Methyltransf_25 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HCM3_LEIBR

TriTrypDb:

LbrM.23.0110 , LBRM2903_230005900

Length:

261

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCM3

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	3
GO:0032259	methylation	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	26	28	PF00675	0.390
CLV_PCSK_SKI1_1	106	110	PF00082	0.325
CLV_PCSK_SKI1_1	202	206	PF00082	0.404
CLV_PCSK_SKI1_1	28	32	PF00082	0.271
CLV_PCSK_SKI1_1	8	12	PF00082	0.467
DEG_Nend_UBRbox_3	1	3	PF02207	0.468
DOC_CYCLIN_RxL_1	24	33	PF00134	0.264
DOC_MAPK_MEF2A_6	236	244	PF00069	0.304
DOC_MAPK_MEF2A_6	35	43	PF00069	0.455
DOC_USP7_MATH_1	59	63	PF00917	0.392
DOC_WW_Pin1_4	132	137	PF00397	0.359
LIG_Actin_WH2_2	180	197	PF00022	0.300
LIG_Actin_WH2_2	223	238	PF00022	0.258
LIG_AP2alpha_2	248	250	PF02296	0.412
LIG_BRCT_BRCA1_1	184	188	PF00533	0.266
LIG_BRCT_BRCA1_1	99	103	PF00533	0.359
LIG_Clathr_ClatBox_1	244	248	PF01394	0.260
LIG_Clathr_ClatBox_1	29	33	PF01394	0.392
LIG_CtBP_PxDLS_1	136	140	PF00389	0.341
LIG_FHA_1	76	82	PF00498	0.184
LIG_FHA_2	219	225	PF00498	0.270
LIG_FHA_2	63	69	PF00498	0.383
LIG_LIR_Gen_1	17	26	PF02991	0.410
LIG_LIR_Gen_1	177	187	PF02991	0.300
LIG_LIR_Gen_1	237	247	PF02991	0.235
LIG_LIR_Gen_1	33	43	PF02991	0.238
LIG_LIR_Nem_3	17	23	PF02991	0.419
LIG_LIR_Nem_3	177	182	PF02991	0.300
LIG_LIR_Nem_3	237	242	PF02991	0.232
LIG_LIR_Nem_3	248	253	PF02991	0.349
LIG_LIR_Nem_3	33	39	PF02991	0.233
LIG_NRBOX	240	246	PF00104	0.253
LIG_NRBOX	71	77	PF00104	0.420
LIG_PCNA_yPIPBox_3	67	76	PF02747	0.301
LIG_SH2_CRK	50	54	PF00017	0.224
LIG_SH2_GRB2like	20	23	PF00017	0.407
LIG_SH2_NCK_1	20	24	PF00017	0.411
LIG_SH2_PTP2	84	87	PF00017	0.359
LIG_SH2_SRC	20	23	PF00017	0.407
LIG_SH2_STAP1	16	20	PF00017	0.302
LIG_SH2_STAT5	189	192	PF00017	0.266
LIG_SH2_STAT5	253	256	PF00017	0.392
LIG_SH2_STAT5	84	87	PF00017	0.300
LIG_SH3_3	243	249	PF00018	0.422
LIG_SH3_3	36	42	PF00018	0.392
LIG_SUMO_SIM_anti_2	138	145	PF11976	0.341
LIG_SUMO_SIM_anti_2	155	160	PF11976	0.221
LIG_SUMO_SIM_anti_2	243	248	PF11976	0.261
LIG_SUMO_SIM_anti_2	71	80	PF11976	0.445
LIG_SUMO_SIM_par_1	243	248	PF11976	0.261
LIG_SUMO_SIM_par_1	28	33	PF11976	0.332
LIG_WRC_WIRS_1	176	181	PF05994	0.359
MOD_CK1_1	135	141	PF00069	0.300
MOD_CK1_1	175	181	PF00069	0.239
MOD_CK1_1	62	68	PF00069	0.348
MOD_CK2_1	104	110	PF00069	0.196
MOD_CK2_1	62	68	PF00069	0.554
MOD_GlcNHglycan	202	205	PF01048	0.448
MOD_GlcNHglycan	257	260	PF01048	0.423
MOD_GlcNHglycan	61	64	PF01048	0.477
MOD_GSK3_1	216	223	PF00069	0.319
MOD_GSK3_1	59	66	PF00069	0.497
MOD_NEK2_1	118	123	PF00069	0.341
MOD_NEK2_1	188	193	PF00069	0.318
MOD_NEK2_1	216	221	PF00069	0.341
MOD_Plk_1	172	178	PF00069	0.439
MOD_Plk_2-3	104	110	PF00069	0.239
MOD_Plk_4	104	110	PF00069	0.297
MOD_ProDKin_1	132	138	PF00069	0.359
MOD_SUMO_for_1	170	173	PF00179	0.341
MOD_SUMO_rev_2	98	108	PF00179	0.295
TRG_DiLeu_BaEn_1	237	242	PF01217	0.231
TRG_DiLeu_BaEn_1	68	73	PF01217	0.593
TRG_ENDOCYTIC_2	20	23	PF00928	0.425
TRG_ENDOCYTIC_2	36	39	PF00928	0.407
TRG_ENDOCYTIC_2	50	53	PF00928	0.225
TRG_ER_diArg_1	54	57	PF00400	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I266	Leptomonas seymouri	53%	100%
A0A0S4J1S6	Bodo saltans	36%	84%
A0A1X0NX63	Trypanosomatidae	42%	100%
A0A3S7WXK7	Leishmania donovani	79%	100%
A4I047	Leishmania infantum	79%	100%
A4IGU3	Xenopus tropicalis	26%	100%
E9AW10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QBG6	Leishmania major	77%	100%