Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin-C

Species:

Leishmania braziliensis

UniProt:

A4HCT2_LEIBR

TriTrypDb:

LbrM.23.0710 , LBRM2903_230014800

Length:

720

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 20

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 31
NetGPI	no	yes: 0, no: 31

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	25
GO:0099080	supramolecular complex	2	25
GO:0099081	supramolecular polymer	3	25
GO:0099512	supramolecular fiber	4	25
GO:0099513	polymeric cytoskeletal fiber	5	25
GO:0110165	cellular anatomical entity	1	25
GO:0005871	kinesin complex	3	3
GO:0005875	microtubule associated complex	2	3
GO:0032991	protein-containing complex	1	3
GO:0005737	cytoplasm	2	3
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0051286	cell tip	3	3
GO:0060187	cell pole	2	3
GO:0097542	ciliary tip	2	1

Expansion

Sequence features

A4HCT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCT2

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	32
GO:0007018	microtubule-based movement	3	32
GO:0009987	cellular process	1	32
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0000902	cell morphogenesis	3	1
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0009653	anatomical structure morphogenesis	2	1
GO:0016043	cellular component organization	3	2
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0030865	cortical cytoskeleton organization	6	1
GO:0031122	cytoplasmic microtubule organization	4	1
GO:0032502	developmental process	1	1
GO:0043622	cortical microtubule organization	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071840	cellular component organization or biogenesis	2	2
GO:0097435	supramolecular fiber organization	4	2
GO:0007019	microtubule depolymerization	5	1
GO:0022411	cellular component disassembly	4	1
GO:0031109	microtubule polymerization or depolymerization	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0051261	protein depolymerization	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	32
GO:0003774	cytoskeletal motor activity	1	32
GO:0003777	microtubule motor activity	2	32
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	32
GO:0005515	protein binding	2	32
GO:0005524	ATP binding	5	32
GO:0008017	microtubule binding	5	32
GO:0008092	cytoskeletal protein binding	3	32
GO:0015631	tubulin binding	4	32
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	32
GO:0030554	adenyl nucleotide binding	5	32
GO:0032553	ribonucleotide binding	3	32
GO:0032555	purine ribonucleotide binding	4	32
GO:0032559	adenyl ribonucleotide binding	5	32
GO:0035639	purine ribonucleoside triphosphate binding	4	32
GO:0036094	small molecule binding	2	32
GO:0043167	ion binding	2	32
GO:0043168	anion binding	3	32
GO:0097159	organic cyclic compound binding	2	32
GO:0097367	carbohydrate derivative binding	2	32
GO:0140657	ATP-dependent activity	1	32
GO:1901265	nucleoside phosphate binding	3	32
