LeishMANIAdb
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Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HCN8_LEIBR
TriTrypDb:
LbrM.23.0260 , LBRM2903_230008400 *
Length:
185

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4HCN8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCN8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 10 12 PF00675 0.604
CLV_NRD_NRD_1 39 41 PF00675 0.567
CLV_PCSK_KEX2_1 10 12 PF00082 0.606
CLV_PCSK_KEX2_1 39 41 PF00082 0.584
CLV_PCSK_SKI1_1 144 148 PF00082 0.440
CLV_Separin_Metazoa 179 183 PF03568 0.615
DEG_APCC_DBOX_1 143 151 PF00400 0.561
DOC_MAPK_gen_1 10 17 PF00069 0.424
DOC_MAPK_MEF2A_6 10 17 PF00069 0.437
DOC_MAPK_NFAT4_5 10 18 PF00069 0.438
DOC_USP7_MATH_1 181 185 PF00917 0.655
DOC_WW_Pin1_4 172 177 PF00397 0.568
LIG_14-3-3_CanoR_1 24 34 PF00244 0.368
LIG_FHA_1 26 32 PF00498 0.483
LIG_FHA_2 109 115 PF00498 0.492
LIG_NRP_CendR_1 182 185 PF00754 0.429
LIG_Pex14_2 88 92 PF04695 0.420
LIG_SH2_STAT5 14 17 PF00017 0.490
LIG_TRAF2_1 111 114 PF00917 0.592
LIG_TRAF2_1 129 132 PF00917 0.485
LIG_UBA3_1 164 170 PF00899 0.531
LIG_WRC_WIRS_1 31 36 PF05994 0.355
LIG_WW_3 179 183 PF00397 0.615
MOD_CK1_1 20 26 PF00069 0.367
MOD_CK2_1 108 114 PF00069 0.491
MOD_GlcNHglycan 156 159 PF01048 0.308
MOD_GSK3_1 16 23 PF00069 0.398
MOD_GSK3_1 88 95 PF00069 0.354
MOD_N-GLC_1 25 30 PF02516 0.683
MOD_NEK2_1 120 125 PF00069 0.493
MOD_NEK2_1 15 20 PF00069 0.422
MOD_NEK2_1 51 56 PF00069 0.439
MOD_NEK2_1 88 93 PF00069 0.360
MOD_NEK2_2 94 99 PF00069 0.219
MOD_PIKK_1 108 114 PF00454 0.491
MOD_PIKK_1 120 126 PF00454 0.474
MOD_PK_1 44 50 PF00069 0.327
MOD_Plk_4 30 36 PF00069 0.506
MOD_Plk_4 88 94 PF00069 0.331
MOD_ProDKin_1 172 178 PF00069 0.572
TRG_ENDOCYTIC_2 14 17 PF00928 0.439
TRG_ER_diArg_1 22 25 PF00400 0.351
TRG_ER_diArg_1 9 11 PF00400 0.407
TRG_Pf-PMV_PEXEL_1 148 153 PF00026 0.469

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2Y2 Leptomonas seymouri 44% 100%
A0A0S4JFQ3 Bodo saltans 31% 100%
A0A3S7WXI2 Leishmania donovani 65% 100%
A4I063 Leishmania infantum 66% 100%
E9AW26 Leishmania mexicana (strain MHOM/GT/2001/U1103) 68% 97%
Q4QBF1 Leishmania major 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS