C2 NT-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCS2_LEIBR

TriTrypDb:

LbrM.23.0610 , LBRM2903_230012200 , LBRM2903_230012300

Length:

973

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCS2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	51	55	PF00656	0.574
CLV_MEL_PAP_1	116	122	PF00089	0.653
CLV_NRD_NRD_1	29	31	PF00675	0.645
CLV_NRD_NRD_1	84	86	PF00675	0.491
CLV_NRD_NRD_1	843	845	PF00675	0.778
CLV_PCSK_KEX2_1	843	845	PF00082	0.778
CLV_PCSK_SKI1_1	196	200	PF00082	0.386
CLV_PCSK_SKI1_1	240	244	PF00082	0.669
CLV_PCSK_SKI1_1	280	284	PF00082	0.389
CLV_PCSK_SKI1_1	337	341	PF00082	0.633
CLV_PCSK_SKI1_1	597	601	PF00082	0.649
DEG_SPOP_SBC_1	489	493	PF00917	0.593
DOC_AGCK_PIF_2	77	82	PF00069	0.586
DOC_CKS1_1	136	141	PF01111	0.737
DOC_CKS1_1	518	523	PF01111	0.845
DOC_CKS1_1	589	594	PF01111	0.548
DOC_CYCLIN_RxL_1	193	201	PF00134	0.380
DOC_CYCLIN_yClb5_NLxxxL_5	468	477	PF00134	0.541
DOC_MAPK_MEF2A_6	864	872	PF00069	0.650
DOC_MAPK_MEF2A_6	946	955	PF00069	0.639
DOC_MAPK_RevD_3	99	114	PF00069	0.394
DOC_PP1_RVXF_1	112	119	PF00149	0.646
DOC_PP1_RVXF_1	71	78	PF00149	0.641
DOC_PP2B_LxvP_1	573	576	PF13499	0.568
DOC_PP2B_LxvP_1	632	635	PF13499	0.834
DOC_PP2B_LxvP_1	925	928	PF13499	0.353
DOC_PP4_FxxP_1	478	481	PF00568	0.578
DOC_PP4_FxxP_1	66	69	PF00568	0.720
DOC_PP4_FxxP_1	94	97	PF00568	0.639
DOC_USP7_MATH_1	106	110	PF00917	0.681
DOC_USP7_MATH_1	332	336	PF00917	0.706
DOC_USP7_MATH_1	452	456	PF00917	0.583
DOC_USP7_MATH_1	489	493	PF00917	0.716
DOC_USP7_MATH_1	569	573	PF00917	0.732
DOC_USP7_MATH_1	576	580	PF00917	0.799
DOC_USP7_MATH_1	601	605	PF00917	0.664
DOC_USP7_MATH_1	945	949	PF00917	0.708
DOC_USP7_UBL2_3	279	283	PF12436	0.668
DOC_USP7_UBL2_3	386	390	PF12436	0.703
DOC_USP7_UBL2_3	86	90	PF12436	0.682
DOC_WW_Pin1_4	135	140	PF00397	0.720
DOC_WW_Pin1_4	262	267	PF00397	0.476
DOC_WW_Pin1_4	366	371	PF00397	0.527
DOC_WW_Pin1_4	443	448	PF00397	0.779
DOC_WW_Pin1_4	517	522	PF00397	0.844
DOC_WW_Pin1_4	532	537	PF00397	0.742
DOC_WW_Pin1_4	588	593	PF00397	0.753
DOC_WW_Pin1_4	615	620	PF00397	0.717
DOC_WW_Pin1_4	625	630	PF00397	0.603
DOC_WW_Pin1_4	635	640	PF00397	0.571
DOC_WW_Pin1_4	65	70	PF00397	0.636
DOC_WW_Pin1_4	873	878	PF00397	0.469
DOC_WW_Pin1_4	962	967	PF00397	0.628
LIG_14-3-3_CanoR_1	144	152	PF00244	0.541
LIG_14-3-3_CanoR_1	224	228	PF00244	0.559
LIG_14-3-3_CanoR_1	85	94	PF00244	0.464
LIG_14-3-3_CanoR_1	933	940	PF00244	0.645
LIG_14-3-3_CterR_2	970	973	PF00244	0.632
