Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCK2_LEIBR

TriTrypDb:

LbrM.22.1520 , LBRM2903_220022000

Length:

808

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	390	394	PF00656	0.379
CLV_NRD_NRD_1	165	167	PF00675	0.421
CLV_NRD_NRD_1	300	302	PF00675	0.444
CLV_NRD_NRD_1	482	484	PF00675	0.760
CLV_NRD_NRD_1	617	619	PF00675	0.563
CLV_NRD_NRD_1	648	650	PF00675	0.359
CLV_NRD_NRD_1	717	719	PF00675	0.590
CLV_PCSK_FUR_1	614	618	PF00082	0.472
CLV_PCSK_KEX2_1	221	223	PF00082	0.399
CLV_PCSK_KEX2_1	300	302	PF00082	0.444
CLV_PCSK_KEX2_1	482	484	PF00082	0.703
CLV_PCSK_KEX2_1	616	618	PF00082	0.500
CLV_PCSK_KEX2_1	648	650	PF00082	0.359
CLV_PCSK_KEX2_1	677	679	PF00082	0.389
CLV_PCSK_KEX2_1	719	721	PF00082	0.635
CLV_PCSK_KEX2_1	805	807	PF00082	0.522
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.399
CLV_PCSK_PC1ET2_1	677	679	PF00082	0.389
CLV_PCSK_PC1ET2_1	719	721	PF00082	0.517
CLV_PCSK_PC1ET2_1	805	807	PF00082	0.575
CLV_PCSK_PC7_1	478	484	PF00082	0.527
CLV_PCSK_SKI1_1	218	222	PF00082	0.510
CLV_PCSK_SKI1_1	411	415	PF00082	0.522
CLV_PCSK_SKI1_1	467	471	PF00082	0.504
CLV_PCSK_SKI1_1	596	600	PF00082	0.365
CLV_PCSK_SKI1_1	688	692	PF00082	0.498
CLV_PCSK_SKI1_1	700	704	PF00082	0.385
CLV_Separin_Metazoa	611	615	PF03568	0.409
DEG_COP1_1	310	317	PF00400	0.412
DEG_SCF_FBW7_1	67	73	PF00400	0.456
DEG_SPOP_SBC_1	291	295	PF00917	0.383
DOC_CKS1_1	511	516	PF01111	0.665
DOC_CKS1_1	67	72	PF01111	0.455
DOC_CYCLIN_RxL_1	218	229	PF00134	0.384
DOC_CYCLIN_RxL_1	697	704	PF00134	0.378
DOC_MAPK_FxFP_2	51	54	PF00069	0.438
DOC_MAPK_gen_1	166	174	PF00069	0.300
DOC_MAPK_gen_1	328	337	PF00069	0.458
DOC_MAPK_gen_1	614	623	PF00069	0.360
DOC_MAPK_MEF2A_6	248	257	PF00069	0.482
DOC_MAPK_MEF2A_6	331	339	PF00069	0.411
DOC_MAPK_MEF2A_6	596	604	PF00069	0.276
DOC_MAPK_RevD_3	286	301	PF00069	0.302
DOC_MAPK_RevD_3	602	617	PF00069	0.274
DOC_PP1_RVXF_1	219	226	PF00149	0.513
DOC_PP1_RVXF_1	698	704	PF00149	0.460
DOC_PP2B_LxvP_1	152	155	PF13499	0.328
DOC_PP2B_LxvP_1	506	509	PF13499	0.503
DOC_PP4_FxxP_1	174	177	PF00568	0.293
DOC_PP4_FxxP_1	352	355	PF00568	0.477
DOC_PP4_FxxP_1	51	54	PF00568	0.438
DOC_USP7_MATH_1	115	119	PF00917	0.308
DOC_USP7_MATH_1	230	234	PF00917	0.490
DOC_USP7_MATH_1	260	264	PF00917	0.453
DOC_USP7_MATH_1	372	376	PF00917	0.451
DOC_USP7_MATH_1	436	440	PF00917	0.406
DOC_USP7_MATH_1	451	455	PF00917	0.319
DOC_USP7_MATH_1	498	502	PF00917	0.635
DOC_USP7_MATH_1	509	513	PF00917	0.692
DOC_USP7_MATH_1	631	635	PF00917	0.429
DOC_USP7_MATH_1	669	673	PF00917	0.476
DOC_USP7_MATH_1	724	728	PF00917	0.501
DOC_USP7_MATH_1	75	79	PF00917	0.573
DOC_USP7_MATH_1	804	808	PF00917	0.617
