V-type proton ATPase subunit G

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

(H+)-ATPase G subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HCP8_LEIBR

TriTrypDb:

LbrM.23.0370 , LBRM2903_230009400

Length:

108

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016469	proton-transporting two-sector ATPase complex	3	10
GO:0016471	vacuolar proton-transporting V-type ATPase complex	5	10
GO:0032991	protein-containing complex	1	10
GO:0033176	proton-transporting V-type ATPase complex	4	10
GO:0098796	membrane protein complex	2	10

Expansion

Sequence features

A4HCP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCP8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0005215	transporter activity	1	10
GO:0008324	monoatomic cation transmembrane transporter activity	4	10
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	10
GO:0015075	monoatomic ion transmembrane transporter activity	3	10
GO:0015078	proton transmembrane transporter activity	5	10
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	10
GO:0015399	primary active transmembrane transporter activity	4	10
GO:0016787	hydrolase activity	2	8
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	10
GO:0022804	active transmembrane transporter activity	3	10
GO:0022853	active monoatomic ion transmembrane transporter activity	4	10
GO:0022857	transmembrane transporter activity	2	10
GO:0022890	inorganic cation transmembrane transporter activity	4	10
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	10
GO:0042626	ATPase-coupled transmembrane transporter activity	2	10
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	10
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	10
GO:0140657	ATP-dependent activity	1	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	27	29	PF00675	0.305
CLV_PCSK_KEX2_1	17	19	PF00082	0.267
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.284
CLV_PCSK_SKI1_1	101	105	PF00082	0.260
CLV_PCSK_SKI1_1	34	38	PF00082	0.327
CLV_PCSK_SKI1_1	42	46	PF00082	0.329
LIG_FHA_2	75	81	PF00498	0.329
LIG_LIR_Nem_3	52	58	PF02991	0.262
LIG_PCNA_yPIPBox_3	4	12	PF02747	0.320
LIG_SH2_STAT3	58	61	PF00017	0.284
LIG_SH2_STAT5	58	61	PF00017	0.171
LIG_TRAF2_1	13	16	PF00917	0.391
MOD_CK2_1	102	108	PF00069	0.339
MOD_CK2_1	74	80	PF00069	0.347
MOD_GlcNHglycan	63	66	PF01048	0.171
MOD_NEK2_1	102	107	PF00069	0.339
MOD_PKA_2	74	80	PF00069	0.284
MOD_Plk_1	42	48	PF00069	0.171
MOD_SUMO_rev_2	78	87	PF00179	0.339
TRG_DiLeu_BaEn_4	82	88	PF01217	0.339
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVY9	Leptomonas seymouri	70%	100%
A0A1X0NX64	Trypanosomatidae	63%	99%
A0A3Q8ICF4	Leishmania donovani	83%	100%
A0A422NW25	Trypanosoma rangeli	67%	99%
A4I074	Leishmania infantum	83%	100%
C9ZUY8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	99%
E9AW37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
O82628	Arabidopsis thaliana	36%	98%
O82629	Arabidopsis thaliana	36%	100%
O82702	Nicotiana tabacum	40%	98%
O82703	Nicotiana tabacum	36%	97%
P91303	Caenorhabditis elegans	31%	86%
Q25532	Manduca sexta	26%	92%
Q4QBE0	Leishmania major	82%	100%
Q54Z13	Dictyostelium discoideum	30%	100%
Q617N0	Caenorhabditis briggsae	31%	86%
Q96LB4	Homo sapiens	28%	92%
Q9SP55	Citrus limon	38%	98%
Q9SZH0	Arabidopsis thaliana	31%	100%