LIG_APCC_ABBA_1	868	873	PF00400	0.682
LIG_BRCT_BRCA1_1	204	208	PF00533	0.569
LIG_BRCT_BRCA1_1	225	229	PF00533	0.648
LIG_CtBP_PxDLS_1	629	633	PF00389	0.574
LIG_FHA_1	147	153	PF00498	0.655
LIG_FHA_1	192	198	PF00498	0.378
LIG_FHA_1	223	229	PF00498	0.675
LIG_FHA_1	241	247	PF00498	0.378
LIG_FHA_1	338	344	PF00498	0.449
LIG_FHA_1	396	402	PF00498	0.680
LIG_FHA_1	468	474	PF00498	0.668
LIG_FHA_1	636	642	PF00498	0.644
LIG_FHA_1	86	92	PF00498	0.478
LIG_FHA_1	935	941	PF00498	0.537
LIG_FHA_2	507	513	PF00498	0.719
LIG_FHA_2	90	96	PF00498	0.475
LIG_LIR_Apic_2	475	481	PF02991	0.574
LIG_LIR_Apic_2	509	514	PF02991	0.814
LIG_LIR_Apic_2	520	526	PF02991	0.563
LIG_LIR_Apic_2	63	69	PF02991	0.711
LIG_LIR_Apic_2	854	860	PF02991	0.664
LIG_LIR_Apic_2	92	97	PF02991	0.635
LIG_LIR_Gen_1	22	28	PF02991	0.468
LIG_LIR_Gen_1	382	392	PF02991	0.712
LIG_LIR_Gen_1	47	56	PF02991	0.401
LIG_LIR_Gen_1	850	861	PF02991	0.392
LIG_LIR_Nem_3	205	211	PF02991	0.575
LIG_LIR_Nem_3	22	27	PF02991	0.467
LIG_LIR_Nem_3	382	387	PF02991	0.557
LIG_LIR_Nem_3	47	53	PF02991	0.384
LIG_LIR_Nem_3	850	856	PF02991	0.685
LIG_LIR_Nem_3	918	924	PF02991	0.438
LIG_LIR_Nem_3	961	967	PF02991	0.637
LIG_NRBOX	194	200	PF00104	0.374
LIG_NRBOX	352	358	PF00104	0.350
LIG_PDZ_Class_2	968	973	PF00595	0.624
LIG_Pex14_2	62	66	PF04695	0.682
LIG_Pex14_2	967	971	PF04695	0.611
LIG_SH2_CRK	857	861	PF00017	0.654
LIG_SH2_PTP2	24	27	PF00017	0.456
LIG_SH2_SRC	375	378	PF00017	0.747
LIG_SH2_SRC	511	514	PF00017	0.821
LIG_SH2_STAP1	251	255	PF00017	0.716
LIG_SH2_STAP1	4	8	PF00017	0.601
LIG_SH2_STAP1	853	857	PF00017	0.387
LIG_SH2_STAT3	251	254	PF00017	0.711
LIG_SH2_STAT3	670	673	PF00017	0.577
LIG_SH2_STAT3	674	677	PF00017	0.573
LIG_SH2_STAT3	689	692	PF00017	0.530
LIG_SH2_STAT3	693	696	PF00017	0.567
LIG_SH2_STAT3	708	711	PF00017	0.691
LIG_SH2_STAT3	712	715	PF00017	0.656
LIG_SH2_STAT3	727	730	PF00017	0.524
LIG_SH2_STAT3	731	734	PF00017	0.514
LIG_SH2_STAT3	746	749	PF00017	0.628
LIG_SH2_STAT3	750	753	PF00017	0.664
LIG_SH2_STAT3	765	768	PF00017	0.569
LIG_SH2_STAT3	769	772	PF00017	0.540
LIG_SH2_STAT3	784	787	PF00017	0.535
LIG_SH2_STAT3	788	791	PF00017	0.565
LIG_SH2_STAT3	803	806	PF00017	0.549
LIG_SH2_STAT3	807	810	PF00017	0.539
LIG_SH2_STAT3	821	824	PF00017	0.531
LIG_SH2_STAT3	825	828	PF00017	0.510
LIG_SH2_STAT5	16	19	PF00017	0.444
LIG_SH2_STAT5	24	27	PF00017	0.412
LIG_SH2_STAT5	352	355	PF00017	0.345
LIG_SH2_STAT5	840	843	PF00017	0.589
LIG_SH2_STAT5	853	856	PF00017	0.625
