tRNA-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative tRNA binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCS8_LEIBR

TriTrypDb:

LbrM.23.0670 , LBRM2903_230014300

Length:

157

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCS8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	8
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.448
CLV_PCSK_KEX2_1	63	65	PF00082	0.308
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.308
CLV_PCSK_SKI1_1	63	67	PF00082	0.308
DOC_MAPK_gen_1	61	69	PF00069	0.465
DOC_MAPK_MEF2A_6	61	69	PF00069	0.465
LIG_14-3-3_CanoR_1	106	110	PF00244	0.410
LIG_FHA_2	134	140	PF00498	0.511
LIG_LIR_Apic_2	3	7	PF02991	0.438
LIG_LIR_Gen_1	40	51	PF02991	0.466
LIG_LIR_Nem_3	40	46	PF02991	0.469
LIG_SH2_GRB2like	11	14	PF00017	0.426
LIG_SH2_SRC	43	46	PF00017	0.482
LIG_SH2_STAP1	11	15	PF00017	0.317
LIG_SH3_3	132	138	PF00018	0.523
LIG_SH3_5	7	11	PF00018	0.346
MOD_CK2_1	133	139	PF00069	0.531
MOD_GSK3_1	100	107	PF00069	0.508
MOD_GSK3_1	133	140	PF00069	0.527
MOD_GSK3_1	26	33	PF00069	0.460
MOD_PIKK_1	111	117	PF00454	0.488
MOD_PKA_2	105	111	PF00069	0.439
MOD_SUMO_for_1	99	102	PF00179	0.508
TRG_ENDOCYTIC_2	43	46	PF00928	0.402
TRG_NLS_MonoExtN_4	61	67	PF00514	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I1	Leptomonas seymouri	75%	99%
A0A0S4IRK4	Bodo saltans	48%	100%
A0A3S7WXL0	Leishmania donovani	88%	100%
A4I0A2	Leishmania infantum	88%	100%
E9AW67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QBB1	Leishmania major	87%	100%