Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCP7_LEIBR

TriTrypDb:

LbrM.23.0360 , LBRM2903_230009300

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HCP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCP7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.344
CLV_NRD_NRD_1	57	59	PF00675	0.264
CLV_NRD_NRD_1	95	97	PF00675	0.399
CLV_PCSK_FUR_1	142	146	PF00082	0.332
CLV_PCSK_KEX2_1	144	146	PF00082	0.344
CLV_PCSK_KEX2_1	57	59	PF00082	0.264
CLV_PCSK_KEX2_1	95	97	PF00082	0.373
CLV_PCSK_SKI1_1	119	123	PF00082	0.430
CLV_PCSK_SKI1_1	40	44	PF00082	0.330
CLV_PCSK_SKI1_1	57	61	PF00082	0.272
CLV_PCSK_SKI1_1	95	99	PF00082	0.354
DEG_Nend_UBRbox_2	1	3	PF02207	0.715
DOC_CYCLIN_RxL_1	90	102	PF00134	0.619
DOC_USP7_MATH_1	121	125	PF00917	0.535
DOC_USP7_MATH_1	182	186	PF00917	0.640
DOC_USP7_UBL2_3	177	181	PF12436	0.630
LIG_FHA_1	11	17	PF00498	0.567
LIG_FHA_1	155	161	PF00498	0.506
LIG_FHA_2	150	156	PF00498	0.597
LIG_FHA_2	36	42	PF00498	0.548
LIG_LIR_Apic_2	133	138	PF02991	0.622
LIG_LIR_Apic_2	43	48	PF02991	0.525
LIG_LIR_Nem_3	111	116	PF02991	0.526
LIG_LIR_Nem_3	178	183	PF02991	0.585
LIG_MYND_2	23	27	PF01753	0.602
LIG_PCNA_PIPBox_1	91	100	PF02747	0.552
LIG_PCNA_yPIPBox_3	90	98	PF02747	0.526
LIG_Pex14_2	208	212	PF04695	0.404
LIG_Pex14_2	215	219	PF04695	0.462
LIG_REV1ctd_RIR_1	98	104	PF16727	0.582
LIG_SH2_CRK	128	132	PF00017	0.538
LIG_SH2_CRK	135	139	PF00017	0.545
LIG_SH2_CRK	166	170	PF00017	0.499
LIG_SH2_CRK	180	184	PF00017	0.527
LIG_SH2_SRC	135	138	PF00017	0.639
LIG_SH2_SRC	33	36	PF00017	0.539
LIG_SH2_STAT5	170	173	PF00017	0.529
LIG_SH2_STAT5	55	58	PF00017	0.519
LIG_SH3_1	135	141	PF00018	0.631
LIG_SH3_3	135	141	PF00018	0.556
LIG_SH3_3	156	162	PF00018	0.539
LIG_TRAF2_1	184	187	PF00917	0.601
LIG_WW_3	22	26	PF00397	0.641
MOD_CK1_1	3	9	PF00069	0.724
MOD_CK2_1	149	155	PF00069	0.636
MOD_CK2_1	35	41	PF00069	0.535
MOD_GlcNHglycan	202	205	PF01048	0.455
MOD_GlcNHglycan	7	10	PF01048	0.387
MOD_GSK3_1	149	156	PF00069	0.638
MOD_NEK2_1	10	15	PF00069	0.587
MOD_NEK2_1	200	205	PF00069	0.346
MOD_NEK2_1	214	219	PF00069	0.394
MOD_NEK2_1	26	31	PF00069	0.526
MOD_NEK2_2	99	104	PF00069	0.579
MOD_Plk_1	154	160	PF00069	0.618
MOD_Plk_1	40	46	PF00069	0.510
MOD_Plk_4	214	220	PF00069	0.448
MOD_Plk_4	26	32	PF00069	0.567
MOD_Plk_4	40	46	PF00069	0.453
MOD_Plk_4	82	88	PF00069	0.474
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.634
TRG_ENDOCYTIC_2	128	131	PF00928	0.539
TRG_ENDOCYTIC_2	180	183	PF00928	0.571
TRG_ER_diArg_1	141	144	PF00400	0.530
TRG_ER_diArg_1	56	58	PF00400	0.466
TRG_ER_diArg_1	94	96	PF00400	0.600
TRG_NES_CRM1_1	120	136	PF08389	0.600
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU7	Leptomonas seymouri	76%	100%
A0A0S4JC90	Bodo saltans	46%	99%
A0A1X0NX56	Trypanosomatidae	63%	100%
A0A3R7NYD4	Trypanosoma rangeli	63%	77%
A0A3S7WXL9	Leishmania donovani	90%	100%
A4I073	Leishmania infantum	90%	100%
C9ZUY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AW36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QBE1	Leishmania major	90%	100%
V5AKG4	Trypanosoma cruzi	61%	77%