Poly(A)-specific ribonuclease PARN

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly(A)-specific ribonuclease PARN, putative

Species:

Leishmania braziliensis

UniProt:

A4HCS6_LEIBR

TriTrypDb:

LbrM.23.0650 , LBRM2903_230012800

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	3
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HCS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCS6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	24
GO:0005488	binding	1	24
GO:0097159	organic cyclic compound binding	2	24
GO:1901363	heterocyclic compound binding	2	24
GO:0000175	3'-5'-RNA exonuclease activity	7	4
GO:0003824	catalytic activity	1	4
GO:0004518	nuclease activity	4	4
GO:0004527	exonuclease activity	5	4
GO:0004532	RNA exonuclease activity	5	4
GO:0004535	poly(A)-specific ribonuclease activity	8	1
GO:0004540	RNA nuclease activity	4	4
GO:0008408	3'-5' exonuclease activity	6	4
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	4
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	4
GO:0140098	catalytic activity, acting on RNA	3	4
GO:0140640	catalytic activity, acting on a nucleic acid	2	4
GO:0003723	RNA binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.421
CLV_C14_Caspase3-7	501	505	PF00656	0.365
CLV_NRD_NRD_1	130	132	PF00675	0.244
CLV_NRD_NRD_1	255	257	PF00675	0.232
CLV_NRD_NRD_1	286	288	PF00675	0.325
CLV_NRD_NRD_1	305	307	PF00675	0.362
CLV_NRD_NRD_1	4	6	PF00675	0.317
CLV_NRD_NRD_1	523	525	PF00675	0.549
CLV_NRD_NRD_1	580	582	PF00675	0.687
CLV_NRD_NRD_1	590	592	PF00675	0.694
CLV_NRD_NRD_1	72	74	PF00675	0.328
CLV_PCSK_FUR_1	253	257	PF00082	0.333
CLV_PCSK_FUR_1	588	592	PF00082	0.538
CLV_PCSK_KEX2_1	130	132	PF00082	0.257
CLV_PCSK_KEX2_1	255	257	PF00082	0.243
CLV_PCSK_KEX2_1	286	288	PF00082	0.276
CLV_PCSK_KEX2_1	4	6	PF00082	0.311
CLV_PCSK_KEX2_1	523	525	PF00082	0.508
CLV_PCSK_KEX2_1	54	56	PF00082	0.266
CLV_PCSK_KEX2_1	580	582	PF00082	0.687
CLV_PCSK_KEX2_1	590	592	PF00082	0.694
CLV_PCSK_KEX2_1	72	74	PF00082	0.205
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.273
CLV_PCSK_SKI1_1	287	291	PF00082	0.276
CLV_PCSK_SKI1_1	296	300	PF00082	0.221
CLV_PCSK_SKI1_1	341	345	PF00082	0.305
CLV_PCSK_SKI1_1	444	448	PF00082	0.333
DEG_APCC_DBOX_1	286	294	PF00400	0.533
DEG_COP1_1	28	39	PF00400	0.499
DEG_Nend_UBRbox_3	1	3	PF02207	0.336
DEG_SPOP_SBC_1	75	79	PF00917	0.457
DOC_MAPK_gen_1	130	136	PF00069	0.443
DOC_MAPK_gen_1	204	213	PF00069	0.537
