Pteridine reductase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine reductase 1

Species:

Leishmania braziliensis

UniProt:

A4HCP1_LEIBR

TriTrypDb:

LbrM.23.0300 , LBRM2903_230008700

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCP1

PDB structure(s): 1e7w_A , 1e7w_B , 1e92_A , 1e92_B , 1e92_C , 1e92_D , 1w0c_A , 1w0c_B , 1w0c_C , 1w0c_D , 1w0c_E , 1w0c_F , 1w0c_G , 1w0c_H , 2bf7_A , 2bf7_B , 2bf7_C , 2bf7_D , 2bfa_A , 2bfa_B , 2bfa_C , 2bfa_D , 2bfm_A , 2bfm_B , 2bfm_C , 2bfm_D , 2bfo_A , 2bfo_B , 2bfo_C , 2bfo_D , 2bfp_A , 2bfp_B , 2bfp_C , 2bfp_D , 2qhx_A , 2qhx_B , 2qhx_C , 2qhx_D , 3h4v_A , 3h4v_B , 3h4v_C , 3h4v_D , 3h4v_E , 3h4v_F , 3h4v_G , 3h4v_H , 5l42_A , 5l42_B , 5l42_C , 5l42_D , 5l4n_A , 5l4n_B , 5l4n_C , 5l4n_D , 6rxc_A , 6rxc_B , 6rxc_C , 6rxc_D , 7pxx_A , 7pxx_B , 7pxx_C , 7pxx_D