LIG_SH2_STAT5	924	927	PF00017	0.369
LIG_SH2_STAT5	957	960	PF00017	0.603
LIG_SH2_STAT5	964	967	PF00017	0.499
LIG_SH3_3	133	139	PF00018	0.692
LIG_SH3_3	224	230	PF00018	0.558
LIG_SH3_3	478	484	PF00018	0.552
LIG_SH3_3	557	563	PF00018	0.610
LIG_SH3_3	586	592	PF00018	0.626
LIG_SH3_3	616	622	PF00018	0.725
LIG_SH3_3	624	630	PF00018	0.696
LIG_SH3_3	939	945	PF00018	0.690
LIG_TRAF2_1	684	687	PF00917	0.558
LIG_TRAF2_1	703	706	PF00917	0.506
LIG_TRAF2_1	722	725	PF00917	0.508
LIG_TRAF2_1	741	744	PF00917	0.506
LIG_TRAF2_1	760	763	PF00917	0.502
LIG_TRAF2_1	832	835	PF00917	0.617
LIG_TRAF2_1	847	850	PF00917	0.758
LIG_TRFH_1	924	928	PF08558	0.369
LIG_UBA3_1	356	361	PF00899	0.647
LIG_WRC_WIRS_1	503	508	PF05994	0.561
MOD_CDK_SPK_2	366	371	PF00069	0.507
MOD_CDK_SPK_2	65	70	PF00069	0.727
MOD_CDK_SPxK_1	873	879	PF00069	0.461
MOD_CDK_SPxxK_3	366	373	PF00069	0.511
MOD_CK1_1	265	271	PF00069	0.718
MOD_CK1_1	623	629	PF00069	0.656
MOD_CK1_1	647	653	PF00069	0.789
MOD_CK1_1	65	71	PF00069	0.718
MOD_CK1_1	912	918	PF00069	0.737
MOD_CK1_1	932	938	PF00069	0.316
MOD_CK2_1	106	112	PF00069	0.392
MOD_CK2_1	286	292	PF00069	0.444
MOD_CK2_1	393	399	PF00069	0.681
MOD_CK2_1	41	47	PF00069	0.538
MOD_CK2_1	450	456	PF00069	0.576
MOD_CK2_1	490	496	PF00069	0.662
MOD_CK2_1	506	512	PF00069	0.709
MOD_CK2_1	844	850	PF00069	0.789
MOD_CK2_1	89	95	PF00069	0.639
MOD_GlcNHglycan	120	123	PF01048	0.660
MOD_GlcNHglycan	152	155	PF01048	0.634
MOD_GlcNHglycan	204	207	PF01048	0.414
MOD_GlcNHglycan	21	24	PF01048	0.429
MOD_GlcNHglycan	231	234	PF01048	0.408
MOD_GlcNHglycan	267	270	PF01048	0.666
MOD_GlcNHglycan	286	291	PF01048	0.669
MOD_GlcNHglycan	492	495	PF01048	0.580
MOD_GlcNHglycan	578	581	PF01048	0.840
MOD_GlcNHglycan	584	587	PF01048	0.562
MOD_GlcNHglycan	613	616	PF01048	0.688
MOD_GSK3_1	114	121	PF00069	0.647
MOD_GSK3_1	146	153	PF00069	0.544
MOD_GSK3_1	181	188	PF00069	0.684
MOD_GSK3_1	355	362	PF00069	0.391
MOD_GSK3_1	37	44	PF00069	0.526
MOD_GSK3_1	439	446	PF00069	0.709
MOD_GSK3_1	502	509	PF00069	0.812
MOD_GSK3_1	576	583	PF00069	0.649
MOD_GSK3_1	611	618	PF00069	0.712
MOD_GSK3_1	640	647	PF00069	0.740
MOD_GSK3_1	85	92	PF00069	0.414
MOD_GSK3_1	905	912	PF00069	0.497
MOD_LATS_1	437	443	PF00433	0.539
MOD_N-GLC_1	42	47	PF02516	0.504
MOD_N-GLC_1	443	448	PF02516	0.569
MOD_N-GLC_1	450	455	PF02516	0.556
MOD_N-GLC_1	532	537	PF02516	0.698
MOD_N-GLC_1	56	61	PF02516	0.433
MOD_N-GLC_1	644	649	PF02516	0.565
MOD_N-GLC_1	75	80	PF02516	0.329