DOC_MAPK_gen_1	233	243	PF00069	0.507
DOC_MAPK_gen_1	362	370	PF00069	0.453
DOC_MAPK_MEF2A_6	236	243	PF00069	0.527
DOC_MAPK_MEF2A_6	245	252	PF00069	0.349
DOC_MAPK_MEF2A_6	60	68	PF00069	0.475
DOC_MAPK_NFAT4_5	236	244	PF00069	0.533
DOC_PP1_RVXF_1	294	300	PF00149	0.467
DOC_PP4_FxxP_1	562	565	PF00568	0.685
DOC_USP7_MATH_1	161	165	PF00917	0.564
DOC_USP7_MATH_1	169	173	PF00917	0.485
DOC_USP7_MATH_1	257	261	PF00917	0.430
DOC_USP7_MATH_1	75	79	PF00917	0.480
DOC_WW_Pin1_4	119	124	PF00397	0.443
DOC_WW_Pin1_4	267	272	PF00397	0.519
DOC_WW_Pin1_4	378	383	PF00397	0.472
DOC_WW_Pin1_4	462	467	PF00397	0.342
DOC_WW_Pin1_4	544	549	PF00397	0.621
LIG_14-3-3_CanoR_1	158	164	PF00244	0.579
LIG_14-3-3_CanoR_1	186	193	PF00244	0.563
LIG_14-3-3_CanoR_1	553	559	PF00244	0.703
LIG_14-3-3_CanoR_1	580	584	PF00244	0.689
LIG_Actin_WH2_2	518	536	PF00022	0.347
LIG_BRCT_BRCA1_1	209	213	PF00533	0.355
LIG_deltaCOP1_diTrp_1	317	320	PF00928	0.533
LIG_eIF4E_1	395	401	PF01652	0.533
LIG_eIF4E_1	96	102	PF01652	0.533
LIG_FHA_1	263	269	PF00498	0.479
LIG_FHA_1	298	304	PF00498	0.533
LIG_FHA_1	348	354	PF00498	0.428
LIG_FHA_1	38	44	PF00498	0.440
LIG_FHA_1	383	389	PF00498	0.442
LIG_FHA_1	417	423	PF00498	0.439
LIG_FHA_1	477	483	PF00498	0.448
LIG_FHA_1	505	511	PF00498	0.373
LIG_FHA_2	109	115	PF00498	0.494
LIG_FHA_2	166	172	PF00498	0.452
LIG_FHA_2	173	179	PF00498	0.430
LIG_FHA_2	458	464	PF00498	0.483
LIG_LIR_Apic_2	560	565	PF02991	0.686
LIG_LIR_Gen_1	317	325	PF02991	0.531
LIG_LIR_Gen_1	363	373	PF02991	0.355
LIG_LIR_Gen_1	411	422	PF02991	0.437
LIG_LIR_Gen_1	59	68	PF02991	0.461
LIG_LIR_Nem_3	21	27	PF02991	0.461
LIG_LIR_Nem_3	246	250	PF02991	0.454
LIG_LIR_Nem_3	292	298	PF02991	0.473
LIG_LIR_Nem_3	317	321	PF02991	0.523
LIG_LIR_Nem_3	363	368	PF02991	0.474
LIG_LIR_Nem_3	393	398	PF02991	0.496
LIG_LIR_Nem_3	411	417	PF02991	0.450
LIG_LIR_Nem_3	59	64	PF02991	0.457
LIG_LIR_Nem_3	6	11	PF02991	0.449
LIG_LYPXL_yS_3	247	250	PF13949	0.386
LIG_MYND_1	541	545	PF01753	0.473
LIG_NRBOX	422	428	PF00104	0.477
LIG_Pex14_1	348	352	PF04695	0.533
LIG_Pex14_2	295	299	PF04695	0.449
LIG_Pex14_2	344	348	PF04695	0.465
LIG_Pex14_2	8	12	PF04695	0.435
LIG_RPA_C_Fungi	181	193	PF08784	0.441
LIG_SH2_CRK	395	399	PF00017	0.352
LIG_SH2_CRK	414	418	PF00017	0.277
LIG_SH2_CRK	61	65	PF00017	0.332
LIG_SH2_NCK_1	395	399	PF00017	0.437
LIG_SH2_NCK_1	61	65	PF00017	0.329
LIG_SH2_PTP2	538	541	PF00017	0.360
LIG_SH2_SRC	395	398	PF00017	0.256
LIG_SH2_SRC	538	541	PF00017	0.521