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	4
GO:0032259	methylation	2	3
GO:0006066	alcohol metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006729	tetrahydrobiopterin biosynthetic process	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0014070	response to organic cyclic compound	4	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019751	polyol metabolic process	4	1
GO:0031427	response to methotrexate	4	1
GO:0034311	diol metabolic process	5	1
GO:0034312	diol biosynthetic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0042221	response to chemical	2	1
GO:0042558	pteridine-containing compound metabolic process	4	1
GO:0042559	pteridine-containing compound biosynthetic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046146	tetrahydrobiopterin metabolic process	5	1
GO:0046165	alcohol biosynthetic process	4	1
GO:0046173	polyol biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0071704	organic substance metabolic process	2	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1
GO:1901698	response to nitrogen compound	3	1
GO:1901700	response to oxygen-containing compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004146	dihydrofolate reductase activity	5	3
GO:0004799	thymidylate synthase activity	6	3
GO:0008168	methyltransferase activity	4	3
GO:0016491	oxidoreductase activity	2	8
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	5
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	4	5
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3
GO:0042083	5,10-methylenetetrahydrofolate-dependent methyltransferase activity	5	3
GO:0047040	pteridine reductase activity	5	5
GO:0004155	6,7-dihydropteridine reductase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	55	57	PF00675	0.514
CLV_PCSK_KEX2_1	17	19	PF00082	0.455
CLV_PCSK_KEX2_1	55	57	PF00082	0.514
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.455
CLV_PCSK_SKI1_1	198	202	PF00082	0.334
CLV_PCSK_SKI1_1	270	274	PF00082	0.394
DOC_CKS1_1	115	120	PF01111	0.334
DOC_MAPK_gen_1	55	63	PF00069	0.476
DOC_USP7_MATH_1	71	75	PF00917	0.471
DOC_USP7_MATH_2	166	172	PF00917	0.251
DOC_WW_Pin1_4	114	119	PF00397	0.334
DOC_WW_Pin1_4	220	225	PF00397	0.408
LIG_14-3-3_CanoR_1	55	63	PF00244	0.584
LIG_BIR_III_2	80	84	PF00653	0.384
LIG_CtBP_PxDLS_1	83	87	PF00389	0.325
LIG_EH1_1	173	181	PF00400	0.394
LIG_eIF4E_1	114	120	PF01652	0.279
LIG_FHA_1	115	121	PF00498	0.334
LIG_FHA_1	144	150	PF00498	0.520
LIG_FHA_1	4	10	PF00498	0.493
LIG_FHA_1	47	53	PF00498	0.427
LIG_FHA_1	70	76	PF00498	0.674
LIG_FHA_2	251	257	PF00498	0.251
LIG_LIR_Apic_2	112	118	PF02991	0.334
LIG_LIR_Gen_1	171	182	PF02991	0.411
LIG_LIR_Nem_3	171	177	PF02991	0.411
LIG_PDZ_Class_1	283	288	PF00595	0.511
LIG_REV1ctd_RIR_1	150	160	PF16727	0.251
LIG_SH2_CRK	174	178	PF00017	0.394
LIG_SH2_NCK_1	174	178	PF00017	0.419
LIG_SH2_STAP1	32	36	PF00017	0.436
LIG_SH2_STAT5	194	197	PF00017	0.430
LIG_SH2_STAT5	271	274	PF00017	0.334
LIG_SUMO_SIM_par_1	6	13	PF11976	0.379
LIG_TRAF2_1	253	256	PF00917	0.251
MOD_CK1_1	3	9	PF00069	0.406
MOD_CK1_1	74	80	PF00069	0.623
MOD_CK2_1	127	133	PF00069	0.289
MOD_CK2_1	249	255	PF00069	0.535
MOD_GlcNHglycan	111	114	PF01048	0.247
MOD_GlcNHglycan	206	209	PF01048	0.334
MOD_GlcNHglycan	234	237	PF01048	0.474
MOD_GlcNHglycan	267	270	PF01048	0.332
MOD_GlcNHglycan	40	43	PF01048	0.577
MOD_GlcNHglycan	58	61	PF01048	0.304
MOD_GlcNHglycan	66	70	PF01048	0.444
MOD_GlcNHglycan	76	79	PF01048	0.690
MOD_GSK3_1	168	175	PF00069	0.251
MOD_GSK3_1	220	227	PF00069	0.251
MOD_GSK3_1	44	51	PF00069	0.521
MOD_GSK3_1	65	72	PF00069	0.454
MOD_N-GLC_1	109	114	PF02516	0.366
MOD_N-GLC_1	172	177	PF02516	0.394
MOD_NEK2_1	143	148	PF00069	0.416
MOD_NEK2_1	189	194	PF00069	0.418
MOD_NEK2_1	204	209	PF00069	0.269
MOD_NEK2_1	263	268	PF00069	0.466
MOD_NEK2_1	48	53	PF00069	0.561
MOD_NEK2_2	224	229	PF00069	0.251
MOD_PKA_2	249	255	PF00069	0.419
MOD_Plk_1	109	115	PF00069	0.334
MOD_Plk_1	172	178	PF00069	0.394
MOD_Plk_1	65	71	PF00069	0.396
MOD_Plk_4	172	178	PF00069	0.394
MOD_Plk_4	224	230	PF00069	0.402
MOD_ProDKin_1	114	120	PF00069	0.334