MOD_N-GLC_1	886	891	PF02516	0.373
MOD_NEK2_1	118	123	PF00069	0.656
MOD_NEK2_1	401	406	PF00069	0.541
MOD_NEK2_1	424	429	PF00069	0.791
MOD_NEK2_1	506	511	PF00069	0.841
MOD_NEK2_1	56	61	PF00069	0.629
MOD_NEK2_1	581	586	PF00069	0.574
MOD_NEK2_1	62	67	PF00069	0.678
MOD_NEK2_1	644	649	PF00069	0.705
MOD_NEK2_1	75	80	PF00069	0.329
MOD_NEK2_1	833	838	PF00069	0.549
MOD_NEK2_2	191	196	PF00069	0.394
MOD_NEK2_2	2	7	PF00069	0.351
MOD_PIKK_1	161	167	PF00454	0.547
MOD_PIKK_1	306	312	PF00454	0.730
MOD_PIKK_1	332	338	PF00454	0.422
MOD_PIKK_1	359	365	PF00454	0.408
MOD_PIKK_1	567	573	PF00454	0.568
MOD_PIKK_1	644	650	PF00454	0.762
MOD_PIKK_1	915	921	PF00454	0.726
MOD_PK_1	281	287	PF00069	0.397
MOD_PKA_1	85	91	PF00069	0.422
MOD_PKA_2	118	124	PF00069	0.655
MOD_PKA_2	223	229	PF00069	0.675
MOD_PKA_2	878	884	PF00069	0.650
MOD_PKA_2	932	938	PF00069	0.643
MOD_PKA_2	945	951	PF00069	0.470
MOD_Plk_1	191	197	PF00069	0.523
MOD_Plk_1	62	68	PF00069	0.699
MOD_Plk_1	75	81	PF00069	0.330
MOD_Plk_1	834	840	PF00069	0.533
MOD_Plk_1	881	887	PF00069	0.628
MOD_Plk_2-3	326	332	PF00069	0.660
MOD_Plk_2-3	393	399	PF00069	0.681
MOD_Plk_4	100	106	PF00069	0.685
MOD_Plk_4	223	229	PF00069	0.675
MOD_Plk_4	352	358	PF00069	0.630
MOD_Plk_4	401	407	PF00069	0.687
MOD_Plk_4	502	508	PF00069	0.560
MOD_Plk_4	881	887	PF00069	0.628
MOD_Plk_4	945	951	PF00069	0.668
MOD_ProDKin_1	135	141	PF00069	0.724
MOD_ProDKin_1	262	268	PF00069	0.466
MOD_ProDKin_1	366	372	PF00069	0.530
MOD_ProDKin_1	443	449	PF00069	0.779
MOD_ProDKin_1	517	523	PF00069	0.844
MOD_ProDKin_1	532	538	PF00069	0.743
MOD_ProDKin_1	588	594	PF00069	0.750
MOD_ProDKin_1	615	621	PF00069	0.717
MOD_ProDKin_1	625	631	PF00069	0.606
MOD_ProDKin_1	635	641	PF00069	0.570
MOD_ProDKin_1	65	71	PF00069	0.627
MOD_ProDKin_1	873	879	PF00069	0.461
MOD_ProDKin_1	962	968	PF00069	0.628
MOD_SUMO_for_1	900	903	PF00179	0.662
MOD_SUMO_rev_2	108	116	PF00179	0.501
MOD_SUMO_rev_2	52	62	PF00179	0.424
MOD_SUMO_rev_2	869	877	PF00179	0.711
TRG_ENDOCYTIC_2	24	27	PF00928	0.456
TRG_ENDOCYTIC_2	374	377	PF00928	0.509
TRG_ENDOCYTIC_2	853	856	PF00928	0.656
TRG_ENDOCYTIC_2	924	927	PF00928	0.369
TRG_ENDOCYTIC_2	964	967	PF00928	0.614
TRG_ER_diArg_1	843	845	PF00400	0.778
TRG_NLS_MonoExtC_3	278	283	PF00514	0.391
TRG_NLS_MonoExtN_4	279	284	PF00514	0.389
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WXK3	Leishmania donovani	63%	100%
A4I096	Leishmania infantum	63%	100%
Q4QBB8	Leishmania major	63%	100%