Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HCS3_LEIBR

TriTrypDb:

LbrM.23.0620 , LBRM2903_230012400

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCS3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	21
GO:0005488	binding	1	21
GO:0036094	small molecule binding	2	21
GO:0097159	organic cyclic compound binding	2	21
GO:1901265	nucleoside phosphate binding	3	21
GO:1901363	heterocyclic compound binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.542
CLV_C14_Caspase3-7	461	465	PF00656	0.630
CLV_NRD_NRD_1	1	3	PF00675	0.616
CLV_NRD_NRD_1	17	19	PF00675	0.313
CLV_NRD_NRD_1	265	267	PF00675	0.560
CLV_NRD_NRD_1	289	291	PF00675	0.370
CLV_PCSK_KEX2_1	136	138	PF00082	0.268
CLV_PCSK_KEX2_1	265	267	PF00082	0.560
CLV_PCSK_KEX2_1	98	100	PF00082	0.401
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.268
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.401
CLV_PCSK_SKI1_1	136	140	PF00082	0.310
CLV_PCSK_SKI1_1	206	210	PF00082	0.323
CLV_PCSK_SKI1_1	43	47	PF00082	0.377
CLV_PCSK_SKI1_1	57	61	PF00082	0.229
DEG_APCC_DBOX_1	205	213	PF00400	0.335
DEG_Nend_UBRbox_1	1	4	PF02207	0.598
DEG_SPOP_SBC_1	458	462	PF00917	0.682
DOC_CYCLIN_RxL_1	131	144	PF00134	0.235
DOC_CYCLIN_yCln2_LP_2	162	168	PF00134	0.455
DOC_MAPK_gen_1	18	24	PF00069	0.373
DOC_MAPK_gen_1	2	10	PF00069	0.401
DOC_MAPK_gen_1	98	105	PF00069	0.401
DOC_MAPK_MEF2A_6	2	10	PF00069	0.401
DOC_PP1_RVXF_1	134	141	PF00149	0.306
DOC_PP1_RVXF_1	28	34	PF00149	0.357
DOC_PP1_RVXF_1	5	11	PF00149	0.369
DOC_PP4_FxxP_1	214	217	PF00568	0.372
DOC_PP4_FxxP_1	285	288	PF00568	0.497
DOC_PP4_FxxP_1	70	73	PF00568	0.401
DOC_SPAK_OSR1_1	347	351	PF12202	0.350
DOC_USP7_MATH_1	119	123	PF00917	0.285
DOC_USP7_MATH_1	170	174	PF00917	0.395
DOC_USP7_MATH_1	458	462	PF00917	0.589
DOC_WW_Pin1_4	174	179	PF00397	0.543
DOC_WW_Pin1_4	246	251	PF00397	0.567
LIG_14-3-3_CanoR_1	223	230	PF00244	0.541
LIG_14-3-3_CanoR_1	30	34	PF00244	0.328
LIG_14-3-3_CanoR_1	352	356	PF00244	0.488
LIG_APCC_ABBAyCdc20_2	136	142	PF00400	0.313
LIG_BRCT_BRCA1_1	176	180	PF00533	0.404
LIG_Clathr_ClatBox_1	138	142	PF01394	0.343
LIG_deltaCOP1_diTrp_1	199	207	PF00928	0.325
LIG_FHA_1	239	245	PF00498	0.535
LIG_FHA_1	320	326	PF00498	0.417
LIG_FHA_1	329	335	PF00498	0.406
LIG_FHA_1	395	401	PF00498	0.426
LIG_FHA_1	438	444	PF00498	0.366
LIG_FHA_1	44	50	PF00498	0.396
LIG_FHA_2	223	229	PF00498	0.475
LIG_FHA_2	275	281	PF00498	0.462
LIG_FHA_2	312	318	PF00498	0.429
LIG_FHA_2	339	345	PF00498	0.469
LIG_LIR_Apic_2	213	217	PF02991	0.414
LIG_LIR_Apic_2	284	288	PF02991	0.504
LIG_LIR_Gen_1	377	385	PF02991	0.388
LIG_LIR_Gen_1	434	444	PF02991	0.367
LIG_LIR_Gen_1	77	84	PF02991	0.323
LIG_LIR_Gen_1	88	95	PF02991	0.303
LIG_LIR_Nem_3	199	205	PF02991	0.323
LIG_LIR_Nem_3	373	379	PF02991	0.502
LIG_LIR_Nem_3	404	410	PF02991	0.414
LIG_LIR_Nem_3	434	439	PF02991	0.447
LIG_LIR_Nem_3	77	81	PF02991	0.323
LIG_LIR_Nem_3	88	94	PF02991	0.303
LIG_MYND_1	189	193	PF01753	0.418
LIG_Pex14_2	311	315	PF04695	0.410
