Agmatinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

agmatinase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HCM0_LEIBR

TriTrypDb:

LbrM.23.0080 , LBRM2903_230005600

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCM0

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006525	arginine metabolic process	6	1
GO:0006576	biogenic amine metabolic process	5	1
GO:0006595	polyamine metabolic process	6	1
GO:0006596	polyamine biosynthetic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009064	glutamine family amino acid metabolic process	5	1
GO:0009308	amine metabolic process	4	1
GO:0009309	amine biosynthetic process	5	1
GO:0009445	putrescine metabolic process	7	1
GO:0009446	putrescine biosynthetic process	8	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0033388	putrescine biosynthetic process from arginine	7	1
GO:0033389	putrescine biosynthetic process from arginine, using agmatinase	8	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0042401	biogenic amine biosynthetic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901605	alpha-amino acid metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	10
GO:0008783	agmatinase activity	5	6
GO:0016787	hydrolase activity	2	7
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	7
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	4	7
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0004053	arginase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.607
CLV_NRD_NRD_1	186	188	PF00675	0.223
CLV_NRD_NRD_1	189	191	PF00675	0.253
CLV_PCSK_KEX2_1	136	138	PF00082	0.219
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.219
CLV_PCSK_SKI1_1	136	140	PF00082	0.219
CLV_PCSK_SKI1_1	163	167	PF00082	0.234
CLV_PCSK_SKI1_1	168	172	PF00082	0.239
CLV_PCSK_SKI1_1	206	210	PF00082	0.219
CLV_PCSK_SKI1_1	248	252	PF00082	0.219
CLV_PCSK_SKI1_1	291	295	PF00082	0.219
DEG_APCC_DBOX_1	247	255	PF00400	0.419
DEG_Nend_Nbox_1	1	3	PF02207	0.362
DOC_CYCLIN_RxL_1	133	143	PF00134	0.419
DOC_CYCLIN_RxL_1	157	169	PF00134	0.444
DOC_CYCLIN_RxL_1	203	213	PF00134	0.424
DOC_MAPK_gen_1	190	200	PF00069	0.416
DOC_MAPK_gen_1	212	222	PF00069	0.419
DOC_MAPK_gen_1	258	267	PF00069	0.419
DOC_MAPK_MEF2A_6	157	166	PF00069	0.468
DOC_MAPK_MEF2A_6	215	224	PF00069	0.419
DOC_PP4_FxxP_1	61	64	PF00568	0.481
DOC_USP7_MATH_1	35	39	PF00917	0.434
DOC_USP7_UBL2_3	168	172	PF12436	0.419
DOC_WW_Pin1_4	236	241	PF00397	0.445
DOC_WW_Pin1_4	46	51	PF00397	0.332
LIG_14-3-3_CanoR_1	137	147	PF00244	0.556
LIG_14-3-3_CanoR_1	180	189	PF00244	0.419
LIG_Actin_WH2_2	158	174	PF00022	0.452
LIG_Actin_WH2_2	280	296	PF00022	0.436
LIG_FHA_1	1	7	PF00498	0.379
LIG_FHA_1	106	112	PF00498	0.420
LIG_FHA_1	271	277	PF00498	0.379
LIG_FHA_1	38	44	PF00498	0.398
LIG_FHA_2	305	311	PF00498	0.456
LIG_FHA_2	321	327	PF00498	0.557
LIG_FHA_2	58	64	PF00498	0.373
LIG_FHA_2	94	100	PF00498	0.401
LIG_IBAR_NPY_1	327	329	PF08397	0.456
LIG_Integrin_RGD_1	278	280	PF01839	0.216
LIG_LIR_Apic_2	58	64	PF02991	0.445
LIG_LIR_Gen_1	54	64	PF02991	0.371
LIG_LIR_Gen_1	98	107	PF02991	0.465
LIG_LIR_Nem_3	113	119	PF02991	0.428
