A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 40 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 24 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 20 |
| NetGPI | no | yes: 0, no: 20 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 2 |
| GO:0110165 | cellular anatomical entity | 1 | 5 |
| GO:0005737 | cytoplasm | 2 | 3 |
| GO:0005730 | nucleolus | 5 | 1 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043228 | non-membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043232 | intracellular non-membrane-bounded organelle | 4 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000413 | protein peptidyl-prolyl isomerization | 7 | 21 |
| GO:0006457 | protein folding | 2 | 21 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 21 |
| GO:0008152 | metabolic process | 1 | 21 |
| GO:0009987 | cellular process | 1 | 21 |
| GO:0018193 | peptidyl-amino acid modification | 5 | 21 |
| GO:0018208 | peptidyl-proline modification | 6 | 21 |
| GO:0019538 | protein metabolic process | 3 | 21 |
| GO:0036211 | protein modification process | 4 | 21 |
| GO:0043170 | macromolecule metabolic process | 3 | 21 |
| GO:0043412 | macromolecule modification | 4 | 21 |
| GO:0044238 | primary metabolic process | 2 | 21 |
| GO:0071704 | organic substance metabolic process | 2 | 21 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 21 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | 3 | 21 |
| GO:0003824 | catalytic activity | 1 | 21 |
| GO:0016853 | isomerase activity | 2 | 21 |
| GO:0016859 | cis-trans isomerase activity | 3 | 21 |
| GO:0140096 | catalytic activity, acting on a protein | 2 | 21 |
| GO:0005488 | binding | 1 | 3 |
| GO:0016018 | cyclosporin A binding | 4 | 3 |
| GO:0033218 | amide binding | 2 | 3 |
| GO:0042277 | peptide binding | 3 | 3 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_PCSK_KEX2_1 | 12 | 14 | PF00082 | 0.521 |
| CLV_PCSK_KEX2_1 | 263 | 265 | PF00082 | 0.440 |
| CLV_PCSK_PC1ET2_1 | 12 | 14 | PF00082 | 0.526 |
| CLV_PCSK_PC1ET2_1 | 263 | 265 | PF00082 | 0.440 |
| CLV_PCSK_SKI1_1 | 220 | 224 | PF00082 | 0.547 |
| CLV_PCSK_SKI1_1 | 24 | 28 | PF00082 | 0.373 |
| CLV_PCSK_SKI1_1 | 242 | 246 | PF00082 | 0.444 |
| CLV_PCSK_SKI1_1 | 249 | 253 | PF00082 | 0.445 |
| CLV_PCSK_SKI1_1 | 281 | 285 | PF00082 | 0.395 |
| DOC_ANK_TNKS_1 | 288 | 295 | PF00023 | 0.450 |
| DOC_MAPK_gen_1 | 180 | 187 | PF00069 | 0.239 |
| DOC_MAPK_MEF2A_6 | 9 | 18 | PF00069 | 0.646 |
| DOC_PP1_RVXF_1 | 152 | 159 | PF00149 | 0.333 |
| DOC_PP1_RVXF_1 | 22 | 28 | PF00149 | 0.373 |
| DOC_USP7_MATH_1 | 213 | 217 | PF00917 | 0.485 |
| DOC_USP7_MATH_1 | 255 | 259 | PF00917 | 0.659 |
| DOC_USP7_MATH_1 | 287 | 291 | PF00917 | 0.584 |
| DOC_USP7_UBL2_3 | 226 | 230 | PF12436 | 0.700 |
| DOC_WW_Pin1_4 | 145 | 150 | PF00397 | 0.229 |
| DOC_WW_Pin1_4 | 233 | 238 | PF00397 | 0.639 |
