Leucine-rich repeat-containing protein 34

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCM9_LEIBR

TriTrypDb:

LbrM.23.0170 , LBRM2903_230006500

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

A4HCM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	259	261	PF00675	0.428
CLV_NRD_NRD_1	320	322	PF00675	0.491
CLV_PCSK_KEX2_1	259	261	PF00082	0.428
CLV_PCSK_KEX2_1	320	322	PF00082	0.497
CLV_PCSK_PC7_1	255	261	PF00082	0.448
CLV_PCSK_SKI1_1	182	186	PF00082	0.459
CLV_PCSK_SKI1_1	320	324	PF00082	0.424
DEG_APCC_DBOX_1	181	189	PF00400	0.440
DEG_Nend_Nbox_1	1	3	PF02207	0.399
DOC_MAPK_MEF2A_6	142	149	PF00069	0.421
DOC_MAPK_MEF2A_6	345	354	PF00069	0.367
DOC_MAPK_NFAT4_5	142	150	PF00069	0.417
DOC_PP2B_LxvP_1	65	68	PF13499	0.397
DOC_USP7_MATH_1	332	336	PF00917	0.380
DOC_USP7_MATH_1	60	64	PF00917	0.450
DOC_WW_Pin1_4	327	332	PF00397	0.462
LIG_14-3-3_CanoR_1	204	209	PF00244	0.454
LIG_14-3-3_CanoR_1	314	320	PF00244	0.453
LIG_14-3-3_CanoR_1	321	325	PF00244	0.354
LIG_14-3-3_CanoR_1	33	38	PF00244	0.434
LIG_BRCT_BRCA1_1	292	296	PF00533	0.230
LIG_FHA_1	158	164	PF00498	0.281
LIG_FHA_1	223	229	PF00498	0.435
LIG_FHA_1	25	31	PF00498	0.418
LIG_FHA_1	328	334	PF00498	0.436
LIG_FHA_1	91	97	PF00498	0.388
LIG_FHA_2	153	159	PF00498	0.230
LIG_FHA_2	205	211	PF00498	0.379
LIG_FHA_2	298	304	PF00498	0.441
LIG_GBD_Chelix_1	194	202	PF00786	0.370
LIG_LIR_Gen_1	338	347	PF02991	0.434
LIG_LIR_Gen_1	36	44	PF02991	0.447
LIG_LIR_Gen_1	95	105	PF02991	0.389
LIG_LIR_LC3C_4	303	308	PF02991	0.411
LIG_LIR_Nem_3	262	266	PF02991	0.324
LIG_LIR_Nem_3	338	344	PF02991	0.380
LIG_LIR_Nem_3	36	40	PF02991	0.467
LIG_LIR_Nem_3	63	69	PF02991	0.378
LIG_LIR_Nem_3	95	101	PF02991	0.385
LIG_LYPXL_S_1	58	62	PF13949	0.261
LIG_LYPXL_yS_3	59	62	PF13949	0.258
LIG_NRBOX	252	258	PF00104	0.344
LIG_PCNA_yPIPBox_3	142	153	PF02747	0.413
LIG_PDZ_Class_2	361	366	PF00595	0.469
LIG_Pex14_1	2	6	PF04695	0.324
LIG_SH2_CRK	69	73	PF00017	0.368
LIG_SH2_CRK	98	102	PF00017	0.366
LIG_SH2_NCK_1	69	73	PF00017	0.308
LIG_SH2_STAT5	215	218	PF00017	0.412
LIG_SH2_STAT5	66	69	PF00017	0.409
LIG_SUMO_SIM_par_1	187	193	PF11976	0.397
LIG_SUMO_SIM_par_1	305	312	PF11976	0.361
LIG_SUMO_SIM_par_1	89	95	PF11976	0.437
LIG_TRAF2_1	207	210	PF00917	0.439
LIG_TYR_ITIM	67	72	PF00017	0.323
LIG_TYR_ITIM	96	101	PF00017	0.375
MOD_CK1_1	100	106	PF00069	0.429
MOD_CK1_1	233	239	PF00069	0.367
MOD_CK1_1	24	30	PF00069	0.479
MOD_CK1_1	312	318	PF00069	0.443
MOD_CK1_1	335	341	PF00069	0.473
MOD_CK1_1	90	96	PF00069	0.426
MOD_CK2_1	203	209	PF00069	0.412
MOD_CK2_1	297	303	PF00069	0.404
MOD_GlcNHglycan	23	26	PF01048	0.443
MOD_GlcNHglycan	232	235	PF01048	0.336
MOD_GlcNHglycan	334	337	PF01048	0.394