LIG_SH2_STAP1	414	418	PF00017	0.290
LIG_SH2_STAP1	452	456	PF00017	0.409
LIG_SH2_STAT5	110	113	PF00017	0.368
LIG_SH2_STAT5	262	265	PF00017	0.450
LIG_SH2_STAT5	352	355	PF00017	0.271
LIG_SH2_STAT5	432	435	PF00017	0.436
LIG_SH2_STAT5	464	467	PF00017	0.352
LIG_SH2_STAT5	538	541	PF00017	0.495
LIG_SH2_STAT5	93	96	PF00017	0.254
LIG_SH3_1	534	540	PF00018	0.345
LIG_SH3_3	117	123	PF00018	0.286
LIG_SH3_3	160	166	PF00018	0.391
LIG_SH3_3	265	271	PF00018	0.364
LIG_SH3_3	383	389	PF00018	0.286
LIG_SH3_3	534	540	PF00018	0.475
LIG_SH3_3	542	548	PF00018	0.563
LIG_SH3_3	82	88	PF00018	0.322
LIG_SH3_3	91	97	PF00018	0.244
LIG_SUMO_SIM_anti_2	265	270	PF11976	0.412
LIG_SUMO_SIM_anti_2	396	402	PF11976	0.256
LIG_SUMO_SIM_par_1	264	270	PF11976	0.396
LIG_SUMO_SIM_par_1	470	475	PF11976	0.323
LIG_TRAF2_1	111	114	PF00917	0.364
LIG_TRAF2_1	270	273	PF00917	0.370
LIG_TRFH_1	100	104	PF08558	0.305
MOD_CK1_1	172	178	PF00069	0.277
MOD_CK1_1	251	257	PF00069	0.358
MOD_CK1_1	498	504	PF00069	0.467
MOD_CK1_1	547	553	PF00069	0.669
MOD_CK1_1	59	65	PF00069	0.399
MOD_CK2_1	108	114	PF00069	0.358
MOD_CK2_1	161	167	PF00069	0.459
MOD_CK2_1	172	178	PF00069	0.270
MOD_CK2_1	267	273	PF00069	0.393
MOD_CK2_1	457	463	PF00069	0.522
MOD_GlcNHglycan	123	126	PF01048	0.401
MOD_GlcNHglycan	259	262	PF01048	0.337
MOD_GlcNHglycan	322	325	PF01048	0.256
MOD_GlcNHglycan	516	519	PF01048	0.501
MOD_GlcNHglycan	78	81	PF01048	0.427
MOD_GSK3_1	161	168	PF00069	0.363
MOD_GSK3_1	209	216	PF00069	0.373
MOD_GSK3_1	37	44	PF00069	0.294
MOD_GSK3_1	378	385	PF00069	0.394
MOD_GSK3_1	500	507	PF00069	0.454
MOD_GSK3_1	547	554	PF00069	0.641
MOD_N-GLC_1	366	371	PF02516	0.384
MOD_N-GLC_1	527	532	PF02516	0.492
MOD_NEK2_1	159	164	PF00069	0.338
MOD_NEK2_1	213	218	PF00069	0.310
MOD_NEK2_1	289	294	PF00069	0.369
MOD_NEK2_1	302	307	PF00069	0.305
MOD_NEK2_1	320	325	PF00069	0.135
MOD_NEK2_1	347	352	PF00069	0.400
MOD_NEK2_1	418	423	PF00069	0.286
MOD_NEK2_1	447	452	PF00069	0.391
MOD_NEK2_1	56	61	PF00069	0.332
MOD_NEK2_1	579	584	PF00069	0.657
MOD_NEK2_2	169	174	PF00069	0.421
MOD_NEK2_2	248	253	PF00069	0.412
MOD_PIKK_1	161	167	PF00454	0.416
MOD_PK_1	207	213	PF00069	0.163
MOD_PKA_2	185	191	PF00069	0.256
MOD_PKA_2	579	585	PF00069	0.691
MOD_PKA_2	59	65	PF00069	0.371
MOD_Plk_1	366	372	PF00069	0.314
MOD_Plk_1	495	501	PF00069	0.488
MOD_Plk_1	527	533	PF00069	0.434
MOD_Plk_4	169	175	PF00069	0.273
MOD_Plk_4	209	215	PF00069	0.429
MOD_Plk_4	396	402	PF00069	0.374
