cobW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CobW/HypB/UreG, nucleotide-binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCK6_LEIBR

TriTrypDb:

LbrM.22.1560 , LBRM2903_220022500

Length:

406

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCK6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.581
CLV_NRD_NRD_1	190	192	PF00675	0.408
CLV_NRD_NRD_1	284	286	PF00675	0.617
CLV_NRD_NRD_1	331	333	PF00675	0.683
CLV_PCSK_KEX2_1	190	192	PF00082	0.408
CLV_PCSK_KEX2_1	284	286	PF00082	0.617
CLV_PCSK_PC7_1	186	192	PF00082	0.408
CLV_PCSK_SKI1_1	190	194	PF00082	0.408
CLV_PCSK_SKI1_1	284	288	PF00082	0.544
CLV_PCSK_SKI1_1	293	297	PF00082	0.445
CLV_PCSK_SKI1_1	358	362	PF00082	0.530
CLV_PCSK_SKI1_1	98	102	PF00082	0.228
DEG_APCC_DBOX_1	292	300	PF00400	0.568
DEG_Nend_UBRbox_1	1	4	PF02207	0.442
DOC_CDC14_PxL_1	117	125	PF14671	0.608
DOC_CYCLIN_RxL_1	281	289	PF00134	0.595
DOC_CYCLIN_RxL_1	290	298	PF00134	0.466
DOC_MAPK_DCC_7	387	396	PF00069	0.480
DOC_MAPK_gen_1	262	268	PF00069	0.597
DOC_MAPK_gen_1	32	40	PF00069	0.608
DOC_MAPK_MEF2A_6	197	205	PF00069	0.391
DOC_MAPK_MEF2A_6	2	10	PF00069	0.531
DOC_MAPK_MEF2A_6	32	40	PF00069	0.608
DOC_PP1_RVXF_1	319	326	PF00149	0.666
DOC_PP1_RVXF_1	356	362	PF00149	0.515
DOC_USP7_MATH_1	137	141	PF00917	0.608
DOC_USP7_MATH_1	151	155	PF00917	0.443
DOC_USP7_MATH_1	196	200	PF00917	0.647
DOC_USP7_MATH_1	214	218	PF00917	0.316
DOC_USP7_MATH_1	52	56	PF00917	0.554
DOC_USP7_MATH_1	58	62	PF00917	0.592
DOC_WW_Pin1_4	286	291	PF00397	0.607
DOC_WW_Pin1_4	387	392	PF00397	0.468
DOC_WW_Pin1_4	394	399	PF00397	0.473
LIG_14-3-3_CanoR_1	326	331	PF00244	0.655
LIG_Actin_WH2_2	269	286	PF00022	0.593
LIG_BRCT_BRCA1_1	209	213	PF00533	0.375
LIG_FHA_1	175	181	PF00498	0.608
LIG_FHA_1	18	24	PF00498	0.473
LIG_FHA_1	268	274	PF00498	0.619
LIG_FHA_1	278	284	PF00498	0.426
LIG_FHA_1	318	324	PF00498	0.434
LIG_FHA_1	84	90	PF00498	0.428
LIG_FHA_2	143	149	PF00498	0.608
LIG_FXI_DFP_1	362	366	PF00024	0.618
LIG_Integrin_RGD_1	159	161	PF01839	0.311
LIG_LIR_Nem_3	335	339	PF02991	0.673
LIG_NRBOX	22	28	PF00104	0.428
LIG_Pex14_2	361	365	PF04695	0.616
LIG_PTB_Apo_2	170	177	PF02174	0.581
LIG_PTB_Phospho_1	170	176	PF10480	0.581
LIG_SH2_NCK_1	238	242	PF00017	0.684
LIG_SH2_PTP2	343	346	PF00017	0.719
LIG_SH2_SRC	238	241	PF00017	0.421
LIG_SH2_STAP1	176	180	PF00017	0.581
LIG_SH2_STAT5	176	179	PF00017	0.581
LIG_SH2_STAT5	206	209	PF00017	0.599
LIG_SH2_STAT5	305	308	PF00017	0.428
LIG_SH2_STAT5	343	346	PF00017	0.719
