Putative spliceosomal U5 snRNP-specific protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

spliceosomal U5 snRNP-specific protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCT6_LEIBR

TriTrypDb:

LbrM.23.0750 , LBRM2903_230016200

Length:

217

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0030532	small nuclear ribonucleoprotein complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	10
GO:0097525	spliceosomal snRNP complex	4	10
GO:0097526	spliceosomal tri-snRNP complex	5	10
GO:0120114	Sm-like protein family complex	2	10
GO:0140513	nuclear protein-containing complex	2	10
GO:1990904	ribonucleoprotein complex	2	10
GO:0005681	spliceosomal complex	3	1
GO:0005682	U5 snRNP	5	4

Expansion

Sequence features

A4HCT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCT6

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	10
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	10
GO:0000398	mRNA splicing, via spliceosome	8	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006397	mRNA processing	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0008380	RNA splicing	7	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016071	mRNA metabolic process	6	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	26	32	PF00089	0.327
CLV_NRD_NRD_1	207	209	PF00675	0.475
CLV_NRD_NRD_1	72	74	PF00675	0.692
CLV_PCSK_KEX2_1	76	78	PF00082	0.692
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.692
CLV_PCSK_SKI1_1	134	138	PF00082	0.405
CLV_PCSK_SKI1_1	24	28	PF00082	0.324
CLV_PCSK_SKI1_1	86	90	PF00082	0.420
DEG_ODPH_VHL_1	118	130	PF01847	0.350
DEG_SPOP_SBC_1	64	68	PF00917	0.520
DOC_MAPK_gen_1	121	130	PF00069	0.405
DOC_MAPK_gen_1	159	167	PF00069	0.401
DOC_MAPK_gen_1	208	215	PF00069	0.525
DOC_MAPK_MEF2A_6	159	167	PF00069	0.296
DOC_PP1_RVXF_1	172	178	PF00149	0.285
DOC_USP7_MATH_1	51	55	PF00917	0.648
DOC_USP7_MATH_1	64	68	PF00917	0.609
LIG_14-3-3_CanoR_1	201	210	PF00244	0.401
LIG_14-3-3_CanoR_1	29	34	PF00244	0.395
LIG_14-3-3_CanoR_1	45	51	PF00244	0.587
LIG_14-3-3_CanoR_1	86	92	PF00244	0.411
LIG_AP2alpha_2	150	152	PF02296	0.405
LIG_BIR_III_4	79	83	PF00653	0.623
LIG_FHA_1	131	137	PF00498	0.327
LIG_FHA_1	210	216	PF00498	0.448
LIG_FHA_2	32	38	PF00498	0.470
LIG_FHA_2	55	61	PF00498	0.651
LIG_LIR_Gen_1	137	145	PF02991	0.342
LIG_LIR_Gen_1	150	158	PF02991	0.359
LIG_LIR_Gen_1	181	192	PF02991	0.401
LIG_LIR_Gen_1	207	215	PF02991	0.534
LIG_LIR_Nem_3	137	142	PF02991	0.417
LIG_LIR_Nem_3	181	187	PF02991	0.401
LIG_LIR_Nem_3	207	213	PF02991	0.529
LIG_NRP_CendR_1	216	217	PF00754	0.516
LIG_SH2_CRK	184	188	PF00017	0.401
LIG_SH2_NCK_1	33	37	PF00017	0.577
LIG_SH2_STAT5	105	108	PF00017	0.452
LIG_SH2_STAT5	125	128	PF00017	0.267
LIG_SH2_STAT5	129	132	PF00017	0.316
LIG_SH2_STAT5	33	36	PF00017	0.562
LIG_SUMO_SIM_anti_2	23	29	PF11976	0.338
LIG_SUMO_SIM_par_1	2	9	PF11976	0.514
LIG_UBA3_1	114	121	PF00899	0.352
MOD_CK1_1	202	208	PF00069	0.383
MOD_CK1_1	31	37	PF00069	0.558
MOD_CK1_1	44	50	PF00069	0.700
MOD_CK1_1	54	60	PF00069	0.716
MOD_CK1_1	62	68	PF00069	0.727
MOD_CK2_1	31	37	PF00069	0.350
MOD_CK2_1	54	60	PF00069	0.734
MOD_GlcNHglycan	20	23	PF01048	0.469
MOD_GlcNHglycan	34	37	PF01048	0.371
MOD_GlcNHglycan	53	56	PF01048	0.575
MOD_GlcNHglycan	67	70	PF01048	0.734
MOD_GlcNHglycan	8	11	PF01048	0.382
MOD_GSK3_1	130	137	PF00069	0.421
MOD_GSK3_1	28	35	PF00069	0.409
MOD_GSK3_1	49	56	PF00069	0.671
MOD_GSK3_1	59	66	PF00069	0.694
MOD_NEK2_1	63	68	PF00069	0.518
MOD_NEK2_1	96	101	PF00069	0.435
MOD_PIKK_1	44	50	PF00454	0.580
MOD_PKA_1	208	214	PF00069	0.408
MOD_PKA_2	28	34	PF00069	0.392
MOD_PKA_2	44	50	PF00069	0.581
MOD_Plk_1	134	140	PF00069	0.405
MOD_Plk_4	124	130	PF00069	0.372
MOD_SUMO_rev_2	202	211	PF00179	0.296
TRG_ENDOCYTIC_2	125	128	PF00928	0.290
TRG_ENDOCYTIC_2	184	187	PF00928	0.401
TRG_ER_diArg_1	106	109	PF00400	0.499
TRG_ER_diArg_1	158	161	PF00400	0.405
TRG_ER_diArg_1	215	217	PF00400	0.484
TRG_ER_FFAT_2	31	39	PF00635	0.525
TRG_NLS_MonoExtC_3	72	77	PF00514	0.692

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILU9	Leptomonas seymouri	68%	100%
A0A1X0NWY8	Trypanosomatidae	49%	100%
A0A3R7KYL3	Trypanosoma rangeli	46%	100%
A0A3S7WXR3	Leishmania donovani	83%	100%
A4I0B6	Leishmania infantum	83%	100%
C9ZV19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AW80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q9U0V5	Leishmania major	83%	100%