Aldose 1-epimerase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldose 1-epimerase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HCQ7_LEIBR

TriTrypDb:

LbrM.23.0460 , LBRM2903_230010500

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCQ7

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	21
GO:0008152	metabolic process	1	21
GO:0044238	primary metabolic process	2	21
GO:0071704	organic substance metabolic process	2	21
GO:0005996	monosaccharide metabolic process	3	6
GO:0019318	hexose metabolic process	4	6
GO:0044281	small molecule metabolic process	2	6
GO:0006006	glucose metabolic process	5	3
GO:0006012	galactose metabolic process	5	3
GO:0009056	catabolic process	2	3
GO:0016052	carbohydrate catabolic process	4	3
GO:0019320	hexose catabolic process	5	3
GO:0019388	galactose catabolic process	6	3
GO:0033499	galactose catabolic process via UDP-galactose	7	3
GO:0044282	small molecule catabolic process	3	3
GO:0046365	monosaccharide catabolic process	4	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	21
GO:0004034	aldose 1-epimerase activity	5	16
GO:0005488	binding	1	21
GO:0016853	isomerase activity	2	21
GO:0016854	racemase and epimerase activity	3	16
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4	16
GO:0030246	carbohydrate binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.540
CLV_C14_Caspase3-7	282	286	PF00656	0.555
CLV_NRD_NRD_1	51	53	PF00675	0.375
CLV_PCSK_SKI1_1	137	141	PF00082	0.299
CLV_PCSK_SKI1_1	184	188	PF00082	0.340
CLV_PCSK_SKI1_1	229	233	PF00082	0.342
DEG_Nend_Nbox_1	1	3	PF02207	0.504
DOC_ANK_TNKS_1	269	276	PF00023	0.524
DOC_PP2B_PxIxI_1	323	329	PF00149	0.524
DOC_USP7_MATH_1	336	340	PF00917	0.583
DOC_USP7_MATH_1	367	371	PF00917	0.463
DOC_USP7_MATH_1	45	49	PF00917	0.503
DOC_USP7_MATH_1	56	60	PF00917	0.465
DOC_USP7_MATH_2	80	86	PF00917	0.463
DOC_WW_Pin1_4	152	157	PF00397	0.488
DOC_WW_Pin1_4	307	312	PF00397	0.494
DOC_WW_Pin1_4	359	364	PF00397	0.479
DOC_WW_Pin1_4	392	397	PF00397	0.580
LIG_14-3-3_CanoR_1	318	327	PF00244	0.443
LIG_Actin_WH2_2	256	272	PF00022	0.441
LIG_AP2alpha_2	20	22	PF02296	0.334
LIG_APCC_ABBA_1	154	159	PF00400	0.472
LIG_APCC_ABBA_1	19	24	PF00400	0.377
LIG_APCC_ABBAyCdc20_2	375	381	PF00400	0.478
LIG_BIR_III_4	337	341	PF00653	0.473
LIG_BRCT_BRCA1_1	147	151	PF00533	0.491
LIG_BRCT_BRCA1_1	239	243	PF00533	0.564
LIG_FHA_1	169	175	PF00498	0.524
LIG_FHA_1	320	326	PF00498	0.474
LIG_FHA_1	84	90	PF00498	0.486
LIG_FHA_2	193	199	PF00498	0.572
LIG_FHA_2	260	266	PF00498	0.519
LIG_FHA_2	277	283	PF00498	0.488
LIG_FHA_2	299	305	PF00498	0.463
LIG_FHA_2	381	387	PF00498	0.530
LIG_FHA_2	393	399	PF00498	0.660
LIG_FHA_2	76	82	PF00498	0.535
LIG_LIR_Gen_1	148	158	PF02991	0.458
LIG_LIR_Gen_1	169	180	PF02991	0.518
LIG_LIR_Gen_1	232	243	PF02991	0.483
LIG_LIR_Gen_1	265	273	PF02991	0.586
LIG_LIR_Gen_1	384	394	PF02991	0.441
LIG_LIR_Gen_1	67	77	PF02991	0.484
LIG_LIR_Nem_3	135	139	PF02991	0.465
LIG_LIR_Nem_3	148	154	PF02991	0.472
LIG_LIR_Nem_3	169	175	PF02991	0.501
LIG_LIR_Nem_3	232	238	PF02991	0.512
LIG_LIR_Nem_3	240	245	PF02991	0.571
LIG_LIR_Nem_3	265	269	PF02991	0.550
LIG_LIR_Nem_3	67	73	PF02991	0.484
LIG_MLH1_MIPbox_1	239	243	PF16413	0.564
LIG_Pex14_2	22	26	PF04695	0.553
LIG_PTB_Apo_2	107	114	PF02174	0.482
LIG_PTB_Apo_2	203	210	PF02174	0.480
LIG_PTB_Phospho_1	107	113	PF10480	0.558
LIG_PTB_Phospho_1	203	209	PF10480	0.480
LIG_SH2_CRK	172	176	PF00017	0.525
LIG_SH2_GRB2like	209	212	PF00017	0.480
LIG_SH2_GRB2like	77	80	PF00017	0.564
LIG_SH2_NCK_1	309	313	PF00017	0.463
LIG_SH2_NCK_1	77	81	PF00017	0.511
LIG_SH2_SRC	289	292	PF00017	0.485
LIG_SH2_SRC	405	408	PF00017	0.518
LIG_SH2_STAP1	329	333	PF00017	0.443
LIG_SH2_STAT3	185	188	PF00017	0.550
LIG_SH2_STAT5	113	116	PF00017	0.589
LIG_SH2_STAT5	138	141	PF00017	0.479
