Phosphoinositide phospholipase C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoinositide-specific phospholipase C, putative

Species:

Leishmania braziliensis

UniProt:

A4HCK9_LEIBR

TriTrypDb:

LbrM.22.1590 , LBRM2903_220022800

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCK9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	9
GO:0007165	signal transduction	2	9
GO:0008152	metabolic process	1	9
GO:0009056	catabolic process	2	9
GO:0009987	cellular process	1	9
GO:0016042	lipid catabolic process	4	9
GO:0035556	intracellular signal transduction	3	9
GO:0044238	primary metabolic process	2	9
GO:0050789	regulation of biological process	2	9
GO:0050794	regulation of cellular process	3	9
GO:0065007	biological regulation	1	9
GO:0071704	organic substance metabolic process	2	9
GO:1901575	organic substance catabolic process	3	9
GO:0048015	phosphatidylinositol-mediated signaling	5	1
GO:0048017	inositol lipid-mediated signaling	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004435	phosphatidylinositol phospholipase C activity	7	9
GO:0004620	phospholipase activity	5	9
GO:0004629	phospholipase C activity	6	9
GO:0005488	binding	1	6
GO:0005509	calcium ion binding	5	6
GO:0008081	phosphoric diester hydrolase activity	5	9
GO:0016298	lipase activity	4	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0042578	phosphoric ester hydrolase activity	4	9
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	485	489	PF00656	0.254
CLV_NRD_NRD_1	428	430	PF00675	0.552
CLV_NRD_NRD_1	677	679	PF00675	0.401
CLV_NRD_NRD_1	681	683	PF00675	0.381
CLV_PCSK_KEX2_1	121	123	PF00082	0.531
CLV_PCSK_KEX2_1	13	15	PF00082	0.551
CLV_PCSK_KEX2_1	145	147	PF00082	0.437
CLV_PCSK_KEX2_1	280	282	PF00082	0.367
CLV_PCSK_KEX2_1	392	394	PF00082	0.408
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.531
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.551
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.437
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.361
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.408
CLV_PCSK_SKI1_1	13	17	PF00082	0.555
CLV_PCSK_SKI1_1	131	135	PF00082	0.481
CLV_PCSK_SKI1_1	139	143	PF00082	0.510
CLV_PCSK_SKI1_1	188	192	PF00082	0.387
CLV_PCSK_SKI1_1	206	210	PF00082	0.491
CLV_PCSK_SKI1_1	280	284	PF00082	0.296
CLV_PCSK_SKI1_1	313	317	PF00082	0.409
CLV_PCSK_SKI1_1	430	434	PF00082	0.421
CLV_PCSK_SKI1_1	455	459	PF00082	0.374
CLV_PCSK_SKI1_1	48	52	PF00082	0.477
CLV_PCSK_SKI1_1	487	491	PF00082	0.310
CLV_PCSK_SKI1_1	542	546	PF00082	0.338
CLV_PCSK_SKI1_1	561	565	PF00082	0.422
CLV_PCSK_SKI1_1	575	579	PF00082	0.308
DEG_APCC_DBOX_1	47	55	PF00400	0.474
DEG_APCC_DBOX_1	486	494	PF00400	0.394
