Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCP9_LEIBR

TriTrypDb:

LbrM.23.0380 , LBRM2903_230009500

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.559
CLV_NRD_NRD_1	210	212	PF00675	0.485
CLV_NRD_NRD_1	277	279	PF00675	0.637
CLV_NRD_NRD_1	30	32	PF00675	0.754
CLV_NRD_NRD_1	34	36	PF00675	0.767
CLV_PCSK_FUR_1	27	31	PF00082	0.530
CLV_PCSK_KEX2_1	131	133	PF00082	0.444
CLV_PCSK_KEX2_1	196	198	PF00082	0.593
CLV_PCSK_KEX2_1	212	214	PF00082	0.604
CLV_PCSK_KEX2_1	277	279	PF00082	0.552
CLV_PCSK_KEX2_1	29	31	PF00082	0.757
CLV_PCSK_KEX2_1	34	36	PF00082	0.765
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.466
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.699
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.690
CLV_PCSK_PC7_1	273	279	PF00082	0.473
CLV_PCSK_PC7_1	30	36	PF00082	0.539
CLV_PCSK_SKI1_1	132	136	PF00082	0.509
CLV_PCSK_SKI1_1	149	153	PF00082	0.517
CLV_PCSK_SKI1_1	178	182	PF00082	0.641
CLV_PCSK_SKI1_1	183	187	PF00082	0.644
CLV_PCSK_SKI1_1	64	68	PF00082	0.663
CLV_PCSK_SKI1_1	97	101	PF00082	0.561
DEG_APCC_DBOX_1	182	190	PF00400	0.458
DEG_Nend_UBRbox_1	1	4	PF02207	0.529
DOC_AGCK_PIF_2	295	300	PF00069	0.580
DOC_CKS1_1	133	138	PF01111	0.389
DOC_MAPK_gen_1	208	217	PF00069	0.631
DOC_MAPK_gen_1	59	68	PF00069	0.420
DOC_MAPK_MEF2A_6	211	219	PF00069	0.755
DOC_MAPK_MEF2A_6	62	70	PF00069	0.540
DOC_PP1_RVXF_1	176	182	PF00149	0.550
DOC_PP4_FxxP_1	219	222	PF00568	0.532
DOC_PP4_FxxP_1	79	82	PF00568	0.443
DOC_USP7_MATH_1	226	230	PF00917	0.726
DOC_USP7_MATH_1	259	263	PF00917	0.624
DOC_USP7_MATH_1	7	11	PF00917	0.598
DOC_USP7_UBL2_3	145	149	PF12436	0.521
DOC_USP7_UBL2_3	208	212	PF12436	0.680
DOC_USP7_UBL2_3	242	246	PF12436	0.617
DOC_WW_Pin1_4	132	137	PF00397	0.436
DOC_WW_Pin1_4	224	229	PF00397	0.702
DOC_WW_Pin1_4	48	53	PF00397	0.588
LIG_CAP-Gly_1	294	300	PF01302	0.574
LIG_FHA_1	65	71	PF00498	0.555
LIG_FHA_1	76	82	PF00498	0.444
LIG_FHA_2	13	19	PF00498	0.607
LIG_FHA_2	189	195	PF00498	0.605
LIG_FHA_2	199	205	PF00498	0.530
LIG_FHA_2	238	244	PF00498	0.672
LIG_FHA_2	262	268	PF00498	0.624
LIG_FHA_2	49	55	PF00498	0.608
LIG_LIR_Apic_2	130	136	PF02991	0.569
LIG_LIR_Apic_2	218	222	PF02991	0.530
LIG_LIR_Apic_2	55	61	PF02991	0.652
LIG_LIR_Apic_2	78	82	PF02991	0.317
LIG_LIR_Gen_1	286	295	PF02991	0.720
LIG_LIR_Nem_3	147	151	PF02991	0.436
LIG_LIR_Nem_3	155	159	PF02991	0.449
LIG_LIR_Nem_3	286	292	PF02991	0.659
LIG_LIR_Nem_3	293	298	PF02991	0.639
LIG_Pex14_1	148	152	PF04695	0.416
LIG_SH2_GRB2like	112	115	PF00017	0.405
LIG_SH2_STAT5	133	136	PF00017	0.591
LIG_SH2_STAT5	159	162	PF00017	0.510
LIG_SH2_STAT5	263	266	PF00017	0.668
LIG_TRAF2_1	15	18	PF00917	0.713
LIG_TRAF2_1	201	204	PF00917	0.608
LIG_TRAF2_1	52	55	PF00917	0.467
LIG_WRC_WIRS_1	76	81	PF05994	0.332
MOD_CK1_1	227	233	PF00069	0.708
MOD_CK2_1	12	18	PF00069	0.611
MOD_CK2_1	188	194	PF00069	0.595
MOD_CK2_1	198	204	PF00069	0.546
MOD_CK2_1	237	243	PF00069	0.584
MOD_CK2_1	48	54	PF00069	0.591
MOD_Cter_Amidation	21	24	PF01082	0.744
MOD_Cter_Amidation	27	30	PF01082	0.654
MOD_Cter_Amidation	32	35	PF01082	0.657
MOD_GlcNHglycan	166	169	PF01048	0.705
MOD_GlcNHglycan	36	39	PF01048	0.690
MOD_GSK3_1	259	266	PF00069	0.713
MOD_GSK3_1	283	290	PF00069	0.729
MOD_GSK3_1	97	104	PF00069	0.476
MOD_LATS_1	281	287	PF00433	0.740
MOD_N-GLC_1	40	45	PF02516	0.659
MOD_NEK2_1	99	104	PF00069	0.469
MOD_PIKK_1	80	86	PF00454	0.310
MOD_PKA_1	34	40	PF00069	0.689
MOD_PKA_2	287	293	PF00069	0.726
MOD_PKA_2	34	40	PF00069	0.684
MOD_PKA_2	89	95	PF00069	0.523
MOD_Plk_2-3	125	131	PF00069	0.493
MOD_Plk_4	134	140	PF00069	0.579
MOD_ProDKin_1	132	138	PF00069	0.428
MOD_ProDKin_1	224	230	PF00069	0.704
MOD_ProDKin_1	48	54	PF00069	0.584
MOD_SUMO_rev_2	142	147	PF00179	0.347
MOD_SUMO_rev_2	261	270	PF00179	0.444
TRG_ER_diArg_1	27	30	PF00400	0.528
TRG_NLS_Bipartite_1	196	215	PF00514	0.460
TRG_NLS_MonoExtN_4	208	215	PF00514	0.691
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P555	Leptomonas seymouri	58%	86%
A0A0S4IRA8	Bodo saltans	25%	95%
A0A1X0NX54	Trypanosomatidae	37%	100%
A0A3Q8IAW9	Leishmania donovani	73%	100%
A0A422NW66	Trypanosoma rangeli	42%	100%
A4I075	Leishmania infantum	73%	100%
C9ZUZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AW38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QBD9	Leishmania major	71%	100%