Integral membrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCR4_LEIBR

TriTrypDb:

LbrM.23.0530 , LBRM2903_230011400

Length:

196

Annotations

LeishMANIAdb annotations

An absolutely unique fold restricted to kinetoplastids. most predictions are too weak to assume any secure topology.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 5
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HCR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	172	174	PF00675	0.457
CLV_NRD_NRD_1	54	56	PF00675	0.484
CLV_PCSK_KEX2_1	172	174	PF00082	0.457
DEG_APCC_DBOX_1	110	118	PF00400	0.249
DOC_CKS1_1	6	11	PF01111	0.537
DOC_CKS1_1	99	104	PF01111	0.321
DOC_CYCLIN_yCln2_LP_2	117	123	PF00134	0.577
DOC_USP7_MATH_1	11	15	PF00917	0.508
DOC_WW_Pin1_4	5	10	PF00397	0.524
DOC_WW_Pin1_4	98	103	PF00397	0.321
LIG_14-3-3_CanoR_1	61	71	PF00244	0.526
LIG_Clathr_ClatBox_1	181	185	PF01394	0.598
LIG_FHA_1	127	133	PF00498	0.501
LIG_FHA_1	156	162	PF00498	0.331
LIG_FHA_1	83	89	PF00498	0.368
LIG_FHA_1	99	105	PF00498	0.283
LIG_KLC1_Yacidic_2	191	196	PF13176	0.607
LIG_LIR_Gen_1	125	136	PF02991	0.430
LIG_LIR_Gen_1	150	160	PF02991	0.356
LIG_LIR_LC3C_4	158	161	PF02991	0.249
LIG_LIR_Nem_3	125	131	PF02991	0.430
LIG_LIR_Nem_3	150	155	PF02991	0.442
LIG_MYND_1	119	123	PF01753	0.430
LIG_MYND_1	179	183	PF01753	0.596
LIG_NRBOX	70	76	PF00104	0.462
LIG_Pex14_1	135	139	PF04695	0.677
LIG_Pex14_2	131	135	PF04695	0.421
LIG_Pex14_2	139	143	PF04695	0.485
LIG_SH2_STAP1	128	132	PF00017	0.430
LIG_SH2_STAT3	51	54	PF00017	0.709
LIG_SH2_STAT5	100	103	PF00017	0.332
LIG_SH2_STAT5	113	116	PF00017	0.416
LIG_SH2_STAT5	128	131	PF00017	0.376
LIG_SH2_STAT5	92	95	PF00017	0.427
LIG_SH3_3	116	122	PF00018	0.171
LIG_SH3_3	180	186	PF00018	0.747
LIG_SH3_3	96	102	PF00018	0.412
LIG_SUMO_SIM_anti_2	158	163	PF11976	0.249
LIG_SUMO_SIM_anti_2	39	44	PF11976	0.430
LIG_TYR_ITIM	90	95	PF00017	0.480
MOD_CK1_1	5	11	PF00069	0.424
MOD_GlcNHglycan	124	127	PF01048	0.430
MOD_GlcNHglycan	13	16	PF01048	0.687
MOD_GlcNHglycan	143	146	PF01048	0.697
MOD_GlcNHglycan	169	172	PF01048	0.579
MOD_GSK3_1	122	129	PF00069	0.430
MOD_GSK3_1	69	76	PF00069	0.266
MOD_GSK3_1	94	101	PF00069	0.354
MOD_NEK2_1	143	148	PF00069	0.446
MOD_NEK2_1	165	170	PF00069	0.501
MOD_NEK2_1	22	27	PF00069	0.466
MOD_NEK2_1	62	67	PF00069	0.430
MOD_NEK2_1	69	74	PF00069	0.376
MOD_NEK2_1	82	87	PF00069	0.399
MOD_NEK2_1	93	98	PF00069	0.370
MOD_PIKK_1	143	149	PF00454	0.494
MOD_PIKK_1	94	100	PF00454	0.444
MOD_Plk_1	83	89	PF00069	0.431
MOD_Plk_2-3	185	191	PF00069	0.717
MOD_Plk_4	155	161	PF00069	0.496
MOD_Plk_4	177	183	PF00069	0.686
MOD_Plk_4	69	75	PF00069	0.423
MOD_Plk_4	83	89	PF00069	0.406
MOD_ProDKin_1	5	11	PF00069	0.524
MOD_ProDKin_1	98	104	PF00069	0.321
TRG_ENDOCYTIC_2	128	131	PF00928	0.430
TRG_ENDOCYTIC_2	92	95	PF00928	0.487
TRG_NLS_MonoExtN_4	52	59	PF00514	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P307	Leptomonas seymouri	60%	69%
A0A3Q8ICG4	Leishmania donovani	83%	69%
A4I089	Leishmania infantum	83%	69%
C9ZV06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	69%
E9AW53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	69%
Q4QBC4	Leishmania major	81%	100%