GO:1901363	heterocyclic compound binding	2	32
GO:0016462	pyrophosphatase activity	5	3
GO:0016817	hydrolase activity, acting on acid anhydrides	3	3
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	3
GO:0016887	ATP hydrolysis activity	7	3
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.523
CLV_C14_Caspase3-7	552	556	PF00656	0.492
CLV_MEL_PAP_1	181	187	PF00089	0.285
CLV_NRD_NRD_1	360	362	PF00675	0.290
CLV_NRD_NRD_1	4	6	PF00675	0.560
CLV_NRD_NRD_1	608	610	PF00675	0.604
CLV_NRD_NRD_1	614	616	PF00675	0.609
CLV_NRD_NRD_1	643	645	PF00675	0.449
CLV_NRD_NRD_1	70	72	PF00675	0.307
CLV_NRD_NRD_1	714	716	PF00675	0.518
CLV_PCSK_KEX2_1	10	12	PF00082	0.549
CLV_PCSK_KEX2_1	360	362	PF00082	0.248
CLV_PCSK_KEX2_1	384	386	PF00082	0.375
CLV_PCSK_KEX2_1	4	6	PF00082	0.557
CLV_PCSK_KEX2_1	603	605	PF00082	0.568
CLV_PCSK_KEX2_1	607	609	PF00082	0.570
CLV_PCSK_KEX2_1	614	616	PF00082	0.537
CLV_PCSK_KEX2_1	634	636	PF00082	0.509
CLV_PCSK_KEX2_1	643	645	PF00082	0.430
CLV_PCSK_KEX2_1	70	72	PF00082	0.296
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.616
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.277
CLV_PCSK_PC1ET2_1	603	605	PF00082	0.496
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.588
CLV_PCSK_PC7_1	604	610	PF00082	0.620
CLV_PCSK_SKI1_1	227	231	PF00082	0.357
CLV_PCSK_SKI1_1	316	320	PF00082	0.288
CLV_PCSK_SKI1_1	500	504	PF00082	0.483
CLV_PCSK_SKI1_1	520	524	PF00082	0.575
CLV_PCSK_SKI1_1	531	535	PF00082	0.524
CLV_PCSK_SKI1_1	715	719	PF00082	0.542
CLV_PCSK_SKI1_1	80	84	PF00082	0.299
CLV_Separin_Metazoa	626	630	PF03568	0.611
CLV_Separin_Metazoa	702	706	PF03568	0.423
DEG_APCC_DBOX_1	327	335	PF00400	0.254
DEG_APCC_DBOX_1	474	482	PF00400	0.553
DEG_APCC_DBOX_1	576	584	PF00400	0.443
DOC_MAPK_gen_1	211	218	PF00069	0.258
DOC_MAPK_gen_1	440	447	PF00069	0.355
DOC_MAPK_gen_1	517	525	PF00069	0.513
DOC_MAPK_MEF2A_6	184	193	PF00069	0.313
DOC_MAPK_MEF2A_6	211	218	PF00069	0.254
DOC_MAPK_MEF2A_6	389	396	PF00069	0.262
DOC_PP4_FxxP_1	19	22	PF00568	0.639
DOC_USP7_MATH_1	169	173	PF00917	0.325
DOC_USP7_MATH_1	183	187	PF00917	0.323
DOC_WW_Pin1_4	202	207	PF00397	0.255
DOC_WW_Pin1_4	4	9	PF00397	0.629
DOC_WW_Pin1_4	419	424	PF00397	0.342
LIG_14-3-3_CanoR_1	11	19	PF00244	0.644
LIG_14-3-3_CanoR_1	110	116	PF00244	0.319
LIG_14-3-3_CanoR_1	204	210	PF00244	0.408
LIG_14-3-3_CanoR_1	283	290	PF00244	0.340
LIG_14-3-3_CanoR_1	41	48	PF00244	0.432
LIG_14-3-3_CanoR_1	414	418	PF00244	0.330
LIG_14-3-3_CanoR_1	442	448	PF00244	0.391
LIG_14-3-3_CanoR_1	705	711	PF00244	0.549
LIG_Actin_WH2_2	219	237	PF00022	0.272
LIG_APCC_ABBA_1	219	224	PF00400	0.315
LIG_BRCT_BRCA1_1	253	257	PF00533	0.349
LIG_Clathr_ClatBox_1	677	681	PF01394	0.370
LIG_deltaCOP1_diTrp_1	88	96	PF00928	0.322
LIG_FHA_1	106	112	PF00498	0.288
LIG_FHA_1	352	358	PF00498	0.367
LIG_FHA_1	400	406	PF00498	0.331
LIG_FHA_1	413	419	PF00498	0.327
LIG_FHA_1	497	503	PF00498	0.606