DEG_SCF_FBW7_1	612	619	PF00400	0.429
DEG_SPOP_SBC_1	562	566	PF00917	0.441
DOC_CYCLIN_RxL_1	183	192	PF00134	0.328
DOC_CYCLIN_RxL_1	278	285	PF00134	0.316
DOC_MAPK_gen_1	121	129	PF00069	0.424
DOC_MAPK_gen_1	142	151	PF00069	0.502
DOC_MAPK_gen_1	429	439	PF00069	0.613
DOC_MAPK_gen_1	484	493	PF00069	0.409
DOC_MAPK_gen_1	573	581	PF00069	0.287
DOC_MAPK_gen_1	678	686	PF00069	0.298
DOC_MAPK_MEF2A_6	573	581	PF00069	0.346
DOC_PP1_RVXF_1	311	317	PF00149	0.296
DOC_PP4_FxxP_1	585	588	PF00568	0.319
DOC_USP7_MATH_1	3	7	PF00917	0.566
DOC_USP7_MATH_1	445	449	PF00917	0.434
DOC_USP7_MATH_1	50	54	PF00917	0.521
DOC_USP7_MATH_1	503	507	PF00917	0.364
DOC_USP7_MATH_1	562	566	PF00917	0.441
DOC_USP7_MATH_1	571	575	PF00917	0.553
DOC_USP7_MATH_1	591	595	PF00917	0.269
DOC_USP7_MATH_1	695	699	PF00917	0.328
DOC_USP7_MATH_2	35	41	PF00917	0.526
DOC_USP7_UBL2_3	13	17	PF12436	0.381
DOC_USP7_UBL2_3	386	390	PF12436	0.305
DOC_USP7_UBL2_3	426	430	PF12436	0.384
DOC_USP7_UBL2_3	434	438	PF12436	0.408
DOC_USP7_UBL2_3	679	683	PF12436	0.456
DOC_WW_Pin1_4	226	231	PF00397	0.556
DOC_WW_Pin1_4	272	277	PF00397	0.361
DOC_WW_Pin1_4	306	311	PF00397	0.254
DOC_WW_Pin1_4	328	333	PF00397	0.299
DOC_WW_Pin1_4	376	381	PF00397	0.342
DOC_WW_Pin1_4	394	399	PF00397	0.500
DOC_WW_Pin1_4	612	617	PF00397	0.429
DOC_WW_Pin1_4	659	664	PF00397	0.254
LIG_14-3-3_CanoR_1	146	152	PF00244	0.459
LIG_14-3-3_CanoR_1	156	164	PF00244	0.448
LIG_14-3-3_CanoR_1	561	570	PF00244	0.569
LIG_14-3-3_CanoR_1	575	580	PF00244	0.268
LIG_14-3-3_CanoR_1	639	644	PF00244	0.377
LIG_14-3-3_CanoR_1	645	655	PF00244	0.387
LIG_14-3-3_CanoR_1	86	90	PF00244	0.648
LIG_Actin_WH2_2	547	563	PF00022	0.254
LIG_Actin_WH2_2	664	680	PF00022	0.270
LIG_AP2alpha_2	600	602	PF02296	0.409
LIG_APCC_ABBA_1	138	143	PF00400	0.578
LIG_APCC_ABBA_1	228	233	PF00400	0.545
LIG_APCC_ABBA_1	603	608	PF00400	0.377
LIG_BRCT_BRCA1_1	228	232	PF00533	0.571
LIG_BRCT_BRCA1_1	252	256	PF00533	0.377
LIG_BRCT_BRCA1_1	360	364	PF00533	0.387
LIG_BRCT_BRCA1_1	39	43	PF00533	0.509
LIG_BRCT_BRCA1_1	598	602	PF00533	0.254
LIG_Clathr_ClatBox_1	576	580	PF01394	0.361
LIG_deltaCOP1_diTrp_1	638	646	PF00928	0.315
LIG_eIF4E_1	661	667	PF01652	0.361
LIG_EVH1_1	587	591	PF00568	0.361
LIG_FHA_1	132	138	PF00498	0.510
LIG_FHA_1	14	20	PF00498	0.446
LIG_FHA_1	213	219	PF00498	0.455
LIG_FHA_1	309	315	PF00498	0.295
LIG_FHA_1	409	415	PF00498	0.621
LIG_FHA_1	531	537	PF00498	0.254
LIG_FHA_1	576	582	PF00498	0.357
LIG_FHA_1	602	608	PF00498	0.440
LIG_FHA_1	617	623	PF00498	0.156
LIG_FHA_1	638	644	PF00498	0.335
LIG_FHA_1	647	653	PF00498	0.275
LIG_FHA_1	86	92	PF00498	0.610
LIG_FHA_1	95	101	PF00498	0.508
LIG_FHA_2	148	154	PF00498	0.423
LIG_FHA_2	200	206	PF00498	0.476
LIG_Integrin_RGD_1	393	395	PF01839	0.577