LIG_SH3_3	104	110	PF00018	0.581
LIG_SH3_3	133	139	PF00018	0.428
LIG_SH3_3	336	342	PF00018	0.692
LIG_SH3_3	392	398	PF00018	0.493
LIG_SUMO_SIM_anti_2	130	136	PF11976	0.428
LIG_SUMO_SIM_anti_2	154	159	PF11976	0.603
LIG_SUMO_SIM_par_1	140	145	PF11976	0.599
LIG_SUMO_SIM_par_1	68	73	PF11976	0.539
LIG_TRAF2_1	254	257	PF00917	0.726
LIG_TRAF2_1	31	34	PF00917	0.608
LIG_TYR_ITIM	334	339	PF00017	0.670
LIG_UBA3_1	26	35	PF00899	0.503
MOD_CDK_SPxxK_3	286	293	PF00069	0.565
MOD_CK1_1	140	146	PF00069	0.503
MOD_CK1_1	17	23	PF00069	0.503
MOD_CK1_1	368	374	PF00069	0.347
MOD_CK1_1	380	386	PF00069	0.357
MOD_CK1_1	56	62	PF00069	0.503
MOD_CK1_1	63	69	PF00069	0.387
MOD_CK1_1	83	89	PF00069	0.172
MOD_CK2_1	316	322	PF00069	0.623
MOD_Cter_Amidation	330	333	PF01082	0.449
MOD_GlcNHglycan	16	19	PF01048	0.503
MOD_GlcNHglycan	209	212	PF01048	0.386
MOD_GlcNHglycan	235	238	PF01048	0.403
MOD_GlcNHglycan	306	309	PF01048	0.591
MOD_GlcNHglycan	310	316	PF01048	0.631
MOD_GlcNHglycan	366	370	PF01048	0.406
MOD_GlcNHglycan	56	59	PF01048	0.490
MOD_GlcNHglycan	72	75	PF01048	0.226
MOD_GSK3_1	14	21	PF00069	0.503
MOD_GSK3_1	295	302	PF00069	0.362
MOD_GSK3_1	376	383	PF00069	0.606
MOD_GSK3_1	52	59	PF00069	0.452
MOD_NEK2_1	14	19	PF00069	0.503
MOD_NEK2_1	142	147	PF00069	0.503
MOD_NEK2_1	233	238	PF00069	0.394
MOD_NEK2_1	26	31	PF00069	0.304
MOD_NEK2_1	276	281	PF00069	0.338
MOD_NEK2_1	295	300	PF00069	0.283
MOD_NEK2_1	365	370	PF00069	0.487
MOD_NEK2_1	377	382	PF00069	0.349
MOD_NEK2_1	53	58	PF00069	0.250
MOD_PIKK_1	368	374	PF00454	0.347
MOD_PKA_2	196	202	PF00069	0.404
MOD_PKA_2	348	354	PF00069	0.693
MOD_Plk_4	137	143	PF00069	0.503
MOD_Plk_4	18	24	PF00069	0.503
MOD_Plk_4	214	220	PF00069	0.608
MOD_Plk_4	295	301	PF00069	0.351
MOD_ProDKin_1	286	292	PF00069	0.600
MOD_ProDKin_1	387	393	PF00069	0.472
MOD_ProDKin_1	394	400	PF00069	0.473
MOD_SUMO_rev_2	255	264	PF00179	0.626
MOD_SUMO_rev_2	28	36	PF00179	0.250
TRG_DiLeu_BaEn_3	33	39	PF01217	0.503
TRG_ENDOCYTIC_2	336	339	PF00928	0.613
TRG_ENDOCYTIC_2	343	346	PF00928	0.603
TRG_ENDOCYTIC_2	99	102	PF00928	0.503
TRG_ER_diArg_1	189	191	PF00400	0.503
TRG_ER_diArg_1	283	285	PF00400	0.612
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J8A6	Bodo saltans	28%	100%
A0A3Q8ILT9	Leishmania donovani	83%	100%
A4I024	Leishmania infantum	83%	100%
E9AVZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
P31521	Pseudomonas chlororaphis	29%	97%
P94400	Bacillus subtilis (strain 168)	27%	100%
Q4QBI2	Leishmania major	83%	100%