LIG_FHA_1	77	83	PF00498	0.254
LIG_FHA_2	112	118	PF00498	0.282
LIG_FHA_2	123	129	PF00498	0.351
LIG_FHA_2	215	221	PF00498	0.259
LIG_FHA_2	25	31	PF00498	0.507
LIG_FHA_2	260	266	PF00498	0.397
LIG_FHA_2	686	692	PF00498	0.406
LIG_LIR_Apic_2	101	106	PF02991	0.262
LIG_LIR_Apic_2	17	22	PF02991	0.571
LIG_LIR_Apic_2	251	256	PF02991	0.285
LIG_LIR_Apic_2	314	320	PF02991	0.209
LIG_LIR_Gen_1	128	138	PF02991	0.347
LIG_LIR_Gen_1	160	169	PF02991	0.319
LIG_LIR_Gen_1	188	197	PF02991	0.274
LIG_LIR_Gen_1	215	226	PF02991	0.266
LIG_LIR_Gen_1	528	535	PF02991	0.453
LIG_LIR_Gen_1	542	551	PF02991	0.396
LIG_LIR_Gen_1	698	707	PF02991	0.427
LIG_LIR_Nem_3	128	133	PF02991	0.335
LIG_LIR_Nem_3	188	193	PF02991	0.274
LIG_LIR_Nem_3	215	221	PF02991	0.311
LIG_LIR_Nem_3	46	51	PF02991	0.334
LIG_LIR_Nem_3	528	532	PF02991	0.565
LIG_LIR_Nem_3	542	548	PF02991	0.549
LIG_LIR_Nem_3	698	704	PF02991	0.630
LIG_NRBOX	400	406	PF00104	0.307
LIG_NRBOX	501	507	PF00104	0.389
LIG_PCNA_yPIPBox_3	119	133	PF02747	0.278
LIG_PTB_Apo_2	184	191	PF02174	0.272
LIG_Rb_pABgroove_1	161	169	PF01858	0.418
LIG_SH2_CRK	130	134	PF00017	0.335
LIG_SH2_CRK	253	257	PF00017	0.278
LIG_SH2_CRK	317	321	PF00017	0.272
LIG_SH2_NCK_1	130	134	PF00017	0.254
LIG_SH2_NCK_1	317	321	PF00017	0.302
LIG_SH2_STAP1	541	545	PF00017	0.568
LIG_SH2_STAP1	597	601	PF00017	0.586
LIG_SH2_STAT3	123	126	PF00017	0.302
LIG_SH2_STAT3	541	544	PF00017	0.362
LIG_SH2_STAT5	161	164	PF00017	0.342
LIG_SH2_STAT5	345	348	PF00017	0.294
LIG_SH2_STAT5	428	431	PF00017	0.255
LIG_SH3_1	389	395	PF00018	0.272
LIG_SH3_2	392	397	PF14604	0.272
LIG_SH3_3	306	312	PF00018	0.194
LIG_SH3_3	389	395	PF00018	0.247
LIG_SUMO_SIM_par_1	664	670	PF11976	0.660
LIG_SUMO_SIM_par_1	78	85	PF11976	0.249
LIG_TRAF2_1	487	490	PF00917	0.630
LIG_TRAF2_1	576	579	PF00917	0.451
LIG_UBA3_1	189	194	PF00899	0.256
LIG_WRC_WIRS_1	112	117	PF05994	0.285
LIG_WRC_WIRS_1	319	324	PF05994	0.297
LIG_WRC_WIRS_1	45	50	PF05994	0.433
MOD_CDK_SPK_2	4	9	PF00069	0.782
MOD_CDK_SPxK_1	4	10	PF00069	0.718
MOD_CDK_SPxxK_3	4	11	PF00069	0.656
MOD_CDK_SPxxK_3	419	426	PF00069	0.272
MOD_CK1_1	101	107	PF00069	0.300
MOD_CK1_1	157	163	PF00069	0.311
MOD_CK1_1	205	211	PF00069	0.241
MOD_CK1_1	294	300	PF00069	0.331
MOD_CK1_1	399	405	PF00069	0.331
MOD_CK1_1	43	49	PF00069	0.410
MOD_CK2_1	214	220	PF00069	0.346
MOD_CK2_1	259	265	PF00069	0.382
MOD_CK2_1	477	483	PF00069	0.474
MOD_CK2_1	685	691	PF00069	0.508
MOD_CK2_1	69	75	PF00069	0.272
MOD_CK2_1	706	712	PF00069	0.679
MOD_Cter_Amidation	382	385	PF01082	0.429
MOD_GlcNHglycan	156	159	PF01048	0.329
MOD_GlcNHglycan	253	256	PF01048	0.309
MOD_GlcNHglycan	348	351	PF01048	0.305
MOD_GlcNHglycan	549	552	PF01048	0.515
MOD_GlcNHglycan	654	658	PF01048	0.626
MOD_GSK3_1	10	17	PF00069	0.675
MOD_GSK3_1	101	108	PF00069	0.298
MOD_GSK3_1	111	118	PF00069	0.249
MOD_GSK3_1	144	151	PF00069	0.285
MOD_GSK3_1	230	237	PF00069	0.365
MOD_GSK3_1	277	284	PF00069	0.334