LIG_LIR_Apic_2	293	298	PF02991	0.369
LIG_LIR_Apic_2	558	562	PF02991	0.426
LIG_LIR_Apic_2	583	588	PF02991	0.309
LIG_LIR_Gen_1	114	124	PF02991	0.551
LIG_LIR_Gen_1	148	158	PF02991	0.450
LIG_LIR_Gen_1	184	193	PF02991	0.451
LIG_LIR_Gen_1	242	252	PF02991	0.452
LIG_LIR_Gen_1	419	428	PF02991	0.498
LIG_LIR_Gen_1	599	610	PF02991	0.371
LIG_LIR_Nem_3	148	154	PF02991	0.412
LIG_LIR_Nem_3	163	167	PF02991	0.327
LIG_LIR_Nem_3	184	189	PF02991	0.438
LIG_LIR_Nem_3	220	226	PF02991	0.398
LIG_LIR_Nem_3	26	32	PF02991	0.356
LIG_LIR_Nem_3	277	282	PF02991	0.338
LIG_LIR_Nem_3	331	336	PF02991	0.324
LIG_LIR_Nem_3	452	457	PF02991	0.393
LIG_LYPXL_yS_3	333	336	PF13949	0.296
LIG_MLH1_MIPbox_1	252	256	PF16413	0.254
LIG_NRBOX	358	364	PF00104	0.414
LIG_NRBOX	459	465	PF00104	0.337
LIG_Pex14_2	364	368	PF04695	0.315
LIG_Pex14_2	602	606	PF04695	0.377
LIG_Pex14_2	627	631	PF04695	0.296
LIG_PTB_Apo_2	621	628	PF02174	0.296
LIG_SH2_CRK	279	283	PF00017	0.361
LIG_SH2_CRK	385	389	PF00017	0.361
LIG_SH2_CRK	454	458	PF00017	0.458
LIG_SH2_CRK	692	696	PF00017	0.525
LIG_SH2_NCK_1	406	410	PF00017	0.487
LIG_SH2_NCK_1	692	696	PF00017	0.553
LIG_SH2_SRC	406	409	PF00017	0.497
LIG_SH2_STAP1	158	162	PF00017	0.508
LIG_SH2_STAT5	169	172	PF00017	0.433
LIG_SH2_STAT5	226	229	PF00017	0.480
LIG_SH2_STAT5	255	258	PF00017	0.301
LIG_SH2_STAT5	264	267	PF00017	0.305
LIG_SH2_STAT5	29	32	PF00017	0.509
LIG_SH2_STAT5	308	311	PF00017	0.324
LIG_SH2_STAT5	422	425	PF00017	0.567
LIG_SH2_STAT5	462	465	PF00017	0.318
LIG_SH2_STAT5	497	500	PF00017	0.321
LIG_SH2_STAT5	553	556	PF00017	0.324
LIG_SH2_STAT5	559	562	PF00017	0.398
LIG_SH2_STAT5	705	708	PF00017	0.532
LIG_SH2_STAT5	83	86	PF00017	0.480
LIG_SH3_3	585	591	PF00018	0.367
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.576
LIG_SUMO_SIM_anti_2	318	324	PF11976	0.361
LIG_SUMO_SIM_anti_2	578	583	PF11976	0.347
LIG_SUMO_SIM_par_1	333	338	PF11976	0.308
LIG_SUMO_SIM_par_1	444	450	PF11976	0.368
LIG_SUMO_SIM_par_1	574	580	PF11976	0.315
LIG_TRAF2_1	58	61	PF00917	0.532
LIG_TRFH_1	553	557	PF08558	0.324
LIG_TYR_ITIM	383	388	PF00017	0.361
LIG_WRC_WIRS_1	8	13	PF05994	0.418
MOD_CDK_SPxxK_3	306	313	PF00069	0.254
MOD_CK1_1	182	188	PF00069	0.518
MOD_CK1_1	260	266	PF00069	0.305
MOD_CK1_1	272	278	PF00069	0.280
MOD_CK1_1	413	419	PF00069	0.589
MOD_CK1_1	472	478	PF00069	0.364
MOD_CK1_1	532	538	PF00069	0.347
MOD_CK1_1	583	589	PF00069	0.384
MOD_CK1_1	596	602	PF00069	0.325
MOD_CK1_1	618	624	PF00069	0.409
MOD_CK1_1	647	653	PF00069	0.254
MOD_CK1_1	68	74	PF00069	0.430
MOD_CK1_1	85	91	PF00069	0.561
MOD_CK2_1	113	119	PF00069	0.444
MOD_CK2_1	160	166	PF00069	0.536
MOD_CK2_1	199	205	PF00069	0.484
MOD_CK2_1	231	237	PF00069	0.511
MOD_CK2_1	271	277	PF00069	0.254
