Cyclic nucleotide-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCN0_LEIBR

TriTrypDb:

LbrM.23.0180 , LBRM2903_230006600

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4HCN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCN0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.324
CLV_C14_Caspase3-7	415	419	PF00656	0.589
CLV_NRD_NRD_1	23	25	PF00675	0.417
CLV_NRD_NRD_1	248	250	PF00675	0.450
CLV_NRD_NRD_1	436	438	PF00675	0.605
CLV_NRD_NRD_1	466	468	PF00675	0.447
CLV_PCSK_KEX2_1	23	25	PF00082	0.339
CLV_PCSK_SKI1_1	105	109	PF00082	0.347
CLV_PCSK_SKI1_1	259	263	PF00082	0.486
CLV_PCSK_SKI1_1	450	454	PF00082	0.520
CLV_PCSK_SKI1_1	481	485	PF00082	0.535
CLV_PCSK_SKI1_1	94	98	PF00082	0.577
DEG_APCC_DBOX_1	104	112	PF00400	0.370
DEG_SPOP_SBC_1	286	290	PF00917	0.355
DOC_CDC14_PxL_1	186	194	PF14671	0.300
DOC_CDC14_PxL_1	241	249	PF14671	0.561
DOC_CYCLIN_RxL_1	160	171	PF00134	0.527
DOC_CYCLIN_RxL_1	253	265	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	386	392	PF00134	0.307
DOC_MAPK_DCC_7	105	113	PF00069	0.457
DOC_MAPK_gen_1	160	169	PF00069	0.505
DOC_MAPK_gen_1	467	475	PF00069	0.450
DOC_MAPK_gen_1	72	80	PF00069	0.496
DOC_MAPK_HePTP_8	497	509	PF00069	0.546
DOC_MAPK_MEF2A_6	105	113	PF00069	0.415
DOC_MAPK_MEF2A_6	312	320	PF00069	0.367
DOC_MAPK_MEF2A_6	500	509	PF00069	0.553
DOC_PP2B_LxvP_1	219	222	PF13499	0.435
DOC_USP7_MATH_1	163	167	PF00917	0.473
DOC_USP7_MATH_1	185	189	PF00917	0.388
DOC_USP7_MATH_1	2	6	PF00917	0.522
DOC_USP7_MATH_1	359	363	PF00917	0.463
DOC_USP7_MATH_1	463	467	PF00917	0.441
DOC_USP7_MATH_1	79	83	PF00917	0.365
DOC_USP7_UBL2_3	229	233	PF12436	0.508
LIG_14-3-3_CanoR_1	162	168	PF00244	0.456
LIG_14-3-3_CanoR_1	249	253	PF00244	0.461
LIG_14-3-3_CanoR_1	285	294	PF00244	0.419
LIG_14-3-3_CanoR_1	373	381	PF00244	0.340
LIG_14-3-3_CanoR_1	397	405	PF00244	0.443
LIG_14-3-3_CanoR_1	450	459	PF00244	0.550
LIG_14-3-3_CanoR_1	467	475	PF00244	0.253
LIG_14-3-3_CanoR_1	500	506	PF00244	0.391
LIG_14-3-3_CanoR_1	511	516	PF00244	0.424
LIG_APCC_ABBA_1	316	321	PF00400	0.550
LIG_BRCT_BRCA1_1	455	459	PF00533	0.288
LIG_CaM_IQ_9	56	72	PF13499	0.380
LIG_Clathr_ClatBox_1	58	62	PF01394	0.359
LIG_EH1_1	458	466	PF00400	0.515
LIG_FHA_1	120	126	PF00498	0.519
LIG_FHA_1	197	203	PF00498	0.554
LIG_FHA_1	281	287	PF00498	0.468
LIG_FHA_1	288	294	PF00498	0.413
LIG_FHA_1	362	368	PF00498	0.481
LIG_FHA_1	385	391	PF00498	0.411
LIG_FHA_1	408	414	PF00498	0.502
LIG_FHA_1	485	491	PF00498	0.499
LIG_FHA_2	198	204	PF00498	0.496
LIG_FHA_2	211	217	PF00498	0.486
LIG_FHA_2	225	231	PF00498	0.339
LIG_FHA_2	249	255	PF00498	0.467
LIG_FHA_2	271	277	PF00498	0.587
LIG_FHA_2	398	404	PF00498	0.495
LIG_FHA_2	410	416	PF00498	0.510
LIG_GBD_Chelix_1	150	158	PF00786	0.493
LIG_Integrin_RGD_1	302	304	PF01839	0.415
LIG_Integrin_RGD_1	329	331	PF01839	0.414
LIG_LIR_Gen_1	191	202	PF02991	0.306
LIG_LIR_Gen_1	428	436	PF02991	0.443
LIG_LIR_Gen_1	504	513	PF02991	0.297
LIG_LIR_LC3C_4	487	490	PF02991	0.415
LIG_LIR_Nem_3	191	197	PF02991	0.298
LIG_LIR_Nem_3	335	340	PF02991	0.446
LIG_LIR_Nem_3	375	381	PF02991	0.314
LIG_LIR_Nem_3	428	434	PF02991	0.401
LIG_LIR_Nem_3	482	488	PF02991	0.444
LIG_LIR_Nem_3	504	509	PF02991	0.484
LIG_LYPXL_yS_3	337	340	PF13949	0.569
LIG_NRBOX	257	263	PF00104	0.575
LIG_PCNA_yPIPBox_3	249	262	PF02747	0.474
LIG_PTB_Apo_2	131	138	PF02174	0.638
LIG_SH2_CRK	19	23	PF00017	0.447