MOD_ProDKin_1	220	226	PF00069	0.408
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.334
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.399
TRG_ENDOCYTIC_2	174	177	PF00928	0.394
TRG_ER_diArg_1	55	57	PF00400	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0B4FP77	Metarhizium brunneum (strain ARSEF 3297)	22%	100%
A0A0B4GT47	Metarhizium anisopliae (strain ARSEF 549)	22%	100%
A0A0B4GU97	Metarhizium guizhouense (strain ARSEF 977)	22%	100%
A0A0B4HVU2	Metarhizium majus (strain ARSEF 297)	22%	100%
A0A0N1HTL2	Leptomonas seymouri	25%	100%
A0A0N1I5Q6	Leptomonas seymouri	63%	100%
A0A0N1PCK0	Leptomonas seymouri	26%	100%
A0A0S4JMY5	Bodo saltans	27%	100%
A0A0S4JTE1	Bodo saltans	27%	100%
A0A165U5V5	Euphorbia lathyris	29%	100%
A0A1A9TAK5	Narcissus pseudonarcissus	28%	100%
A0A1C9II22	Narcissus aff. pseudonarcissus MK-2014	28%	100%
A0A1L9WLH9	Aspergillus aculeatus (strain ATCC 16872 / CBS 172.66 / WB 5094)	23%	100%
A0A1V0QSC6	Hericium erinaceus	24%	100%
A0A1X0NG18	Trypanosomatidae	49%	100%
A0A1X0NVZ6	Trypanosomatidae	26%	100%
A0A1X0P0X1	Trypanosomatidae	24%	100%
A0A2H3D8Y2	Armillaria gallica	27%	100%
A0A2I1C3T5	Aspergillus novofumigatus (strain IBT 16806)	25%	100%
A0A3Q8IF11	Leishmania donovani	27%	100%
A0A3S7WXI3	Leishmania donovani	76%	100%
A0A422NCL5	Trypanosoma rangeli	26%	100%
A0A5B8YU81	Pestalotiopsis microspora	24%	100%
A0A8F5SIS3	Salvia officinalis	26%	100%
A0A8F5XX49	Salvia officinalis	30%	100%
A3F5F0	Sinopodophyllum hexandrum	30%	100%
A4HDR5	Leishmania braziliensis	27%	100%
A4I067	Leishmania infantum	76%	100%
A4I111	Leishmania infantum	27%	100%
A7B3K3	Ruminococcus gnavus (strain ATCC 29149 / VPI C7-9)	28%	100%
A7DY56	Cochlearia officinalis	25%	100%
A9CES4	Agrobacterium fabrum (strain C58 / ATCC 33970)	24%	100%
B0ZT44	Elsinoe fawcettii	25%	100%
C1C4R8	Lithobates catesbeianus	28%	100%
C8WGQ3	Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B)	25%	100%
C8WJW0	Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B)	28%	100%
D4A1J4	Rattus norvegicus	30%	100%
E9ACW4	Leishmania major	27%	98%
E9AW30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E9AX49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9EHG1	Metarhizium acridum (strain CQMa 102)	22%	100%
E9ET40	Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075)	23%	100%
F1SWA0	Zingiber zerumbet	26%	100%
F9XMW6	Zymoseptoria tritici (strain CBS 115943 / IPO323)	25%	100%
G0RNA2	Hypocrea jecorina (strain QM6a)	27%	95%
G3YG17	Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7)	25%	97%
G4N1P8	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	25%	100%
G4N290	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	32%	100%
G5EGA6	Caenorhabditis elegans	25%	100%
G9FRD7	Clostridium sardiniense	27%	100%
H9BFQ0	Erythroxylum coca	27%	100%
H9BFQ2	Erythroxylum coca	30%	100%
L7I518	Magnaporthe oryzae (strain Y34)	25%	100%
O02691	Bos taurus	27%	100%
O07399	Mycobacterium avium	27%	100%
O07575	Bacillus subtilis (strain 168)	28%	100%
O31680	Bacillus subtilis (strain 168)	29%	100%
O31767	Bacillus subtilis (strain 168)	26%	100%
O34308	Bacillus subtilis (strain 168)	26%	100%
O34717	Bacillus subtilis (strain 168)	28%	100%
O34782	Bacillus subtilis (strain 168)	28%	100%
O34896	Bacillus subtilis (strain 168)	22%	100%
O49332	Arabidopsis thaliana	25%	100%
O54438	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	27%	100%
O67610	Aquifex aeolicus (strain VF5)	29%	100%
O69264	Cupriavidus sp. (strain PS12)	24%	100%
P06234	Rhizobium meliloti (strain 1021)	28%	100%
P07772	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	25%	100%
P07999	Priestia megaterium	26%	100%
P08074	Mus musculus	27%	100%
P08694	Pseudomonas furukawaii	31%	100%
P0A0H9	Staphylococcus aureus (strain Mu50 / ATCC 700699)	29%	100%
P0A0I0	Staphylococcus aureus (strain MW2)	29%	100%
P0A169	Pseudomonas putida	25%	100%
P0A170	Pseudomonas sp. (strain C18)	26%	100%
P0A2C9	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	30%	100%
P0A2D0	Salmonella typhi	30%	100%
P0A2D1	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	100%
