Metallo-beta-lactamase family protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-beta-lactamase family protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HCS9_LEIBR

TriTrypDb:

LbrM.23.0680 , LBRM2903_230014400

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCS9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.428
CLV_NRD_NRD_1	209	211	PF00675	0.551
CLV_NRD_NRD_1	337	339	PF00675	0.389
CLV_NRD_NRD_1	349	351	PF00675	0.396
CLV_NRD_NRD_1	62	64	PF00675	0.517
CLV_PCSK_FUR_1	335	339	PF00082	0.388
CLV_PCSK_KEX2_1	337	339	PF00082	0.407
CLV_PCSK_KEX2_1	349	351	PF00082	0.413
CLV_PCSK_KEX2_1	62	64	PF00082	0.491
CLV_PCSK_SKI1_1	15	19	PF00082	0.643
CLV_PCSK_SKI1_1	211	215	PF00082	0.512
CLV_PCSK_SKI1_1	281	285	PF00082	0.266
DEG_APCC_DBOX_1	186	194	PF00400	0.487
DEG_Nend_Nbox_1	1	3	PF02207	0.577
DEG_SCF_FBW7_1	263	269	PF00400	0.360
DOC_CDC14_PxL_1	4	12	PF14671	0.437
DOC_CKS1_1	263	268	PF01111	0.360
DOC_CYCLIN_RxL_1	12	22	PF00134	0.421
DOC_CYCLIN_RxL_1	278	287	PF00134	0.286
DOC_MAPK_gen_1	210	216	PF00069	0.587
DOC_MAPK_gen_1	335	345	PF00069	0.508
DOC_MAPK_gen_1	98	106	PF00069	0.309
DOC_PP1_RVXF_1	279	285	PF00149	0.266
DOC_PP2B_LxvP_1	275	278	PF13499	0.266
DOC_USP7_MATH_1	165	169	PF00917	0.410
DOC_USP7_MATH_1	300	304	PF00917	0.411
DOC_USP7_MATH_1	58	62	PF00917	0.430
DOC_USP7_UBL2_3	47	51	PF12436	0.484
DOC_WW_Pin1_4	220	225	PF00397	0.512
DOC_WW_Pin1_4	262	267	PF00397	0.266
DOC_WW_Pin1_4	71	76	PF00397	0.366
LIG_14-3-3_CanoR_1	194	198	PF00244	0.268
LIG_14-3-3_CanoR_1	247	252	PF00244	0.318
LIG_14-3-3_CanoR_1	25	29	PF00244	0.412
LIG_14-3-3_CanoR_1	329	334	PF00244	0.354
LIG_14-3-3_CanoR_1	66	72	PF00244	0.390
LIG_Actin_WH2_2	113	128	PF00022	0.462
LIG_Actin_WH2_2	32	49	PF00022	0.433
LIG_APCC_ABBAyCdc20_2	101	107	PF00400	0.440
LIG_BIR_III_2	171	175	PF00653	0.401
LIG_BRCT_BRCA1_1	247	251	PF00533	0.451
LIG_Clathr_ClatBox_1	311	315	PF01394	0.489
LIG_DCNL_PONY_1	1	4	PF03556	0.555
LIG_deltaCOP1_diTrp_1	110	119	PF00928	0.305
LIG_deltaCOP1_diTrp_1	166	173	PF00928	0.306
LIG_FHA_1	120	126	PF00498	0.395
LIG_FHA_1	283	289	PF00498	0.322
LIG_FHA_1	319	325	PF00498	0.332
LIG_FHA_1	34	40	PF00498	0.363
LIG_FHA_1	72	78	PF00498	0.432
LIG_FHA_2	68	74	PF00498	0.379
LIG_LIR_Gen_1	114	121	PF02991	0.315
LIG_LIR_Gen_1	43	53	PF02991	0.522
LIG_LIR_Nem_3	114	119	PF02991	0.317
LIG_LIR_Nem_3	178	183	PF02991	0.300
LIG_LIR_Nem_3	196	201	PF02991	0.528
LIG_LIR_Nem_3	248	254	PF02991	0.349
LIG_LIR_Nem_3	43	48	PF02991	0.512
LIG_Pex14_1	169	173	PF04695	0.307
LIG_PTB_Apo_2	192	199	PF02174	0.486
LIG_PTB_Phospho_1	192	198	PF10480	0.485
LIG_SH2_CRK	291	295	PF00017	0.300
LIG_SH2_GRB2like	203	206	PF00017	0.305
LIG_SH2_GRB2like	84	87	PF00017	0.457
LIG_SH2_SRC	84	87	PF00017	0.457
LIG_SH2_STAP1	203	207	PF00017	0.525
LIG_SH2_STAP1	347	351	PF00017	0.512
LIG_SH2_STAT3	203	206	PF00017	0.457
LIG_SH2_STAT5	201	204	PF00017	0.420
LIG_SH2_STAT5	262	265	PF00017	0.281
LIG_SH2_STAT5	44	47	PF00017	0.481
LIG_SH3_1	221	227	PF00018	0.384
LIG_SH3_2	8	13	PF14604	0.438
LIG_SH3_3	221	227	PF00018	0.512
LIG_SH3_3	260	266	PF00018	0.411
LIG_SH3_3	294	300	PF00018	0.298
LIG_SH3_3	319	325	PF00018	0.340
LIG_SH3_3	5	11	PF00018	0.645
LIG_SUMO_SIM_par_1	309	315	PF11976	0.489
LIG_TYR_ITIM	289	294	PF00017	0.300
MOD_CK1_1	196	202	PF00069	0.471
MOD_CK1_1	242	248	PF00069	0.372
MOD_CK1_1	310	316	PF00069	0.489
MOD_CK2_1	247	253	PF00069	0.458
MOD_CK2_1	67	73	PF00069	0.389
MOD_GlcNHglycan	122	125	PF01048	0.429
MOD_GlcNHglycan	242	245	PF01048	0.452
MOD_GlcNHglycan	302	305	PF01048	0.399
MOD_GSK3_1	115	122	PF00069	0.354
MOD_GSK3_1	242	249	PF00069	0.371
MOD_GSK3_1	262	269	PF00069	0.244
MOD_GSK3_1	67	74	PF00069	0.385
MOD_LATS_1	327	333	PF00433	0.350
MOD_N-GLC_1	245	250	PF02516	0.507
MOD_N-GLC_1	30	35	PF02516	0.376
MOD_NEK2_1	119	124	PF00069	0.342
MOD_NEK2_1	130	135	PF00069	0.260
MOD_NEK2_1	193	198	PF00069	0.429
MOD_NEK2_1	24	29	PF00069	0.344
MOD_NEK2_1	240	245	PF00069	0.382
MOD_NEK2_1	273	278	PF00069	0.369
MOD_NEK2_1	307	312	PF00069	0.271
MOD_NEK2_2	67	72	PF00069	0.387
MOD_PKA_2	125	131	PF00069	0.386
MOD_PKA_2	193	199	PF00069	0.293
MOD_PKA_2	24	30	PF00069	0.410
MOD_PKA_2	246	252	PF00069	0.319
MOD_PKA_2	328	334	PF00069	0.350
MOD_PKA_2	355	361	PF00069	0.411
MOD_PKA_2	58	64	PF00069	0.441
MOD_Plk_1	165	171	PF00069	0.455
MOD_Plk_1	30	36	PF00069	0.377
MOD_Plk_1	318	324	PF00069	0.339
MOD_Plk_4	115	121	PF00069	0.458
MOD_Plk_4	165	171	PF00069	0.455
MOD_Plk_4	193	199	PF00069	0.521
MOD_Plk_4	247	253	PF00069	0.360
MOD_Plk_4	255	261	PF00069	0.331
MOD_Plk_4	307	313	PF00069	0.318
MOD_Plk_4	318	324	PF00069	0.290
MOD_ProDKin_1	220	226	PF00069	0.513
MOD_ProDKin_1	262	268	PF00069	0.266
MOD_ProDKin_1	71	77	PF00069	0.358
TRG_DiLeu_BaEn_1	73	78	PF01217	0.483
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.359
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.411
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.721
TRG_ENDOCYTIC_2	180	183	PF00928	0.336
TRG_ENDOCYTIC_2	291	294	PF00928	0.300
TRG_NES_CRM1_1	138	151	PF08389	0.350
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I936	Leptomonas seymouri	79%	95%
A0A0S4IRF9	Bodo saltans	45%	100%
A0A1X0NXH8	Trypanosomatidae	51%	100%
A0A3Q8ICH4	Leishmania donovani	87%	96%
A0A422MYI7	Trypanosoma rangeli	51%	100%
A4I0A3	Leishmania infantum	87%	96%
C9ZV29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AW68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	96%
Q4QBB0	Leishmania major	87%	100%
V5BFN3	Trypanosoma cruzi	52%	100%