Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCS4_LEIBR

TriTrypDb:

LbrM.23.0630 , LBRM2903_230012600

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.540
CLV_NRD_NRD_1	103	105	PF00675	0.525
CLV_NRD_NRD_1	170	172	PF00675	0.553
CLV_NRD_NRD_1	197	199	PF00675	0.587
CLV_NRD_NRD_1	217	219	PF00675	0.641
CLV_NRD_NRD_1	279	281	PF00675	0.536
CLV_NRD_NRD_1	357	359	PF00675	0.554
CLV_PCSK_KEX2_1	103	105	PF00082	0.485
CLV_PCSK_KEX2_1	170	172	PF00082	0.601
CLV_PCSK_KEX2_1	197	199	PF00082	0.587
CLV_PCSK_KEX2_1	219	221	PF00082	0.620
CLV_PCSK_KEX2_1	344	346	PF00082	0.564
CLV_PCSK_KEX2_1	357	359	PF00082	0.378
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.600
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.550
CLV_PCSK_SKI1_1	347	351	PF00082	0.427
CLV_PCSK_SKI1_1	357	361	PF00082	0.482
DOC_ANK_TNKS_1	226	233	PF00023	0.689
DOC_CKS1_1	27	32	PF01111	0.596
DOC_CYCLIN_RxL_1	205	217	PF00134	0.625
DOC_CYCLIN_RxL_1	301	312	PF00134	0.591
DOC_CYCLIN_RxL_1	355	365	PF00134	0.474
DOC_PP1_RVXF_1	302	309	PF00149	0.630
DOC_PP1_RVXF_1	355	362	PF00149	0.454
DOC_PP1_RVXF_1	81	88	PF00149	0.520
DOC_PP4_FxxP_1	87	90	PF00568	0.509
DOC_USP7_MATH_1	110	114	PF00917	0.566
DOC_USP7_MATH_1	233	237	PF00917	0.552
DOC_USP7_MATH_1	302	306	PF00917	0.661
DOC_USP7_MATH_1	4	8	PF00917	0.620
DOC_USP7_MATH_2	221	227	PF00917	0.697
DOC_USP7_UBL2_3	120	124	PF12436	0.548
DOC_WW_Pin1_4	129	134	PF00397	0.615
DOC_WW_Pin1_4	162	167	PF00397	0.620
DOC_WW_Pin1_4	190	195	PF00397	0.546
DOC_WW_Pin1_4	26	31	PF00397	0.612
DOC_WW_Pin1_4	86	91	PF00397	0.509
LIG_14-3-3_CanoR_1	170	174	PF00244	0.553
LIG_14-3-3_CanoR_1	253	259	PF00244	0.554
LIG_14-3-3_CanoR_1	358	366	PF00244	0.582
LIG_APCC_ABBA_1	308	313	PF00400	0.489
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_BIR_III_4	75	79	PF00653	0.488
LIG_BRCT_BRCA1_1	304	308	PF00533	0.549
LIG_BRCT_BRCA1_1	44	48	PF00533	0.544
LIG_CSL_BTD_1	191	194	PF09270	0.531
LIG_FHA_1	156	162	PF00498	0.676
LIG_FHA_1	191	197	PF00498	0.538
LIG_FHA_1	243	249	PF00498	0.548
LIG_FHA_1	348	354	PF00498	0.469
LIG_FHA_1	35	41	PF00498	0.465
LIG_FHA_2	255	261	PF00498	0.558
LIG_FHA_2	312	318	PF00498	0.545
LIG_FHA_2	322	328	PF00498	0.447
LIG_FHA_2	335	341	PF00498	0.341
LIG_FHA_2	360	366	PF00498	0.584
LIG_FHA_2	56	62	PF00498	0.420
LIG_LIR_Gen_1	113	122	PF02991	0.747
LIG_LIR_Gen_1	319	328	PF02991	0.469
LIG_LIR_Nem_3	113	117	PF02991	0.755
LIG_LIR_Nem_3	305	311	PF02991	0.542
LIG_LIR_Nem_3	319	325	PF02991	0.569
LIG_LIR_Nem_3	45	51	PF02991	0.503
LIG_RPA_C_Fungi	143	155	PF08784	0.534
LIG_SH2_PTP2	322	325	PF00017	0.467
LIG_SH2_STAT5	100	103	PF00017	0.428
LIG_SH2_STAT5	114	117	PF00017	0.562
