AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HCM8_LEIBR

TriTrypDb:

LbrM.23.0160 , LBRM2903_230006400

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HCM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCM8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006654	phosphatidic acid biosynthetic process	6	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0042592	homeostatic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046473	phosphatidic acid metabolic process	6	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0048878	chemical homeostasis	4	1
GO:0055088	lipid homeostasis	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	1
GO:0016746	acyltransferase activity	3	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	1
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0042171	lysophosphatidic acid acyltransferase activity	6	1
GO:0052689	carboxylic ester hydrolase activity	4	1
GO:0071617	lysophospholipid acyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.184
CLV_C14_Caspase3-7	373	377	PF00656	0.305
CLV_NRD_NRD_1	12	14	PF00675	0.768
CLV_NRD_NRD_1	163	165	PF00675	0.374
CLV_NRD_NRD_1	192	194	PF00675	0.263
CLV_NRD_NRD_1	273	275	PF00675	0.327
CLV_NRD_NRD_1	28	30	PF00675	0.546
CLV_NRD_NRD_1	72	74	PF00675	0.323
CLV_PCSK_KEX2_1	11	13	PF00082	0.747
CLV_PCSK_KEX2_1	163	165	PF00082	0.374
CLV_PCSK_KEX2_1	192	194	PF00082	0.263
CLV_PCSK_KEX2_1	273	275	PF00082	0.327
CLV_PCSK_KEX2_1	28	30	PF00082	0.568
CLV_PCSK_KEX2_1	336	338	PF00082	0.341
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.341
CLV_PCSK_PC7_1	24	30	PF00082	0.463
CLV_PCSK_PC7_1	7	13	PF00082	0.585
CLV_PCSK_SKI1_1	246	250	PF00082	0.317
CLV_PCSK_SKI1_1	310	314	PF00082	0.288
CLV_PCSK_SKI1_1	48	52	PF00082	0.431
CLV_Separin_Metazoa	360	364	PF03568	0.184
DEG_COP1_1	398	406	PF00400	0.346
DEG_MDM2_SWIB_1	279	287	PF02201	0.240
DEG_Nend_UBRbox_3	1	3	PF02207	0.481
DOC_CDC14_PxL_1	238	246	PF14671	0.184
DOC_CYCLIN_RxL_1	214	226	PF00134	0.190
DOC_MAPK_gen_1	118	127	PF00069	0.298
DOC_MAPK_gen_1	192	198	PF00069	0.212
DOC_MAPK_gen_1	336	344	PF00069	0.355
DOC_MAPK_gen_1	363	371	PF00069	0.288
DOC_MAPK_MEF2A_6	118	127	PF00069	0.298
DOC_MAPK_MEF2A_6	336	344	PF00069	0.243
DOC_MAPK_MEF2A_6	363	371	PF00069	0.288
DOC_PP1_RVXF_1	218	225	PF00149	0.289
DOC_PP4_FxxP_1	153	156	PF00568	0.327
DOC_PP4_FxxP_1	191	194	PF00568	0.240
DOC_PP4_FxxP_1	224	227	PF00568	0.263
DOC_USP7_MATH_1	103	107	PF00917	0.651
DOC_USP7_MATH_1	167	171	PF00917	0.184
DOC_USP7_MATH_1	302	306	PF00917	0.262
DOC_USP7_MATH_1	322	326	PF00917	0.158
DOC_USP7_UBL2_3	114	118	PF12436	0.416
DOC_WW_Pin1_4	105	110	PF00397	0.634
DOC_WW_Pin1_4	402	407	PF00397	0.434
LIG_14-3-3_CanoR_1	163	172	PF00244	0.390
LIG_14-3-3_CanoR_1	370	375	PF00244	0.412
LIG_Actin_RPEL_3	230	249	PF02755	0.301
LIG_Actin_WH2_2	248	264	PF00022	0.317
LIG_APCC_ABBA_1	221	226	PF00400	0.184
LIG_APCC_ABBAyCdc20_2	220	226	PF00400	0.184
LIG_deltaCOP1_diTrp_1	280	286	PF00928	0.357
LIG_FHA_1	102	108	PF00498	0.720
LIG_FHA_1	351	357	PF00498	0.262
LIG_FHA_1	381	387	PF00498	0.252
LIG_FHA_1	67	73	PF00498	0.446
LIG_FHA_1	89	95	PF00498	0.492
LIG_FHA_2	229	235	PF00498	0.184
LIG_FHA_2	290	296	PF00498	0.412
LIG_FHA_2	371	377	PF00498	0.331
LIG_FHA_2	39	45	PF00498	0.300
LIG_Integrin_RGD_1	232	234	PF01839	0.184
LIG_LIR_Apic_2	190	194	PF02991	0.245
LIG_LIR_Gen_1	280	290	PF02991	0.412
LIG_LIR_Gen_1	291	302	PF02991	0.288
LIG_LIR_Nem_3	146	151	PF02991	0.255
LIG_LIR_Nem_3	176	181	PF02991	0.389
LIG_LIR_Nem_3	201	205	PF02991	0.310
LIG_LIR_Nem_3	280	286	PF02991	0.322
