Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCN1_LEIBR

TriTrypDb:

LbrM.23.0190 , LBRM2903_230006700

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HCN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCN1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.636
CLV_NRD_NRD_1	143	145	PF00675	0.640
CLV_NRD_NRD_1	149	151	PF00675	0.694
CLV_NRD_NRD_1	80	82	PF00675	0.525
CLV_PCSK_KEX2_1	143	145	PF00082	0.541
CLV_PCSK_KEX2_1	149	151	PF00082	0.519
CLV_PCSK_KEX2_1	80	82	PF00082	0.525
CLV_PCSK_SKI1_1	126	130	PF00082	0.497
CLV_Separin_Metazoa	41	45	PF03568	0.588
DEG_APCC_DBOX_1	134	142	PF00400	0.344
DOC_CYCLIN_yClb5_NLxxxL_5	153	159	PF00134	0.304
DOC_MAPK_gen_1	189	197	PF00069	0.626
DOC_MAPK_HePTP_8	88	100	PF00069	0.304
DOC_MAPK_MEF2A_6	189	197	PF00069	0.585
DOC_MAPK_MEF2A_6	91	100	PF00069	0.400
LIG_14-3-3_CanoR_1	135	139	PF00244	0.391
LIG_FHA_1	182	188	PF00498	0.681
LIG_FHA_1	196	202	PF00498	0.594
LIG_FHA_2	3	9	PF00498	0.617
LIG_FHA_2	90	96	PF00498	0.410
LIG_PDZ_Class_2	211	216	PF00595	0.568
LIG_RPA_C_Fungi	139	151	PF08784	0.422
LIG_SH2_STAT5	167	170	PF00017	0.315
LIG_SH3_3	180	186	PF00018	0.422
LIG_SH3_3	190	196	PF00018	0.439
LIG_TRAF2_1	202	205	PF00917	0.471
LIG_TRAF2_1	73	76	PF00917	0.410
MOD_CK1_1	105	111	PF00069	0.421
MOD_CK1_1	157	163	PF00069	0.576
MOD_CK1_1	200	206	PF00069	0.470
MOD_CK1_1	3	9	PF00069	0.510
MOD_CK2_1	2	8	PF00069	0.611
MOD_CK2_1	35	41	PF00069	0.535
MOD_GlcNHglycan	131	134	PF01048	0.347
MOD_GlcNHglycan	159	162	PF01048	0.505
MOD_GlcNHglycan	57	60	PF01048	0.330
MOD_GSK3_1	191	198	PF00069	0.469
MOD_GSK3_1	3	10	PF00069	0.664
MOD_N-GLC_1	102	107	PF02516	0.426
MOD_NEK2_1	129	134	PF00069	0.457
MOD_NEK2_1	155	160	PF00069	0.431
MOD_NEK2_1	34	39	PF00069	0.532
MOD_NEK2_1	89	94	PF00069	0.582
MOD_NMyristoyl	1	7	PF02799	0.598
MOD_PIKK_1	35	41	PF00454	0.463
MOD_PK_1	144	150	PF00069	0.432
MOD_PKA_2	134	140	PF00069	0.417
MOD_PKA_2	66	72	PF00069	0.450
MOD_Plk_1	102	108	PF00069	0.424
MOD_Plk_1	155	161	PF00069	0.456
MOD_SUMO_for_1	98	101	PF00179	0.485
TRG_DiLeu_BaEn_1	102	107	PF01217	0.426
TRG_ENDOCYTIC_2	167	170	PF00928	0.312
TRG_ER_diArg_1	148	150	PF00400	0.448
TRG_ER_diArg_1	80	82	PF00400	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJU2	Leptomonas seymouri	55%	100%
A0A3S7WXJ0	Leishmania donovani	76%	95%
A4I055	Leishmania infantum	76%	95%
E9AW18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	95%
Q4QBF8	Leishmania major	75%	100%