LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HCR5_LEIBR
TriTrypDb:
LbrM.23.0540 , LBRM2903_230011500
Length:
98

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCR5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCR5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_FUR_1 14 18 PF00082 0.371
CLV_PCSK_KEX2_1 16 18 PF00082 0.494
CLV_PCSK_PC1ET2_1 16 18 PF00082 0.370
CLV_PCSK_SKI1_1 5 9 PF00082 0.619
CLV_PCSK_SKI1_1 50 54 PF00082 0.511
CLV_PCSK_SKI1_1 64 68 PF00082 0.562
DEG_APCC_DBOX_1 47 55 PF00400 0.330
DOC_MAPK_gen_1 36 46 PF00069 0.591
DOC_PP1_RVXF_1 48 54 PF00149 0.443
DOC_PP4_FxxP_1 93 96 PF00568 0.456
LIG_14-3-3_CanoR_1 80 85 PF00244 0.453
LIG_FHA_1 8 14 PF00498 0.394
LIG_FHA_2 7 13 PF00498 0.603
LIG_LIR_Gen_1 73 79 PF02991 0.476
LIG_Pex14_2 93 97 PF04695 0.679
LIG_SH2_SRC 22 25 PF00017 0.522
LIG_SH2_STAP1 62 66 PF00017 0.556
MOD_CK1_1 83 89 PF00069 0.668
MOD_CK2_1 6 12 PF00069 0.609
MOD_GSK3_1 79 86 PF00069 0.663
MOD_NEK2_1 79 84 PF00069 0.542
MOD_NEK2_2 62 67 PF00069 0.545
MOD_PKA_2 79 85 PF00069 0.450
MOD_PKB_1 28 36 PF00069 0.398
TRG_ENDOCYTIC_2 74 77 PF00928 0.423
TRG_Pf-PMV_PEXEL_1 16 20 PF00026 0.367

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZM7 Leptomonas seymouri 63% 100%
A0A3S7WXN8 Leishmania donovani 79% 100%
A4I090 Leishmania infantum 80% 100%
C9ZV07 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9AW54 Leishmania mexicana (strain MHOM/GT/2001/U1103) 71% 100%
Q4QBC3 Leishmania major 74% 100%
V5D8H0 Trypanosoma cruzi 60% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS