DUF1767 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1767), putative

Species:

Leishmania braziliensis

UniProt:

A4HCM2_LEIBR

TriTrypDb:

LbrM.23.0100 , LBRM2903_230005800

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.521
CLV_NRD_NRD_1	261	263	PF00675	0.562
CLV_PCSK_KEX2_1	107	109	PF00082	0.304
CLV_PCSK_KEX2_1	180	182	PF00082	0.561
CLV_PCSK_KEX2_1	261	263	PF00082	0.562
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.304
CLV_PCSK_PC7_1	103	109	PF00082	0.304
CLV_PCSK_SKI1_1	107	111	PF00082	0.304
CLV_PCSK_SKI1_1	130	134	PF00082	0.230
CLV_PCSK_SKI1_1	210	214	PF00082	0.505
CLV_PCSK_SKI1_1	78	82	PF00082	0.268
DOC_CKS1_1	135	140	PF01111	0.504
DOC_MAPK_gen_1	107	114	PF00069	0.504
DOC_MAPK_gen_1	9	16	PF00069	0.453
DOC_MAPK_MEF2A_6	107	114	PF00069	0.504
DOC_MAPK_NFAT4_5	107	115	PF00069	0.504
DOC_USP7_MATH_1	255	259	PF00917	0.516
DOC_USP7_MATH_1	88	92	PF00917	0.496
DOC_WW_Pin1_4	134	139	PF00397	0.504
LIG_14-3-3_CanoR_1	103	110	PF00244	0.474
LIG_14-3-3_CanoR_1	111	121	PF00244	0.445
LIG_APCC_ABBA_1	142	147	PF00400	0.472
LIG_APCC_ABBAyCdc20_2	141	147	PF00400	0.471
LIG_FHA_1	126	132	PF00498	0.559
LIG_FHA_1	79	85	PF00498	0.461
LIG_FHA_2	135	141	PF00498	0.504
LIG_FHA_2	30	36	PF00498	0.504
LIG_FHA_2	88	94	PF00498	0.437
LIG_Integrin_isoDGR_2	233	235	PF01839	0.511
LIG_LIR_Nem_3	328	334	PF02991	0.578
LIG_LIR_Nem_3	336	342	PF02991	0.489
LIG_MYND_3	121	125	PF01753	0.404
LIG_SH2_SRC	242	245	PF00017	0.513
LIG_SH2_STAP1	12	16	PF00017	0.512
LIG_SH2_STAP1	251	255	PF00017	0.514
LIG_SH2_STAT3	251	254	PF00017	0.513
LIG_SH2_STAT5	20	23	PF00017	0.530
LIG_SH2_STAT5	308	311	PF00017	0.528
LIG_SH3_3	116	122	PF00018	0.514
LIG_SH3_3	80	86	PF00018	0.461
LIG_SUMO_SIM_anti_2	158	166	PF11976	0.458
LIG_TRAF2_1	90	93	PF00917	0.478
MOD_CDK_SPxxK_3	134	141	PF00069	0.504
MOD_CK1_1	160	166	PF00069	0.506
MOD_CK1_1	27	33	PF00069	0.472
MOD_CK2_1	134	140	PF00069	0.488
MOD_CK2_1	29	35	PF00069	0.504
MOD_CK2_1	37	43	PF00069	0.504
MOD_CK2_1	87	93	PF00069	0.512
MOD_Cter_Amidation	259	262	PF01082	0.554
MOD_GlcNHglycan	16	19	PF01048	0.220
MOD_GlcNHglycan	217	220	PF01048	0.740
MOD_GlcNHglycan	244	247	PF01048	0.579
MOD_GlcNHglycan	288	291	PF01048	0.577
MOD_GlcNHglycan	62	65	PF01048	0.287
MOD_GSK3_1	10	17	PF00069	0.521
MOD_GSK3_1	210	217	PF00069	0.688
MOD_GSK3_1	238	245	PF00069	0.510
MOD_GSK3_1	74	81	PF00069	0.498
MOD_N-GLC_1	103	108	PF02516	0.312
MOD_N-GLC_1	160	165	PF02516	0.271
MOD_N-GLC_1	210	215	PF02516	0.493
MOD_N-GLC_1	255	260	PF02516	0.657
MOD_N-GLC_1	74	79	PF02516	0.304
MOD_N-GLC_2	152	154	PF02516	0.304
MOD_N-GLC_2	307	309	PF02516	0.501
MOD_NEK2_1	124	129	PF00069	0.479
MOD_NEK2_1	157	162	PF00069	0.471
MOD_PIKK_1	57	63	PF00454	0.423
MOD_PIKK_1	78	84	PF00454	0.461
MOD_PKA_2	102	108	PF00069	0.474
MOD_PKA_2	238	244	PF00069	0.564
MOD_PKA_2	272	278	PF00069	0.559
MOD_Plk_1	124	130	PF00069	0.499
MOD_Plk_1	160	166	PF00069	0.471
MOD_Plk_1	210	216	PF00069	0.495
MOD_Plk_1	255	261	PF00069	0.521
MOD_Plk_4	160	166	PF00069	0.504
MOD_Plk_4	49	55	PF00069	0.451
MOD_ProDKin_1	134	140	PF00069	0.504
TRG_DiLeu_BaEn_4	92	98	PF01217	0.404
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.461
TRG_ER_diArg_1	180	182	PF00400	0.557
TRG_ER_diArg_1	261	264	PF00400	0.567
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.314
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI0	Leptomonas seymouri	72%	100%
A0A0S4IYS0	Bodo saltans	39%	95%
A0A3S7WXE9	Leishmania donovani	74%	99%
A4I046	Leishmania infantum	75%	99%
E9AW09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4QBG7	Leishmania major	73%	100%