Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCQ8_LEIBR

TriTrypDb:

LbrM.23.0470 , LBRM2903_230010600

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCQ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.439
CLV_C14_Caspase3-7	55	59	PF00656	0.468
CLV_NRD_NRD_1	10	12	PF00675	0.493
CLV_NRD_NRD_1	232	234	PF00675	0.296
CLV_PCSK_KEX2_1	232	234	PF00082	0.296
DEG_Nend_UBRbox_3	1	3	PF02207	0.292
DEG_SCF_FBW7_1	158	165	PF00400	0.433
DOC_CKS1_1	159	164	PF01111	0.433
DOC_CYCLIN_yClb3_PxF_3	224	230	PF00134	0.371
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.263
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.432
DOC_MAPK_gen_1	309	317	PF00069	0.317
DOC_MAPK_MEF2A_6	309	317	PF00069	0.317
DOC_PP2B_LxvP_1	205	208	PF13499	0.438
DOC_PP4_FxxP_1	222	225	PF00568	0.293
DOC_PP4_MxPP_1	156	159	PF00568	0.321
DOC_USP7_MATH_1	162	166	PF00917	0.711
DOC_USP7_MATH_1	237	241	PF00917	0.288
DOC_USP7_MATH_1	292	296	PF00917	0.533
DOC_WW_Pin1_4	158	163	PF00397	0.596
DOC_WW_Pin1_4	200	205	PF00397	0.409
DOC_WW_Pin1_4	81	86	PF00397	0.638
LIG_14-3-3_CanoR_1	125	129	PF00244	0.415
LIG_14-3-3_CanoR_1	151	157	PF00244	0.449
LIG_14-3-3_CanoR_1	309	314	PF00244	0.404
LIG_APCC_ABBA_1	108	113	PF00400	0.450
LIG_APCC_ABBA_1	315	320	PF00400	0.404
LIG_BRCT_BRCA1_1	137	141	PF00533	0.305
LIG_FHA_1	81	87	PF00498	0.650
LIG_FHA_2	195	201	PF00498	0.356
LIG_FHA_2	260	266	PF00498	0.422
LIG_LIR_Gen_1	218	228	PF02991	0.459
LIG_LIR_Gen_1	254	263	PF02991	0.432
LIG_LIR_Gen_1	58	68	PF02991	0.391
LIG_LIR_Nem_3	218	223	PF02991	0.443
LIG_LIR_Nem_3	254	259	PF02991	0.435
LIG_LIR_Nem_3	5	10	PF02991	0.300
LIG_LIR_Nem_3	58	63	PF02991	0.336
LIG_PCNA_PIPBox_1	1	10	PF02747	0.307
LIG_PTB_Apo_2	67	74	PF02174	0.522
LIG_SH2_GRB2like	117	120	PF00017	0.459
LIG_SH2_STAP1	111	115	PF00017	0.294
LIG_SH2_STAP1	117	121	PF00017	0.322
LIG_SH2_STAP1	60	64	PF00017	0.385
LIG_SH2_STAT3	117	120	PF00017	0.466
LIG_SH2_STAT3	183	186	PF00017	0.403
LIG_SH2_STAT5	135	138	PF00017	0.348
LIG_SH2_STAT5	183	186	PF00017	0.403
LIG_SH2_STAT5	256	259	PF00017	0.419
LIG_SH2_STAT5	7	10	PF00017	0.321
LIG_SH3_3	156	162	PF00018	0.365
LIG_SH3_3	218	224	PF00018	0.365
LIG_SH3_3	231	237	PF00018	0.358
LIG_SH3_3	94	100	PF00018	0.457
LIG_TYR_ITSM	3	10	PF00017	0.309
LIG_WW_3	157	161	PF00397	0.384
MOD_CK1_1	75	81	PF00069	0.552
MOD_CK2_1	194	200	PF00069	0.364
MOD_GlcNHglycan	105	108	PF01048	0.341
MOD_GlcNHglycan	143	146	PF01048	0.514
MOD_GlcNHglycan	253	256	PF01048	0.495
MOD_GlcNHglycan	91	94	PF01048	0.616
MOD_GSK3_1	120	127	PF00069	0.495
MOD_GSK3_1	135	142	PF00069	0.499
MOD_GSK3_1	158	165	PF00069	0.613
MOD_GSK3_1	168	175	PF00069	0.607
MOD_GSK3_1	194	201	PF00069	0.324
MOD_GSK3_1	251	258	PF00069	0.405
MOD_GSK3_1	75	82	PF00069	0.620
MOD_N-GLC_1	79	84	PF02516	0.666
MOD_NEK2_1	141	146	PF00069	0.466
MOD_NEK2_1	150	155	PF00069	0.431
MOD_NEK2_1	194	199	PF00069	0.350
MOD_NEK2_1	251	256	PF00069	0.408
MOD_NEK2_1	79	84	PF00069	0.679
MOD_NEK2_2	46	51	PF00069	0.374
MOD_PKA_2	124	130	PF00069	0.374
MOD_PKA_2	150	156	PF00069	0.549
MOD_PKA_2	169	175	PF00069	0.725
MOD_PKA_2	213	219	PF00069	0.319
MOD_Plk_1	284	290	PF00069	0.451
MOD_Plk_4	124	130	PF00069	0.396
MOD_Plk_4	226	232	PF00069	0.373
MOD_Plk_4	3	9	PF00069	0.318
MOD_ProDKin_1	158	164	PF00069	0.608
MOD_ProDKin_1	200	206	PF00069	0.409
MOD_ProDKin_1	81	87	PF00069	0.640
TRG_ENDOCYTIC_2	111	114	PF00928	0.327
TRG_ENDOCYTIC_2	256	259	PF00928	0.362
TRG_ENDOCYTIC_2	60	63	PF00928	0.332
TRG_ENDOCYTIC_2	7	10	PF00928	0.321
TRG_ER_diArg_1	231	233	PF00400	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5K0	Leptomonas seymouri	55%	100%
A0A0S4JDC4	Bodo saltans	34%	100%
A0A1X0NXD8	Trypanosomatidae	45%	100%
A0A3R7MEG1	Trypanosoma rangeli	43%	100%
A0A3S5H7B7	Leishmania donovani	81%	100%
A4I083	Leishmania infantum	81%	100%
C9ZV00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AW47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QBD0	Leishmania major	81%	100%
V5ASF5	Trypanosoma cruzi	42%	100%