Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HCT7_LEIBR

TriTrypDb:

LbrM.23.0760 , LBRM2903_230016300

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCT7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.582
CLV_C14_Caspase3-7	696	700	PF00656	0.633
CLV_MEL_PAP_1	33	39	PF00089	0.513
CLV_NRD_NRD_1	218	220	PF00675	0.749
CLV_NRD_NRD_1	229	231	PF00675	0.416
CLV_NRD_NRD_1	236	238	PF00675	0.613
CLV_NRD_NRD_1	241	243	PF00675	0.628
CLV_NRD_NRD_1	422	424	PF00675	0.581
CLV_NRD_NRD_1	54	56	PF00675	0.551
CLV_PCSK_KEX2_1	207	209	PF00082	0.607
CLV_PCSK_KEX2_1	218	220	PF00082	0.515
CLV_PCSK_KEX2_1	236	238	PF00082	0.681
CLV_PCSK_KEX2_1	241	243	PF00082	0.648
CLV_PCSK_KEX2_1	422	424	PF00082	0.581
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.607
CLV_PCSK_PC7_1	237	243	PF00082	0.542
CLV_PCSK_SKI1_1	165	169	PF00082	0.480
CLV_PCSK_SKI1_1	207	211	PF00082	0.541
CLV_PCSK_SKI1_1	236	240	PF00082	0.643
CLV_PCSK_SKI1_1	260	264	PF00082	0.685
CLV_PCSK_SKI1_1	504	508	PF00082	0.570
CLV_PCSK_SKI1_1	582	586	PF00082	0.673
CLV_PCSK_SKI1_1	95	99	PF00082	0.533
DEG_APCC_DBOX_1	164	172	PF00400	0.473
DEG_APCC_DBOX_1	708	716	PF00400	0.432
DEG_SCF_FBW7_1	319	326	PF00400	0.676
DEG_SPOP_SBC_1	107	111	PF00917	0.646
DEG_SPOP_SBC_1	516	520	PF00917	0.546
DEG_SPOP_SBC_1	63	67	PF00917	0.645
DOC_CKS1_1	328	333	PF01111	0.549
DOC_CKS1_1	529	534	PF01111	0.567
DOC_CYCLIN_RxL_1	92	102	PF00134	0.488
DOC_MAPK_gen_1	595	604	PF00069	0.629
DOC_MAPK_JIP1_4	463	469	PF00069	0.496
DOC_MAPK_MEF2A_6	28	37	PF00069	0.657
DOC_MAPK_MEF2A_6	463	471	PF00069	0.491
DOC_MAPK_MEF2A_6	709	717	PF00069	0.434
DOC_PP1_RVXF_1	6	13	PF00149	0.618
DOC_PP2B_LxvP_1	550	553	PF13499	0.512
DOC_PP4_FxxP_1	93	96	PF00568	0.476
DOC_USP7_MATH_1	107	111	PF00917	0.679
DOC_USP7_MATH_1	18	22	PF00917	0.575
DOC_USP7_MATH_1	274	278	PF00917	0.577
DOC_USP7_MATH_1	386	390	PF00917	0.608
DOC_USP7_MATH_1	445	449	PF00917	0.509
DOC_USP7_MATH_1	515	519	PF00917	0.653
DOC_USP7_MATH_1	563	567	PF00917	0.570
DOC_USP7_MATH_1	575	579	PF00917	0.640
DOC_USP7_MATH_1	63	67	PF00917	0.537
DOC_USP7_MATH_1	630	634	PF00917	0.534
DOC_USP7_MATH_1	643	647	PF00917	0.494
DOC_USP7_MATH_1	70	74	PF00917	0.568
DOC_USP7_UBL2_3	203	207	PF12436	0.611
DOC_USP7_UBL2_3	339	343	PF12436	0.627
DOC_WW_Pin1_4	127	132	PF00397	0.667
DOC_WW_Pin1_4	244	249	PF00397	0.668
DOC_WW_Pin1_4	319	324	PF00397	0.672
DOC_WW_Pin1_4	327	332	PF00397	0.617
DOC_WW_Pin1_4	479	484	PF00397	0.535
DOC_WW_Pin1_4	521	526	PF00397	0.660
DOC_WW_Pin1_4	528	533	PF00397	0.588
DOC_WW_Pin1_4	538	543	PF00397	0.542
DOC_WW_Pin1_4	628	633	PF00397	0.624
DOC_WW_Pin1_4	679	684	PF00397	0.529
LIG_14-3-3_CanoR_1	218	226	PF00244	0.522
LIG_14-3-3_CanoR_1	230	234	PF00244	0.419
LIG_14-3-3_CanoR_1	265	273	PF00244	0.607
LIG_14-3-3_CanoR_1	36	44	PF00244	0.514
LIG_14-3-3_CanoR_1	55	64	PF00244	0.612
LIG_14-3-3_CanoR_1	582	591	PF00244	0.655
LIG_Actin_WH2_2	280	298	PF00022	0.641
LIG_APCC_ABBAyCdc20_2	376	382	PF00400	0.485
