CCR4-NOT transcription complex subunit 11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCL4_LEIBR

TriTrypDb:

LbrM.23.0020 , LBRM2903_230005000

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	11
GO:0030014	CCR4-NOT complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0140535	intracellular protein-containing complex	2	11

Expansion

Sequence features

A4HCL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCL4

Function

Biological processes
Term	Name	Level	Count
GO:0009892	negative regulation of metabolic process	4	11
GO:0010468	regulation of gene expression	5	11
GO:0010605	negative regulation of macromolecule metabolic process	5	11
GO:0010629	negative regulation of gene expression	6	11
GO:0019222	regulation of metabolic process	3	11
GO:0031047	RNA-mediated gene silencing	7	11
GO:0048519	negative regulation of biological process	3	11
GO:0050789	regulation of biological process	2	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006417	regulation of translation	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009987	cellular process	1	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0017148	negative regulation of translation	7	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034249	negative regulation of amide metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051248	negative regulation of protein metabolic process	6	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1
GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	219	221	PF00675	0.525
CLV_NRD_NRD_1	24	26	PF00675	0.441
CLV_NRD_NRD_1	48	50	PF00675	0.486
CLV_PCSK_KEX2_1	213	215	PF00082	0.486
CLV_PCSK_KEX2_1	48	50	PF00082	0.527
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.486
CLV_PCSK_SKI1_1	213	217	PF00082	0.414
CLV_PCSK_SKI1_1	344	348	PF00082	0.559
CLV_PCSK_SKI1_1	350	354	PF00082	0.541
CLV_PCSK_SKI1_1	49	53	PF00082	0.485
DEG_APCC_DBOX_1	358	366	PF00400	0.538
DEG_APCC_KENBOX_2	346	350	PF00400	0.462
DEG_Nend_UBRbox_4	1	3	PF02207	0.524
DOC_MAPK_gen_1	344	354	PF00069	0.407
DOC_PP2B_LxvP_1	168	171	PF13499	0.638
DOC_PP2B_LxvP_1	267	270	PF13499	0.397
DOC_USP7_MATH_1	192	196	PF00917	0.616
DOC_USP7_MATH_1	219	223	PF00917	0.598
DOC_USP7_MATH_1	270	274	PF00917	0.466
DOC_USP7_MATH_1	31	35	PF00917	0.515
DOC_USP7_UBL2_3	123	127	PF12436	0.596
DOC_USP7_UBL2_3	58	62	PF12436	0.471
DOC_USP7_UBL2_3	65	69	PF12436	0.477
DOC_WW_Pin1_4	244	249	PF00397	0.556
LIG_14-3-3_CanoR_1	297	302	PF00244	0.535
LIG_14-3-3_CanoR_1	308	318	PF00244	0.414
LIG_Clathr_ClatBox_1	40	44	PF01394	0.384
LIG_FHA_1	10	16	PF00498	0.551
LIG_FHA_1	152	158	PF00498	0.629
LIG_FHA_1	163	169	PF00498	0.551
LIG_FHA_1	172	178	PF00498	0.544
LIG_FHA_1	291	297	PF00498	0.349
LIG_FHA_2	324	330	PF00498	0.563
LIG_FHA_2	33	39	PF00498	0.470
LIG_FHA_2	58	64	PF00498	0.554
LIG_FHA_2	72	78	PF00498	0.466
LIG_LIR_Apic_2	186	192	PF02991	0.517
LIG_LIR_Gen_1	165	173	PF02991	0.450
LIG_LIR_Gen_1	34	43	PF02991	0.462