DOC_USP7_MATH_1	98	102	PF00917	0.344
DOC_WW_Pin1_4	136	141	PF00397	0.477
DOC_WW_Pin1_4	185	190	PF00397	0.588
DOC_WW_Pin1_4	228	233	PF00397	0.471
DOC_WW_Pin1_4	258	263	PF00397	0.464
DOC_WW_Pin1_4	35	40	PF00397	0.583
DOC_WW_Pin1_4	363	368	PF00397	0.556
DOC_WW_Pin1_4	414	419	PF00397	0.399
DOC_WW_Pin1_4	507	512	PF00397	0.667
DOC_WW_Pin1_4	63	68	PF00397	0.594
DOC_WW_Pin1_4	766	771	PF00397	0.504
LIG_14-3-3_CanoR_1	300	308	PF00244	0.451
LIG_14-3-3_CanoR_1	467	476	PF00244	0.559
LIG_14-3-3_CanoR_1	503	509	PF00244	0.661
LIG_14-3-3_CanoR_1	596	601	PF00244	0.384
LIG_14-3-3_CanoR_1	616	622	PF00244	0.493
LIG_14-3-3_CanoR_1	700	706	PF00244	0.469
LIG_14-3-3_CanoR_1	708	713	PF00244	0.480
LIG_14-3-3_CanoR_1	81	89	PF00244	0.412
LIG_Actin_WH2_2	207	223	PF00022	0.398
LIG_Actin_WH2_2	42	60	PF00022	0.438
LIG_BIR_II_1	1	5	PF00653	0.425
LIG_BRCT_BRCA1_1	25	29	PF00533	0.451
LIG_BRCT_BRCA1_1	438	442	PF00533	0.460
LIG_BRCT_BRCA1_1	500	504	PF00533	0.497
LIG_BRCT_BRCA1_1	656	660	PF00533	0.463
LIG_CSL_BTD_1	148	151	PF09270	0.323
LIG_CtBP_PxDLS_1	367	371	PF00389	0.443
LIG_EH1_1	606	614	PF00400	0.421
LIG_eIF4E_1	607	613	PF01652	0.417
LIG_FHA_1	101	107	PF00498	0.519
LIG_FHA_1	118	124	PF00498	0.373
LIG_FHA_1	189	195	PF00498	0.440
LIG_FHA_1	270	276	PF00498	0.338
LIG_FHA_1	292	298	PF00498	0.467
LIG_FHA_1	489	495	PF00498	0.559
LIG_FHA_1	564	570	PF00498	0.560
LIG_FHA_1	597	603	PF00498	0.325
LIG_FHA_1	669	675	PF00498	0.542
LIG_FHA_1	697	703	PF00498	0.576
LIG_FHA_1	71	77	PF00498	0.493
LIG_FHA_2	128	134	PF00498	0.479
LIG_FHA_2	185	191	PF00498	0.671
LIG_FHA_2	606	612	PF00498	0.388
LIG_FHA_2	633	639	PF00498	0.575
LIG_Integrin_RGD_1	127	129	PF01839	0.534
LIG_LIR_Apic_2	349	355	PF02991	0.451
LIG_LIR_Apic_2	362	367	PF02991	0.358
LIG_LIR_Apic_2	50	54	PF02991	0.464
LIG_LIR_Gen_1	101	108	PF02991	0.363
LIG_LIR_Nem_3	101	105	PF02991	0.372
LIG_LIR_Nem_3	50	56	PF02991	0.436
LIG_MAD2	222	230	PF02301	0.329
LIG_SH2_CRK	211	215	PF00017	0.422
LIG_SH2_CRK	597	601	PF00017	0.431
LIG_SH2_CRK	65	69	PF00017	0.607
LIG_SH2_NCK_1	25	29	PF00017	0.473
LIG_SH2_NCK_1	597	601	PF00017	0.353
LIG_SH2_NCK_1	65	69	PF00017	0.464
LIG_SH2_STAP1	25	29	PF00017	0.451
LIG_SH2_STAP1	597	601	PF00017	0.353
LIG_SH2_STAT3	122	125	PF00017	0.477
LIG_SH2_STAT5	107	110	PF00017	0.433
LIG_SH2_STAT5	122	125	PF00017	0.268
LIG_SH2_STAT5	22	25	PF00017	0.588
LIG_SH2_STAT5	541	544	PF00017	0.329
LIG_SH2_STAT5	551	554	PF00017	0.415
LIG_SH2_STAT5	558	561	PF00017	0.369
LIG_SH2_STAT5	607	610	PF00017	0.353
LIG_SH2_STAT5	679	682	PF00017	0.441
LIG_SH2_STAT5	749	752	PF00017	0.554
LIG_SH3_3	145	151	PF00018	0.362
LIG_SH3_3	247	253	PF00018	0.431
