Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCR1_LEIBR

TriTrypDb:

LbrM.23.0500 , LBRM2903_230010900

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.699
CLV_NRD_NRD_1	207	209	PF00675	0.437
CLV_PCSK_KEX2_1	207	209	PF00082	0.437
CLV_PCSK_KEX2_1	235	237	PF00082	0.727
CLV_PCSK_KEX2_1	7	9	PF00082	0.625
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.727
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.547
CLV_PCSK_SKI1_1	112	116	PF00082	0.783
CLV_PCSK_SKI1_1	180	184	PF00082	0.619
CLV_PCSK_SKI1_1	301	305	PF00082	0.586
DEG_ODPH_VHL_1	163	176	PF01847	0.422
DEG_SPOP_SBC_1	123	127	PF00917	0.581
DOC_CYCLIN_yCln2_LP_2	154	157	PF00134	0.517
DOC_PP2B_LxvP_1	154	157	PF13499	0.654
DOC_PP2B_LxvP_1	163	166	PF13499	0.508
DOC_USP7_MATH_1	123	127	PF00917	0.770
DOC_USP7_MATH_1	19	23	PF00917	0.607
DOC_USP7_MATH_1	262	266	PF00917	0.741
DOC_USP7_MATH_1	325	329	PF00917	0.768
DOC_USP7_MATH_1	334	338	PF00917	0.630
DOC_WW_Pin1_4	124	129	PF00397	0.692
DOC_WW_Pin1_4	131	136	PF00397	0.738
DOC_WW_Pin1_4	281	286	PF00397	0.787
DOC_WW_Pin1_4	44	49	PF00397	0.552
LIG_14-3-3_CanoR_1	112	117	PF00244	0.782
LIG_14-3-3_CanoR_1	15	19	PF00244	0.711
LIG_14-3-3_CanoR_1	21	30	PF00244	0.608
LIG_14-3-3_CanoR_1	267	272	PF00244	0.678
LIG_14-3-3_CanoR_1	50	59	PF00244	0.782
LIG_14-3-3_CanoR_1	75	79	PF00244	0.590
LIG_14-3-3_CanoR_1	8	13	PF00244	0.765
LIG_Actin_WH2_2	300	318	PF00022	0.590
LIG_BIR_II_1	1	5	PF00653	0.801
LIG_EVH1_1	155	159	PF00568	0.635
LIG_FHA_1	102	108	PF00498	0.750
LIG_FHA_1	15	21	PF00498	0.569
LIG_FHA_1	189	195	PF00498	0.551
LIG_FHA_1	212	218	PF00498	0.688
LIG_FHA_1	221	227	PF00498	0.771
LIG_FHA_1	282	288	PF00498	0.826
LIG_FHA_1	302	308	PF00498	0.627
LIG_Integrin_isoDGR_2	242	244	PF01839	0.564
LIG_LIR_Apic_2	119	123	PF02991	0.805
LIG_LIR_Apic_2	77	81	PF02991	0.492
LIG_MYND_1	153	157	PF01753	0.720
LIG_PDZ_Class_2	339	344	PF00595	0.663
LIG_SH2_CRK	73	77	PF00017	0.500
LIG_SH2_CRK	78	82	PF00017	0.466
LIG_SH2_NCK_1	34	38	PF00017	0.531
LIG_SH2_NCK_1	78	82	PF00017	0.538
LIG_SH2_SRC	78	81	PF00017	0.639
LIG_SH2_STAP1	32	36	PF00017	0.702
LIG_SH2_STAT5	34	37	PF00017	0.661
LIG_SH3_3	150	156	PF00018	0.721
LIG_SH3_3	24	30	PF00018	0.618
LIG_SH3_3	282	288	PF00018	0.662
LIG_SH3_3	294	300	PF00018	0.785
LIG_SUMO_SIM_par_1	173	179	PF11976	0.616
MOD_CDC14_SPxK_1	47	50	PF00782	0.551
MOD_CDK_SPxK_1	44	50	PF00069	0.552
MOD_CK1_1	121	127	PF00069	0.567
MOD_CK1_1	136	142	PF00069	0.579
MOD_CK1_1	2	8	PF00069	0.669
MOD_CK1_1	261	267	PF00069	0.801
MOD_CK1_1	280	286	PF00069	0.576
MOD_CK1_1	328	334	PF00069	0.593
MOD_CK1_1	55	61	PF00069	0.762
MOD_GlcNHglycan	135	138	PF01048	0.687
MOD_GlcNHglycan	23	26	PF01048	0.798
MOD_GlcNHglycan	252	255	PF01048	0.786
MOD_GlcNHglycan	260	263	PF01048	0.664
MOD_GlcNHglycan	322	326	PF01048	0.749
MOD_GSK3_1	112	119	PF00069	0.690
MOD_GSK3_1	258	265	PF00069	0.790
MOD_GSK3_1	277	284	PF00069	0.515
MOD_GSK3_1	28	35	PF00069	0.720
MOD_GSK3_1	321	328	PF00069	0.598
MOD_GSK3_1	44	51	PF00069	0.551
MOD_N-GLC_2	108	110	PF02516	0.541
MOD_NEK2_1	101	106	PF00069	0.701
MOD_NEK2_1	188	193	PF00069	0.594
MOD_NEK2_1	20	25	PF00069	0.786
MOD_NEK2_1	277	282	PF00069	0.804
MOD_NEK2_1	36	41	PF00069	0.558
MOD_NEK2_1	84	89	PF00069	0.667
MOD_PIKK_1	101	107	PF00454	0.789
MOD_PIKK_1	118	124	PF00454	0.661
MOD_PIKK_1	188	194	PF00454	0.498
MOD_PIKK_1	262	268	PF00454	0.789
MOD_PIKK_1	325	331	PF00454	0.726
MOD_PIKK_1	36	42	PF00454	0.669
MOD_PK_1	267	273	PF00069	0.646
MOD_PKA_2	14	20	PF00069	0.647
MOD_PKA_2	146	152	PF00069	0.612
MOD_PKA_2	49	55	PF00069	0.793
MOD_PKA_2	74	80	PF00069	0.665
MOD_PKA_2	84	90	PF00069	0.661
MOD_Plk_4	146	152	PF00069	0.549
MOD_ProDKin_1	124	130	PF00069	0.692
MOD_ProDKin_1	131	137	PF00069	0.736
MOD_ProDKin_1	281	287	PF00069	0.788
MOD_ProDKin_1	44	50	PF00069	0.552
TRG_DiLeu_BaEn_1	190	195	PF01217	0.604
TRG_DiLeu_BaEn_2	337	343	PF01217	0.666
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.539
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.786
TRG_ENDOCYTIC_2	73	76	PF00928	0.498
TRG_ER_diArg_1	206	208	PF00400	0.437
TRG_ER_diArg_1	236	239	PF00400	0.792
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.791
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9J6	Leptomonas seymouri	35%	100%
A0A3S7WXL1	Leishmania donovani	61%	99%
A4I086	Leishmania infantum	62%	99%
E9AW50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	98%
Q4QBC7	Leishmania major	62%	100%