LIG_SH2_CRK	356	360	PF00017	0.384
LIG_SH2_CRK	485	489	PF00017	0.411
LIG_SH2_GRB2like	132	135	PF00017	0.595
LIG_SH2_NCK_1	235	239	PF00017	0.332
LIG_SH2_PTP2	194	197	PF00017	0.308
LIG_SH2_PTP2	319	322	PF00017	0.348
LIG_SH2_SRC	235	238	PF00017	0.578
LIG_SH2_SRC	356	359	PF00017	0.473
LIG_SH2_STAP1	10	14	PF00017	0.292
LIG_SH2_STAT5	101	104	PF00017	0.469
LIG_SH2_STAT5	13	16	PF00017	0.465
LIG_SH2_STAT5	194	197	PF00017	0.405
LIG_SH2_STAT5	205	208	PF00017	0.497
LIG_SH2_STAT5	240	243	PF00017	0.555
LIG_SH2_STAT5	319	322	PF00017	0.511
LIG_SH2_STAT5	332	335	PF00017	0.360
LIG_SH2_STAT5	424	427	PF00017	0.456
LIG_SH3_3	19	25	PF00018	0.452
LIG_SH3_3	220	226	PF00018	0.587
LIG_SH3_3	337	343	PF00018	0.572
LIG_SUMO_SIM_par_1	121	126	PF11976	0.463
LIG_TRAF2_1	213	216	PF00917	0.540
LIG_TRAF2_1	272	275	PF00917	0.351
LIG_TYR_ITIM	192	197	PF00017	0.299
LIG_UBA3_1	308	312	PF00899	0.437
MOD_CK1_1	188	194	PF00069	0.426
MOD_CK1_1	336	342	PF00069	0.518
MOD_CK1_1	451	457	PF00069	0.533
MOD_CK2_1	210	216	PF00069	0.525
MOD_CK2_1	224	230	PF00069	0.411
MOD_CK2_1	248	254	PF00069	0.453
MOD_CK2_1	270	276	PF00069	0.531
MOD_CK2_1	285	291	PF00069	0.363
MOD_CK2_1	36	42	PF00069	0.552
MOD_CK2_1	397	403	PF00069	0.453
MOD_CK2_1	409	415	PF00069	0.538
MOD_CK2_1	511	517	PF00069	0.482
MOD_GlcNHglycan	145	148	PF01048	0.523
MOD_GlcNHglycan	312	315	PF01048	0.394
MOD_GlcNHglycan	431	434	PF01048	0.497
MOD_GlcNHglycan	517	522	PF01048	0.521
MOD_GSK3_1	119	126	PF00069	0.401
MOD_GSK3_1	133	140	PF00069	0.418
MOD_GSK3_1	266	273	PF00069	0.455
MOD_GSK3_1	369	376	PF00069	0.362
MOD_GSK3_1	399	406	PF00069	0.410
MOD_GSK3_1	448	455	PF00069	0.403
MOD_GSK3_1	501	508	PF00069	0.369
MOD_GSK3_1	517	524	PF00069	0.412
MOD_N-GLC_1	133	138	PF02516	0.637
MOD_N-GLC_1	266	271	PF02516	0.417
MOD_NEK2_1	137	142	PF00069	0.659
MOD_NEK2_1	197	202	PF00069	0.470
MOD_NEK2_1	325	330	PF00069	0.453
MOD_NEK2_1	333	338	PF00069	0.418
MOD_NEK2_1	484	489	PF00069	0.469
MOD_PIKK_1	138	144	PF00454	0.687
MOD_PIKK_1	168	174	PF00454	0.516
MOD_PIKK_1	2	8	PF00454	0.513
MOD_PIKK_1	384	390	PF00454	0.310
MOD_PIKK_1	79	85	PF00454	0.560
MOD_PKA_2	248	254	PF00069	0.472
MOD_PKA_2	372	378	PF00069	0.453
MOD_Plk_1	133	139	PF00069	0.566
MOD_Plk_2-3	248	254	PF00069	0.496
MOD_Plk_2-3	403	409	PF00069	0.309
MOD_Plk_4	127	133	PF00069	0.450
MOD_Plk_4	28	34	PF00069	0.487
MOD_Plk_4	336	342	PF00069	0.537
MOD_Plk_4	361	367	PF00069	0.533
MOD_Plk_4	409	415	PF00069	0.538
MOD_Plk_4	501	507	PF00069	0.311
MOD_Plk_4	8	14	PF00069	0.388
MOD_Plk_4	95	101	PF00069	0.571
MOD_SUMO_rev_2	57	65	PF00179	0.378
TRG_DiLeu_BaEn_3	275	281	PF01217	0.326
TRG_ENDOCYTIC_2	19	22	PF00928	0.498
TRG_ENDOCYTIC_2	194	197	PF00928	0.308
TRG_ENDOCYTIC_2	319	322	PF00928	0.563
TRG_ENDOCYTIC_2	337	340	PF00928	0.281
TRG_ENDOCYTIC_2	485	488	PF00928	0.460
TRG_ER_diArg_1	159	162	PF00400	0.550
TRG_ER_diArg_1	22	24	PF00400	0.340
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	496	501	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4S8	Leptomonas seymouri	55%	94%
A0A0S4JG45	Bodo saltans	32%	86%
A0A1X0NG29	Trypanosomatidae	37%	96%
A0A3S5H7B5	Leishmania donovani	77%	100%
A0A422NNY9	Trypanosoma rangeli	22%	100%
A0A422NVZ8	Trypanosoma rangeli	39%	100%
A4I054	Leishmania infantum	77%	100%
E9AW17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QBF9	Leishmania major	79%	100%