Proteasome assembly chaperone 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCL5_LEIBR

TriTrypDb:

LbrM.23.0030 , LBRM2903_230005100

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCL5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.572
CLV_NRD_NRD_1	260	262	PF00675	0.453
CLV_NRD_NRD_1	35	37	PF00675	0.592
CLV_PCSK_KEX2_1	260	262	PF00082	0.428
CLV_PCSK_KEX2_1	35	37	PF00082	0.648
CLV_PCSK_SKI1_1	139	143	PF00082	0.494
DEG_APCC_DBOX_1	138	146	PF00400	0.281
DOC_CKS1_1	238	243	PF01111	0.355
DOC_MAPK_gen_1	102	111	PF00069	0.606
DOC_MAPK_MEF2A_6	139	147	PF00069	0.390
DOC_PP1_RVXF_1	3	9	PF00149	0.697
DOC_PP4_FxxP_1	93	96	PF00568	0.550
DOC_USP7_MATH_1	218	222	PF00917	0.303
DOC_WW_Pin1_4	237	242	PF00397	0.326
LIG_14-3-3_CanoR_1	283	292	PF00244	0.474
LIG_14-3-3_CanoR_1	71	76	PF00244	0.489
LIG_FHA_1	27	33	PF00498	0.696
LIG_FHA_1	275	281	PF00498	0.511
LIG_FHA_1	285	291	PF00498	0.487
LIG_FHA_1	44	50	PF00498	0.393
LIG_FHA_2	266	272	PF00498	0.526
LIG_LIR_Gen_1	138	147	PF02991	0.530
LIG_LIR_Gen_1	252	262	PF02991	0.296
LIG_LIR_Gen_1	7	16	PF02991	0.579
LIG_LIR_Gen_1	74	84	PF02991	0.448
LIG_LIR_Nem_3	138	143	PF02991	0.486
LIG_LIR_Nem_3	252	257	PF02991	0.307
LIG_LIR_Nem_3	7	11	PF02991	0.561
LIG_LIR_Nem_3	74	79	PF02991	0.421
LIG_PDZ_Class_2	287	292	PF00595	0.392
LIG_Rb_LxCxE_1	12	33	PF01857	0.463
LIG_SH2_NCK_1	227	231	PF00017	0.396
LIG_SH2_STAP1	76	80	PF00017	0.303
LIG_SH3_3	108	114	PF00018	0.400
LIG_SH3_3	235	241	PF00018	0.415
LIG_SUMO_SIM_anti_2	151	157	PF11976	0.306
LIG_SUMO_SIM_anti_2	221	228	PF11976	0.401
LIG_SUMO_SIM_anti_2	234	240	PF11976	0.421
LIG_SUMO_SIM_par_1	234	240	PF11976	0.499
LIG_SUMO_SIM_par_1	26	34	PF11976	0.691
LIG_TYR_ITIM	225	230	PF00017	0.392
MOD_CDK_SPxxK_3	237	244	PF00069	0.359
MOD_CK1_1	178	184	PF00069	0.382
MOD_CK1_1	67	73	PF00069	0.365
MOD_CK2_1	242	248	PF00069	0.488
MOD_CK2_1	71	77	PF00069	0.530
MOD_CK2_1	83	89	PF00069	0.536
MOD_GlcNHglycan	227	230	PF01048	0.412
MOD_GlcNHglycan	85	88	PF01048	0.592
MOD_GlcNHglycan	98	101	PF01048	0.608
MOD_GSK3_1	174	181	PF00069	0.404
MOD_GSK3_1	200	207	PF00069	0.401
MOD_GSK3_1	26	33	PF00069	0.602
MOD_GSK3_1	6	13	PF00069	0.552
MOD_GSK3_1	67	74	PF00069	0.499
MOD_N-GLC_2	17	19	PF02516	0.503
MOD_NEK2_1	10	15	PF00069	0.574
MOD_NEK2_1	165	170	PF00069	0.329
MOD_NEK2_1	210	215	PF00069	0.356
MOD_NEK2_1	242	247	PF00069	0.570
MOD_NEK2_1	284	289	PF00069	0.480
MOD_NEK2_1	41	46	PF00069	0.442
MOD_NEK2_1	62	67	PF00069	0.486
MOD_NEK2_1	83	88	PF00069	0.589
MOD_PIKK_1	218	224	PF00454	0.468
MOD_PIKK_1	284	290	PF00454	0.445
MOD_PK_1	71	77	PF00069	0.555
MOD_PKA_2	249	255	PF00069	0.526
MOD_PKA_2	282	288	PF00069	0.472
MOD_Plk_1	25	31	PF00069	0.700
MOD_Plk_2-3	26	32	PF00069	0.689
MOD_Plk_2-3	265	271	PF00069	0.539
MOD_Plk_4	178	184	PF00069	0.416
MOD_Plk_4	204	210	PF00069	0.497
MOD_Plk_4	249	255	PF00069	0.604
MOD_Plk_4	265	271	PF00069	0.437
MOD_ProDKin_1	237	243	PF00069	0.343
MOD_SUMO_rev_2	265	275	PF00179	0.510
TRG_Cilium_Arf4_1	288	292	PF00025	0.320
TRG_ENDOCYTIC_2	227	230	PF00928	0.397
TRG_ENDOCYTIC_2	76	79	PF00928	0.311
TRG_ER_diArg_1	259	261	PF00400	0.460
TRG_NES_CRM1_1	173	188	PF08389	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJU6	Leptomonas seymouri	35%	100%
A0A1X0NX74	Trypanosomatidae	28%	97%
A0A3Q8IAU7	Leishmania donovani	74%	100%
A0A3R7KT29	Trypanosoma rangeli	25%	93%
A4I039	Leishmania infantum	75%	100%
C9ZUX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	96%
E9AW02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QBH4	Leishmania major	75%	100%
V5B6S5	Trypanosoma cruzi	28%	92%