Putative cyclophilin 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 3, putative

Species:

Leishmania braziliensis

UniProt:

A4HCM6_LEIBR

TriTrypDb:

LbrM.23.0140 , LBRM2903_230006200

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HCM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCM6

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0018193	peptidyl-amino acid modification	5	9
GO:0018208	peptidyl-proline modification	6	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	9
GO:0003824	catalytic activity	1	9
GO:0016853	isomerase activity	2	9
GO:0016859	cis-trans isomerase activity	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.305
CLV_C14_Caspase3-7	75	79	PF00656	0.190
CLV_NRD_NRD_1	40	42	PF00675	0.356
CLV_PCSK_KEX2_1	40	42	PF00082	0.356
CLV_PCSK_SKI1_1	41	45	PF00082	0.353
DEG_Nend_UBRbox_2	1	3	PF02207	0.477
DOC_CYCLIN_yCln2_LP_2	145	151	PF00134	0.345
DOC_PP1_RVXF_1	38	45	PF00149	0.356
DOC_SPAK_OSR1_1	103	107	PF12202	0.236
DOC_USP7_MATH_1	165	169	PF00917	0.549
DOC_WW_Pin1_4	106	111	PF00397	0.361
DOC_WW_Pin1_4	144	149	PF00397	0.262
DOC_WW_Pin1_4	73	78	PF00397	0.327
DOC_WW_Pin1_4	90	95	PF00397	0.417
LIG_14-3-3_CanoR_1	103	109	PF00244	0.356
LIG_14-3-3_CanoR_1	133	139	PF00244	0.257
LIG_Actin_WH2_2	145	163	PF00022	0.285
LIG_FHA_1	115	121	PF00498	0.381
LIG_FHA_1	176	182	PF00498	0.595
LIG_FHA_2	64	70	PF00498	0.327
LIG_LIR_Gen_1	20	30	PF02991	0.356
LIG_LIR_Nem_3	140	146	PF02991	0.277
LIG_LIR_Nem_3	18	22	PF02991	0.358
LIG_LIR_Nem_3	28	33	PF02991	0.294
LIG_SH2_CRK	125	129	PF00017	0.328
LIG_SH2_CRK	146	150	PF00017	0.296
LIG_SH2_GRB2like	22	25	PF00017	0.300
LIG_SH2_NCK_1	146	150	PF00017	0.296
LIG_SH2_STAP1	177	181	PF00017	0.437
LIG_SH2_STAT5	177	180	PF00017	0.437
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.296
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.185
LIG_SUMO_SIM_par_1	104	109	PF11976	0.356
LIG_SUMO_SIM_par_1	177	183	PF11976	0.431
LIG_TYR_ITIM	144	149	PF00017	0.327
MOD_CK1_1	147	153	PF00069	0.387
MOD_CK1_1	183	189	PF00069	0.656
MOD_CK2_1	63	69	PF00069	0.356
MOD_GlcNHglycan	125	128	PF01048	0.267
MOD_GlcNHglycan	155	158	PF01048	0.328
MOD_GlcNHglycan	162	165	PF01048	0.533
MOD_GlcNHglycan	167	170	PF01048	0.537
MOD_GlcNHglycan	35	38	PF01048	0.269
MOD_GSK3_1	123	130	PF00069	0.391
MOD_GSK3_1	160	167	PF00069	0.491
MOD_GSK3_1	171	178	PF00069	0.553
MOD_GSK3_1	183	190	PF00069	0.495
MOD_GSK3_1	61	68	PF00069	0.419
MOD_GSK3_1	88	95	PF00069	0.359
MOD_N-GLC_2	24	26	PF02516	0.356
MOD_NEK2_1	10	15	PF00069	0.280
MOD_NEK2_1	104	109	PF00069	0.262
MOD_NEK2_1	114	119	PF00069	0.381
MOD_NEK2_1	160	165	PF00069	0.532
MOD_NEK2_1	33	38	PF00069	0.246
MOD_PKA_2	132	138	PF00069	0.185
MOD_PKA_2	160	166	PF00069	0.603
MOD_PKA_2	183	189	PF00069	0.460
MOD_Plk_1	114	120	PF00069	0.356
MOD_Plk_4	147	153	PF00069	0.356
MOD_Plk_4	183	189	PF00069	0.517
MOD_Plk_4	26	32	PF00069	0.361
MOD_Plk_4	78	84	PF00069	0.213
MOD_ProDKin_1	106	112	PF00069	0.361
MOD_ProDKin_1	144	150	PF00069	0.262
MOD_ProDKin_1	73	79	PF00069	0.327
MOD_ProDKin_1	90	96	PF00069	0.417
TRG_ENDOCYTIC_2	125	128	PF00928	0.296
TRG_ENDOCYTIC_2	146	149	PF00928	0.262
TRG_ENDOCYTIC_2	22	25	PF00928	0.356
TRG_ER_diArg_1	39	41	PF00400	0.358
TRG_NES_CRM1_1	129	142	PF08389	0.185

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4M9	Leptomonas seymouri	61%	100%
A0A0S4J465	Bodo saltans	27%	79%
A0A1X0NGT2	Trypanosomatidae	38%	97%
A0A3S7WXE3	Leishmania donovani	78%	100%
A0A422NW48	Trypanosoma rangeli	41%	97%
A4I050	Leishmania infantum	78%	100%
E9AW13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
P0C1I4	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	30%	100%
P0CP84	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	31%	100%
P0CP85	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	31%	100%
P52018	Caenorhabditis elegans	21%	100%
P87051	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q2U6U0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	28%	100%
Q4I1Y1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	28%	100%
Q4P6X6	Ustilago maydis (strain 521 / FGSC 9021)	27%	100%
Q4QBG3	Leishmania major	77%	100%
Q4WCR3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	28%	100%
Q5ASQ0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	100%
Q7SF72	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	31%	100%
Q8X191	Aspergillus niger	30%	100%
Q9NI62	Dictyostelium discoideum	31%	100%
Q9SIH1	Arabidopsis thaliana	30%	100%