Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCK7_LEIBR

TriTrypDb:

LbrM.22.1570 , LBRM2903_220022600

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCK7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.565
CLV_C14_Caspase3-7	282	286	PF00656	0.566
CLV_C14_Caspase3-7	568	572	PF00656	0.498
CLV_NRD_NRD_1	386	388	PF00675	0.500
CLV_NRD_NRD_1	417	419	PF00675	0.408
CLV_NRD_NRD_1	436	438	PF00675	0.223
CLV_NRD_NRD_1	502	504	PF00675	0.536
CLV_NRD_NRD_1	51	53	PF00675	0.434
CLV_PCSK_KEX2_1	386	388	PF00082	0.500
CLV_PCSK_KEX2_1	417	419	PF00082	0.408
CLV_PCSK_KEX2_1	436	438	PF00082	0.223
CLV_PCSK_KEX2_1	502	504	PF00082	0.488
CLV_PCSK_KEX2_1	51	53	PF00082	0.379
CLV_PCSK_KEX2_1	564	566	PF00082	0.325
CLV_PCSK_KEX2_1	604	606	PF00082	0.493
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.325
CLV_PCSK_PC1ET2_1	604	606	PF00082	0.392
CLV_PCSK_SKI1_1	218	222	PF00082	0.394
CLV_PCSK_SKI1_1	387	391	PF00082	0.599
CLV_PCSK_SKI1_1	417	421	PF00082	0.488
CLV_PCSK_SKI1_1	452	456	PF00082	0.373
CLV_PCSK_SKI1_1	502	506	PF00082	0.471
CLV_PCSK_SKI1_1	518	522	PF00082	0.443
CLV_PCSK_SKI1_1	584	588	PF00082	0.297
DEG_APCC_DBOX_1	416	424	PF00400	0.486
DEG_APCC_DBOX_1	604	612	PF00400	0.339
DEG_Nend_Nbox_1	1	3	PF02207	0.654
DEG_SPOP_SBC_1	186	190	PF00917	0.641
DEG_SPOP_SBC_1	504	508	PF00917	0.444
DEG_SPOP_SBC_1	92	96	PF00917	0.283
DOC_CYCLIN_RxL_1	414	422	PF00134	0.496
DOC_MAPK_gen_1	321	330	PF00069	0.447
DOC_MAPK_gen_1	343	353	PF00069	0.368
DOC_MAPK_gen_1	417	425	PF00069	0.385
DOC_MAPK_MEF2A_6	321	330	PF00069	0.456
DOC_MAPK_MEF2A_6	346	353	PF00069	0.424
DOC_PP1_RVXF_1	232	239	PF00149	0.387
DOC_PP1_RVXF_1	516	523	PF00149	0.361
DOC_PP2B_LxvP_1	126	129	PF13499	0.500
DOC_USP7_MATH_1	115	119	PF00917	0.556
DOC_USP7_MATH_1	139	143	PF00917	0.438
DOC_USP7_MATH_1	186	190	PF00917	0.646
DOC_USP7_MATH_1	223	227	PF00917	0.405
DOC_USP7_MATH_1	462	466	PF00917	0.541
DOC_USP7_MATH_1	504	508	PF00917	0.543
DOC_WW_Pin1_4	135	140	PF00397	0.454
DOC_WW_Pin1_4	182	187	PF00397	0.476
DOC_WW_Pin1_4	219	224	PF00397	0.470
DOC_WW_Pin1_4	589	594	PF00397	0.481
LIG_14-3-3_CanoR_1	178	186	PF00244	0.651
LIG_14-3-3_CanoR_1	3	8	PF00244	0.436
LIG_14-3-3_CanoR_1	37	45	PF00244	0.645
LIG_14-3-3_CanoR_1	386	390	PF00244	0.551
LIG_14-3-3_CanoR_1	418	424	PF00244	0.418
LIG_14-3-3_CanoR_1	436	440	PF00244	0.218
LIG_14-3-3_CanoR_1	502	510	PF00244	0.468
LIG_14-3-3_CanoR_1	528	536	PF00244	0.378
LIG_APCC_ABBA_1	22	27	PF00400	0.501
LIG_APCC_ABBA_1	304	309	PF00400	0.398
LIG_APCC_ABBA_1	519	524	PF00400	0.425
LIG_APCC_ABBAyCdc20_2	518	524	PF00400	0.270
LIG_CaM_IQ_9	260	275	PF13499	0.417
LIG_Clathr_ClatBox_1	423	427	PF01394	0.391
