A2M domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HCS5_LEIBR

TriTrypDb:

LbrM.23.0640 , LBRM2903_230012700

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCS5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.542
CLV_NRD_NRD_1	208	210	PF00675	0.564
CLV_NRD_NRD_1	244	246	PF00675	0.676
CLV_NRD_NRD_1	581	583	PF00675	0.544
CLV_PCSK_KEX2_1	208	210	PF00082	0.564
CLV_PCSK_KEX2_1	244	246	PF00082	0.676
CLV_PCSK_KEX2_1	514	516	PF00082	0.814
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.814
CLV_PCSK_SKI1_1	366	370	PF00082	0.436
CLV_PCSK_SKI1_1	442	446	PF00082	0.434
CLV_PCSK_SKI1_1	552	556	PF00082	0.496
CLV_PCSK_SKI1_1	63	67	PF00082	0.593
DEG_Nend_UBRbox_3	1	3	PF02207	0.538
DEG_SCF_FBW7_2	159	165	PF00400	0.549
DEG_SPOP_SBC_1	356	360	PF00917	0.592
DOC_CDC14_PxL_1	472	480	PF14671	0.434
DOC_CKS1_1	159	164	PF01111	0.549
DOC_MAPK_DCC_7	442	451	PF00069	0.472
DOC_MAPK_MEF2A_6	273	280	PF00069	0.570
DOC_MAPK_MEF2A_6	366	373	PF00069	0.432
DOC_MAPK_NFAT4_5	273	281	PF00069	0.573
DOC_MAPK_NFAT4_5	366	374	PF00069	0.482
DOC_PP1_RVXF_1	7	13	PF00149	0.506
DOC_PP2B_LxvP_1	278	281	PF13499	0.505
DOC_USP7_MATH_1	119	123	PF00917	0.652
DOC_USP7_MATH_1	182	186	PF00917	0.757
DOC_USP7_MATH_1	191	195	PF00917	0.663
DOC_USP7_MATH_1	248	252	PF00917	0.765
DOC_WW_Pin1_4	111	116	PF00397	0.710
DOC_WW_Pin1_4	134	139	PF00397	0.656
DOC_WW_Pin1_4	151	156	PF00397	0.640
DOC_WW_Pin1_4	158	163	PF00397	0.748
DOC_WW_Pin1_4	208	213	PF00397	0.593
DOC_WW_Pin1_4	22	27	PF00397	0.652
DOC_WW_Pin1_4	239	244	PF00397	0.607
DOC_WW_Pin1_4	357	362	PF00397	0.471
DOC_WW_Pin1_4	444	449	PF00397	0.462
DOC_WW_Pin1_4	507	512	PF00397	0.711
LIG_14-3-3_CanoR_1	145	151	PF00244	0.639
LIG_14-3-3_CanoR_1	38	44	PF00244	0.546
LIG_14-3-3_CanoR_1	382	390	PF00244	0.408
LIG_14-3-3_CanoR_1	552	558	PF00244	0.497
LIG_14-3-3_CanoR_1	603	607	PF00244	0.570
LIG_Actin_WH2_2	273	291	PF00022	0.348
LIG_APCC_ABBA_1	563	568	PF00400	0.366
LIG_BRCT_BRCA1_1	384	388	PF00533	0.568
LIG_BRCT_BRCA1_1	560	564	PF00533	0.421
LIG_BRCT_BRCA1_1	78	82	PF00533	0.567
LIG_CtBP_PxDLS_1	178	182	PF00389	0.529
LIG_deltaCOP1_diTrp_1	75	82	PF00928	0.496
LIG_FHA_1	119	125	PF00498	0.720
LIG_FHA_1	145	151	PF00498	0.676
LIG_FHA_1	190	196	PF00498	0.517
LIG_FHA_1	273	279	PF00498	0.480
LIG_FHA_1	291	297	PF00498	0.331
LIG_FHA_1	357	363	PF00498	0.524
LIG_FHA_1	375	381	PF00498	0.357
LIG_FHA_1	40	46	PF00498	0.541
LIG_FHA_1	439	445	PF00498	0.442
LIG_FHA_2	14	20	PF00498	0.664
LIG_FHA_2	165	171	PF00498	0.732
LIG_FHA_2	384	390	PF00498	0.489
LIG_LIR_Apic_2	492	498	PF02991	0.643
LIG_LIR_Gen_1	46	56	PF02991	0.557
LIG_LIR_Gen_1	465	476	PF02991	0.429
LIG_LIR_Gen_1	556	565	PF02991	0.294
LIG_LIR_Gen_1	6	15	PF02991	0.416
LIG_LIR_Gen_1	64	71	PF02991	0.381
LIG_LIR_Gen_1	75	85	PF02991	0.396
