Tropomyosin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Tropomyosin

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCM1_LEIBR

TriTrypDb:

LbrM.23.0090 , LBRM2903_230005700

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.546
CLV_NRD_NRD_1	303	305	PF00675	0.477
CLV_NRD_NRD_1	341	343	PF00675	0.550
CLV_NRD_NRD_1	359	361	PF00675	0.458
CLV_NRD_NRD_1	45	47	PF00675	0.482
CLV_NRD_NRD_1	9	11	PF00675	0.666
CLV_PCSK_KEX2_1	201	203	PF00082	0.580
CLV_PCSK_KEX2_1	340	342	PF00082	0.556
CLV_PCSK_KEX2_1	80	82	PF00082	0.635
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.580
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.662
CLV_PCSK_SKI1_1	117	121	PF00082	0.419
CLV_PCSK_SKI1_1	180	184	PF00082	0.536
CLV_PCSK_SKI1_1	201	205	PF00082	0.491
CLV_PCSK_SKI1_1	22	26	PF00082	0.547
CLV_PCSK_SKI1_1	220	224	PF00082	0.456
CLV_PCSK_SKI1_1	244	248	PF00082	0.648
DEG_Nend_UBRbox_1	1	4	PF02207	0.432
DOC_ANK_TNKS_1	13	20	PF00023	0.482
DOC_MAPK_gen_1	176	184	PF00069	0.609
DOC_MAPK_gen_1	327	336	PF00069	0.374
DOC_MAPK_MEF2A_6	220	229	PF00069	0.455
DOC_MAPK_NFAT4_5	220	228	PF00069	0.466
DOC_MAPK_RevD_3	32	47	PF00069	0.535
DOC_USP7_MATH_1	260	264	PF00917	0.486
DOC_USP7_MATH_1	312	316	PF00917	0.472
DOC_USP7_MATH_1	79	83	PF00917	0.625
DOC_USP7_MATH_1	97	101	PF00917	0.414
DOC_USP7_UBL2_3	103	107	PF12436	0.387
DOC_WW_Pin1_4	24	29	PF00397	0.655
LIG_14-3-3_CanoR_1	117	126	PF00244	0.555
LIG_14-3-3_CanoR_1	180	185	PF00244	0.621
LIG_Actin_WH2_2	139	157	PF00022	0.364
LIG_Actin_WH2_2	229	246	PF00022	0.594
LIG_CtBP_PxDLS_1	28	32	PF00389	0.604
LIG_FHA_1	176	182	PF00498	0.600
LIG_FHA_1	185	191	PF00498	0.594
LIG_FHA_1	46	52	PF00498	0.479
LIG_FHA_2	1	7	PF00498	0.669
LIG_FHA_2	116	122	PF00498	0.599
LIG_FHA_2	232	238	PF00498	0.454
LIG_FHA_2	312	318	PF00498	0.522
LIG_FHA_2	81	87	PF00498	0.566
LIG_FHA_2	94	100	PF00498	0.570
LIG_LIR_Gen_1	245	255	PF02991	0.671
LIG_LIR_Nem_3	159	164	PF02991	0.421
LIG_LIR_Nem_3	189	194	PF02991	0.454
LIG_LIR_Nem_3	245	250	PF02991	0.637
LIG_LIR_Nem_3	333	338	PF02991	0.373
LIG_SH2_CRK	191	195	PF00017	0.497
LIG_SH2_STAT5	335	338	PF00017	0.345
LIG_SH3_4	192	199	PF00018	0.361
LIG_SUMO_SIM_par_1	221	226	PF11976	0.467
LIG_TRAF2_1	150	153	PF00917	0.564
MOD_CK1_1	111	117	PF00069	0.284
MOD_CK1_1	221	227	PF00069	0.466
MOD_CK1_1	27	33	PF00069	0.510
MOD_CK1_1	281	287	PF00069	0.482
MOD_CK1_1	45	51	PF00069	0.432
MOD_CK1_1	91	97	PF00069	0.623
MOD_CK2_1	115	121	PF00069	0.630
MOD_CK2_1	231	237	PF00069	0.455
MOD_CK2_1	27	33	PF00069	0.529
MOD_CK2_1	311	317	PF00069	0.519
MOD_CK2_1	93	99	PF00069	0.648
MOD_GlcNHglycan	261	265	PF01048	0.720
MOD_GlcNHglycan	272	277	PF01048	0.581
MOD_GlcNHglycan	90	93	PF01048	0.634
MOD_GSK3_1	107	114	PF00069	0.567
MOD_GSK3_1	180	187	PF00069	0.603
MOD_GSK3_1	214	221	PF00069	0.540
MOD_GSK3_1	312	319	PF00069	0.462
MOD_GSK3_1	65	72	PF00069	0.633
MOD_GSK3_1	93	100	PF00069	0.616
MOD_N-GLC_1	206	211	PF02516	0.491
MOD_N-GLC_1	214	219	PF02516	0.460
MOD_N-GLC_1	355	360	PF02516	0.347
MOD_N-GLC_1	55	60	PF02516	0.495
MOD_NEK2_1	211	216	PF00069	0.494
MOD_NEK2_1	336	341	PF00069	0.557
MOD_NEK2_2	55	60	PF00069	0.368
MOD_PIKK_1	184	190	PF00454	0.660
MOD_PKA_1	80	86	PF00069	0.643
MOD_PKA_2	211	217	PF00069	0.479
MOD_PKA_2	281	287	PF00069	0.466
MOD_PKA_2	45	51	PF00069	0.499
MOD_PKA_2	80	86	PF00069	0.645
MOD_PKA_2	88	94	PF00069	0.696
MOD_Plk_1	355	361	PF00069	0.584
MOD_Plk_1	55	61	PF00069	0.633
MOD_Plk_1	65	71	PF00069	0.615
MOD_Plk_2-3	115	121	PF00069	0.619
MOD_Plk_2-3	33	39	PF00069	0.388
MOD_Plk_4	218	224	PF00069	0.354
MOD_Plk_4	281	287	PF00069	0.427
MOD_ProDKin_1	24	30	PF00069	0.645
MOD_SUMO_for_1	41	44	PF00179	0.368
MOD_SUMO_rev_2	27	37	PF00179	0.439
MOD_SUMO_rev_2	290	299	PF00179	0.483
MOD_SUMO_rev_2	300	307	PF00179	0.446
MOD_SUMO_rev_2	73	82	PF00179	0.620
TRG_ENDOCYTIC_2	161	164	PF00928	0.493
TRG_ENDOCYTIC_2	191	194	PF00928	0.500
TRG_ER_diArg_1	227	230	PF00400	0.444
TRG_ER_diArg_1	340	342	PF00400	0.616
TRG_NES_CRM1_1	33	44	PF08389	0.524
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	195	200	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV61	Leptomonas seymouri	72%	87%
A0A0S4J5N8	Bodo saltans	36%	84%
A0A1X0NXM5	Trypanosomatidae	45%	87%
A0A3S7WXH9	Leishmania donovani	80%	87%
A0A422N5Q1	Trypanosoma rangeli	43%	87%
A4I045	Leishmania infantum	80%	87%
C9ZUY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	87%
E9AW08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	87%
Q4QBG8	Leishmania major	78%	100%
V5B6S0	Trypanosoma cruzi	46%	73%