LIG_deltaCOP1_diTrp_1	427	435	PF00928	0.293
LIG_FAT_LD_1	13	21	PF03623	0.398
LIG_FHA_1	139	145	PF00498	0.454
LIG_FHA_1	190	196	PF00498	0.556
LIG_FHA_1	244	250	PF00498	0.498
LIG_FHA_1	300	306	PF00498	0.435
LIG_FHA_1	356	362	PF00498	0.414
LIG_FHA_1	379	385	PF00498	0.423
LIG_FHA_1	401	407	PF00498	0.497
LIG_FHA_1	536	542	PF00498	0.400
LIG_FHA_1	573	579	PF00498	0.341
LIG_FHA_1	88	94	PF00498	0.311
LIG_FHA_2	566	572	PF00498	0.533
LIG_FHA_2	84	90	PF00498	0.379
LIG_GBD_Chelix_1	228	236	PF00786	0.260
LIG_IBAR_NPY_1	23	25	PF08397	0.510
LIG_LIR_Gen_1	160	170	PF02991	0.387
LIG_LIR_Gen_1	324	333	PF02991	0.382
LIG_LIR_Gen_1	335	344	PF02991	0.358
LIG_LIR_Gen_1	427	434	PF02991	0.424
LIG_LIR_Gen_1	465	472	PF02991	0.377
LIG_LIR_Nem_3	156	162	PF02991	0.385
LIG_LIR_Nem_3	324	328	PF02991	0.408
LIG_LIR_Nem_3	335	339	PF02991	0.402
LIG_LIR_Nem_3	398	402	PF02991	0.465
LIG_LIR_Nem_3	427	433	PF02991	0.431
LIG_LIR_Nem_3	465	469	PF02991	0.406
LIG_LIR_Nem_3	598	602	PF02991	0.369
LIG_NRBOX	12	18	PF00104	0.404
LIG_NRBOX	419	425	PF00104	0.499
LIG_PDZ_Class_2	612	617	PF00595	0.490
LIG_Pex14_1	385	389	PF04695	0.470
LIG_SH2_PTP2	162	165	PF00017	0.384
LIG_SH2_PTP2	325	328	PF00017	0.426
LIG_SH2_STAP1	159	163	PF00017	0.266
LIG_SH2_STAT3	577	580	PF00017	0.468
LIG_SH2_STAT5	162	165	PF00017	0.413
LIG_SH2_STAT5	168	171	PF00017	0.422
LIG_SH2_STAT5	325	328	PF00017	0.430
LIG_SH2_STAT5	355	358	PF00017	0.276
LIG_SH2_STAT5	365	368	PF00017	0.217
LIG_SH2_STAT5	402	405	PF00017	0.358
LIG_SH2_STAT5	577	580	PF00017	0.478
LIG_SH2_STAT5	98	101	PF00017	0.450
LIG_SH3_3	109	115	PF00018	0.547
LIG_SH3_3	169	175	PF00018	0.402
LIG_SH3_3	246	252	PF00018	0.507
LIG_SUMO_SIM_anti_2	118	125	PF11976	0.467
LIG_SUMO_SIM_anti_2	188	197	PF11976	0.387
LIG_SUMO_SIM_anti_2	42	49	PF11976	0.395
LIG_SUMO_SIM_anti_2	422	427	PF11976	0.471
LIG_SUMO_SIM_par_1	422	427	PF11976	0.329
LIG_SUMO_SIM_par_1	89	97	PF11976	0.388
LIG_UBA3_1	443	452	PF00899	0.281
LIG_WRC_WIRS_1	255	260	PF05994	0.316
MOD_CDK_SPxxK_3	589	596	PF00069	0.476
MOD_CK1_1	110	116	PF00069	0.519
MOD_CK1_1	138	144	PF00069	0.448
MOD_CK1_1	177	183	PF00069	0.587
MOD_CK1_1	185	191	PF00069	0.626
MOD_CK1_1	388	394	PF00069	0.526
MOD_CK1_1	465	471	PF00069	0.451
MOD_CK1_1	497	503	PF00069	0.572
MOD_CK1_1	506	512	PF00069	0.563
MOD_CK1_1	527	533	PF00069	0.297
MOD_CK1_1	87	93	PF00069	0.499
MOD_CK1_1	94	100	PF00069	0.374
MOD_CK2_1	116	122	PF00069	0.467
MOD_CK2_1	40	46	PF00069	0.497
MOD_CK2_1	508	514	PF00069	0.558
MOD_CK2_1	83	89	PF00069	0.429
MOD_GlcNHglycan	118	121	PF01048	0.691
MOD_GlcNHglycan	141	144	PF01048	0.448
MOD_GlcNHglycan	155	158	PF01048	0.536
MOD_GlcNHglycan	159	162	PF01048	0.452
MOD_GlcNHglycan	214	217	PF01048	0.324
MOD_GlcNHglycan	276	279	PF01048	0.417
MOD_GlcNHglycan	299	302	PF01048	0.382
MOD_GlcNHglycan	495	499	PF01048	0.538
MOD_GlcNHglycan	529	532	PF01048	0.438
MOD_GlcNHglycan	68	71	PF01048	0.494
MOD_GSK3_1	135	142	PF00069	0.419
MOD_GSK3_1	153	160	PF00069	0.603
MOD_GSK3_1	174	181	PF00069	0.581
MOD_GSK3_1	182	189	PF00069	0.643
MOD_GSK3_1	219	226	PF00069	0.506
MOD_GSK3_1	313	320	PF00069	0.425
MOD_GSK3_1	493	500	PF00069	0.519
MOD_GSK3_1	502	509	PF00069	0.612
MOD_GSK3_1	83	90	PF00069	0.569
MOD_N-GLC_1	100	105	PF02516	0.305
MOD_NEK2_1	144	149	PF00069	0.552
MOD_NEK2_1	299	304	PF00069	0.306
MOD_NEK2_1	307	312	PF00069	0.308
MOD_NEK2_1	317	322	PF00069	0.496
MOD_NEK2_1	372	377	PF00069	0.372
MOD_NEK2_1	419	424	PF00069	0.481
MOD_NEK2_1	493	498	PF00069	0.503
MOD_NEK2_1	82	87	PF00069	0.518
MOD_NEK2_1	91	96	PF00069	0.573
MOD_PIKK_1	292	298	PF00454	0.325
MOD_PIKK_1	363	369	PF00454	0.252
MOD_PKA_1	502	508	PF00069	0.451
MOD_PKA_2	107	113	PF00069	0.420
MOD_PKA_2	177	183	PF00069	0.666
MOD_PKA_2	313	319	PF00069	0.324
MOD_PKA_2	385	391	PF00069	0.535
MOD_PKA_2	435	441	PF00069	0.540
MOD_PKA_2	493	499	PF00069	0.522
MOD_PKA_2	502	508	PF00069	0.668
MOD_PKA_2	527	533	PF00069	0.385
MOD_Plk_1	18	24	PF00069	0.529
MOD_Plk_4	107	113	PF00069	0.377
MOD_Plk_4	200	206	PF00069	0.584
MOD_Plk_4	224	230	PF00069	0.468
MOD_Plk_4	419	425	PF00069	0.415
MOD_Plk_4	465	471	PF00069	0.519
MOD_Plk_4	8	14	PF00069	0.667
MOD_Plk_4	87	93	PF00069	0.320
MOD_Plk_4	94	100	PF00069	0.258
MOD_ProDKin_1	135	141	PF00069	0.453
MOD_ProDKin_1	182	188	PF00069	0.471
MOD_ProDKin_1	219	225	PF00069	0.469
MOD_ProDKin_1	589	595	PF00069	0.481
MOD_SUMO_rev_2	590	597	PF00179	0.532
TRG_DiLeu_BaEn_1	532	537	PF01217	0.403
TRG_DiLeu_BaEn_4	359	365	PF01217	0.410
TRG_DiLeu_BaLyEn_6	415	420	PF01217	0.441
TRG_DiLeu_BaLyEn_6	515	520	PF01217	0.262
TRG_ENDOCYTIC_2	162	165	PF00928	0.413
TRG_ENDOCYTIC_2	25	28	PF00928	0.502
TRG_ENDOCYTIC_2	325	328	PF00928	0.430
TRG_ER_diArg_1	385	387	PF00400	0.500
TRG_ER_diArg_1	417	419	PF00400	0.411
TRG_ER_diArg_1	435	437	PF00400	0.233
TRG_ER_diArg_1	501	503	PF00400	0.445
TRG_ER_diArg_1	51	53	PF00400	0.519
TRG_ER_diArg_1	61	64	PF00400	0.322
TRG_NES_CRM1_1	231	245	PF08389	0.309
TRG_Pf-PMV_PEXEL_1	576	580	PF00026	0.311
TRG_Pf-PMV_PEXEL_1	584	588	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK4	Leptomonas seymouri	45%	100%
A0A1X0NU19	Trypanosomatidae	28%	100%
A0A3R7K6E0	Trypanosoma rangeli	29%	100%
A0A3S5H7B4	Leishmania donovani	76%	100%
A4I025	Leishmania infantum	76%	100%
E9AVZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QBI1	Leishmania major	76%	100%