LIG_LIR_Nem_3	11	15	PF02991	0.457
LIG_LIR_Nem_3	46	52	PF02991	0.434
LIG_LIR_Nem_3	465	471	PF02991	0.428
LIG_LIR_Nem_3	556	560	PF02991	0.480
LIG_LIR_Nem_3	561	567	PF02991	0.420
LIG_LIR_Nem_3	6	10	PF02991	0.458
LIG_LIR_Nem_3	75	81	PF02991	0.500
LIG_NRBOX	477	483	PF00104	0.499
LIG_PCNA_PIPBox_1	1	10	PF02747	0.341
LIG_PDZ_Class_2	603	608	PF00595	0.597
LIG_Pex14_1	78	82	PF04695	0.442
LIG_PTB_Apo_2	21	28	PF02174	0.495
LIG_SH2_CRK	49	53	PF00017	0.345
LIG_SH2_CRK	495	499	PF00017	0.658
LIG_SH2_CRK	557	561	PF00017	0.416
LIG_SH2_GRB2like	49	52	PF00017	0.514
LIG_SH2_NCK_1	49	53	PF00017	0.345
LIG_SH2_SRC	49	52	PF00017	0.333
LIG_SH2_STAP1	146	150	PF00017	0.482
LIG_SH2_STAP1	274	278	PF00017	0.493
LIG_SH2_STAP1	466	470	PF00017	0.476
LIG_SH2_STAP1	49	53	PF00017	0.598
LIG_SH2_STAP1	491	495	PF00017	0.625
LIG_SH2_STAT5	146	149	PF00017	0.538
LIG_SH2_STAT5	274	277	PF00017	0.548
LIG_SH2_STAT5	466	469	PF00017	0.455
LIG_SH2_STAT5	480	483	PF00017	0.329
LIG_SH2_STAT5	489	492	PF00017	0.552
LIG_SH2_STAT5	559	562	PF00017	0.423
LIG_SH3_3	113	119	PF00018	0.725
LIG_SH3_3	156	162	PF00018	0.549
LIG_SH3_3	23	29	PF00018	0.733
LIG_SH3_3	296	302	PF00018	0.453
LIG_SH3_3	456	462	PF00018	0.347
LIG_SUMO_SIM_anti_2	169	176	PF11976	0.544
LIG_SUMO_SIM_par_1	316	323	PF11976	0.405
LIG_SUMO_SIM_par_1	435	441	PF11976	0.450
LIG_SUMO_SIM_par_1	442	447	PF11976	0.421
LIG_TRAF2_1	17	20	PF00917	0.711
LIG_TYR_ITIM	47	52	PF00017	0.322
LIG_TYR_ITIM	555	560	PF00017	0.332
LIG_UBA3_1	436	442	PF00899	0.402
LIG_WRC_WIRS_1	4	9	PF05994	0.324
MOD_CDC14_SPxK_1	242	245	PF00782	0.684
MOD_CDK_SPK_2	151	156	PF00069	0.558
MOD_CDK_SPK_2	239	244	PF00069	0.679
MOD_CDK_SPxK_1	151	157	PF00069	0.530
MOD_CDK_SPxK_1	239	245	PF00069	0.684
MOD_CDK_SPxxK_3	507	514	PF00069	0.704
MOD_CK1_1	151	157	PF00069	0.721
MOD_CK1_1	166	172	PF00069	0.585
MOD_CK1_1	185	191	PF00069	0.455
MOD_CK1_1	203	209	PF00069	0.505
MOD_CK1_1	272	278	PF00069	0.475
MOD_CK1_1	328	334	PF00069	0.441
MOD_CK1_1	357	363	PF00069	0.524
MOD_CK1_1	507	513	PF00069	0.794
MOD_CK1_1	533	539	PF00069	0.503
MOD_CK1_1	558	564	PF00069	0.504
MOD_CK1_1	585	591	PF00069	0.789
MOD_CK1_1	73	79	PF00069	0.366
MOD_CK1_1	95	101	PF00069	0.506
MOD_CK2_1	13	19	PF00069	0.641
MOD_CK2_1	164	170	PF00069	0.791
MOD_CK2_1	98	104	PF00069	0.663
MOD_Cter_Amidation	512	515	PF01082	0.696
MOD_GlcNHglycan	130	133	PF01048	0.571
MOD_GlcNHglycan	150	153	PF01048	0.511
MOD_GlcNHglycan	202	205	PF01048	0.722
MOD_GlcNHglycan	220	224	PF01048	0.667
MOD_GlcNHglycan	249	253	PF01048	0.654
MOD_GlcNHglycan	335	338	PF01048	0.589
MOD_GlcNHglycan	341	344	PF01048	0.408
MOD_GlcNHglycan	511	514	PF01048	0.650
MOD_GlcNHglycan	521	524	PF01048	0.672
MOD_GlcNHglycan	526	529	PF01048	0.647
MOD_GlcNHglycan	579	582	PF01048	0.765
MOD_GlcNHglycan	587	590	PF01048	0.749
MOD_GlcNHglycan	96	100	PF01048	0.475