LIG_LIR_Nem_3	165	169	PF02991	0.448
LIG_LIR_Nem_3	34	40	PF02991	0.428
LIG_NRBOX	231	237	PF00104	0.486
LIG_NRP_CendR_1	382	383	PF00754	0.560
LIG_PCNA_yPIPBox_3	297	311	PF02747	0.405
LIG_SH2_CRK	37	41	PF00017	0.391
LIG_SH2_PTP2	189	192	PF00017	0.399
LIG_SH2_STAP1	37	41	PF00017	0.410
LIG_SH2_STAT5	189	192	PF00017	0.579
LIG_SH2_STAT5	19	22	PF00017	0.546
LIG_SH2_STAT5	59	62	PF00017	0.603
LIG_SH3_3	175	181	PF00018	0.589
LIG_SUMO_SIM_par_1	195	202	PF11976	0.619
LIG_SUMO_SIM_par_1	38	44	PF11976	0.388
LIG_TRAF2_1	141	144	PF00917	0.356
LIG_TRAF2_1	181	184	PF00917	0.675
LIG_UBA3_1	169	176	PF00899	0.564
LIG_WRC_WIRS_1	307	312	PF05994	0.466
MOD_CK1_1	105	111	PF00069	0.522
MOD_CK1_1	222	228	PF00069	0.501
MOD_CK1_1	239	245	PF00069	0.501
MOD_CK2_1	110	116	PF00069	0.546
MOD_CK2_1	323	329	PF00069	0.630
MOD_CK2_1	367	373	PF00069	0.526
MOD_CK2_1	57	63	PF00069	0.540
MOD_CK2_1	71	77	PF00069	0.514
MOD_Cter_Amidation	66	69	PF01082	0.460
MOD_GlcNHglycan	194	197	PF01048	0.591
MOD_GlcNHglycan	201	204	PF01048	0.611
MOD_GlcNHglycan	270	273	PF01048	0.490
MOD_GSK3_1	147	154	PF00069	0.593
MOD_GSK3_1	199	206	PF00069	0.521
MOD_GSK3_1	249	256	PF00069	0.541
MOD_GSK3_1	306	313	PF00069	0.428
MOD_GSK3_1	323	330	PF00069	0.358
MOD_GSK3_1	5	12	PF00069	0.532
MOD_GSK3_1	57	64	PF00069	0.577
MOD_GSK3_1	67	74	PF00069	0.525
MOD_N-GLC_1	162	167	PF02516	0.700
MOD_N-GLC_1	236	241	PF02516	0.529
MOD_NEK2_1	151	156	PF00069	0.689
MOD_NEK2_1	199	204	PF00069	0.638
MOD_NEK2_1	236	241	PF00069	0.408
MOD_NEK2_1	296	301	PF00069	0.442
MOD_NEK2_1	310	315	PF00069	0.362
MOD_NEK2_1	334	339	PF00069	0.334
MOD_NEK2_1	365	370	PF00069	0.547
MOD_NEK2_1	71	76	PF00069	0.517
MOD_NEK2_2	32	37	PF00069	0.505
MOD_NEK2_2	327	332	PF00069	0.512
MOD_PK_1	110	116	PF00069	0.496
MOD_PK_1	297	303	PF00069	0.452
MOD_PKA_2	219	225	PF00069	0.527
MOD_PKA_2	296	302	PF00069	0.452
MOD_Plk_1	162	168	PF00069	0.440
MOD_Plk_1	236	242	PF00069	0.514
MOD_Plk_4	147	153	PF00069	0.649
MOD_Plk_4	236	242	PF00069	0.401
MOD_Plk_4	261	267	PF00069	0.415
MOD_Plk_4	290	296	PF00069	0.350
MOD_Plk_4	297	303	PF00069	0.376
MOD_Plk_4	310	316	PF00069	0.248
MOD_Plk_4	32	38	PF00069	0.465
MOD_ProDKin_1	244	250	PF00069	0.554
MOD_SUMO_for_1	141	144	PF00179	0.531
MOD_SUMO_rev_2	63	70	PF00179	0.502
MOD_SUMO_rev_2	95	104	PF00179	0.557
TRG_DiLeu_BaEn_1	10	15	PF01217	0.476
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.521
TRG_ENDOCYTIC_2	37	40	PF00928	0.416
TRG_ER_diArg_1	47	49	PF00400	0.529
TRG_NES_CRM1_1	42	55	PF08389	0.475
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4T3	Leptomonas seymouri	73%	88%
A0A0S4J1J3	Bodo saltans	31%	85%
A0A1X0NX78	Trypanosomatidae	43%	88%
A0A3R7NCY2	Trypanosoma rangeli	42%	88%
A0A3S7WXH7	Leishmania donovani	90%	100%
A4I038	Leishmania infantum	90%	100%
C9ZUX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	88%
E9AW01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QBH5	Leishmania major	88%	100%
V5BBD7	Trypanosoma cruzi	43%	88%