LIG_SH2_NCK_1	391	395	PF00017	0.577
LIG_SH2_PTP2	91	94	PF00017	0.313
LIG_SH2_STAT3	438	441	PF00017	0.313
LIG_SH2_STAT5	203	206	PF00017	0.301
LIG_SH2_STAT5	243	246	PF00017	0.483
LIG_SH2_STAT5	438	441	PF00017	0.462
LIG_SH2_STAT5	91	94	PF00017	0.313
LIG_SUMO_SIM_anti_2	85	91	PF11976	0.373
LIG_TYR_ITIM	89	94	PF00017	0.315
MOD_CK1_1	242	248	PF00069	0.478
MOD_CK1_1	93	99	PF00069	0.320
MOD_CK2_1	119	125	PF00069	0.365
MOD_CK2_1	274	280	PF00069	0.477
MOD_GlcNHglycan	121	124	PF01048	0.373
MOD_GlcNHglycan	26	29	PF01048	0.304
MOD_GlcNHglycan	270	273	PF01048	0.464
MOD_GlcNHglycan	449	452	PF01048	0.442
MOD_GlcNHglycan	461	464	PF01048	0.637
MOD_GSK3_1	170	177	PF00069	0.426
MOD_GSK3_1	238	245	PF00069	0.521
MOD_GSK3_1	246	253	PF00069	0.595
MOD_GSK3_1	303	310	PF00069	0.470
MOD_GSK3_1	458	465	PF00069	0.624
MOD_GSK3_1	90	97	PF00069	0.420
MOD_NEK2_1	11	16	PF00069	0.325
MOD_NEK2_1	141	146	PF00069	0.401
MOD_NEK2_1	172	177	PF00069	0.461
MOD_NEK2_1	283	288	PF00069	0.463
MOD_NEK2_1	311	316	PF00069	0.381
MOD_PIKK_1	146	152	PF00454	0.320
MOD_PIKK_1	260	266	PF00454	0.488
MOD_PIKK_1	437	443	PF00454	0.339
MOD_PKA_1	2	8	PF00069	0.301
MOD_PKA_1	431	437	PF00069	0.466
MOD_PKA_2	222	228	PF00069	0.506
MOD_PKA_2	289	295	PF00069	0.398
MOD_PKA_2	29	35	PF00069	0.362
MOD_PKA_2	351	357	PF00069	0.435
MOD_Plk_1	238	244	PF00069	0.487
MOD_Plk_1	283	289	PF00069	0.449
MOD_Plk_1	319	325	PF00069	0.421
MOD_Plk_1	444	450	PF00069	0.277
MOD_Plk_4	176	182	PF00069	0.495
MOD_Plk_4	239	245	PF00069	0.529
MOD_Plk_4	29	35	PF00069	0.283
MOD_Plk_4	328	334	PF00069	0.463
MOD_Plk_4	74	80	PF00069	0.350
MOD_ProDKin_1	174	180	PF00069	0.537
MOD_ProDKin_1	246	252	PF00069	0.565
TRG_DiLeu_BaEn_3	384	390	PF01217	0.391
TRG_DiLeu_BaLyEn_6	134	139	PF01217	0.308
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.356
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.543
TRG_ENDOCYTIC_2	379	382	PF00928	0.598
TRG_ENDOCYTIC_2	78	81	PF00928	0.323
TRG_ENDOCYTIC_2	91	94	PF00928	0.295
TRG_ER_diArg_1	265	267	PF00400	0.481
TRG_ER_diArg_1	345	348	PF00400	0.558
TRG_Pf-PMV_PEXEL_1	137	142	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.201

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P740	Leptomonas seymouri	62%	100%
A0A0N1I5Z7	Leptomonas seymouri	31%	100%
A0A0N1I7E8	Leptomonas seymouri	32%	100%
A0A1X0NX10	Trypanosomatidae	32%	100%
A0A1X0NX22	Trypanosomatidae	37%	100%
A0A1X0NXP4	Trypanosomatidae	29%	100%
A0A3Q8IM07	Leishmania donovani	30%	100%
A0A3S7WXP2	Leishmania donovani	78%	100%
A0A3S7WXT7	Leishmania donovani	32%	100%
A4I097	Leishmania infantum	78%	100%
A4I0B8	Leishmania infantum	32%	100%
E9AH12	Leishmania infantum	30%	100%
E9AW61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9AW62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AW82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4QBB6	Leishmania major	30%	81%
Q4QBB7	Leishmania major	77%	100%
Q9U0V7	Leishmania major	32%	82%
V5BH08	Trypanosoma cruzi	35%	100%