MOD_GSK3_1	105	112	PF00069	0.627
MOD_GSK3_1	140	147	PF00069	0.647
MOD_GSK3_1	169	176	PF00069	0.740
MOD_GSK3_1	185	192	PF00069	0.686
MOD_GSK3_1	200	207	PF00069	0.684
MOD_GSK3_1	356	363	PF00069	0.473
MOD_GSK3_1	39	46	PF00069	0.522
MOD_GSK3_1	438	445	PF00069	0.502
MOD_GSK3_1	519	526	PF00069	0.668
MOD_GSK3_1	573	580	PF00069	0.696
MOD_GSK3_1	94	101	PF00069	0.613
MOD_N-GLC_1	126	131	PF02516	0.568
MOD_N-GLC_1	198	203	PF02516	0.723
MOD_N-GLC_1	369	374	PF02516	0.455
MOD_N-GLC_1	429	434	PF02516	0.654
MOD_NEK2_1	110	115	PF00069	0.786
MOD_NEK2_1	140	145	PF00069	0.642
MOD_NEK2_1	163	168	PF00069	0.693
MOD_NEK2_1	173	178	PF00069	0.723
MOD_NEK2_1	190	195	PF00069	0.522
MOD_NEK2_1	269	274	PF00069	0.490
MOD_NEK2_1	319	324	PF00069	0.656
MOD_NEK2_1	325	330	PF00069	0.584
MOD_NEK2_1	369	374	PF00069	0.489
MOD_NEK2_1	383	388	PF00069	0.445
MOD_NEK2_1	390	395	PF00069	0.496
MOD_NEK2_1	416	421	PF00069	0.514
MOD_NEK2_1	43	48	PF00069	0.451
MOD_NEK2_1	481	486	PF00069	0.531
MOD_NEK2_1	555	560	PF00069	0.436
MOD_NEK2_1	571	576	PF00069	0.578
MOD_NEK2_1	8	13	PF00069	0.487
MOD_PIKK_1	481	487	PF00454	0.602
MOD_PK_1	105	111	PF00069	0.552
MOD_PKA_1	582	588	PF00069	0.542
MOD_PKA_2	144	150	PF00069	0.734
MOD_PKA_2	43	49	PF00069	0.429
MOD_PKA_2	504	510	PF00069	0.795
MOD_PKA_2	533	539	PF00069	0.577
MOD_PKA_2	585	591	PF00069	0.773
MOD_PKA_2	602	608	PF00069	0.341
MOD_Plk_1	164	170	PF00069	0.655
MOD_Plk_1	369	375	PF00069	0.473
MOD_Plk_1	429	435	PF00069	0.645
MOD_Plk_2-3	464	470	PF00069	0.484
MOD_Plk_4	105	111	PF00069	0.552
MOD_Plk_4	169	175	PF00069	0.721
MOD_Plk_4	185	191	PF00069	0.676
MOD_Plk_4	3	9	PF00069	0.508
MOD_Plk_4	320	326	PF00069	0.448
MOD_Plk_4	417	423	PF00069	0.697
MOD_Plk_4	533	539	PF00069	0.575
MOD_Plk_4	555	561	PF00069	0.486
MOD_Plk_4	61	67	PF00069	0.562
MOD_ProDKin_1	111	117	PF00069	0.707
MOD_ProDKin_1	134	140	PF00069	0.654
MOD_ProDKin_1	151	157	PF00069	0.644
MOD_ProDKin_1	158	164	PF00069	0.747
MOD_ProDKin_1	208	214	PF00069	0.592
MOD_ProDKin_1	22	28	PF00069	0.648
MOD_ProDKin_1	239	245	PF00069	0.612
MOD_ProDKin_1	357	363	PF00069	0.470
MOD_ProDKin_1	444	450	PF00069	0.469
MOD_ProDKin_1	507	513	PF00069	0.713
MOD_SUMO_rev_2	268	275	PF00179	0.312
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.428
TRG_DiLeu_BaLyEn_6	411	416	PF01217	0.483
TRG_ENDOCYTIC_2	49	52	PF00928	0.585
TRG_ENDOCYTIC_2	557	560	PF00928	0.470
TRG_ENDOCYTIC_2	566	569	PF00928	0.455
TRG_ER_diArg_1	243	245	PF00400	0.692
TRG_Pf-PMV_PEXEL_1	244	249	PF00026	0.733

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ40	Leptomonas seymouri	48%	97%
A0A3Q8ICM5	Leishmania donovani	75%	99%
A4I099	Leishmania infantum	75%	99%
E9AW64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4QBB4	Leishmania major	75%	99%
V5D8G7	Trypanosoma cruzi	28%	100%