SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCR7_LEIBR

TriTrypDb:

LbrM.23.0560 , LBRM2903_230011700

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCR7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.412
CLV_PCSK_KEX2_1	28	30	PF00082	0.470
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.470
CLV_PCSK_SKI1_1	7	11	PF00082	0.410
DEG_APCC_DBOX_1	6	14	PF00400	0.469
DOC_CKS1_1	235	240	PF01111	0.536
DOC_MAPK_gen_1	35	42	PF00069	0.295
DOC_MAPK_MEF2A_6	125	133	PF00069	0.496
DOC_PP1_RVXF_1	339	345	PF00149	0.411
DOC_PP1_RVXF_1	37	43	PF00149	0.293
DOC_PP2B_LxvP_1	182	185	PF13499	0.496
DOC_PP2B_LxvP_1	255	258	PF13499	0.496
DOC_PP2B_LxvP_1	98	101	PF13499	0.536
DOC_PP4_FxxP_1	282	285	PF00568	0.455
DOC_USP7_MATH_1	113	117	PF00917	0.411
DOC_USP7_MATH_1	191	195	PF00917	0.500
DOC_USP7_MATH_1	233	237	PF00917	0.518
DOC_USP7_MATH_1	266	270	PF00917	0.554
DOC_WW_Pin1_4	12	17	PF00397	0.428
DOC_WW_Pin1_4	234	239	PF00397	0.455
DOC_WW_Pin1_4	43	48	PF00397	0.572
LIG_CtBP_PxDLS_1	326	332	PF00389	0.384
LIG_eIF4E_1	58	64	PF01652	0.355
LIG_FHA_1	134	140	PF00498	0.464
LIG_FHA_1	79	85	PF00498	0.536
LIG_FHA_2	200	206	PF00498	0.473
LIG_FHA_2	51	57	PF00498	0.412
LIG_GBD_Chelix_1	174	182	PF00786	0.252
LIG_LIR_Apic_2	281	285	PF02991	0.536
LIG_LIR_Gen_1	159	165	PF02991	0.469
LIG_LIR_Gen_1	168	179	PF02991	0.415
LIG_LIR_Gen_1	93	103	PF02991	0.460
LIG_LIR_Nem_3	136	140	PF02991	0.452
LIG_LIR_Nem_3	159	163	PF02991	0.469
LIG_LIR_Nem_3	168	174	PF02991	0.415
LIG_LIR_Nem_3	22	26	PF02991	0.467
LIG_LIR_Nem_3	93	99	PF02991	0.475
LIG_PCNA_PIPBox_1	192	201	PF02747	0.473
LIG_PCNA_yPIPBox_3	121	134	PF02747	0.458
LIG_PCNA_yPIPBox_3	54	64	PF02747	0.417
LIG_SH2_GRB2like	160	163	PF00017	0.473
LIG_SH2_STAP1	212	216	PF00017	0.545
LIG_SH2_STAP1	218	222	PF00017	0.540
LIG_SH2_STAT3	232	235	PF00017	0.536
LIG_SH2_STAT5	137	140	PF00017	0.449
LIG_SH2_STAT5	160	163	PF00017	0.442
LIG_SH2_STAT5	26	29	PF00017	0.365
LIG_SH2_STAT5	58	61	PF00017	0.363
LIG_SH3_3	273	279	PF00018	0.443
LIG_SH3_3	297	303	PF00018	0.536
LIG_SH3_3	307	313	PF00018	0.536
LIG_SH3_3	73	79	PF00018	0.498
LIG_SUMO_SIM_anti_2	296	302	PF11976	0.455
LIG_SUMO_SIM_anti_2	72	79	PF11976	0.384
MOD_CDK_SPxxK_3	234	241	PF00069	0.496
MOD_CK1_1	194	200	PF00069	0.536
MOD_CK1_1	22	28	PF00069	0.258
MOD_CK1_1	3	9	PF00069	0.632
MOD_CK2_1	199	205	PF00069	0.455
MOD_CK2_1	290	296	PF00069	0.455
MOD_CK2_1	67	73	PF00069	0.384
MOD_GlcNHglycan	149	152	PF01048	0.296
MOD_GlcNHglycan	189	192	PF01048	0.307
MOD_GlcNHglycan	259	262	PF01048	0.319
MOD_GlcNHglycan	268	271	PF01048	0.274
MOD_GSK3_1	187	194	PF00069	0.515
MOD_N-GLC_1	290	295	PF02516	0.191
MOD_N-GLC_1	30	35	PF02516	0.271
MOD_NEK2_1	133	138	PF00069	0.481
MOD_NEK2_1	19	24	PF00069	0.473
MOD_NEK2_1	199	204	PF00069	0.447
MOD_NEK2_1	216	221	PF00069	0.453
MOD_PIKK_1	199	205	PF00454	0.464
MOD_Plk_1	119	125	PF00069	0.458
MOD_Plk_1	327	333	PF00069	0.473
MOD_Plk_4	102	108	PF00069	0.501
MOD_Plk_4	133	139	PF00069	0.452
MOD_Plk_4	19	25	PF00069	0.457
MOD_Plk_4	271	277	PF00069	0.536
MOD_ProDKin_1	12	18	PF00069	0.424
MOD_ProDKin_1	234	240	PF00069	0.455
MOD_ProDKin_1	43	49	PF00069	0.582
MOD_SUMO_for_1	324	327	PF00179	0.530
TRG_ENDOCYTIC_2	137	140	PF00928	0.442
TRG_ENDOCYTIC_2	160	163	PF00928	0.442
TRG_ENDOCYTIC_2	218	221	PF00928	0.540
TRG_ER_diArg_1	37	40	PF00400	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P305	Leptomonas seymouri	70%	98%
A0A0S4JT92	Bodo saltans	30%	100%
A0A1X0NX61	Trypanosomatidae	48%	100%
A0A3Q8IAX9	Leishmania donovani	87%	99%
A4I091	Leishmania infantum	87%	99%
C9ZV09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AW55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QBC2	Leishmania major	84%	100%
V5BCF3	Trypanosoma cruzi	47%	100%