LIG_SH3_3	285	291	PF00018	0.355
LIG_SH3_3	311	317	PF00018	0.502
LIG_SH3_3	33	39	PF00018	0.568
LIG_SH3_3	508	514	PF00018	0.751
LIG_SH3_3	64	70	PF00018	0.548
LIG_SH3_3	764	770	PF00018	0.651
LIG_SH3_4	639	646	PF00018	0.501
LIG_SUMO_SIM_anti_2	608	614	PF11976	0.420
LIG_SUMO_SIM_anti_2	741	748	PF11976	0.443
LIG_SUMO_SIM_par_1	213	219	PF11976	0.349
LIG_SUMO_SIM_par_1	255	261	PF11976	0.467
LIG_SUMO_SIM_par_1	45	50	PF11976	0.434
LIG_SUMO_SIM_par_1	598	603	PF11976	0.419
LIG_SUMO_SIM_par_1	628	635	PF11976	0.454
LIG_TRAF2_1	330	333	PF00917	0.351
LIG_TRAF2_1	366	369	PF00917	0.540
LIG_TRFH_1	226	230	PF08558	0.325
LIG_TRFH_1	351	355	PF08558	0.466
LIG_TYR_ITIM	209	214	PF00017	0.428
LIG_TYR_ITIM	595	600	PF00017	0.355
LIG_Vh1_VBS_1	79	97	PF01044	0.383
LIG_WRC_WIRS_1	48	53	PF05994	0.440
LIG_WRC_WIRS_1	76	81	PF05994	0.469
MOD_CK1_1	188	194	PF00069	0.531
MOD_CK1_1	233	239	PF00069	0.495
MOD_CK1_1	292	298	PF00069	0.528
MOD_CK1_1	346	352	PF00069	0.332
MOD_CK1_1	375	381	PF00069	0.580
MOD_CK1_1	445	451	PF00069	0.518
MOD_CK1_1	454	460	PF00069	0.559
MOD_CK1_1	461	467	PF00069	0.584
MOD_CK1_1	507	513	PF00069	0.700
MOD_CK1_1	564	570	PF00069	0.530
MOD_CK1_1	66	72	PF00069	0.457
MOD_CK1_1	753	759	PF00069	0.408
MOD_CK1_1	769	775	PF00069	0.600
MOD_CK2_1	136	142	PF00069	0.397
MOD_CK2_1	327	333	PF00069	0.315
MOD_CK2_1	363	369	PF00069	0.586
MOD_CK2_1	414	420	PF00069	0.393
MOD_CK2_1	605	611	PF00069	0.471
MOD_CK2_1	616	622	PF00069	0.483
MOD_CK2_1	669	675	PF00069	0.497
MOD_CK2_1	724	730	PF00069	0.530
MOD_CK2_1	745	751	PF00069	0.467
MOD_GlcNHglycan	197	200	PF01048	0.366
MOD_GlcNHglycan	232	235	PF01048	0.520
MOD_GlcNHglycan	294	297	PF01048	0.447
MOD_GlcNHglycan	304	307	PF01048	0.488
MOD_GlcNHglycan	311	314	PF01048	0.599
MOD_GlcNHglycan	374	377	PF01048	0.576
MOD_GlcNHglycan	438	441	PF01048	0.405
MOD_GlcNHglycan	444	447	PF01048	0.401
MOD_GlcNHglycan	453	456	PF01048	0.418
MOD_GlcNHglycan	460	463	PF01048	0.529
MOD_GlcNHglycan	506	509	PF01048	0.510
MOD_GlcNHglycan	530	533	PF01048	0.563
MOD_GlcNHglycan	542	545	PF01048	0.459
MOD_GlcNHglycan	561	564	PF01048	0.552
MOD_GlcNHglycan	566	569	PF01048	0.564
MOD_GlcNHglycan	7	10	PF01048	0.392
MOD_GlcNHglycan	763	766	PF01048	0.590
MOD_GlcNHglycan	86	89	PF01048	0.424
MOD_GSK3_1	181	188	PF00069	0.660
MOD_GSK3_1	224	231	PF00069	0.409
MOD_GSK3_1	232	239	PF00069	0.415
MOD_GSK3_1	265	272	PF00069	0.431
MOD_GSK3_1	359	366	PF00069	0.574
MOD_GSK3_1	400	407	PF00069	0.568
MOD_GSK3_1	454	461	PF00069	0.627
MOD_GSK3_1	488	495	PF00069	0.672
MOD_GSK3_1	498	505	PF00069	0.627
MOD_GSK3_1	5	12	PF00069	0.508
MOD_GSK3_1	520	527	PF00069	0.635
MOD_GSK3_1	559	566	PF00069	0.537