LIG_LIR_Nem_3	291	297	PF02991	0.357
LIG_LYPXL_S_1	240	244	PF13949	0.184
LIG_LYPXL_yS_3	241	244	PF13949	0.184
LIG_NRBOX	256	262	PF00104	0.262
LIG_NRBOX	357	363	PF00104	0.288
LIG_NRBOX	50	56	PF00104	0.284
LIG_PALB2_WD40_1	181	189	PF16756	0.357
LIG_PCNA_yPIPBox_3	254	262	PF02747	0.236
LIG_PDZ_Class_2	405	410	PF00595	0.547
LIG_Pex14_2	224	228	PF04695	0.263
LIG_Pex14_2	279	283	PF04695	0.240
LIG_SH2_CRK	294	298	PF00017	0.357
LIG_SH2_NCK_1	372	376	PF00017	0.204
LIG_SH2_SRC	296	299	PF00017	0.357
LIG_SH2_STAP1	151	155	PF00017	0.246
LIG_SH2_STAP1	294	298	PF00017	0.240
LIG_SH2_STAP1	318	322	PF00017	0.288
LIG_SH2_STAP1	33	37	PF00017	0.563
LIG_SH2_STAT5	177	180	PF00017	0.390
LIG_SH2_STAT5	181	184	PF00017	0.357
LIG_SH2_STAT5	296	299	PF00017	0.240
LIG_SH2_STAT5	372	375	PF00017	0.184
LIG_SH3_1	12	18	PF00018	0.506
LIG_SH3_3	12	18	PF00018	0.534
LIG_SH3_3	263	269	PF00018	0.257
LIG_SH3_3	400	406	PF00018	0.364
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.240
LIG_SUMO_SIM_anti_2	324	333	PF11976	0.184
LIG_SUMO_SIM_par_1	353	360	PF11976	0.281
LIG_TRAF2_1	117	120	PF00917	0.371
LIG_WW_3	25	29	PF00397	0.591
MOD_CK1_1	398	404	PF00069	0.416
MOD_CK1_1	86	92	PF00069	0.465
MOD_CK1_1	93	99	PF00069	0.692
MOD_CK2_1	167	173	PF00069	0.319
MOD_CK2_1	38	44	PF00069	0.304
MOD_GlcNHglycan	165	168	PF01048	0.287
MOD_GlcNHglycan	85	88	PF01048	0.571
MOD_GSK3_1	101	108	PF00069	0.464
MOD_GSK3_1	163	170	PF00069	0.336
MOD_GSK3_1	31	38	PF00069	0.540
MOD_GSK3_1	391	398	PF00069	0.369
MOD_GSK3_1	402	409	PF00069	0.497
MOD_GSK3_1	86	93	PF00069	0.452
MOD_N-GLC_1	19	24	PF02516	0.502
MOD_N-GLC_1	350	355	PF02516	0.184
MOD_N-GLC_1	83	88	PF02516	0.564
MOD_NEK2_1	198	203	PF00069	0.353
MOD_NEK2_1	205	210	PF00069	0.353
MOD_PIKK_1	19	25	PF00454	0.603
MOD_PIKK_1	38	44	PF00454	0.548
MOD_PKA_1	163	169	PF00069	0.327
MOD_PKA_1	391	397	PF00069	0.235
MOD_PKA_2	163	169	PF00069	0.386
MOD_PKB_1	368	376	PF00069	0.288
MOD_Plk_1	38	44	PF00069	0.330
MOD_Plk_1	398	404	PF00069	0.452
MOD_Plk_2-3	289	295	PF00069	0.184
MOD_Plk_4	289	295	PF00069	0.438
MOD_Plk_4	302	308	PF00069	0.175
MOD_Plk_4	31	37	PF00069	0.569
MOD_Plk_4	322	328	PF00069	0.263
MOD_Plk_4	345	351	PF00069	0.227
MOD_ProDKin_1	105	111	PF00069	0.633
MOD_ProDKin_1	402	408	PF00069	0.440
MOD_SUMO_for_1	117	120	PF00179	0.409
TRG_DiLeu_BaEn_1	122	127	PF01217	0.263
TRG_DiLeu_BaEn_1	357	362	PF01217	0.288
TRG_DiLeu_BaEn_3	119	125	PF01217	0.258
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.281
TRG_ENDOCYTIC_2	241	244	PF00928	0.184
TRG_ENDOCYTIC_2	294	297	PF00928	0.357
TRG_ENDOCYTIC_2	33	36	PF00928	0.571
TRG_ER_diArg_1	10	13	PF00400	0.566
TRG_ER_diArg_1	191	193	PF00400	0.263
TRG_ER_diArg_1	27	29	PF00400	0.496
TRG_ER_diArg_1	272	274	PF00400	0.327
TRG_ER_diArg_1	367	370	PF00400	0.288
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.288
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.184
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P520	Leptomonas seymouri	58%	100%
A0A1X0NG89	Trypanosomatidae	40%	100%
A0A3S7WXG3	Leishmania donovani	75%	100%
A0A422NW44	Trypanosoma rangeli	41%	99%
A4I052	Leishmania infantum	75%	100%
E9AW15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
O02218	Caenorhabditis elegans	27%	100%
O22975	Arabidopsis thaliana	26%	98%
P53264	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	92%
Q0J0A4	Oryza sativa subsp. japonica	25%	99%
Q4QBG1	Leishmania major	69%	100%
Q5EA59	Bos taurus	32%	100%
Q8TB40	Homo sapiens	29%	100%
Q8VD66	Mus musculus	29%	100%
V5B077	Trypanosoma cruzi	43%	100%