AMPKBI domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

5'-AMP-activated protein kinase subunit beta, putative

Species:

Leishmania braziliensis

UniProt:

A4HCR3_LEIBR

TriTrypDb:

LbrM.23.0520 , LBRM2903_230011300

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0031588	nucleotide-activated protein kinase complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1902911	protein kinase complex	5	12
GO:1990234	transferase complex	3	12
GO:0005634	nucleus	5	1
GO:0005777	peroxisome	6	1
GO:0005929	cilium	4	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HCR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCR3

Function

Biological processes
Term	Name	Level	Count
GO:0001932	regulation of protein phosphorylation	7	12
GO:0007165	signal transduction	2	12
GO:0009987	cellular process	1	12
GO:0019220	regulation of phosphate metabolic process	6	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031399	regulation of protein modification process	6	12
GO:0042325	regulation of phosphorylation	7	12
GO:0043549	regulation of kinase activity	5	12
GO:0045859	regulation of protein kinase activity	6	12
GO:0050789	regulation of biological process	2	12
GO:0050790	regulation of catalytic activity	3	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051174	regulation of phosphorus metabolic process	5	12
GO:0051246	regulation of protein metabolic process	5	12
GO:0051338	regulation of transferase activity	4	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0065009	regulation of molecular function	2	12
GO:0080090	regulation of primary metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.581
CLV_C14_Caspase3-7	92	96	PF00656	0.320
CLV_NRD_NRD_1	175	177	PF00675	0.443
CLV_NRD_NRD_1	239	241	PF00675	0.263
CLV_NRD_NRD_1	46	48	PF00675	0.413
CLV_PCSK_KEX2_1	239	241	PF00082	0.286
DEG_ODPH_VHL_1	100	111	PF01847	0.616
DEG_SCF_FBW7_1	186	193	PF00400	0.248
DOC_CKS1_1	191	196	PF01111	0.261
DOC_CKS1_1	63	68	PF01111	0.342
DOC_CYCLIN_yCln2_LP_2	128	134	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	224	230	PF00134	0.248
DOC_MAPK_DCC_7	176	184	PF00069	0.271
DOC_MAPK_gen_1	135	145	PF00069	0.517
DOC_MAPK_gen_1	176	184	PF00069	0.282
DOC_MAPK_gen_1	199	208	PF00069	0.391
DOC_MAPK_gen_1	47	54	PF00069	0.285
DOC_MAPK_MEF2A_6	176	184	PF00069	0.296
DOC_MAPK_MEF2A_6	47	54	PF00069	0.266
DOC_PP2B_LxvP_1	224	227	PF13499	0.248
DOC_PP2B_LxvP_1	75	78	PF13499	0.342
DOC_SPAK_OSR1_1	85	89	PF12202	0.263
DOC_USP7_MATH_1	269	273	PF00917	0.599
DOC_USP7_MATH_1	46	50	PF00917	0.233
DOC_WW_Pin1_4	103	108	PF00397	0.605
DOC_WW_Pin1_4	186	191	PF00397	0.274
DOC_WW_Pin1_4	62	67	PF00397	0.317
LIG_14-3-3_CanoR_1	3	7	PF00244	0.613
LIG_14-3-3_CanoR_1	47	51	PF00244	0.273
LIG_BIR_II_1	1	5	PF00653	0.491
LIG_deltaCOP1_diTrp_1	163	172	PF00928	0.511
LIG_EVH1_1	6	10	PF00568	0.589
LIG_FHA_1	123	129	PF00498	0.698
LIG_FHA_1	140	146	PF00498	0.333
LIG_FHA_1	19	25	PF00498	0.650
LIG_FHA_1	255	261	PF00498	0.308
LIG_FHA_1	26	32	PF00498	0.483
LIG_FHA_1	95	101	PF00498	0.303
