Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCN2_LEIBR

TriTrypDb:

LbrM.23.0200 , LBRM2903_230006800

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCN2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.382
CLV_C14_Caspase3-7	65	69	PF00656	0.290
CLV_C14_Caspase3-7	93	97	PF00656	0.582
CLV_NRD_NRD_1	193	195	PF00675	0.323
CLV_NRD_NRD_1	225	227	PF00675	0.543
CLV_NRD_NRD_1	234	236	PF00675	0.431
CLV_NRD_NRD_1	26	28	PF00675	0.507
CLV_PCSK_KEX2_1	225	227	PF00082	0.540
CLV_PCSK_KEX2_1	234	236	PF00082	0.431
CLV_PCSK_KEX2_1	26	28	PF00082	0.543
DEG_APCC_DBOX_1	233	241	PF00400	0.496
DEG_Nend_UBRbox_2	1	3	PF02207	0.525
DOC_MAPK_gen_1	194	200	PF00069	0.350
DOC_PP2B_LxvP_1	120	123	PF13499	0.344
DOC_PP4_FxxP_1	248	251	PF00568	0.383
DOC_USP7_MATH_1	170	174	PF00917	0.410
DOC_USP7_MATH_1	69	73	PF00917	0.435
DOC_USP7_MATH_1	8	12	PF00917	0.557
DOC_USP7_MATH_1	85	89	PF00917	0.677
DOC_WW_Pin1_4	26	31	PF00397	0.568
LIG_14-3-3_CanoR_1	54	63	PF00244	0.492
LIG_BRCT_BRCA1_1	195	199	PF00533	0.241
LIG_EH_1	245	249	PF12763	0.350
LIG_eIF4E_1	148	154	PF01652	0.364
LIG_FHA_2	110	116	PF00498	0.477
LIG_FHA_2	122	128	PF00498	0.537
LIG_FHA_2	228	234	PF00498	0.391
LIG_FHA_2	63	69	PF00498	0.288
LIG_LIR_Gen_1	133	144	PF02991	0.522
LIG_LIR_Nem_3	102	108	PF02991	0.437
LIG_LIR_Nem_3	124	128	PF02991	0.502
LIG_LIR_Nem_3	133	139	PF02991	0.426
LIG_LIR_Nem_3	256	262	PF02991	0.534
LIG_LIR_Nem_3	263	269	PF02991	0.526
LIG_LIR_Nem_3	29	35	PF02991	0.315
LIG_MYND_1	247	251	PF01753	0.570
LIG_SH2_NCK_1	181	185	PF00017	0.262
LIG_SH2_SRC	66	69	PF00017	0.410
LIG_SH2_STAP1	125	129	PF00017	0.503
LIG_SH2_STAP1	132	136	PF00017	0.486
LIG_SH2_STAT5	107	110	PF00017	0.357
LIG_SH2_STAT5	119	122	PF00017	0.308
LIG_SH2_STAT5	128	131	PF00017	0.386
LIG_SH2_STAT5	132	135	PF00017	0.391
LIG_SH2_STAT5	148	151	PF00017	0.239
LIG_SH2_STAT5	204	207	PF00017	0.252
LIG_SH2_STAT5	66	69	PF00017	0.308
MOD_CDK_SPxxK_3	26	33	PF00069	0.514
MOD_CK1_1	57	63	PF00069	0.494
MOD_CK1_1	88	94	PF00069	0.610
MOD_CK2_1	16	22	PF00069	0.628
MOD_CK2_1	227	233	PF00069	0.474
MOD_GlcNHglycan	10	13	PF01048	0.661
MOD_GlcNHglycan	56	59	PF01048	0.664
MOD_GSK3_1	84	91	PF00069	0.579
MOD_GSK3_1	92	99	PF00069	0.475
MOD_NEK2_1	130	135	PF00069	0.449
MOD_NEK2_1	193	198	PF00069	0.283
MOD_NEK2_1	44	49	PF00069	0.365
MOD_NEK2_2	163	168	PF00069	0.380
MOD_PKA_2	193	199	PF00069	0.239
MOD_Plk_1	130	136	PF00069	0.494
MOD_Plk_1	170	176	PF00069	0.489
MOD_Plk_4	170	176	PF00069	0.253
MOD_Plk_4	44	50	PF00069	0.274
MOD_Plk_4	62	68	PF00069	0.280
MOD_ProDKin_1	26	32	PF00069	0.551
TRG_DiLeu_BaEn_2	243	249	PF01217	0.333
TRG_ENDOCYTIC_2	119	122	PF00928	0.312
TRG_ENDOCYTIC_2	259	262	PF00928	0.560
TRG_ER_diArg_1	25	27	PF00400	0.564
TRG_ER_diArg_1	35	38	PF00400	0.564
TRG_Pf-PMV_PEXEL_1	79	84	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAY1	Leptomonas seymouri	54%	100%
A0A3Q8ICJ3	Leishmania donovani	75%	91%
A0A422NVZ5	Trypanosoma rangeli	36%	100%
A4I056	Leishmania infantum	76%	91%
E9AW19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	92%
Q4QBF7	Leishmania major	77%	100%
V5AYT6	Trypanosoma cruzi	36%	100%
V5D0F5	Trypanosoma cruzi	36%	100%