EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HCS0_LEIBR

TriTrypDb:

LbrM.23.0590 , LBRM2903_230012000

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCS0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005509	calcium ion binding	5	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.453
CLV_NRD_NRD_1	13	15	PF00675	0.641
CLV_NRD_NRD_1	133	135	PF00675	0.674
CLV_PCSK_KEX2_1	105	107	PF00082	0.801
CLV_PCSK_KEX2_1	13	15	PF00082	0.641
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.801
CLV_PCSK_SKI1_1	139	143	PF00082	0.714
CLV_PCSK_SKI1_1	210	214	PF00082	0.564
CLV_PCSK_SKI1_1	302	306	PF00082	0.542
CLV_Separin_Metazoa	72	76	PF03568	0.617
DEG_COP1_1	223	232	PF00400	0.410
DEG_SPOP_SBC_1	211	215	PF00917	0.578
DOC_CDC14_PxL_1	197	205	PF14671	0.546
DOC_MAPK_MEF2A_6	42	51	PF00069	0.555
DOC_PP2B_PxIxI_1	172	178	PF00149	0.490
DOC_PP2B_PxIxI_1	46	52	PF00149	0.385
DOC_USP7_MATH_1	116	120	PF00917	0.639
DOC_USP7_MATH_1	141	145	PF00917	0.725
DOC_USP7_MATH_1	163	167	PF00917	0.670
DOC_USP7_MATH_1	212	216	PF00917	0.671
DOC_USP7_UBL2_3	135	139	PF12436	0.781
DOC_WW_Pin1_4	142	147	PF00397	0.702
DOC_WW_Pin1_4	165	170	PF00397	0.712
DOC_WW_Pin1_4	175	180	PF00397	0.630
DOC_WW_Pin1_4	98	103	PF00397	0.803
LIG_14-3-3_CanoR_1	106	116	PF00244	0.752
LIG_14-3-3_CanoR_1	134	142	PF00244	0.653
LIG_14-3-3_CanoR_1	14	22	PF00244	0.561
LIG_APCC_ABBA_1	197	202	PF00400	0.607
LIG_BIR_III_4	239	243	PF00653	0.608
LIG_eIF4E_1	16	22	PF01652	0.631
LIG_FHA_1	16	22	PF00498	0.540
LIG_FHA_1	169	175	PF00498	0.614
LIG_FHA_2	236	242	PF00498	0.349
LIG_FHA_2	295	301	PF00498	0.500
LIG_LIR_Gen_1	189	198	PF02991	0.552
LIG_LIR_Gen_1	231	240	PF02991	0.577
LIG_LIR_Gen_1	45	54	PF02991	0.633
LIG_LIR_Nem_3	189	193	PF02991	0.415
LIG_LIR_Nem_3	231	236	PF02991	0.512
LIG_LIR_Nem_3	45	51	PF02991	0.650
LIG_LYPXL_S_1	199	203	PF13949	0.543
LIG_LYPXL_yS_3	200	203	PF13949	0.547
LIG_NRBOX	193	199	PF00104	0.382
LIG_PCNA_yPIPBox_3	60	74	PF02747	0.643
LIG_SH2_SRC	32	35	PF00017	0.413
LIG_SH2_STAP1	251	255	PF00017	0.336
LIG_SH2_STAT5	16	19	PF00017	0.640
LIG_SH2_STAT5	195	198	PF00017	0.454
LIG_SH3_3	174	180	PF00018	0.676
LIG_SH3_3	224	230	PF00018	0.662
LIG_SUMO_SIM_anti_2	69	75	PF11976	0.457
LIG_SUMO_SIM_par_1	170	178	PF11976	0.585
LIG_SUMO_SIM_par_1	293	300	PF11976	0.585
LIG_TRAF2_1	66	69	PF00917	0.627
LIG_TRAF2_1	7	10	PF00917	0.635
LIG_TRAF2_1	84	87	PF00917	0.444
LIG_TYR_ITIM	198	203	PF00017	0.541
MOD_CDK_SPxxK_3	98	105	PF00069	0.795
MOD_CK1_1	119	125	PF00069	0.656
MOD_CK1_1	164	170	PF00069	0.732
MOD_CK1_1	178	184	PF00069	0.384
MOD_CK1_1	98	104	PF00069	0.795
MOD_CK2_1	63	69	PF00069	0.610
MOD_Cter_Amidation	103	106	PF01082	0.546
MOD_GlcNHglycan	128	131	PF01048	0.768
MOD_GlcNHglycan	158	161	PF01048	0.786
MOD_GlcNHglycan	163	166	PF01048	0.795
MOD_GlcNHglycan	180	183	PF01048	0.431
MOD_GlcNHglycan	190	193	PF01048	0.428
MOD_GlcNHglycan	207	210	PF01048	0.498
MOD_GlcNHglycan	214	217	PF01048	0.643
MOD_GlcNHglycan	222	225	PF01048	0.582
MOD_GlcNHglycan	3	6	PF01048	0.419
MOD_GlcNHglycan	34	37	PF01048	0.705
MOD_GlcNHglycan	51	54	PF01048	0.408
MOD_GlcNHglycan	78	81	PF01048	0.578
MOD_GSK3_1	107	114	PF00069	0.728
MOD_GSK3_1	115	122	PF00069	0.661
MOD_GSK3_1	161	168	PF00069	0.718
MOD_GSK3_1	178	185	PF00069	0.473
MOD_NEK2_1	188	193	PF00069	0.492
MOD_NEK2_1	61	66	PF00069	0.455
MOD_NEK2_1	76	81	PF00069	0.542
MOD_NEK2_1	95	100	PF00069	0.516
MOD_PIKK_1	116	122	PF00454	0.797
MOD_PIKK_1	63	69	PF00454	0.517
MOD_PIKK_1	95	101	PF00454	0.590
MOD_PKA_1	105	111	PF00069	0.728
MOD_PKA_2	105	111	PF00069	0.665
MOD_PKA_2	133	139	PF00069	0.647
MOD_PKA_2	205	211	PF00069	0.714
MOD_ProDKin_1	142	148	PF00069	0.704
MOD_ProDKin_1	165	171	PF00069	0.711
MOD_ProDKin_1	175	181	PF00069	0.633
MOD_ProDKin_1	98	104	PF00069	0.801
TRG_DiLeu_BaEn_1	259	264	PF01217	0.676
TRG_DiLeu_BaEn_1	69	74	PF01217	0.429
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.611
TRG_ENDOCYTIC_2	195	198	PF00928	0.508
TRG_ENDOCYTIC_2	200	203	PF00928	0.547
TRG_ER_diArg_1	13	15	PF00400	0.641
TRG_NES_CRM1_1	280	293	PF08389	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT7	Leptomonas seymouri	39%	94%
A0A3Q8IEH7	Leishmania donovani	71%	100%
A4I094	Leishmania infantum	71%	100%
C9ZV52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	84%
E9ACS4	Leishmania major	67%	100%
E9AW58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%