LIG_BIR_II_1	1	5	PF00653	0.465
LIG_BIR_III_3	1	5	PF00653	0.465
LIG_BIR_III_4	297	301	PF00653	0.673
LIG_BRCT_BRCA1_1	540	544	PF00533	0.530
LIG_CaM_IQ_9	491	506	PF13499	0.485
LIG_FHA_1	164	170	PF00498	0.403
LIG_FHA_1	266	272	PF00498	0.538
LIG_FHA_1	43	49	PF00498	0.536
LIG_FHA_1	501	507	PF00498	0.762
LIG_FHA_1	541	547	PF00498	0.577
LIG_FHA_1	559	565	PF00498	0.549
LIG_FHA_1	583	589	PF00498	0.718
LIG_FHA_1	624	630	PF00498	0.545
LIG_FHA_1	63	69	PF00498	0.568
LIG_FHA_2	292	298	PF00498	0.507
LIG_FHA_2	324	330	PF00498	0.595
LIG_FHA_2	409	415	PF00498	0.528
LIG_FHA_2	442	448	PF00498	0.581
LIG_LIR_Apic_2	409	413	PF02991	0.525
LIG_LIR_Apic_2	91	96	PF02991	0.478
LIG_LIR_Gen_1	261	271	PF02991	0.743
LIG_LIR_Gen_1	282	291	PF02991	0.617
LIG_LIR_Gen_1	395	405	PF02991	0.508
LIG_LIR_Gen_1	615	623	PF02991	0.628
LIG_LIR_Gen_1	88	98	PF02991	0.555
LIG_LIR_Nem_3	261	266	PF02991	0.745
LIG_LIR_Nem_3	395	401	PF02991	0.509
LIG_LIR_Nem_3	436	441	PF02991	0.609
LIG_LIR_Nem_3	615	619	PF02991	0.648
LIG_LIR_Nem_3	640	644	PF02991	0.685
LIG_LIR_Nem_3	88	93	PF02991	0.550
LIG_NRBOX	167	173	PF00104	0.540
LIG_SH2_CRK	13	17	PF00017	0.566
LIG_SH2_GRB2like	648	651	PF00017	0.662
LIG_SH2_GRB2like	663	666	PF00017	0.502
LIG_SH2_STAT3	492	495	PF00017	0.495
LIG_SH2_STAT5	151	154	PF00017	0.601
LIG_SH2_STAT5	466	469	PF00017	0.513
LIG_SH2_STAT5	492	495	PF00017	0.495
LIG_SH2_STAT5	648	651	PF00017	0.516
LIG_SH3_1	343	349	PF00018	0.597
LIG_SH3_3	328	334	PF00018	0.570
LIG_SH3_3	343	349	PF00018	0.585
LIG_SH3_3	38	44	PF00018	0.601
LIG_SH3_3	506	512	PF00018	0.587
LIG_SH3_3	522	528	PF00018	0.637
LIG_SH3_4	203	210	PF00018	0.610
LIG_SUMO_SIM_anti_2	145	151	PF11976	0.525
LIG_SUMO_SIM_anti_2	399	405	PF11976	0.571
LIG_UBA3_1	168	176	PF00899	0.650
MOD_CDK_SPxxK_3	628	635	PF00069	0.537
MOD_CK1_1	102	108	PF00069	0.653
MOD_CK1_1	110	116	PF00069	0.626
MOD_CK1_1	139	145	PF00069	0.620
MOD_CK1_1	185	191	PF00069	0.448
MOD_CK1_1	247	253	PF00069	0.648
MOD_CK1_1	261	267	PF00069	0.784
MOD_CK1_1	311	317	PF00069	0.611
MOD_CK1_1	378	384	PF00069	0.709
MOD_CK1_1	458	464	PF00069	0.480
MOD_CK1_1	524	530	PF00069	0.649
MOD_CK1_1	54	60	PF00069	0.620
MOD_CK1_1	554	560	PF00069	0.565
MOD_CK1_1	566	572	PF00069	0.543
MOD_CK1_1	589	595	PF00069	0.691
MOD_CK1_1	631	637	PF00069	0.649
MOD_CK1_1	646	652	PF00069	0.493
MOD_CK1_1	682	688	PF00069	0.565
MOD_CK1_1	689	695	PF00069	0.632
MOD_CK1_1	73	79	PF00069	0.633
MOD_CK2_1	441	447	PF00069	0.579
MOD_Cter_Amidation	239	242	PF01082	0.545
MOD_GlcNHglycan	101	104	PF01048	0.581
MOD_GlcNHglycan	110	113	PF01048	0.568
MOD_GlcNHglycan	120	123	PF01048	0.695
MOD_GlcNHglycan	138	141	PF01048	0.535
MOD_GlcNHglycan	184	187	PF01048	0.530
MOD_GlcNHglycan	20	23	PF01048	0.597
MOD_GlcNHglycan	221	224	PF01048	0.497
MOD_GlcNHglycan	301	304	PF01048	0.798
MOD_GlcNHglycan	382	386	PF01048	0.565
MOD_GlcNHglycan	447	450	PF01048	0.623
MOD_GlcNHglycan	475	478	PF01048	0.503
MOD_GlcNHglycan	565	568	PF01048	0.630
MOD_GlcNHglycan	591	594	PF01048	0.686
