ProDKin_1	351	357	PF00069	0.688
MOD_ProDKin_1	376	382	PF00069	0.590
MOD_ProDKin_1	415	421	PF00069	0.606
MOD_ProDKin_1	43	49	PF00069	0.625
MOD_ProDKin_1	471	477	PF00069	0.679
MOD_ProDKin_1	502	508	PF00069	0.562
MOD_ProDKin_1	8	14	PF00069	0.554
TRG_ENDOCYTIC_2	17	20	PF00928	0.544
TRG_ENDOCYTIC_2	541	544	PF00928	0.599
TRG_ENDOCYTIC_2	80	83	PF00928	0.658
TRG_ER_diArg_1	176	178	PF00400	0.524
TRG_ER_diArg_1	301	303	PF00400	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEZ5	Leptomonas seymouri	45%	91%
A0A3S7WXP3	Leishmania donovani	77%	100%
A4I0C3	Leishmania infantum	77%	100%
E9AW87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QB91	Leishmania major	78%	100%