P0A2D2	Salmonella typhi	26%	100%
P0A5Y5	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	27%	100%
P0A9P9	Escherichia coli (strain K12)	27%	100%
P0A9Q0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	27%	100%
P0AEK2	Escherichia coli (strain K12)	30%	100%
P0AEK3	Shigella flexneri	30%	100%
P0AET8	Escherichia coli (strain K12)	26%	100%
P0AET9	Escherichia coli O157:H7	26%	100%
P0C0Y4	Alternaria alternata	26%	100%
P0CG22	Homo sapiens	26%	100%
P0CU75	Passalora fulva	23%	100%
P0DOV5	Pseudomonas putida	28%	100%
P10528	Priestia megaterium	26%	100%
P12310	Bacillus subtilis (strain 168)	25%	100%
P14697	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	28%	100%
P16542	Streptomyces violaceoruber	28%	100%
P16543	Streptomyces violaceoruber	32%	100%
P17611	Azospirillum brasilense	27%	100%
P28643	Cuphea lanceolata	26%	90%
P33207	Arabidopsis thaliana	28%	90%
P33368	Escherichia coli (strain K12)	30%	100%
P37079	Klebsiella pneumoniae	29%	100%
P37440	Escherichia coli (strain K12)	25%	100%
P37769	Escherichia coli (strain K12)	24%	100%
P38004	Chlamydia trachomatis (strain D/UW-3/Cx)	26%	100%
P39482	Priestia megaterium	26%	100%
P39483	Priestia megaterium	26%	100%
P39484	Priestia megaterium	27%	100%
P39485	Priestia megaterium	27%	100%
P39640	Bacillus subtilis (strain 168)	25%	100%
P39644	Bacillus subtilis (strain 168)	24%	100%
P40288	Priestia megaterium	26%	100%
P41177	Streptomyces virginiae	27%	100%
P42317	Bacillus subtilis (strain 168)	26%	100%
P42556	Leishmania tarentolae	73%	100%
P43713	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	100%
P44481	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	24%	100%
P46331	Bacillus subtilis (strain 168)	24%	100%
P47227	Paraburkholderia xenovorans (strain LB400)	29%	100%
P50162	Datura stramonium	25%	100%
P50163	Datura stramonium	28%	100%
P50164	Hyoscyamus niger	26%	100%
P50165	Datura stramonium	28%	100%
P50199	Gluconobacter oxydans (strain 621H)	26%	100%
P50200	Paeniclostridium sordellii	30%	100%
P50941	Rickettsia prowazekii (strain Madrid E)	26%	100%
P51831	Bacillus subtilis (strain 168)	28%	100%
P52037	Escherichia coli (strain K12)	26%	100%
P55336	Vibrio harveyi	28%	100%
P55541	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	30%	100%
P55575	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	27%	100%
P66775	Staphylococcus aureus (strain Mu50 / ATCC 700699)	27%	100%
P66776	Staphylococcus aureus (strain MW2)	27%	100%
P66782	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	28%	100%
P69166	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	30%	100%
P71079	Bacillus subtilis (strain 168)	29%	100%
P71534	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	29%	100%
P72220	Pseudomonas putida	31%	100%
P72332	Rhizobium sp. (strain N33)	28%	100%
P73574	Synechocystis sp. (strain PCC 6803 / Kazusa)	32%	100%
P76633	Escherichia coli (strain K12)	26%	100%
P80869	Bacillus subtilis (strain 168)	26%	100%
P80873	Bacillus subtilis (strain 168)	24%	100%
P94681	Comamonas testosteroni	27%	100%
P99093	Staphylococcus aureus (strain N315)	29%	100%
P99120	Staphylococcus aureus (strain N315)	27%	100%
P9WGQ8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	100%
P9WGQ9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	100%
P9WGR8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	28%	100%
P9WGR9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
P9WGT0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	30%	100%
P9WGT1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	100%
P9WGT2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	100%
P9WGT3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	100%
Q01782	Leishmania major	73%	100%
Q04520	Raoultella terrigena	27%	100%
Q05528	Dickeya dadantii (strain 3937)	26%	100%
Q08632	Picea abies	28%	100%
Q10216	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q1JP75	Bos taurus	28%	100%
Q29529	Sus scrofa	27%	100%
Q2UEK6	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	28%	100%
Q3KPT7	Xenopus laevis	28%	100%
Q3T046	Bos taurus	30%	100%