MOD_GlcNHglycan	60	63	PF01048	0.634
MOD_GlcNHglycan	688	691	PF01048	0.609
MOD_GlcNHglycan	693	696	PF01048	0.574
MOD_GlcNHglycan	70	73	PF01048	0.560
MOD_GlcNHglycan	722	725	PF01048	0.523
MOD_GSK3_1	102	109	PF00069	0.604
MOD_GSK3_1	125	132	PF00069	0.634
MOD_GSK3_1	261	268	PF00069	0.566
MOD_GSK3_1	286	293	PF00069	0.644
MOD_GSK3_1	299	306	PF00069	0.542
MOD_GSK3_1	307	314	PF00069	0.616
MOD_GSK3_1	317	324	PF00069	0.595
MOD_GSK3_1	441	448	PF00069	0.558
MOD_GSK3_1	451	458	PF00069	0.543
MOD_GSK3_1	475	482	PF00069	0.553
MOD_GSK3_1	51	58	PF00069	0.796
MOD_GSK3_1	517	524	PF00069	0.640
MOD_GSK3_1	540	547	PF00069	0.650
MOD_GSK3_1	551	558	PF00069	0.540
MOD_GSK3_1	559	566	PF00069	0.607
MOD_GSK3_1	582	589	PF00069	0.627
MOD_GSK3_1	64	71	PF00069	0.748
MOD_GSK3_1	679	686	PF00069	0.528
MOD_N-GLC_1	479	484	PF02516	0.515
MOD_N-GLC_1	623	628	PF02516	0.679
MOD_NEK2_1	108	113	PF00069	0.656
MOD_NEK2_1	229	234	PF00069	0.602
MOD_NEK2_1	286	291	PF00069	0.574
MOD_NEK2_1	408	413	PF00069	0.519
MOD_NEK2_1	467	472	PF00069	0.575
MOD_NEK2_1	494	499	PF00069	0.622
MOD_NEK2_1	544	549	PF00069	0.581
MOD_NEK2_1	555	560	PF00069	0.583
MOD_NEK2_1	623	628	PF00069	0.612
MOD_NEK2_1	97	102	PF00069	0.505
MOD_NEK2_2	258	263	PF00069	0.521
MOD_NEK2_2	279	284	PF00069	0.633
MOD_NEK2_2	375	380	PF00069	0.487
MOD_PIKK_1	582	588	PF00454	0.606
MOD_PIKK_1	618	624	PF00454	0.654
MOD_PKA_1	236	242	PF00069	0.686
MOD_PKA_1	55	61	PF00069	0.611
MOD_PKA_2	229	235	PF00069	0.577
MOD_PKA_2	236	242	PF00069	0.586
MOD_PKA_2	264	270	PF00069	0.507
MOD_PKA_2	35	41	PF00069	0.514
MOD_PKA_2	375	381	PF00069	0.493
MOD_PKA_2	54	60	PF00069	0.563
MOD_PKA_2	672	678	PF00069	0.652
MOD_Plk_1	314	320	PF00069	0.623
MOD_Plk_1	586	592	PF00069	0.609
MOD_Plk_1	600	606	PF00069	0.618
MOD_Plk_4	139	145	PF00069	0.647
MOD_Plk_4	267	273	PF00069	0.504
MOD_Plk_4	375	381	PF00069	0.506
MOD_Plk_4	64	70	PF00069	0.657
MOD_Plk_4	643	649	PF00069	0.528
MOD_ProDKin_1	127	133	PF00069	0.669
MOD_ProDKin_1	244	250	PF00069	0.667
MOD_ProDKin_1	319	325	PF00069	0.673
MOD_ProDKin_1	327	333	PF00069	0.618
MOD_ProDKin_1	479	485	PF00069	0.534
MOD_ProDKin_1	521	527	PF00069	0.660
MOD_ProDKin_1	528	534	PF00069	0.588
MOD_ProDKin_1	538	544	PF00069	0.541
MOD_ProDKin_1	628	634	PF00069	0.623
MOD_ProDKin_1	679	685	PF00069	0.528
MOD_SUMO_rev_2	20	30	PF00179	0.513
TRG_DiLeu_BaEn_1	148	153	PF01217	0.579
TRG_DiLeu_BaEn_4	486	492	PF01217	0.504
TRG_DiLeu_BaLyEn_6	509	514	PF01217	0.594
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.481
TRG_ENDOCYTIC_2	438	441	PF00928	0.556
TRG_ENDOCYTIC_2	466	469	PF00928	0.513
TRG_ER_diArg_1	235	237	PF00400	0.668
TRG_ER_diArg_1	421	423	PF00400	0.556
TRG_ER_diArg_1	670	673	PF00400	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I942	Leptomonas seymouri	39%	80%
A0A3S7WXM2	Leishmania donovani	71%	82%
A4I0B7	Leishmania infantum	71%	82%
E9AW81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	82%
Q9U0V6	Leishmania major	70%	100%