Putative trypanothione synthetase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

trypanothione synthetase, putative

Species:

Leishmania braziliensis

UniProt:

A4HCR0_LEIBR

TriTrypDb:

LbrM.23.0490 , LBRM2903_230010800

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCR0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016874	ligase activity	2	7
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	7
GO:0016880	acid-ammonia (or amide) ligase activity	4	7
GO:0047479	trypanothione synthase activity	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.463
CLV_NRD_NRD_1	64	66	PF00675	0.440
CLV_PCSK_KEX2_1	12	14	PF00082	0.436
CLV_PCSK_KEX2_1	64	66	PF00082	0.440
CLV_PCSK_SKI1_1	72	76	PF00082	0.460
DEG_APCC_DBOX_1	15	23	PF00400	0.293
DEG_SPOP_SBC_1	126	130	PF00917	0.185
DOC_CYCLIN_RxL_1	69	77	PF00134	0.253
DOC_MAPK_gen_1	12	19	PF00069	0.393
DOC_PP2B_LxvP_1	73	76	PF13499	0.240
DOC_PP4_FxxP_1	172	175	PF00568	0.185
DOC_SPAK_OSR1_1	221	225	PF12202	0.345
DOC_USP7_MATH_1	120	124	PF00917	0.248
DOC_USP7_MATH_1	161	165	PF00917	0.254
DOC_USP7_UBL2_3	146	150	PF12436	0.292
DOC_WW_Pin1_4	116	121	PF00397	0.275
DOC_WW_Pin1_4	171	176	PF00397	0.330
DOC_WW_Pin1_4	95	100	PF00397	0.393
LIG_14-3-3_CanoR_1	16	20	PF00244	0.392
LIG_14-3-3_CanoR_1	65	75	PF00244	0.254
LIG_14-3-3_CterR_2	248	253	PF00244	0.473
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_BRCT_BRCA1_1	209	213	PF00533	0.310
LIG_FHA_1	1	7	PF00498	0.464
LIG_FHA_1	230	236	PF00498	0.483
LIG_FHA_1	68	74	PF00498	0.334
LIG_FHA_2	16	22	PF00498	0.294
LIG_FHA_2	181	187	PF00498	0.334
LIG_FHA_2	237	243	PF00498	0.557
LIG_LIR_Apic_2	171	175	PF02991	0.334
LIG_LIR_Gen_1	232	241	PF02991	0.393
LIG_LIR_Nem_3	174	179	PF02991	0.308
LIG_LIR_Nem_3	232	237	PF02991	0.342
LIG_LIR_Nem_3	49	55	PF02991	0.378
LIG_Pex14_2	172	176	PF04695	0.185
LIG_Pex14_2	62	66	PF04695	0.240
LIG_SH2_CRK	209	213	PF00017	0.444
LIG_SH2_GRB2like	33	36	PF00017	0.362
LIG_SH2_NCK_1	209	213	PF00017	0.411
LIG_SH2_STAP1	209	213	PF00017	0.317
LIG_SH2_STAT3	25	28	PF00017	0.310
LIG_SH2_STAT3	55	58	PF00017	0.240
LIG_SH2_STAT5	200	203	PF00017	0.477
LIG_SH2_STAT5	223	226	PF00017	0.350
LIG_SH2_STAT5	25	28	PF00017	0.480
LIG_SH2_STAT5	47	50	PF00017	0.292
LIG_SH2_STAT5	82	85	PF00017	0.334
LIG_SH2_STAT5	89	92	PF00017	0.334
LIG_SH3_3	103	109	PF00018	0.326
LIG_SUMO_SIM_par_1	2	10	PF11976	0.697
LIG_UBA3_1	212	219	PF00899	0.270
MOD_CK1_1	113	119	PF00069	0.302
MOD_CK1_1	171	177	PF00069	0.330
MOD_CK1_1	229	235	PF00069	0.245
MOD_CK1_1	34	40	PF00069	0.399
MOD_CK1_1	4	10	PF00069	0.682
MOD_CK1_1	85	91	PF00069	0.279
MOD_CK2_1	236	242	PF00069	0.466
MOD_Cter_Amidation	10	13	PF01082	0.441
MOD_GlcNHglycan	114	118	PF01048	0.553
MOD_GlcNHglycan	209	212	PF01048	0.315
MOD_GlcNHglycan	9	12	PF01048	0.484
MOD_GSK3_1	116	123	PF00069	0.369
MOD_GSK3_1	229	236	PF00069	0.429
MOD_GSK3_1	31	38	PF00069	0.501
MOD_N-GLC_1	34	39	PF02516	0.417
MOD_NEK2_1	1	6	PF00069	0.610
MOD_NEK2_1	67	72	PF00069	0.334
MOD_NEK2_2	15	20	PF00069	0.521
MOD_OFUCOSY	80	87	PF10250	0.535
MOD_PKA_2	15	21	PF00069	0.386
MOD_PKA_2	247	253	PF00069	0.470
MOD_Plk_4	1	7	PF00069	0.597
MOD_Plk_4	161	167	PF00069	0.259
MOD_Plk_4	236	242	PF00069	0.372
MOD_Plk_4	85	91	PF00069	0.203
MOD_ProDKin_1	116	122	PF00069	0.275
MOD_ProDKin_1	171	177	PF00069	0.330
MOD_ProDKin_1	95	101	PF00069	0.393
MOD_SUMO_rev_2	119	129	PF00179	0.271
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.334
TRG_ENDOCYTIC_2	209	212	PF00928	0.449
TRG_ER_diArg_1	64	66	PF00400	0.241
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II02	Leptomonas seymouri	62%	100%
A0A0S4IVA9	Bodo saltans	37%	83%
A0A3S7WXK4	Leishmania donovani	73%	78%
A0A422N6B5	Trypanosoma rangeli	38%	100%
A4I085	Leishmania infantum	71%	78%
C9ZV01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AW49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	85%
Q4QBC8	Leishmania major	69%	100%
V5BCE6	Trypanosoma cruzi	37%	88%