MOD_CK2_1	394	400	PF00069	0.600
MOD_CK2_1	470	476	PF00069	0.342
MOD_CK2_1	55	61	PF00069	0.521
MOD_CK2_1	659	665	PF00069	0.361
MOD_GlcNHglycan	110	114	PF01048	0.416
MOD_GlcNHglycan	233	236	PF01048	0.458
MOD_GlcNHglycan	39	42	PF01048	0.516
MOD_GlcNHglycan	443	446	PF01048	0.414
MOD_GlcNHglycan	450	454	PF01048	0.398
MOD_GlcNHglycan	582	585	PF01048	0.321
MOD_GlcNHglycan	76	79	PF01048	0.424
MOD_GSK3_1	109	116	PF00069	0.464
MOD_GSK3_1	127	134	PF00069	0.433
MOD_GSK3_1	152	159	PF00069	0.466
MOD_GSK3_1	212	219	PF00069	0.474
MOD_GSK3_1	256	263	PF00069	0.305
MOD_GSK3_1	268	275	PF00069	0.305
MOD_GSK3_1	3	10	PF00069	0.589
MOD_GSK3_1	372	379	PF00069	0.347
MOD_GSK3_1	410	417	PF00069	0.622
MOD_GSK3_1	437	444	PF00069	0.413
MOD_GSK3_1	445	452	PF00069	0.372
MOD_GSK3_1	503	510	PF00069	0.363
MOD_GSK3_1	571	578	PF00069	0.412
MOD_GSK3_1	612	619	PF00069	0.340
MOD_GSK3_1	66	73	PF00069	0.446
MOD_N-GLC_1	127	132	PF02516	0.448
MOD_N-GLC_1	257	262	PF02516	0.245
MOD_N-GLC_1	37	42	PF02516	0.530
MOD_N-GLC_1	493	498	PF02516	0.414
MOD_NEK2_1	127	132	PF00069	0.434
MOD_NEK2_1	248	253	PF00069	0.314
MOD_NEK2_1	256	261	PF00069	0.282
MOD_NEK2_1	388	393	PF00069	0.262
MOD_NEK2_1	43	48	PF00069	0.382
MOD_NEK2_1	498	503	PF00069	0.385
MOD_NEK2_1	508	513	PF00069	0.245
MOD_NEK2_1	66	71	PF00069	0.406
MOD_NEK2_2	601	606	PF00069	0.409
MOD_NMyristoyl	1	7	PF02799	0.587
MOD_PKA_1	13	19	PF00069	0.435
MOD_PKA_1	145	151	PF00069	0.383
MOD_PKA_2	13	19	PF00069	0.368
MOD_PKA_2	145	151	PF00069	0.576
MOD_PKA_2	177	183	PF00069	0.485
MOD_PKA_2	372	378	PF00069	0.254
MOD_PKA_2	644	650	PF00069	0.446
MOD_PKA_2	85	91	PF00069	0.651
MOD_Plk_1	113	119	PF00069	0.462
MOD_Plk_1	152	158	PF00069	0.411
MOD_Plk_1	248	254	PF00069	0.254
MOD_Plk_1	37	43	PF00069	0.523
MOD_Plk_1	458	464	PF00069	0.425
MOD_Plk_1	493	499	PF00069	0.414
MOD_Plk_1	571	577	PF00069	0.466
MOD_Plk_1	637	643	PF00069	0.251
MOD_Plk_2-3	160	166	PF00069	0.452
MOD_Plk_2-3	199	205	PF00069	0.487
MOD_Plk_4	260	266	PF00069	0.317
MOD_Plk_4	358	364	PF00069	0.418
MOD_Plk_4	372	378	PF00069	0.235
MOD_Plk_4	458	464	PF00069	0.416
MOD_Plk_4	493	499	PF00069	0.361
MOD_Plk_4	50	56	PF00069	0.396
MOD_Plk_4	601	607	PF00069	0.382
MOD_Plk_4	647	653	PF00069	0.313
MOD_Plk_4	695	701	PF00069	0.427
MOD_ProDKin_1	226	232	PF00069	0.555
MOD_ProDKin_1	272	278	PF00069	0.361
MOD_ProDKin_1	306	312	PF00069	0.254
MOD_ProDKin_1	328	334	PF00069	0.299
MOD_ProDKin_1	376	382	PF00069	0.342
MOD_ProDKin_1	394	400	PF00069	0.511
MOD_ProDKin_1	612	618	PF00069	0.429
MOD_ProDKin_1	659	665	PF00069	0.254
MOD_SUMO_rev_2	114	123	PF00179	0.499
MOD_SUMO_rev_2	233	241	PF00179	0.487
MOD_SUMO_rev_2	472	479	PF00179	0.240
TRG_DiLeu_BaEn_1	119	124	PF01217	0.458