LIG_SH2_STAT5	185	188	PF00017	0.555
LIG_SH2_STAT5	235	238	PF00017	0.491
LIG_SH2_STAT5	242	245	PF00017	0.449
LIG_SH2_STAT5	329	332	PF00017	0.513
LIG_SH2_STAT5	358	361	PF00017	0.501
LIG_SH2_STAT5	77	80	PF00017	0.538
LIG_SH3_3	212	218	PF00018	0.527
LIG_SH3_3	357	363	PF00018	0.493
LIG_SH3_3	48	54	PF00018	0.558
LIG_SUMO_SIM_par_1	290	297	PF11976	0.524
LIG_SUMO_SIM_par_1	324	330	PF11976	0.405
LIG_TRAF2_1	279	282	PF00917	0.463
LIG_TRAF2_1	395	398	PF00917	0.635
MOD_CDK_SPxxK_3	307	314	PF00069	0.524
MOD_CDK_SPxxK_3	392	399	PF00069	0.478
MOD_CK1_1	192	198	PF00069	0.573
MOD_CK1_1	310	316	PF00069	0.495
MOD_CK2_1	276	282	PF00069	0.485
MOD_CK2_1	298	304	PF00069	0.632
MOD_CK2_1	380	386	PF00069	0.518
MOD_CK2_1	392	398	PF00069	0.658
MOD_CK2_1	75	81	PF00069	0.532
MOD_GlcNHglycan	12	15	PF01048	0.682
MOD_GlcNHglycan	176	179	PF01048	0.354
MOD_GlcNHglycan	337	341	PF01048	0.316
MOD_GlcNHglycan	349	352	PF01048	0.323
MOD_GlcNHglycan	58	61	PF01048	0.260
MOD_GSK3_1	166	173	PF00069	0.565
MOD_GSK3_1	189	196	PF00069	0.536
MOD_GSK3_1	22	29	PF00069	0.443
MOD_GSK3_1	243	250	PF00069	0.602
MOD_GSK3_1	294	301	PF00069	0.598
MOD_N-GLC_1	193	198	PF02516	0.294
MOD_N-GLC_1	202	207	PF02516	0.303
MOD_NEK2_1	1	6	PF00069	0.705
MOD_NEK2_1	166	171	PF00069	0.532
MOD_NEK2_1	187	192	PF00069	0.537
MOD_NEK2_1	22	27	PF00069	0.451
MOD_NEK2_1	75	80	PF00069	0.587
MOD_NEK2_2	298	303	PF00069	0.564
MOD_NEK2_2	45	50	PF00069	0.545
MOD_PIKK_1	1	7	PF00454	0.776
MOD_PKB_1	316	324	PF00069	0.443
MOD_Plk_1	144	150	PF00069	0.409
MOD_Plk_1	192	198	PF00069	0.466
MOD_Plk_1	246	252	PF00069	0.562
MOD_Plk_1	298	304	PF00069	0.564
MOD_Plk_2-3	193	199	PF00069	0.405
MOD_Plk_4	170	176	PF00069	0.497
MOD_Plk_4	197	203	PF00069	0.484
MOD_ProDKin_1	152	158	PF00069	0.488
MOD_ProDKin_1	307	313	PF00069	0.494
MOD_ProDKin_1	359	365	PF00069	0.479
MOD_ProDKin_1	392	398	PF00069	0.582
MOD_SUMO_rev_2	105	111	PF00179	0.420
TRG_DiLeu_BaEn_1	135	140	PF01217	0.564
TRG_ENDOCYTIC_2	172	175	PF00928	0.499
TRG_ENDOCYTIC_2	209	212	PF00928	0.480
TRG_ENDOCYTIC_2	235	238	PF00928	0.529
TRG_ENDOCYTIC_2	242	245	PF00928	0.534
TRG_ENDOCYTIC_2	266	269	PF00928	0.526
TRG_ER_diArg_1	315	318	PF00400	0.444
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0E0RXA9	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	22%	94%
A0A0N0P441	Leptomonas seymouri	35%	100%
A0A0N0P558	Leptomonas seymouri	73%	100%
A0A0N1PBB3	Leptomonas seymouri	37%	100%
A0A1X0NJ33	Trypanosomatidae	36%	100%
A0A1X0NX70	Trypanosomatidae	57%	100%
A0A3R7MXQ5	Trypanosoma rangeli	55%	100%
A0A3S7WXI1	Leishmania donovani	84%	100%
A0A3S7X8W5	Leishmania donovani	34%	100%
A0A3S7X8Z3	Leishmania donovani	37%	100%
A0A422N115	Trypanosoma rangeli	37%	100%
A4I082	Leishmania infantum	85%	100%
A4IAZ4	Leishmania infantum	34%	100%
D4AMB9	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	25%	93%
E9AES2	Leishmania major	34%	99%
E9AES3	Leishmania major	37%	100%
E9AW46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9B5X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B5X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
P05149	Acinetobacter calcoaceticus	32%	100%
P0A9C3	Escherichia coli (strain K12)	30%	100%
P0A9C4	Shigella flexneri	30%	100%
P21955	Streptococcus thermophilus	27%	100%
P31765	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	100%
P38893	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P53757	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q03PA4	Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947)	26%	100%
Q4QBD1	Leishmania major	86%	100%
Q5EA79	Bos taurus	32%	100%
Q5R8U1	Pongo abelii	30%	100%
Q66HG4	Rattus norvegicus	31%	100%
Q8K157	Mus musculus	31%	100%
Q96C23	Homo sapiens	31%	100%
Q9GKX6	Sus scrofa	33%	100%
V5B7Z0	Trypanosoma cruzi	55%	100%