| LIG_14-3-3_CanoR_1 | 184 | 193 | PF00244 | 0.349 |
| LIG_14-3-3_CanoR_1 | 220 | 228 | PF00244 | 0.602 |
| LIG_14-3-3_CanoR_1 | 3 | 7 | PF00244 | 0.606 |
| LIG_APCC_ABBA_1 | 41 | 46 | PF00400 | 0.333 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.557 |
| LIG_BIR_III_2 | 250 | 254 | PF00653 | 0.453 |
| LIG_BRCT_BRCA1_1 | 138 | 142 | PF00533 | 0.333 |
| LIG_FHA_1 | 146 | 152 | PF00498 | 0.286 |
| LIG_FHA_1 | 223 | 229 | PF00498 | 0.457 |
| LIG_FHA_2 | 106 | 112 | PF00498 | 0.295 |
| LIG_FHA_2 | 97 | 103 | PF00498 | 0.295 |
| LIG_LIR_Gen_1 | 77 | 87 | PF02991 | 0.422 |
| LIG_LIR_LC3C_4 | 229 | 234 | PF02991 | 0.459 |
| LIG_LIR_Nem_3 | 53 | 58 | PF02991 | 0.282 |
| LIG_LIR_Nem_3 | 77 | 82 | PF02991 | 0.419 |
| LIG_MLH1_MIPbox_1 | 138 | 142 | PF16413 | 0.333 |
| LIG_PTB_Apo_2 | 73 | 80 | PF02174 | 0.337 |
| LIG_SH2_STAP1 | 44 | 48 | PF00017 | 0.239 |
| LIG_SH3_3 | 231 | 237 | PF00018 | 0.614 |
| MOD_CK1_1 | 178 | 184 | PF00069 | 0.261 |
| MOD_CK1_1 | 2 | 8 | PF00069 | 0.534 |
| MOD_CK2_1 | 287 | 293 | PF00069 | 0.520 |
| MOD_CK2_1 | 96 | 102 | PF00069 | 0.295 |
| MOD_Cter_Amidation | 10 | 13 | PF01082 | 0.447 |
| MOD_GlcNHglycan | 114 | 117 | PF01048 | 0.277 |
| MOD_GlcNHglycan | 177 | 180 | PF01048 | 0.295 |
| MOD_GlcNHglycan | 290 | 293 | PF01048 | 0.456 |
| MOD_GlcNHglycan | 67 | 70 | PF01048 | 0.295 |
| MOD_GSK3_1 | 174 | 181 | PF00069 | 0.397 |
| MOD_GSK3_1 | 44 | 51 | PF00069 | 0.300 |
| MOD_GSK3_1 | 96 | 103 | PF00069 | 0.333 |
| MOD_N-GLC_1 | 136 | 141 | PF02516 | 0.333 |
| MOD_N-GLC_1 | 255 | 260 | PF02516 | 0.525 |
| MOD_N-GLC_1 | 96 | 101 | PF02516 | 0.333 |
| MOD_NEK2_1 | 142 | 147 | PF00069 | 0.324 |
| MOD_NEK2_1 | 174 | 179 | PF00069 | 0.371 |
| MOD_NEK2_1 | 18 | 23 | PF00069 | 0.443 |
| MOD_NEK2_1 | 232 | 237 | PF00069 | 0.511 |
| MOD_NEK2_2 | 100 | 105 | PF00069 | 0.333 |
| MOD_NEK2_2 | 74 | 79 | PF00069 | 0.365 |
| MOD_PIKK_1 | 136 | 142 | PF00454 | 0.333 |
| MOD_PKA_2 | 119 | 125 | PF00069 | 0.280 |
| MOD_PKA_2 | 2 | 8 | PF00069 | 0.640 |
| MOD_PKA_2 | 288 | 294 | PF00069 | 0.430 |
| MOD_Plk_1 | 110 | 116 | PF00069 | 0.333 |
| MOD_Plk_4 | 100 | 106 | PF00069 | 0.333 |
| MOD_Plk_4 | 74 | 80 | PF00069 | 0.365 |
| MOD_ProDKin_1 | 145 | 151 | PF00069 | 0.229 |
| MOD_ProDKin_1 | 233 | 239 | PF00069 | 0.638 |
| MOD_SUMO_rev_2 | 224 | 233 | PF00179 | 0.507 |
| MOD_SUMO_rev_2 | 235 | 244 | PF00179 | 0.422 |
| MOD_SUMO_rev_2 | 28 | 36 | PF00179 | 0.255 |
| TRG_ER_diArg_1 | 182 | 185 | PF00400 | 0.232 |
| TRG_ER_diArg_1 | 276 | 279 | PF00400 | 0.401 |
| TRG_NLS_Bipartite_1 | 248 | 266 | PF00514 | 0.604 |
| TRG_NLS_MonoExtC_3 | 261 | 266 | PF00514 | 0.463 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P364 | Leptomonas seymouri | 43% | 100% |
| A0A0N0P523 | Leptomonas seymouri | 73% | 100% |
| A0A0N1PDY0 | Leptomonas seymouri | 32% | 100% |
| A0A1X0NTS4 | Trypanosomatidae | 46% | 100% |
