acidPPc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PAP2 superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4HCT0_LEIBR

TriTrypDb:

LbrM.23.0690 , LBRM2903_230014500

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	5
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HCT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCT0

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	4
GO:0006487	protein N-linked glycosylation	5	4
GO:0006629	lipid metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0019538	protein metabolic process	3	4
GO:0036211	protein modification process	4	4
GO:0043170	macromolecule metabolic process	3	4
GO:0043412	macromolecule modification	4	4
GO:0043413	macromolecule glycosylation	3	4
GO:0044238	primary metabolic process	2	4
GO:0070085	glycosylation	2	4
GO:0071704	organic substance metabolic process	2	4
GO:1901564	organonitrogen compound metabolic process	3	4
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016462	pyrophosphatase activity	5	4
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	4
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	4
GO:0047874	dolichyldiphosphatase activity	6	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	231	233	PF00675	0.433
CLV_PCSK_KEX2_1	231	233	PF00082	0.433
CLV_PCSK_KEX2_1	57	59	PF00082	0.414
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.424
CLV_PCSK_SKI1_1	231	235	PF00082	0.409
CLV_PCSK_SKI1_1	54	58	PF00082	0.370
DEG_Nend_Nbox_1	1	3	PF02207	0.708
DOC_CKS1_1	112	117	PF01111	0.407
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.280
DOC_MAPK_MEF2A_6	184	192	PF00069	0.280
DOC_PP1_RVXF_1	141	147	PF00149	0.426
DOC_PP1_RVXF_1	191	198	PF00149	0.226
DOC_PP2B_LxvP_1	188	191	PF13499	0.469
DOC_PP4_FxxP_1	112	115	PF00568	0.356
DOC_USP7_MATH_1	207	211	PF00917	0.464
DOC_USP7_MATH_1	50	54	PF00917	0.507
DOC_USP7_UBL2_3	57	61	PF12436	0.597
DOC_WW_Pin1_4	111	116	PF00397	0.403
DOC_WW_Pin1_4	69	74	PF00397	0.540
LIG_14-3-3_CanoR_1	231	240	PF00244	0.687
LIG_14-3-3_CanoR_1	96	104	PF00244	0.407
LIG_Actin_WH2_2	127	145	PF00022	0.382
LIG_BRCT_BRCA1_1	81	85	PF00533	0.501
LIG_FHA_1	112	118	PF00498	0.218
LIG_FHA_1	221	227	PF00498	0.601
LIG_FHA_1	34	40	PF00498	0.319
LIG_FHA_1	99	105	PF00498	0.342
LIG_LIR_Apic_2	110	115	PF02991	0.393
LIG_LIR_Apic_2	123	127	PF02991	0.345
LIG_LIR_Gen_1	82	92	PF02991	0.417
LIG_LIR_Nem_3	15	19	PF02991	0.380
LIG_LIR_Nem_3	82	88	PF02991	0.436
LIG_SH2_CRK	16	20	PF00017	0.249
LIG_SH2_PTP2	124	127	PF00017	0.287
LIG_SH2_STAP1	135	139	PF00017	0.430
LIG_SH2_STAT3	113	116	PF00017	0.226
LIG_SH2_STAT3	28	31	PF00017	0.579
LIG_SH2_STAT3	92	95	PF00017	0.501
LIG_SH2_STAT5	113	116	PF00017	0.239
LIG_SH2_STAT5	124	127	PF00017	0.473
LIG_SH2_STAT5	158	161	PF00017	0.501
LIG_SH2_STAT5	176	179	PF00017	0.432
LIG_SH2_STAT5	28	31	PF00017	0.340
LIG_SH2_STAT5	32	35	PF00017	0.412
LIG_SH2_STAT5	9	12	PF00017	0.577
LIG_SH3_1	70	76	PF00018	0.556
LIG_SH3_3	112	118	PF00018	0.356
LIG_SH3_3	63	69	PF00018	0.569
LIG_SH3_3	70	76	PF00018	0.521
LIG_SUMO_SIM_par_1	130	136	PF11976	0.413
LIG_SUMO_SIM_par_1	35	40	PF11976	0.226
LIG_WRC_WIRS_1	38	43	PF05994	0.249
MOD_CK1_1	174	180	PF00069	0.483
MOD_CK1_1	220	226	PF00069	0.770
MOD_CK1_1	40	46	PF00069	0.341
MOD_Cter_Amidation	229	232	PF01082	0.413
MOD_GlcNHglycan	118	121	PF01048	0.471
MOD_GlcNHglycan	173	176	PF01048	0.657
MOD_GlcNHglycan	180	183	PF01048	0.560
MOD_GlcNHglycan	203	206	PF01048	0.468
MOD_GlcNHglycan	219	222	PF01048	0.442
MOD_GSK3_1	107	114	PF00069	0.386
MOD_GSK3_1	116	123	PF00069	0.298
MOD_GSK3_1	174	181	PF00069	0.303
MOD_GSK3_1	197	204	PF00069	0.468
MOD_GSK3_1	220	227	PF00069	0.716
MOD_GSK3_1	33	40	PF00069	0.371
MOD_GSK3_1	74	81	PF00069	0.556
MOD_N-GLC_1	107	112	PF02516	0.607
MOD_N-GLC_1	12	17	PF02516	0.412
MOD_N-GLC_1	171	176	PF02516	0.652
MOD_NEK2_1	1	6	PF00069	0.661
MOD_NEK2_1	107	112	PF00069	0.277
MOD_NEK2_1	197	202	PF00069	0.451
MOD_NEK2_2	133	138	PF00069	0.501
MOD_NEK2_2	87	92	PF00069	0.341
MOD_Plk_1	107	113	PF00069	0.407
MOD_Plk_1	12	18	PF00069	0.489
MOD_Plk_4	107	113	PF00069	0.344
MOD_Plk_4	120	126	PF00069	0.219
MOD_Plk_4	133	139	PF00069	0.464
MOD_Plk_4	197	203	PF00069	0.299
MOD_Plk_4	33	39	PF00069	0.349
MOD_Plk_4	81	87	PF00069	0.440
MOD_ProDKin_1	111	117	PF00069	0.403
MOD_ProDKin_1	69	75	PF00069	0.540
TRG_ENDOCYTIC_2	16	19	PF00928	0.390
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7E3	Leptomonas seymouri	47%	100%
A0A0S4JMP4	Bodo saltans	28%	96%
A0A3S7WXN1	Leishmania donovani	77%	100%
A4I0A4	Leishmania infantum	77%	100%
E9AW69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QBA9	Leishmania major	75%	100%