Putative beta propeller protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Beta propeller protein 1

Species:

Leishmania braziliensis

UniProt:

A4HCL6_LEIBR

TriTrypDb:

LbrM.23.0040 , LBRM2903_230005200

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	1
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

A4HCL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCL6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006356	regulation of transcription by RNA polymerase I	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045943	positive regulation of transcription by RNA polymerase I	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.388
CLV_NRD_NRD_1	230	232	PF00675	0.450
CLV_NRD_NRD_1	386	388	PF00675	0.306
CLV_NRD_NRD_1	77	79	PF00675	0.501
CLV_NRD_NRD_1	9	11	PF00675	0.592
CLV_PCSK_KEX2_1	285	287	PF00082	0.523
CLV_PCSK_KEX2_1	386	388	PF00082	0.306
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.523
CLV_PCSK_SKI1_1	258	262	PF00082	0.501
CLV_PCSK_SKI1_1	363	367	PF00082	0.324
CLV_PCSK_SKI1_1	387	391	PF00082	0.284
CLV_PCSK_SKI1_1	407	411	PF00082	0.239
CLV_PCSK_SKI1_1	439	443	PF00082	0.371
CLV_PCSK_SKI1_1	445	449	PF00082	0.353
CLV_Separin_Metazoa	383	387	PF03568	0.363
DEG_Nend_Nbox_1	1	3	PF02207	0.618
DEG_SPOP_SBC_1	305	309	PF00917	0.528
DOC_CKS1_1	234	239	PF01111	0.557
DOC_CYCLIN_RxL_1	255	264	PF00134	0.520
DOC_CYCLIN_RxL_1	400	410	PF00134	0.363
DOC_MAPK_gen_1	118	126	PF00069	0.465
DOC_MAPK_gen_1	346	354	PF00069	0.201
DOC_MAPK_gen_1	386	394	PF00069	0.306
DOC_MAPK_gen_1	452	460	PF00069	0.427
DOC_MAPK_gen_1	78	85	PF00069	0.393
DOC_MAPK_MEF2A_6	386	394	PF00069	0.306
DOC_PP1_RVXF_1	222	229	PF00149	0.457
DOC_PP1_RVXF_1	348	355	PF00149	0.453
DOC_PP1_RVXF_1	402	409	PF00149	0.322
DOC_PP1_RVXF_1	437	444	PF00149	0.201
DOC_PP2B_LxvP_1	62	65	PF13499	0.439
DOC_USP7_MATH_1	132	136	PF00917	0.540
DOC_USP7_MATH_1	304	308	PF00917	0.450
DOC_USP7_UBL2_3	337	341	PF12436	0.586
DOC_WW_Pin1_4	101	106	PF00397	0.416
DOC_WW_Pin1_4	233	238	PF00397	0.554
LIG_14-3-3_CanoR_1	155	164	PF00244	0.361
LIG_14-3-3_CanoR_1	407	416	PF00244	0.363
LIG_Actin_WH2_2	267	282	PF00022	0.548
LIG_APCC_ABBA_1	473	478	PF00400	0.589
LIG_BRCT_BRCA1_1	121	125	PF00533	0.559
LIG_BRCT_BRCA1_1	439	443	PF00533	0.391
LIG_BRCT_BRCA1_1	81	85	PF00533	0.370
LIG_Clathr_ClatBox_1	225	229	PF01394	0.369
LIG_eIF4E_1	44	50	PF01652	0.281
LIG_FHA_1	137	143	PF00498	0.454
LIG_FHA_1	156	162	PF00498	0.306
LIG_FHA_1	200	206	PF00498	0.450
LIG_FHA_1	24	30	PF00498	0.252
LIG_FHA_1	243	249	PF00498	0.393
LIG_FHA_1	260	266	PF00498	0.345
LIG_FHA_1	307	313	PF00498	0.525
LIG_FHA_1	4	10	PF00498	0.537
LIG_FHA_1	408	414	PF00498	0.391
LIG_FHA_1	465	471	PF00498	0.195
LIG_FHA_2	105	111	PF00498	0.444
LIG_FHA_2	186	192	PF00498	0.547
LIG_FHA_2	306	312	PF00498	0.524
LIG_FHA_2	378	384	PF00498	0.306
LIG_FHA_2	426	432	PF00498	0.363
LIG_LIR_Apic_2	3	8	PF02991	0.481
LIG_LIR_Gen_1	21	31	PF02991	0.529
LIG_LIR_Gen_1	379	389	PF02991	0.412
LIG_LIR_Gen_1	410	418	PF02991	0.387
LIG_LIR_Gen_1	420	430	PF02991	0.245
LIG_LIR_Gen_1	56	65	PF02991	0.486
LIG_LIR_Nem_3	21	27	PF02991	0.545
LIG_LIR_Nem_3	379	384	PF02991	0.412
LIG_LIR_Nem_3	420	426	PF02991	0.309
LIG_LIR_Nem_3	427	433	PF02991	0.304
LIG_LIR_Nem_3	56	62	PF02991	0.466
LIG_MLH1_MIPbox_1	439	443	PF16413	0.391
LIG_NRBOX	256	262	PF00104	0.524
LIG_Pex14_2	239	243	PF04695	0.524
LIG_Pex14_2	426	430	PF04695	0.419
LIG_PTB_Apo_2	281	288	PF02174	0.559
LIG_REV1ctd_RIR_1	440	449	PF16727	0.391