LIG_SH2_STAT5	322	325	PF00017	0.467
LIG_SH3_3	24	30	PF00018	0.663
LIG_TRAF2_1	336	339	PF00917	0.542
LIG_WRC_WIRS_1	114	119	PF05994	0.628
MOD_CDK_SPxxK_3	190	197	PF00069	0.562
MOD_CK1_1	113	119	PF00069	0.553
MOD_CK1_1	15	21	PF00069	0.665
MOD_CK1_1	162	168	PF00069	0.541
MOD_CK1_1	206	212	PF00069	0.669
MOD_CK1_1	22	28	PF00069	0.813
MOD_CK1_1	226	232	PF00069	0.682
MOD_CK1_1	236	242	PF00069	0.647
MOD_CK1_1	251	257	PF00069	0.687
MOD_CK1_1	268	274	PF00069	0.549
MOD_CK1_1	279	285	PF00069	0.709
MOD_CK1_1	288	294	PF00069	0.718
MOD_CK1_1	316	322	PF00069	0.575
MOD_CK1_1	55	61	PF00069	0.431
MOD_CK2_1	254	260	PF00069	0.556
MOD_CK2_1	334	340	PF00069	0.465
MOD_CK2_1	359	365	PF00069	0.572
MOD_CK2_1	67	73	PF00069	0.425
MOD_GlcNHglycan	14	17	PF01048	0.642
MOD_GlcNHglycan	161	164	PF01048	0.654
MOD_GlcNHglycan	186	189	PF01048	0.616
MOD_GlcNHglycan	228	231	PF01048	0.686
MOD_GlcNHglycan	24	27	PF01048	0.615
MOD_GlcNHglycan	262	265	PF01048	0.620
MOD_GlcNHglycan	300	303	PF01048	0.529
MOD_GlcNHglycan	354	357	PF01048	0.631
MOD_GlcNHglycan	6	9	PF01048	0.597
MOD_GlcNHglycan	95	98	PF01048	0.473
MOD_GSK3_1	15	22	PF00069	0.595
MOD_GSK3_1	155	162	PF00069	0.532
MOD_GSK3_1	180	187	PF00069	0.612
MOD_GSK3_1	248	255	PF00069	0.634
MOD_GSK3_1	298	305	PF00069	0.629
MOD_GSK3_1	309	316	PF00069	0.526
MOD_N-GLC_1	19	24	PF02516	0.614
MOD_NEK2_1	265	270	PF00069	0.584
MOD_NEK2_1	311	316	PF00069	0.669
MOD_NEK2_1	66	71	PF00069	0.441
MOD_NEK2_2	302	307	PF00069	0.644
MOD_PIKK_1	236	242	PF00454	0.668
MOD_PIKK_1	248	254	PF00454	0.548
MOD_PIKK_1	334	340	PF00454	0.537
MOD_PKA_2	169	175	PF00069	0.552
MOD_PKA_2	204	210	PF00069	0.681
MOD_PKA_2	226	232	PF00069	0.639
MOD_PKA_2	252	258	PF00069	0.558
MOD_PKA_2	279	285	PF00069	0.534
MOD_Plk_1	149	155	PF00069	0.539
MOD_Plk_1	203	209	PF00069	0.602
MOD_Plk_1	66	72	PF00069	0.428
MOD_Plk_2-3	67	73	PF00069	0.332
MOD_Plk_4	110	116	PF00069	0.639
MOD_Plk_4	149	155	PF00069	0.597
MOD_Plk_4	293	299	PF00069	0.513
MOD_Plk_4	34	40	PF00069	0.393
MOD_Plk_4	67	73	PF00069	0.441
MOD_ProDKin_1	129	135	PF00069	0.618
MOD_ProDKin_1	162	168	PF00069	0.622
MOD_ProDKin_1	190	196	PF00069	0.548
MOD_ProDKin_1	26	32	PF00069	0.605
MOD_ProDKin_1	86	92	PF00069	0.500
MOD_SUMO_rev_2	215	221	PF00179	0.684
TRG_ENDOCYTIC_2	114	117	PF00928	0.753
TRG_ENDOCYTIC_2	322	325	PF00928	0.467
TRG_ER_diArg_1	196	198	PF00400	0.593
TRG_ER_diArg_1	218	221	PF00400	0.733
TRG_ER_diArg_1	357	359	PF00400	0.447
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE95	Leptomonas seymouri	48%	94%
A0A3S5H7B8	Leishmania donovani	74%	100%
A4I098	Leishmania infantum	74%	80%
E9AW63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QBB5	Leishmania major	78%	100%