LIG_LIR_Nem_3	133	138	PF02991	0.333
LIG_LIR_Nem_3	217	221	PF02991	0.419
LIG_LIR_Nem_3	54	59	PF02991	0.368
LIG_LIR_Nem_3	73	79	PF02991	0.341
LIG_LIR_Nem_3	98	104	PF02991	0.490
LIG_PCNA_yPIPBox_3	286	299	PF02747	0.453
LIG_PTB_Apo_2	41	48	PF02174	0.395
LIG_PTB_Phospho_1	41	47	PF10480	0.389
LIG_SH2_CRK	135	139	PF00017	0.419
LIG_SH2_PTP2	101	104	PF00017	0.469
LIG_SH2_PTP2	116	119	PF00017	0.425
LIG_SH2_SRC	116	119	PF00017	0.419
LIG_SH2_STAT5	101	104	PF00017	0.447
LIG_SH2_STAT5	116	119	PF00017	0.376
LIG_SH2_STAT5	301	304	PF00017	0.394
LIG_SH3_3	225	231	PF00018	0.428
LIG_SH3_3	234	240	PF00018	0.445
LIG_SH3_3	64	70	PF00018	0.479
LIG_SUMO_SIM_anti_2	141	148	PF11976	0.420
LIG_TRAF2_1	307	310	PF00917	0.489
LIG_TYR_ITIM	195	200	PF00017	0.364
LIG_UBA3_1	253	261	PF00899	0.461
LIG_WW_3	12	16	PF00397	0.405
MOD_CDK_SPK_2	46	51	PF00069	0.366
MOD_CK1_1	151	157	PF00069	0.457
MOD_CK1_1	239	245	PF00069	0.364
MOD_CK1_1	304	310	PF00069	0.431
MOD_CK1_1	93	99	PF00069	0.463
MOD_CK2_1	304	310	PF00069	0.433
MOD_CK2_1	57	63	PF00069	0.459
MOD_GlcNHglycan	119	122	PF01048	0.226
MOD_GlcNHglycan	124	128	PF01048	0.233
MOD_GlcNHglycan	15	18	PF01048	0.487
MOD_GlcNHglycan	183	186	PF01048	0.265
MOD_GlcNHglycan	241	244	PF01048	0.171
MOD_GlcNHglycan	31	34	PF01048	0.436
MOD_GlcNHglycan	91	95	PF01048	0.164
MOD_GSK3_1	102	109	PF00069	0.435
MOD_GSK3_1	147	154	PF00069	0.458
MOD_GSK3_1	239	246	PF00069	0.541
MOD_GSK3_1	86	93	PF00069	0.399
MOD_N-GLC_1	86	91	PF02516	0.241
MOD_N-GLC_2	179	181	PF02516	0.303
MOD_NEK2_1	282	287	PF00069	0.491
MOD_NEK2_1	29	34	PF00069	0.428
MOD_NEK2_1	293	298	PF00069	0.414
MOD_NEK2_1	37	42	PF00069	0.448
MOD_NEK2_2	243	248	PF00069	0.364
MOD_NEK2_2	57	62	PF00069	0.333
MOD_PIKK_1	282	288	PF00454	0.436
MOD_PIKK_1	302	308	PF00454	0.258
MOD_Plk_1	57	63	PF00069	0.342
MOD_Plk_4	293	299	PF00069	0.392
MOD_Plk_4	70	76	PF00069	0.384
MOD_ProDKin_1	236	242	PF00069	0.445
MOD_ProDKin_1	46	52	PF00069	0.337
MOD_SUMO_rev_2	183	189	PF00179	0.420
TRG_DiLeu_BaEn_2	71	77	PF01217	0.295
TRG_ENDOCYTIC_2	101	104	PF00928	0.517
TRG_ENDOCYTIC_2	116	119	PF00928	0.370
TRG_ENDOCYTIC_2	135	138	PF00928	0.354
TRG_ENDOCYTIC_2	197	200	PF00928	0.419
TRG_ENDOCYTIC_2	218	221	PF00928	0.436
TRG_ENDOCYTIC_2	56	59	PF00928	0.349
TRG_ER_diArg_1	314	317	PF00400	0.576
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.219
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.236
TRG_Pf-PMV_PEXEL_1	316	321	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJA1	Leptomonas seymouri	79%	100%
A0A1X0NYK7	Trypanosomatidae	67%	100%
A0A3Q8IBD4	Leishmania donovani	89%	100%
A2AS89	Mus musculus	27%	93%
A4I044	Leishmania infantum	89%	100%
A8GIX7	Serratia proteamaculans (strain 568)	22%	100%
C9ZUY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AW07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QBG9	Leishmania major	88%	100%
Q61176	Mus musculus	27%	100%
Q7N122	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	25%	100%
Q7VRG4	Blochmannia floridanus	26%	100%
Q95KM0	Oryctolagus cuniculus	25%	100%
Q9ZPF5	Arabidopsis thaliana	24%	97%
V5BBD2	Trypanosoma cruzi	67%	100%