LIG_SH2_NCK_1	44	48	PF00017	0.439
LIG_SH2_SRC	359	362	PF00017	0.391
LIG_SH2_SRC	44	47	PF00017	0.488
LIG_SH2_STAP1	177	181	PF00017	0.454
LIG_SH2_STAP1	253	257	PF00017	0.483
LIG_SH2_STAP1	31	35	PF00017	0.390
LIG_SH2_STAP1	433	437	PF00017	0.335
LIG_SH2_STAP1	81	85	PF00017	0.490
LIG_SH2_STAT5	113	116	PF00017	0.559
LIG_SH2_STAT5	160	163	PF00017	0.454
LIG_SH2_STAT5	412	415	PF00017	0.427
LIG_SH2_STAT5	436	439	PF00017	0.427
LIG_SH2_STAT5	92	95	PF00017	0.431
LIG_SH3_3	410	416	PF00018	0.391
LIG_SH3_3	99	105	PF00018	0.261
LIG_SH3_4	337	344	PF00018	0.529
LIG_SUMO_SIM_anti_2	457	462	PF11976	0.351
LIG_TRAF2_1	212	215	PF00917	0.555
LIG_TRAF2_1	380	383	PF00917	0.306
LIG_WRC_WIRS_1	378	383	PF05994	0.427
MOD_CK1_1	104	110	PF00069	0.446
MOD_CK1_1	135	141	PF00069	0.468
MOD_CK1_1	168	174	PF00069	0.538
MOD_CK1_1	242	248	PF00069	0.388
MOD_CK1_1	259	265	PF00069	0.330
MOD_CK2_1	104	110	PF00069	0.437
MOD_CK2_1	144	150	PF00069	0.313
MOD_CK2_1	296	302	PF00069	0.468
MOD_CK2_1	305	311	PF00069	0.456
MOD_CK2_1	376	382	PF00069	0.306
MOD_GlcNHglycan	121	124	PF01048	0.297
MOD_GlcNHglycan	132	135	PF01048	0.215
MOD_GlcNHglycan	167	170	PF01048	0.253
MOD_GlcNHglycan	173	176	PF01048	0.255
MOD_GlcNHglycan	196	199	PF01048	0.477
MOD_GlcNHglycan	433	436	PF01048	0.399
MOD_GlcNHglycan	448	451	PF01048	0.369
MOD_GSK3_1	132	139	PF00069	0.454
MOD_GSK3_1	14	21	PF00069	0.637
MOD_GSK3_1	270	277	PF00069	0.465
MOD_GSK3_1	306	313	PF00069	0.439
MOD_GSK3_1	364	371	PF00069	0.313
MOD_N-GLC_1	274	279	PF02516	0.326
MOD_N-GLC_1	79	84	PF02516	0.503
MOD_NEK2_1	194	199	PF00069	0.374
MOD_NEK2_1	239	244	PF00069	0.425
MOD_NEK2_1	418	423	PF00069	0.333
MOD_NEK2_1	464	469	PF00069	0.314
MOD_NEK2_1	51	56	PF00069	0.432
MOD_NEK2_2	23	28	PF00069	0.590
MOD_NEK2_2	310	315	PF00069	0.261
MOD_PIKK_1	199	205	PF00454	0.497
MOD_PK_1	18	24	PF00069	0.625
MOD_PK_1	79	85	PF00069	0.464
MOD_Plk_1	135	141	PF00069	0.454
MOD_Plk_1	3	9	PF00069	0.541
MOD_Plk_1	310	316	PF00069	0.477
MOD_Plk_1	398	404	PF00069	0.306
MOD_Plk_1	464	470	PF00069	0.322
MOD_Plk_1	79	85	PF00069	0.499
MOD_Plk_2-3	144	150	PF00069	0.539
MOD_Plk_4	168	174	PF00069	0.520
MOD_Plk_4	244	250	PF00069	0.414
MOD_Plk_4	310	316	PF00069	0.418
MOD_Plk_4	418	424	PF00069	0.322
MOD_Plk_4	425	431	PF00069	0.322
MOD_Plk_4	437	443	PF00069	0.322
MOD_ProDKin_1	101	107	PF00069	0.426
MOD_ProDKin_1	233	239	PF00069	0.553
MOD_SUMO_rev_2	82	91	PF00179	0.410
TRG_DiLeu_BaEn_1	319	324	PF01217	0.647
TRG_DiLeu_BaEn_1	351	356	PF01217	0.201
TRG_DiLeu_BaEn_2	205	211	PF01217	0.470
TRG_ENDOCYTIC_2	412	415	PF00928	0.370
TRG_ER_diArg_1	385	387	PF00400	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N2	Leptomonas seymouri	78%	99%
A0A0S4J5C8	Bodo saltans	47%	96%
A0A1X0NXU5	Trypanosomatidae	55%	100%
A0A3S7WXD4	Leishmania donovani	88%	100%
A0A422N5S6	Trypanosoma rangeli	53%	99%
A2RRU3	Rattus norvegicus	28%	91%
A4I040	Leishmania infantum	88%	100%
A7MB12	Bos taurus	28%	92%
C9ZUX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AW03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O82266	Arabidopsis thaliana	22%	90%
O94365	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	97%
Q04305	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	93%
Q4QBH3	Leishmania major	89%	100%
Q5F3D7	Gallus gallus	28%	92%
Q5REE0	Pongo abelii	27%	92%
Q5XGE2	Xenopus tropicalis	28%	93%
Q7ZW33	Danio rerio	28%	92%
Q7ZXZ2	Xenopus laevis	29%	93%
Q8C7V3	Mus musculus	28%	91%
Q8TED0	Homo sapiens	27%	92%
V5D2J8	Trypanosoma cruzi	51%	99%