LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HCN6_LEIBR
TriTrypDb:
LbrM.23.0240 , LBRM2903_230008100 *
Length:
152

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4HCN6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCN6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 23 25 PF00675 0.392
CLV_NRD_NRD_1 3 5 PF00675 0.466
CLV_PCSK_KEX2_1 126 128 PF00082 0.575
CLV_PCSK_KEX2_1 23 25 PF00082 0.392
CLV_PCSK_KEX2_1 3 5 PF00082 0.466
CLV_PCSK_PC1ET2_1 126 128 PF00082 0.575
CLV_PCSK_SKI1_1 4 8 PF00082 0.494
CLV_PCSK_SKI1_1 64 68 PF00082 0.380
DOC_CKS1_1 67 72 PF01111 0.626
DOC_PP1_RVXF_1 1 8 PF00149 0.685
DOC_PP1_RVXF_1 62 68 PF00149 0.574
DOC_PP4_FxxP_1 109 112 PF00568 0.395
DOC_PP4_FxxP_1 67 70 PF00568 0.569
DOC_USP7_MATH_1 56 60 PF00917 0.633
DOC_WW_Pin1_4 33 38 PF00397 0.580
DOC_WW_Pin1_4 48 53 PF00397 0.723
DOC_WW_Pin1_4 66 71 PF00397 0.638
LIG_14-3-3_CanoR_1 23 33 PF00244 0.697
LIG_FHA_2 142 148 PF00498 0.378
LIG_PDZ_Class_3 147 152 PF00595 0.431
LIG_Pex14_1 44 48 PF04695 0.581
LIG_RPA_C_Fungi 19 31 PF08784 0.478
LIG_SH2_STAT5 116 119 PF00017 0.506
LIG_SH3_3 81 87 PF00018 0.477
LIG_SUMO_SIM_anti_2 102 108 PF11976 0.327
LIG_WRC_WIRS_1 45 50 PF05994 0.460
MOD_CDK_SPxK_1 66 72 PF00069 0.603
MOD_CK1_1 47 53 PF00069 0.584
MOD_CK1_1 99 105 PF00069 0.233
MOD_CK2_1 141 147 PF00069 0.625
MOD_GlcNHglycan 118 121 PF01048 0.381
MOD_GlcNHglycan 60 63 PF01048 0.632
MOD_GlcNHglycan 98 102 PF01048 0.316
MOD_GSK3_1 35 42 PF00069 0.527
MOD_GSK3_1 44 51 PF00069 0.695
MOD_GSK3_1 56 63 PF00069 0.567
MOD_N-GLC_1 24 29 PF02516 0.480
MOD_NEK2_1 26 31 PF00069 0.509
MOD_PKA_2 141 147 PF00069 0.460
MOD_PKA_2 96 102 PF00069 0.320
MOD_Plk_4 99 105 PF00069 0.333
MOD_ProDKin_1 33 39 PF00069 0.457
MOD_ProDKin_1 48 54 PF00069 0.659
MOD_ProDKin_1 66 72 PF00069 0.538
MOD_SUMO_rev_2 119 128 PF00179 0.524
MOD_SUMO_rev_2 145 152 PF00179 0.626
TRG_ER_diArg_1 3 5 PF00400 0.706
TRG_ER_diArg_1 80 83 PF00400 0.543

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2J6 Leptomonas seymouri 48% 100%
A0A3Q8IFQ1 Leishmania donovani 64% 100%
A4I061 Leishmania infantum 64% 100%
E9ACS2 Leishmania major 61% 100%
E9AW24 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS