RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCK8_LEIBR

TriTrypDb:

LbrM.22.1580 , LBRM2903_220022700

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCK8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	274	276	PF00675	0.287
CLV_NRD_NRD_1	550	552	PF00675	0.514
CLV_NRD_NRD_1	604	606	PF00675	0.568
CLV_PCSK_KEX2_1	274	276	PF00082	0.287
CLV_PCSK_KEX2_1	418	420	PF00082	0.458
CLV_PCSK_KEX2_1	550	552	PF00082	0.542
CLV_PCSK_KEX2_1	604	606	PF00082	0.549
CLV_PCSK_KEX2_1	784	786	PF00082	0.310
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.511
CLV_PCSK_PC1ET2_1	784	786	PF00082	0.310
CLV_PCSK_SKI1_1	261	265	PF00082	0.498
CLV_PCSK_SKI1_1	274	278	PF00082	0.287
CLV_PCSK_SKI1_1	366	370	PF00082	0.530
CLV_PCSK_SKI1_1	604	608	PF00082	0.525
CLV_PCSK_SKI1_1	94	98	PF00082	0.454
DEG_APCC_DBOX_1	5	13	PF00400	0.695
DEG_APCC_DBOX_1	596	604	PF00400	0.567
DEG_Nend_Nbox_1	1	3	PF02207	0.469
DOC_CYCLIN_RxL_1	366	374	PF00134	0.575
DOC_CYCLIN_RxL_1	601	611	PF00134	0.583
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.571
DOC_MAPK_gen_1	25	35	PF00069	0.666
DOC_MAPK_gen_1	373	382	PF00069	0.557
DOC_MAPK_gen_1	547	557	PF00069	0.539
DOC_MAPK_gen_1	604	610	PF00069	0.541
DOC_MAPK_gen_1	770	779	PF00069	0.496
DOC_MAPK_MEF2A_6	28	37	PF00069	0.408
DOC_MAPK_MEF2A_6	550	559	PF00069	0.523
DOC_MAPK_MEF2A_6	770	779	PF00069	0.496
DOC_MAPK_NFAT4_5	28	36	PF00069	0.412
DOC_PP2B_LxvP_1	264	267	PF13499	0.509
DOC_PP2B_LxvP_1	35	38	PF13499	0.599
DOC_PP2B_LxvP_1	84	87	PF13499	0.498
DOC_PP4_FxxP_1	697	700	PF00568	0.488
DOC_USP7_MATH_1	151	155	PF00917	0.508
DOC_USP7_MATH_1	220	224	PF00917	0.366
DOC_USP7_MATH_1	414	418	PF00917	0.492
DOC_USP7_MATH_1	464	468	PF00917	0.493
DOC_WW_Pin1_4	514	519	PF00397	0.502
DOC_WW_Pin1_4	545	550	PF00397	0.571
DOC_WW_Pin1_4	55	60	PF00397	0.592
DOC_WW_Pin1_4	633	638	PF00397	0.431
LIG_14-3-3_CanoR_1	163	168	PF00244	0.536
LIG_14-3-3_CanoR_1	233	238	PF00244	0.538
LIG_14-3-3_CanoR_1	294	298	PF00244	0.371
LIG_14-3-3_CanoR_1	302	312	PF00244	0.300
LIG_14-3-3_CanoR_1	425	432	PF00244	0.411
LIG_14-3-3_CanoR_1	597	601	PF00244	0.452
LIG_14-3-3_CanoR_1	605	611	PF00244	0.444
LIG_14-3-3_CanoR_1	613	618	PF00244	0.407
LIG_Actin_WH2_2	132	150	PF00022	0.514
LIG_Actin_WH2_2	248	263	PF00022	0.477
LIG_Actin_WH2_2	79	96	PF00022	0.550
LIG_BIR_III_2	727	731	PF00653	0.317
LIG_BRCT_BRCA1_1	153	157	PF00533	0.619
LIG_BRCT_BRCA1_1	331	335	PF00533	0.458
LIG_BRCT_BRCA1_1	635	639	PF00533	0.514
LIG_BRCT_BRCA1_1	657	661	PF00533	0.575
LIG_CaM_NSCaTE_8	256	263	PF13499	0.485
LIG_Clathr_ClatBox_1	607	611	PF01394	0.580
LIG_CtBP_PxDLS_1	249	253	PF00389	0.566
LIG_eIF4E_1	803	809	PF01652	0.387
LIG_FHA_1	103	109	PF00498	0.543
LIG_FHA_1	129	135	PF00498	0.448
LIG_FHA_1	419	425	PF00498	0.378
LIG_FHA_1	550	556	PF00498	0.453
LIG_FHA_1	793	799	PF00498	0.587
LIG_Integrin_isoDGR_2	71	73	PF01839	0.385
LIG_LIR_Apic_2	450	456	PF02991	0.308
LIG_LIR_Gen_1	129	139	PF02991	0.401
LIG_LIR_Gen_1	154	162	PF02991	0.466
LIG_LIR_Gen_1	18	29	PF02991	0.513
LIG_LIR_Gen_1	205	215	PF02991	0.472
LIG_LIR_Gen_1	296	305	PF02991	0.300
LIG_LIR_Gen_1	322	327	PF02991	0.454
LIG_LIR_Gen_1	332	342	PF02991	0.369
LIG_LIR_Nem_3	154	160	PF02991	0.464
LIG_LIR_Nem_3	161	167	PF02991	0.366
LIG_LIR_Nem_3	18	24	PF02991	0.587
LIG_LIR_Nem_3	205	210	PF02991	0.483
LIG_LIR_Nem_3	296	300	PF02991	0.335
LIG_LIR_Nem_3	322	326	PF02991	0.424
LIG_LIR_Nem_3	332	338	PF02991	0.420
LIG_NRBOX	187	193	PF00104	0.537
LIG_PDZ_Class_2	804	809	PF00595	0.533
LIG_Pex14_1	171	175	PF04695	0.476
LIG_PTB_Apo_2	120	127	PF02174	0.421
LIG_REV1ctd_RIR_1	124	134	PF16727	0.520
LIG_SH2_NCK_1	589	593	PF00017	0.541
LIG_SH2_PTP2	207	210	PF00017	0.478
LIG_SH2_STAP1	803	807	PF00017	0.571
LIG_SH2_STAT3	690	693	PF00017	0.533
LIG_SH2_STAT5	207	210	PF00017	0.382
LIG_SH2_STAT5	525	528	PF00017	0.444
LIG_SH2_STAT5	589	592	PF00017	0.446
LIG_SH2_STAT5	674	677	PF00017	0.503
LIG_SH3_3	139	145	PF00018	0.496
LIG_SH3_3	517	523	PF00018	0.401
LIG_SH3_3	768	774	PF00018	0.554
LIG_SH3_3	84	90	PF00018	0.440
LIG_SUMO_SIM_par_1	606	611	PF11976	0.577
LIG_TRAF2_1	268	271	PF00917	0.380
LIG_UBA3_1	364	369	PF00899	0.407
LIG_WRC_WIRS_1	323	328	PF05994	0.476
MOD_CDK_SPK_2	545	550	PF00069	0.540
MOD_CDK_SPxK_1	545	551	PF00069	0.545
MOD_CK1_1	128	134	PF00069	0.528
MOD_CK1_1	427	433	PF00069	0.475
MOD_CK1_1	494	500	PF00069	0.533
MOD_CK1_1	538	544	PF00069	0.456
MOD_CK1_1	545	551	PF00069	0.472
MOD_CK1_1	599	605	PF00069	0.528
MOD_CK1_1	653	659	PF00069	0.506
MOD_CK2_1	749	755	PF00069	0.483
MOD_GlcNHglycan	153	156	PF01048	0.502
MOD_GlcNHglycan	177	180	PF01048	0.577
MOD_GlcNHglycan	308	311	PF01048	0.504
MOD_GlcNHglycan	377	380	PF01048	0.537
MOD_GlcNHglycan	398	401	PF01048	0.571
MOD_GlcNHglycan	426	429	PF01048	0.496
MOD_GlcNHglycan	505	508	PF01048	0.315
MOD_GlcNHglycan	55	58	PF01048	0.600
MOD_GlcNHglycan	566	569	PF01048	0.483
MOD_GlcNHglycan	657	660	PF01048	0.551
MOD_GlcNHglycan	751	754	PF01048	0.545
MOD_GSK3_1	158	165	PF00069	0.353
MOD_GSK3_1	220	227	PF00069	0.358
MOD_GSK3_1	414	421	PF00069	0.320
MOD_GSK3_1	535	542	PF00069	0.512
MOD_GSK3_1	545	552	PF00069	0.549
MOD_GSK3_1	633	640	PF00069	0.481
MOD_GSK3_1	646	653	PF00069	0.456
MOD_GSK3_1	681	688	PF00069	0.527
MOD_N-GLC_1	464	469	PF02516	0.542
MOD_N-GLC_1	535	540	PF02516	0.458
MOD_NEK2_1	134	139	PF00069	0.336
MOD_NEK2_1	215	220	PF00069	0.515
MOD_NEK2_1	424	429	PF00069	0.536
MOD_NEK2_1	458	463	PF00069	0.457
MOD_NEK2_1	53	58	PF00069	0.493
MOD_NEK2_1	535	540	PF00069	0.458
MOD_NEK2_1	555	560	PF00069	0.538
MOD_NEK2_1	676	681	PF00069	0.469
MOD_NEK2_1	791	796	PF00069	0.484
MOD_NEK2_1	97	102	PF00069	0.508
MOD_NEK2_2	596	601	PF00069	0.526
MOD_NEK2_2	646	651	PF00069	0.515
MOD_OFUCOSY	444	451	PF10250	0.533
MOD_OFUCOSY	739	745	PF10250	0.288
MOD_PIKK_1	220	226	PF00454	0.365
MOD_PK_1	651	657	PF00069	0.603
MOD_PKA_1	418	424	PF00069	0.406
MOD_PKA_2	162	168	PF00069	0.532
MOD_PKA_2	293	299	PF00069	0.470
MOD_PKA_2	418	424	PF00069	0.496
MOD_PKA_2	549	555	PF00069	0.463
MOD_PKA_2	573	579	PF00069	0.381
MOD_PKA_2	596	602	PF00069	0.487
MOD_PKA_2	676	682	PF00069	0.524
MOD_PKB_1	373	381	PF00069	0.615
MOD_PKB_1	747	755	PF00069	0.551
MOD_Plk_1	128	134	PF00069	0.506
MOD_Plk_1	328	334	PF00069	0.524
MOD_Plk_1	464	470	PF00069	0.452
MOD_Plk_1	492	498	PF00069	0.471
MOD_Plk_1	535	541	PF00069	0.439
MOD_Plk_1	73	79	PF00069	0.595
MOD_Plk_4	134	140	PF00069	0.532
MOD_Plk_4	163	169	PF00069	0.535
MOD_Plk_4	202	208	PF00069	0.386
MOD_Plk_4	293	299	PF00069	0.470
MOD_Plk_4	322	328	PF00069	0.449
MOD_Plk_4	341	347	PF00069	0.239
MOD_Plk_4	427	433	PF00069	0.531
MOD_Plk_4	535	541	PF00069	0.499
MOD_Plk_4	555	561	PF00069	0.538
MOD_Plk_4	657	663	PF00069	0.554
MOD_Plk_4	79	85	PF00069	0.551
MOD_ProDKin_1	514	520	PF00069	0.511
MOD_ProDKin_1	545	551	PF00069	0.576
MOD_ProDKin_1	55	61	PF00069	0.582
MOD_ProDKin_1	633	639	PF00069	0.428
TRG_DiLeu_BaEn_1	315	320	PF01217	0.286
TRG_DiLeu_BaEn_1	360	365	PF01217	0.539
TRG_DiLeu_BaEn_1	701	706	PF01217	0.530
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.440
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.453
TRG_ENDOCYTIC_2	207	210	PF00928	0.478
TRG_ENDOCYTIC_2	403	406	PF00928	0.497
TRG_ER_diArg_1	274	276	PF00400	0.287
TRG_ER_diArg_1	549	551	PF00400	0.587
TRG_ER_diArg_1	6	9	PF00400	0.669
TRG_ER_diArg_1	603	605	PF00400	0.545
TRG_ER_diArg_1	747	750	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.287
TRG_Pf-PMV_PEXEL_1	720	724	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	73	78	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBG1	Leptomonas seymouri	56%	86%
A0A0S4JKR3	Bodo saltans	28%	72%
A0A1X0P744	Trypanosomatidae	33%	90%
A0A3Q8ICH8	Leishmania donovani	83%	88%
A4I026	Leishmania infantum	83%	88%
D0A544	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	90%
E9AVZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	88%
Q4QBI0	Leishmania major	82%	100%