| A0A1X0NXG7 | Trypanosomatidae | 64% | 100% |
| A0A3Q8ICB3 | Leishmania donovani | 48% | 100% |
| A0A3Q8IIG9 | Leishmania donovani | 45% | 84% |
| A0A3R7RE54 | Trypanosoma rangeli | 62% | 100% |
| A0A3S5H7U6 | Leishmania donovani | 66% | 100% |
| A0A3S7WXF4 | Leishmania donovani | 83% | 100% |
| A0A3S7WYD9 | Leishmania donovani | 29% | 100% |
| A0A3S7X325 | Leishmania donovani | 35% | 100% |
| A0A3S7X410 | Leishmania donovani | 60% | 100% |
| A0A3S7XB52 | Leishmania donovani | 39% | 100% |
| A0A422N490 | Trypanosoma rangeli | 46% | 100% |
| A4HCI8 | Leishmania braziliensis | 45% | 100% |
| A4HHU7 | Leishmania braziliensis | 36% | 100% |
| A4HIW9 | Leishmania braziliensis | 56% | 100% |
| A4HLM4 | Leishmania braziliensis | 70% | 100% |
| A4HPH9 | Leishmania braziliensis | 38% | 100% |
| A4I004 | Leishmania infantum | 48% | 100% |
| A4I042 | Leishmania infantum | 83% | 100% |
| A4I0X0 | Leishmania infantum | 29% | 100% |
| A4I4Z7 | Leishmania infantum | 35% | 100% |
| A4I698 | Leishmania infantum | 60% | 100% |
| A4I935 | Leishmania infantum | 66% | 100% |
| A4IC14 | Leishmania infantum | 45% | 84% |
| A4IDA1 | Leishmania infantum | 39% | 100% |
| A8X8D0 | Caenorhabditis briggsae | 46% | 95% |
| C9ZUX8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 60% | 98% |
| D4AY02 | Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) | 53% | 100% |
| E9AQT1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 82% |
| E9AT91 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 39% | 100% |
| E9AVX7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 48% | 100% |
| E9AW05 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 81% | 100% |
| E9AWX4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 27% | 100% |
| E9B0C7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 34% | 100% |
| E9B1F3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 57% | 100% |
| E9B400 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 66% | 100% |
| E9B705 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 47% | 84% |
| O93826 | Arthroderma benhamiae | 53% | 100% |
| P0C1I1 | Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) | 50% | 81% |
| Q4P0V4 | Ustilago maydis (strain 521 / FGSC 9021) | 53% | 74% |
| Q4Q1A6 | Leishmania major | 39% | 100% |
| Q4Q424 | Leishmania major | 66% | 100% |
| Q4Q6Q9 | Leishmania major | 61% | 100% |
| Q4Q7V7 | Leishmania major | 35% | 100% |
| Q4QAK0 | Leishmania major | 29% | 100% |
| Q4QBH1 | Leishmania major | 82% | 99% |
| Q4QBK2 | Leishmania major | 48% | 100% |
| Q5UP71 | Acanthamoeba polyphaga mimivirus | 27% | 100% |
| Q7S7Z6 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 48% | 100% |
| Q9LIK6 | Arabidopsis thaliana | 42% | 100% |
| Q9P3X9 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 49% | 79% |
| V5B2A0 | Trypanosoma cruzi | 61% | 100% |