Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCP6_LEIBR

TriTrypDb:

LbrM.23.0350 , LBRM2903_230009200

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.589
CLV_C14_Caspase3-7	181	185	PF00656	0.752
CLV_NRD_NRD_1	240	242	PF00675	0.520
CLV_NRD_NRD_1	46	48	PF00675	0.559
CLV_PCSK_KEX2_1	240	242	PF00082	0.520
CLV_PCSK_KEX2_1	46	48	PF00082	0.559
CLV_PCSK_SKI1_1	154	158	PF00082	0.401
DOC_CKS1_1	194	199	PF01111	0.607
DOC_CYCLIN_yCln2_LP_2	258	264	PF00134	0.416
DOC_MAPK_DCC_7	215	223	PF00069	0.577
DOC_MAPK_MEF2A_6	215	223	PF00069	0.577
DOC_PP2B_LxvP_1	76	79	PF13499	0.457
DOC_PP2B_LxvP_1	9	12	PF13499	0.482
DOC_USP7_MATH_1	20	24	PF00917	0.576
DOC_USP7_MATH_1	66	70	PF00917	0.472
DOC_WW_Pin1_4	103	108	PF00397	0.499
DOC_WW_Pin1_4	162	167	PF00397	0.693
DOC_WW_Pin1_4	193	198	PF00397	0.630
DOC_WW_Pin1_4	208	213	PF00397	0.463
DOC_WW_Pin1_4	36	41	PF00397	0.491
LIG_14-3-3_CanoR_1	215	219	PF00244	0.589
LIG_14-3-3_CanoR_1	46	55	PF00244	0.577
LIG_Actin_WH2_2	126	141	PF00022	0.484
LIG_BIR_II_1	1	5	PF00653	0.714
LIG_eIF4E_1	231	237	PF01652	0.608
LIG_EVH1_1	9	13	PF00568	0.484
LIG_FHA_1	205	211	PF00498	0.474
LIG_FHA_2	127	133	PF00498	0.396
LIG_FHA_2	59	65	PF00498	0.532
LIG_LIR_Apic_2	191	197	PF02991	0.660
LIG_LIR_Apic_2	249	255	PF02991	0.574
LIG_LIR_Gen_1	69	79	PF02991	0.494
LIG_LIR_Nem_3	69	74	PF02991	0.483
LIG_NRP_CendR_1	268	270	PF00754	0.519
LIG_SH2_CRK	194	198	PF00017	0.623
LIG_SH2_NCK_1	252	256	PF00017	0.529
LIG_SH2_STAT5	71	74	PF00017	0.498
LIG_SH3_3	112	118	PF00018	0.453
LIG_SH3_3	7	13	PF00018	0.685
LIG_SH3_3	86	92	PF00018	0.724
LIG_WRC_WIRS_1	71	76	PF05994	0.302
LIG_WW_1	12	15	PF00397	0.595
MOD_CDK_SPxxK_3	193	200	PF00069	0.602
MOD_CDK_SPxxK_3	208	215	PF00069	0.547
MOD_CDK_SPxxK_3	36	43	PF00069	0.489
MOD_CK1_1	105	111	PF00069	0.684
MOD_CK1_1	14	20	PF00069	0.705
MOD_CK1_1	162	168	PF00069	0.687
MOD_CK2_1	126	132	PF00069	0.353
MOD_CK2_1	182	188	PF00069	0.678
MOD_GlcNHglycan	1	4	PF01048	0.734
MOD_GlcNHglycan	107	110	PF01048	0.633
MOD_GlcNHglycan	167	170	PF01048	0.757
MOD_GlcNHglycan	17	20	PF01048	0.591
MOD_GSK3_1	11	18	PF00069	0.684
MOD_GSK3_1	161	168	PF00069	0.649
MOD_GSK3_1	204	211	PF00069	0.470
MOD_GSK3_1	262	269	PF00069	0.503
MOD_GSK3_1	66	73	PF00069	0.437
MOD_GSK3_1	77	84	PF00069	0.535
MOD_N-GLC_1	162	167	PF02516	0.484
MOD_NEK2_1	206	211	PF00069	0.478
MOD_NEK2_1	27	32	PF00069	0.582
MOD_NEK2_2	222	227	PF00069	0.291
MOD_PIKK_1	81	87	PF00454	0.670
MOD_PKA_1	46	52	PF00069	0.386
MOD_PKA_2	214	220	PF00069	0.591
MOD_PKA_2	45	51	PF00069	0.644
MOD_Plk_1	126	132	PF00069	0.490
MOD_Plk_4	126	132	PF00069	0.430
MOD_Plk_4	214	220	PF00069	0.537
MOD_Plk_4	232	238	PF00069	0.403
MOD_Plk_4	70	76	PF00069	0.475
MOD_ProDKin_1	103	109	PF00069	0.497
MOD_ProDKin_1	162	168	PF00069	0.691
MOD_ProDKin_1	193	199	PF00069	0.615
MOD_ProDKin_1	208	214	PF00069	0.459
MOD_ProDKin_1	36	42	PF00069	0.493
MOD_SUMO_rev_2	179	187	PF00179	0.577
TRG_DiLeu_BaEn_2	69	75	PF01217	0.307
TRG_ENDOCYTIC_2	71	74	PF00928	0.495
TRG_ER_diArg_1	174	177	PF00400	0.530
TRG_ER_diArg_1	239	241	PF00400	0.488
TRG_ER_diArg_1	45	47	PF00400	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Y3	Leptomonas seymouri	52%	92%
A0A1X0NXL5	Trypanosomatidae	34%	100%
A0A3Q8ICG3	Leishmania donovani	72%	99%
A4I072	Leishmania infantum	72%	99%
C9ZUY6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AW35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4QBE2	Leishmania major	76%	99%