MOD_GSK3_1	399	406	PF00069	0.349
MOD_GSK3_1	40	47	PF00069	0.533
MOD_GSK3_1	413	420	PF00069	0.367
MOD_GSK3_1	431	438	PF00069	0.377
MOD_GSK3_1	477	484	PF00069	0.561
MOD_N-GLC_1	169	174	PF02516	0.306
MOD_N-GLC_1	291	296	PF02516	0.301
MOD_N-GLC_1	352	357	PF02516	0.352
MOD_N-GLC_1	364	369	PF02516	0.337
MOD_N-GLC_2	146	148	PF02516	0.287
MOD_NEK2_1	115	120	PF00069	0.274
MOD_NEK2_1	234	239	PF00069	0.346
MOD_NEK2_1	301	306	PF00069	0.325
MOD_NEK2_1	396	401	PF00069	0.359
MOD_NEK2_1	405	410	PF00069	0.322
MOD_NEK2_1	417	422	PF00069	0.327
MOD_NEK2_1	435	440	PF00069	0.375
MOD_NEK2_1	467	472	PF00069	0.617
MOD_NEK2_1	481	486	PF00069	0.508
MOD_NEK2_1	76	81	PF00069	0.418
MOD_NEK2_1	98	103	PF00069	0.328
MOD_PIKK_1	12	18	PF00454	0.631
MOD_PIKK_1	122	128	PF00454	0.283
MOD_PIKK_1	277	283	PF00454	0.400
MOD_PIKK_1	321	327	PF00454	0.370
MOD_PK_1	10	16	PF00069	0.538
MOD_PKA_1	10	16	PF00069	0.583
MOD_PKA_2	10	16	PF00069	0.598
MOD_PKA_2	183	189	PF00069	0.303
MOD_PKA_2	234	240	PF00069	0.325
MOD_PKA_2	277	283	PF00069	0.325
MOD_PKA_2	396	402	PF00069	0.327
MOD_PKA_2	40	46	PF00069	0.409
MOD_PKA_2	413	419	PF00069	0.327
MOD_PKA_2	481	487	PF00069	0.527
MOD_PKA_2	496	502	PF00069	0.530
MOD_PKA_2	69	75	PF00069	0.286
MOD_Plk_1	214	220	PF00069	0.341
MOD_Plk_1	352	358	PF00069	0.345
MOD_Plk_1	43	49	PF00069	0.353
MOD_Plk_1	467	473	PF00069	0.631
MOD_Plk_1	98	104	PF00069	0.288
MOD_Plk_2-3	584	590	PF00069	0.419
MOD_Plk_2-3	69	75	PF00069	0.285
MOD_Plk_4	159	165	PF00069	0.317
MOD_Plk_4	214	220	PF00069	0.385
MOD_Plk_4	301	307	PF00069	0.298
MOD_Plk_4	352	358	PF00069	0.350
MOD_Plk_4	396	402	PF00069	0.321
MOD_Plk_4	413	419	PF00069	0.428
MOD_Plk_4	443	449	PF00069	0.371
MOD_Plk_4	501	507	PF00069	0.389
MOD_Plk_4	78	84	PF00069	0.284
MOD_Plk_4	98	104	PF00069	0.256
MOD_ProDKin_1	202	208	PF00069	0.255
MOD_ProDKin_1	4	10	PF00069	0.630
MOD_ProDKin_1	419	425	PF00069	0.342
MOD_SUMO_for_1	487	490	PF00179	0.413
MOD_SUMO_for_1	58	61	PF00179	0.312
MOD_SUMO_for_1	595	598	PF00179	0.452
MOD_SUMO_rev_2	308	318	PF00179	0.227
MOD_SUMO_rev_2	573	583	PF00179	0.466
MOD_SUMO_rev_2	584	592	PF00179	0.517
MOD_SUMO_rev_2	670	678	PF00179	0.458
MOD_SUMO_rev_2	72	82	PF00179	0.207
TRG_ENDOCYTIC_2	130	133	PF00928	0.290
TRG_ENDOCYTIC_2	161	164	PF00928	0.322
TRG_ENDOCYTIC_2	535	538	PF00928	0.532
TRG_ENDOCYTIC_2	701	704	PF00928	0.429
TRG_ER_diArg_1	3	5	PF00400	0.567
TRG_ER_diArg_1	359	361	PF00400	0.247
TRG_ER_diArg_1	53	56	PF00400	0.342
TRG_ER_diArg_1	607	609	PF00400	0.657
TRG_ER_diArg_1	642	644	PF00400	0.451
TRG_NES_CRM1_1	302	314	PF08389	0.297
TRG_NLS_MonoExtN_4	8	13	PF00514	0.525
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.298
TRG_Pf-PMV_PEXEL_1	493	498	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	634	638	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	643	647	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	653	658	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.251