LIG_FHA_2	149	155	PF00498	0.477
LIG_FHA_2	209	215	PF00498	0.311
LIG_LIR_Gen_1	49	57	PF02991	0.282
LIG_LIR_Gen_1	69	79	PF02991	0.248
LIG_LIR_Nem_3	175	181	PF02991	0.274
LIG_LIR_Nem_3	28	32	PF02991	0.392
LIG_LIR_Nem_3	49	54	PF02991	0.282
LIG_LIR_Nem_3	58	62	PF02991	0.220
LIG_LIR_Nem_3	68	74	PF02991	0.293
LIG_LYPXL_yS_3	178	181	PF13949	0.263
LIG_RPA_C_Fungi	42	54	PF08784	0.277
LIG_SH2_CRK	188	192	PF00017	0.248
LIG_SH2_CRK	256	260	PF00017	0.289
LIG_SH2_CRK	84	88	PF00017	0.308
LIG_SH2_PTP2	51	54	PF00017	0.282
LIG_SH2_STAP1	256	260	PF00017	0.282
LIG_SH2_STAT3	35	38	PF00017	0.480
LIG_SH2_STAT5	188	191	PF00017	0.248
LIG_SH2_STAT5	236	239	PF00017	0.248
LIG_SH2_STAT5	252	255	PF00017	0.263
LIG_SH2_STAT5	256	259	PF00017	0.263
LIG_SH2_STAT5	51	54	PF00017	0.282
LIG_SH3_1	177	183	PF00018	0.263
LIG_SH3_1	60	66	PF00018	0.167
LIG_SH3_3	104	110	PF00018	0.659
LIG_SH3_3	113	119	PF00018	0.701
LIG_SH3_3	121	127	PF00018	0.669
LIG_SH3_3	177	183	PF00018	0.288
LIG_SH3_3	263	269	PF00018	0.544
LIG_SH3_3	4	10	PF00018	0.608
LIG_SH3_3	60	66	PF00018	0.350
LIG_SH3_3	96	102	PF00018	0.341
LIG_SUMO_SIM_par_1	226	231	PF11976	0.330
LIG_TYR_ITAM	69	87	PF00017	0.342
LIG_TYR_ITIM	186	191	PF00017	0.248
LIG_TYR_ITIM	260	265	PF00017	0.391
MOD_CK1_1	2	8	PF00069	0.559
MOD_CK1_1	272	278	PF00069	0.678
MOD_CK1_1	67	73	PF00069	0.263
MOD_CK2_1	148	154	PF00069	0.541
MOD_CK2_1	208	214	PF00069	0.173
MOD_GSK3_1	186	193	PF00069	0.263
MOD_NEK2_1	1	6	PF00069	0.651
MOD_NEK2_1	122	127	PF00069	0.583
MOD_NEK2_1	172	177	PF00069	0.455
MOD_NEK2_1	228	233	PF00069	0.248
MOD_NEK2_1	246	251	PF00069	0.282
MOD_NEK2_2	139	144	PF00069	0.490
MOD_NEK2_2	46	51	PF00069	0.167
MOD_PIKK_1	122	128	PF00454	0.686
MOD_PIKK_1	94	100	PF00454	0.263
MOD_PKA_2	198	204	PF00069	0.303
MOD_PKA_2	2	8	PF00069	0.697
MOD_PKA_2	46	52	PF00069	0.167
MOD_Plk_4	139	145	PF00069	0.489
MOD_Plk_4	193	199	PF00069	0.391
MOD_Plk_4	255	261	PF00069	0.311
MOD_Plk_4	46	52	PF00069	0.214
MOD_Plk_4	67	73	PF00069	0.263
MOD_ProDKin_1	103	109	PF00069	0.608
MOD_ProDKin_1	186	192	PF00069	0.274
MOD_ProDKin_1	62	68	PF00069	0.317
TRG_ENDOCYTIC_2	178	181	PF00928	0.256
TRG_ENDOCYTIC_2	188	191	PF00928	0.236
TRG_ENDOCYTIC_2	256	259	PF00928	0.257
TRG_ENDOCYTIC_2	262	265	PF00928	0.349
TRG_ENDOCYTIC_2	51	54	PF00928	0.282
TRG_ENDOCYTIC_2	72	75	PF00928	0.249
TRG_ENDOCYTIC_2	84	87	PF00928	0.250
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9V7	Leptomonas seymouri	78%	82%
A0A0S4IRW9	Bodo saltans	42%	75%
A0A1X0NX44	Trypanosomatidae	56%	82%
A0A3Q8ICH1	Leishmania donovani	88%	82%
A0A3R7K3F4	Trypanosoma rangeli	57%	93%
A4I088	Leishmania infantum	88%	82%
C9ZV05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	90%
E9AW52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O43741	Homo sapiens	27%	100%
P80386	Rattus norvegicus	26%	100%
Q4QBC5	Leishmania major	89%	100%
Q5BIS9	Bos taurus	26%	100%
Q6PAM0	Mus musculus	27%	100%
Q9QZH4	Rattus norvegicus	27%	100%
Q9R078	Mus musculus	26%	100%
V5ASF8	Trypanosoma cruzi	57%	91%