MOD_GlcNHglycan	62	65	PF01048	0.400
MOD_GSK3_1	20	27	PF00069	0.520
MOD_GSK3_1	262	269	PF00069	0.224
MOD_GSK3_1	295	302	PF00069	0.407
MOD_GSK3_1	86	93	PF00069	0.260
MOD_N-GLC_1	115	120	PF02516	0.455
MOD_N-GLC_1	204	209	PF02516	0.357
MOD_N-GLC_1	70	75	PF02516	0.339
MOD_NEK2_1	157	162	PF00069	0.362
MOD_NEK2_1	230	235	PF00069	0.328
MOD_NEK2_1	266	271	PF00069	0.318
MOD_NEK2_1	309	314	PF00069	0.487
MOD_NEK2_2	54	59	PF00069	0.238
MOD_PIKK_1	243	249	PF00454	0.380
MOD_PKA_1	320	326	PF00069	0.415
MOD_PKA_2	203	209	PF00069	0.435
MOD_PKA_2	320	326	PF00069	0.459
MOD_Plk_1	115	121	PF00069	0.457
MOD_Plk_1	157	163	PF00069	0.464
MOD_Plk_1	204	210	PF00069	0.340
MOD_Plk_2-3	262	268	PF00069	0.217
MOD_Plk_2-3	297	303	PF00069	0.433
MOD_Plk_4	190	196	PF00069	0.410
MOD_Plk_4	222	228	PF00069	0.421
MOD_Plk_4	320	326	PF00069	0.448
MOD_Plk_4	54	60	PF00069	0.360
MOD_Plk_4	87	93	PF00069	0.448
MOD_ProDKin_1	327	333	PF00069	0.456
TRG_DiLeu_BaEn_1	357	362	PF01217	0.293
TRG_DiLeu_BaEn_1	75	80	PF01217	0.420
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.380
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.425
TRG_ENDOCYTIC_2	215	218	PF00928	0.419
TRG_ENDOCYTIC_2	59	62	PF00928	0.353
TRG_ENDOCYTIC_2	69	72	PF00928	0.295
TRG_ENDOCYTIC_2	98	101	PF00928	0.379
TRG_ER_diArg_1	319	321	PF00400	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N0	Leptomonas seymouri	60%	100%
A0A0N1I317	Leptomonas seymouri	24%	92%
A0A0S4JGH2	Bodo saltans	33%	100%
A0A0S4JV86	Bodo saltans	23%	97%
A0A1X0NG92	Trypanosomatidae	40%	100%
A0A1X0NTY3	Trypanosomatidae	24%	82%
A0A1X0P4Z4	Trypanosomatidae	25%	93%
A0A3Q8IDE6	Leishmania donovani	24%	92%
A0A3R7L7Y9	Trypanosoma rangeli	26%	82%
A0A3R7NL91	Trypanosoma rangeli	23%	92%
A0A3R7NVI2	Trypanosoma rangeli	24%	88%
A0A3S7WXH1	Leishmania donovani	88%	100%
A0A3S7WZL6	Leishmania donovani	25%	85%
A0A422NW39	Trypanosoma rangeli	39%	99%
A0JPI9	Rattus norvegicus	27%	76%
A4HEQ6	Leishmania braziliensis	27%	88%
A4I053	Leishmania infantum	88%	100%
A4I1Y5	Leishmania infantum	25%	85%
A4I2T1	Leishmania infantum	24%	92%
C9ZS33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	82%
D0A5Z5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	88%
E9ADA9	Leishmania major	23%	92%
E9AW16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AY32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	77%
E9AZ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	92%
Q0VAA2	Homo sapiens	26%	75%
Q4Q9E1	Leishmania major	25%	100%
Q4QBG0	Leishmania major	88%	100%
Q4V8D9	Rattus norvegicus	31%	88%
Q6ZQY2	Homo sapiens	28%	93%
Q8IZ02	Homo sapiens	29%	79%
Q9DAM1	Mus musculus	31%	88%
Q9LE82	Arabidopsis thaliana	23%	68%
Q9M651	Arabidopsis thaliana	26%	67%