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A068FIK2	Gossypium hirsutum	30%	70%
A0A0N1I1K9	Leptomonas seymouri	24%	100%
A0A0N1IMQ7	Leptomonas seymouri	26%	67%
A0A0N1PDD6	Leptomonas seymouri	74%	95%
A0A0S4IR67	Bodo saltans	58%	92%
A0A0S4J2K1	Bodo saltans	32%	75%
A0A0S4JRN9	Bodo saltans	33%	100%
A0A0S4KL43	Bodo saltans	26%	100%
A0A0S4KM02	Bodo saltans	33%	71%
A0A1X0NNL3	Trypanosomatidae	30%	70%
A0A1X0NWZ8	Trypanosomatidae	63%	97%
A0A3Q8IAZ2	Leishmania donovani	82%	100%
A0A3Q8IEL2	Leishmania donovani	31%	100%
A0A3Q8IIF6	Leishmania donovani	28%	67%
A0A3R7KHX7	Trypanosoma rangeli	30%	97%
A0A3R7LER1	Trypanosoma rangeli	31%	79%
A0A3R7NW09	Trypanosoma rangeli	29%	69%
A0A3S7WY84	Leishmania donovani	32%	100%
A0A3S7X9Y1	Leishmania donovani	25%	100%
A0A422NEQ8	Trypanosoma rangeli	70%	95%
A0A422NMD1	Trypanosoma rangeli	24%	100%
A4H7S0	Leishmania braziliensis	28%	67%
A4HAQ7	Leishmania braziliensis	32%	100%
A4HDC2	Leishmania braziliensis	32%	100%
A4HND6	Leishmania braziliensis	26%	100%
A4HQ31	Leishmania braziliensis	23%	100%
A4HSA6	Leishmania infantum	28%	100%
A4I0A6	Leishmania infantum	82%	100%
A4I0Q2	Leishmania infantum	32%	100%
A4I4V3	Leishmania infantum	31%	100%
A4I9W6	Leishmania infantum	28%	67%
A4IC09	Leishmania infantum	25%	100%
C9ZTV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	81%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	96%
D0A8T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AEA0	Leishmania major	31%	100%
E9AEA1	Leishmania major	31%	100%
E9AFU7	Leishmania major	25%	100%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AW71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AWQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AXS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	67%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B6Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
F4K4C5	Arabidopsis thaliana	28%	94%
O59751	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	92%
Q0WN69	Arabidopsis thaliana	30%	70%
Q4QAR9	Leishmania major	32%	100%
Q6H638	Oryza sativa subsp. japonica	29%	81%
Q9I869	Xenopus laevis	28%	100%
Q9NF78	Leishmania major	82%	100%
Q9SCJ4	Arabidopsis thaliana	27%	89%
V5B325	Trypanosoma cruzi	32%	87%
V5B6Q5	Trypanosoma cruzi	25%	100%
V5D733	Trypanosoma cruzi	60%	96%