MOD_Plk_4	418	424	PF00069	0.253
MOD_Plk_4	495	501	PF00069	0.454
MOD_Plk_4	554	560	PF00069	0.558
MOD_Plk_4	59	65	PF00069	0.407
MOD_ProDKin_1	119	125	PF00069	0.287
MOD_ProDKin_1	267	273	PF00069	0.393
MOD_ProDKin_1	378	384	PF00069	0.327
MOD_ProDKin_1	462	468	PF00069	0.353
MOD_ProDKin_1	544	550	PF00069	0.625
TRG_DiLeu_BaEn_1	285	290	PF01217	0.256
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.499
TRG_ENDOCYTIC_2	141	144	PF00928	0.286
TRG_ENDOCYTIC_2	247	250	PF00928	0.206
TRG_ENDOCYTIC_2	395	398	PF00928	0.286
TRG_ENDOCYTIC_2	414	417	PF00928	0.260
TRG_ENDOCYTIC_2	61	64	PF00928	0.322
TRG_ER_diArg_1	129	131	PF00400	0.305
TRG_ER_diArg_1	155	158	PF00400	0.330
TRG_ER_diArg_1	252	255	PF00400	0.293
TRG_ER_diArg_1	3	5	PF00400	0.391
TRG_ER_diArg_1	361	364	PF00400	0.310
TRG_ER_diArg_1	523	525	PF00400	0.549
TRG_ER_diArg_1	579	581	PF00400	0.679
TRG_ER_diArg_1	587	590	PF00400	0.641
TRG_ER_diArg_1	71	73	PF00400	0.393
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	523	527	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P603	Leptomonas seymouri	27%	100%
A0A0N1ILJ1	Leptomonas seymouri	68%	97%
A0A0S4IMW3	Bodo saltans	26%	100%
A0A0S4J225	Bodo saltans	28%	81%
A0A1X0NLC6	Trypanosomatidae	24%	100%
A0A1X0NXI3	Trypanosomatidae	42%	98%
A0A3Q8ICI3	Leishmania donovani	87%	99%
A0A3R7K5K5	Trypanosoma rangeli	27%	100%
A0A3S7X9D8	Leishmania donovani	26%	87%
A0A3S7XC77	Leishmania donovani	27%	100%
A0A422N5N5	Trypanosoma rangeli	48%	100%
A4HQF5	Leishmania braziliensis	26%	100%
A4I0A0	Leishmania infantum	87%	99%
A4IBC6	Leishmania infantum	26%	87%
A4IC91	Leishmania infantum	27%	100%
B2RXZ1	Mus musculus	25%	100%
C9ZV58	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A3T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AF58	Leishmania major	26%	87%
E9AU71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AW65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
E9B6B4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	87%
H9JAQ7	Bombyx mori	24%	100%
O95453	Homo sapiens	22%	93%
P69341	Bos taurus	23%	93%
Q4Q0C3	Leishmania major	27%	100%
Q4QBB3	Leishmania major	89%	100%
Q5R6R6	Pongo abelii	23%	100%
Q5RC51	Pongo abelii	22%	93%
Q7ZU92	Danio rerio	25%	90%
Q8NA58	Homo sapiens	23%	100%
Q8VDG3	Mus musculus	24%	95%
Q8W4C3	Arabidopsis thaliana	21%	96%
Q90ZA1	Xenopus laevis	24%	94%
Q9LG26	Arabidopsis thaliana	22%	86%
V5ASU9	Trypanosoma cruzi	25%	100%
V5BCG2	Trypanosoma cruzi	46%	100%