Q45219	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	31%	100%
Q46381	Comamonas testosteroni	29%	100%
Q48436	Klebsiella pneumoniae	28%	100%
Q49117	Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)	29%	100%
Q4A054	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	25%	100%
Q4QAC7	Leishmania major	26%	91%
Q51576	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	29%	100%
Q53882	Streptomyces sp. (strain C5)	31%	100%
Q561X9	Danio rerio	27%	100%
Q56840	Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)	28%	100%
Q59787	Cereibacter sphaeroides	26%	100%
Q5BH34	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	24%	100%
Q5FPE5	Gluconobacter oxydans (strain 621H)	28%	100%
Q5HGK2	Staphylococcus aureus (strain COL)	29%	100%
Q5HJP2	Staphylococcus aureus (strain COL)	27%	100%
Q5HKG6	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	26%	100%
Q5HPW0	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	30%	100%
Q5KTS5	Daucus carota	28%	99%
Q5LA59	Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow)	29%	100%
Q5P5I4	Aromatoleum aromaticum (strain EbN1)	24%	100%
Q5RBV3	Pongo abelii	28%	99%
Q5RCF8	Pongo abelii	30%	100%
Q5RCH8	Pongo abelii	28%	95%
Q68VY7	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	26%	100%
Q6G9Y2	Staphylococcus aureus (strain MSSA476)	29%	100%
Q6GCZ8	Staphylococcus aureus (strain MSSA476)	27%	100%
Q6GHK4	Staphylococcus aureus (strain MRSA252)	29%	100%
Q6GKH9	Staphylococcus aureus (strain MRSA252)	27%	100%
Q6TMA3	Rhodococcus sp. (strain TK6)	28%	100%
Q75KH3	Oryza sativa subsp. japonica	30%	96%
Q7FAE1	Oryza sativa subsp. japonica	31%	100%
Q7SHI4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	34%	100%
Q7Z4W1	Homo sapiens	26%	100%
Q89AG9	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	26%	100%
Q8CPI3	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	30%	100%
Q8CQD2	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	27%	100%
Q8GAV9	Comamonas sp. (strain NCIMB 9872)	30%	100%
Q8JIS3	Gallus gallus	26%	100%
Q8JZV9	Mus musculus	30%	100%
Q8KWT4	Bacillus subtilis	25%	100%
Q8RX32	Arabidopsis thaliana	27%	100%
Q8SPU8	Bos taurus	31%	100%
Q8VID1	Rattus norvegicus	27%	100%
Q8WNV7	Sus scrofa	28%	100%
Q8XBJ4	Escherichia coli O157:H7	25%	100%
Q91X52	Mus musculus	27%	100%
Q91XV4	Mesocricetus auratus	28%	100%
Q920N9	Cavia porcellus	27%	100%
Q920P0	Rattus norvegicus	29%	100%
Q92EU6	Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)	25%	100%
Q92RN6	Rhizobium meliloti (strain 1021)	26%	100%
Q937L4	Comamonas testosteroni	30%	100%
Q93X62	Brassica napus	28%	90%
Q93X67	Brassica napus	29%	88%
Q93X68	Brassica napus	27%	91%
Q949M2	Brassica napus	28%	100%
Q949M3	Brassica napus	28%	91%
Q94KL8	Podophyllum peltatum	30%	100%
Q99714	Homo sapiens	26%	100%
Q99LB2	Mus musculus	28%	100%
Q99MZ7	Mus musculus	27%	95%
Q9BPX1	Homo sapiens	29%	100%
Q9BTZ2	Homo sapiens	29%	100%
Q9BUT1	Homo sapiens	29%	100%
Q9BY49	Homo sapiens	26%	95%
Q9C826	Arabidopsis thaliana	27%	100%
Q9FZ42	Arabidopsis thaliana	27%	100%
Q9GKX2	Oryctolagus cuniculus	29%	100%
Q9JIF5	Cavia porcellus	30%	95%
Q9KQH7	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	28%	100%
Q9L9F8	Streptomyces niveus	28%	100%
Q9LBG2	Leifsonia aquatica	28%	100%
Q9LHT0	Arabidopsis thaliana	27%	100%
Q9MA93	Arabidopsis thaliana	27%	100%
Q9MYP6	Bos taurus	29%	100%
Q9NUI1	Homo sapiens	28%	99%
Q9PKF7	Chlamydia muridarum (strain MoPn / Nigg)	27%	100%
Q9S9W2	Arabidopsis thaliana	27%	100%
Q9SQR4	Arabidopsis thaliana	23%	100%
Q9URX0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q9WVK3	Rattus norvegicus	25%	95%
Q9WYG0	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	28%	100%
Q9X248	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	31%	100%
Q9X6U2	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	23%	100%
Q9Z8P2	Chlamydia pneumoniae	24%	100%
Q9ZNN8	Corynebacterium glutamicum	28%	100%
Q9ZW03	Arabidopsis thaliana	28%	100%
Q9ZW14	Arabidopsis thaliana	27%	100%
Q9ZW19	Arabidopsis thaliana	26%	100%
Q9ZW20	Arabidopsis thaliana	27%	100%
T2KLZ8	Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1)	24%	100%