TRG_DiLeu_BaEn_1	205	210	PF01217	0.569
TRG_DiLeu_BaEn_1	358	363	PF01217	0.254
TRG_DiLeu_BaEn_1	572	577	PF01217	0.330
TRG_DiLeu_LyEn_5	572	577	PF01217	0.330
TRG_ENDOCYTIC_2	117	120	PF00928	0.507
TRG_ENDOCYTIC_2	245	248	PF00928	0.377
TRG_ENDOCYTIC_2	279	282	PF00928	0.361
TRG_ENDOCYTIC_2	29	32	PF00928	0.367
TRG_ENDOCYTIC_2	333	336	PF00928	0.327
TRG_ENDOCYTIC_2	385	388	PF00928	0.361
TRG_ENDOCYTIC_2	422	425	PF00928	0.479
TRG_ENDOCYTIC_2	454	457	PF00928	0.392
TRG_NES_CRM1_1	597	608	PF08389	0.254
TRG_NLS_MonoExtC_3	428	433	PF00514	0.391
TRG_NLS_MonoExtN_4	426	433	PF00514	0.517
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	575	580	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWX7	Leptomonas seymouri	68%	100%
A0A0N1I1N0	Leptomonas seymouri	34%	97%
A0A0N1IKD7	Leptomonas seymouri	31%	95%
A0A0S4ITT3	Bodo saltans	29%	82%
A0A0S4J9Y4	Bodo saltans	37%	100%
A0A0S4JUS2	Bodo saltans	32%	100%
A0A0S4KHF2	Bodo saltans	24%	100%
A0A1X0NUU1	Trypanosomatidae	46%	99%
A0A1X0P2K1	Trypanosomatidae	30%	97%
A0A3Q8IF05	Leishmania donovani	34%	97%
A0A3S7X8U7	Leishmania donovani	31%	98%
A0A422N571	Trypanosoma rangeli	47%	100%
A4HM43	Leishmania braziliensis	32%	98%
A4I027	Leishmania infantum	72%	91%
A4I5X4	Leishmania infantum	34%	97%
A4IAQ5	Leishmania infantum	31%	98%
A5D6R3	Danio rerio	33%	91%
D0A7A3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AEI1	Leishmania major	30%	100%
E9B168	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	97%
E9B5P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	98%
P10688	Rattus norvegicus	35%	94%
P10895	Bos taurus	35%	94%
P21671	Bos taurus	32%	90%
P32383	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	82%
P40977	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	79%
P51178	Homo sapiens	34%	94%
Q02158	Dictyostelium discoideum	30%	89%
Q1RML2	Bos taurus	28%	100%
Q2VRL0	Gallus gallus	31%	100%
Q32NH8	Xenopus laevis	33%	94%
Q39032	Arabidopsis thaliana	31%	100%
Q39033	Arabidopsis thaliana	28%	100%
Q4Q6Z7	Leishmania major	35%	100%
Q4QBH9	Leishmania major	66%	99%
Q4R6L3	Macaca fascicularis	32%	89%
Q56W08	Arabidopsis thaliana	29%	100%
Q5FX52	Rattus norvegicus	30%	100%
Q5RET0	Pongo abelii	33%	93%
Q62711	Rattus norvegicus	31%	92%
Q6NMA7	Arabidopsis thaliana	23%	100%
Q7YRU3	Sus scrofa	28%	100%
Q86YW0	Homo sapiens	29%	100%
Q8GV43	Arabidopsis thaliana	28%	100%
Q8K2J0	Mus musculus	33%	91%
Q8K3R3	Mus musculus	30%	88%
Q8K4D7	Mus musculus	31%	100%
Q8N3E9	Homo sapiens	33%	90%
Q8R3B1	Mus musculus	35%	94%
Q8SPR7	Sus scrofa	33%	92%
Q944C1	Arabidopsis thaliana	29%	100%
Q944C2	Arabidopsis thaliana	27%	100%
Q9BRC7	Homo sapiens	33%	93%
Q9LY51	Arabidopsis thaliana	28%	100%
Q9STZ3	Arabidopsis thaliana	23%	100%