MOD_GSK3_1	596	603	PF00069	0.408
MOD_GSK3_1	652	659	PF00069	0.475
MOD_GSK3_1	66	73	PF00069	0.479
MOD_GSK3_1	741	748	PF00069	0.545
MOD_GSK3_1	75	82	PF00069	0.731
MOD_GSK3_1	750	757	PF00069	0.614
MOD_N-GLC_1	426	431	PF02516	0.559
MOD_NEK2_1	210	215	PF00069	0.349
MOD_NEK2_1	23	28	PF00069	0.445
MOD_NEK2_1	284	289	PF00069	0.510
MOD_NEK2_1	308	313	PF00069	0.623
MOD_NEK2_1	370	375	PF00069	0.580
MOD_NEK2_1	399	404	PF00069	0.476
MOD_NEK2_1	423	428	PF00069	0.496
MOD_NEK2_1	442	447	PF00069	0.492
MOD_NEK2_1	47	52	PF00069	0.438
MOD_NEK2_1	504	509	PF00069	0.801
MOD_NEK2_1	520	525	PF00069	0.562
MOD_NEK2_1	660	665	PF00069	0.513
MOD_NEK2_1	696	701	PF00069	0.348
MOD_NEK2_1	745	750	PF00069	0.502
MOD_NEK2_1	754	759	PF00069	0.589
MOD_NEK2_1	786	791	PF00069	0.572
MOD_NEK2_1	798	803	PF00069	0.589
MOD_NEK2_2	216	221	PF00069	0.402
MOD_NEK2_2	656	661	PF00069	0.290
MOD_PIKK_1	236	242	PF00454	0.353
MOD_PIKK_1	722	728	PF00454	0.519
MOD_PK_1	617	623	PF00069	0.464
MOD_PKA_1	616	622	PF00069	0.398
MOD_PKA_2	299	305	PF00069	0.398
MOD_PKA_2	327	333	PF00069	0.469
MOD_PKA_2	343	349	PF00069	0.365
MOD_PKA_2	502	508	PF00069	0.643
MOD_PKA_2	616	622	PF00069	0.426
MOD_PKA_2	80	86	PF00069	0.714
MOD_PKB_1	614	622	PF00069	0.379
MOD_Plk_1	269	275	PF00069	0.396
MOD_Plk_1	426	432	PF00069	0.557
MOD_Plk_1	750	756	PF00069	0.525
MOD_Plk_2-3	387	393	PF00069	0.365
MOD_Plk_4	210	216	PF00069	0.362
MOD_Plk_4	284	290	PF00069	0.394
MOD_Plk_4	404	410	PF00069	0.456
MOD_Plk_4	445	451	PF00069	0.519
MOD_Plk_4	47	53	PF00069	0.440
MOD_Plk_4	605	611	PF00069	0.326
MOD_Plk_4	656	662	PF00069	0.302
MOD_Plk_4	708	714	PF00069	0.479
MOD_Plk_4	75	81	PF00069	0.468
MOD_ProDKin_1	136	142	PF00069	0.480
MOD_ProDKin_1	185	191	PF00069	0.579
MOD_ProDKin_1	228	234	PF00069	0.471
MOD_ProDKin_1	258	264	PF00069	0.464
MOD_ProDKin_1	35	41	PF00069	0.586
MOD_ProDKin_1	363	369	PF00069	0.557
MOD_ProDKin_1	414	420	PF00069	0.393
MOD_ProDKin_1	507	513	PF00069	0.668
MOD_ProDKin_1	63	69	PF00069	0.594
MOD_ProDKin_1	766	772	PF00069	0.503
MOD_SUMO_rev_2	111	121	PF00179	0.423
TRG_DiLeu_BaEn_1	741	746	PF01217	0.482
TRG_DiLeu_BaEn_2	141	147	PF01217	0.299
TRG_DiLeu_BaLyEn_6	101	106	PF01217	0.445
TRG_DiLeu_BaLyEn_6	697	702	PF01217	0.470
TRG_ENDOCYTIC_2	211	214	PF00928	0.429
TRG_ENDOCYTIC_2	597	600	PF00928	0.345
TRG_ENDOCYTIC_2	607	610	PF00928	0.319
TRG_ER_diArg_1	299	301	PF00400	0.457
TRG_ER_diArg_1	482	484	PF00400	0.677
TRG_ER_diArg_1	615	618	PF00400	0.488
TRG_ER_diArg_1	647	649	PF00400	0.354
TRG_NES_CRM1_1	343	354	PF08389	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJC5	Leptomonas seymouri	47%	100%
A0A1X0NTM2	Trypanosomatidae	27%	100%
A0A3S7WXI7	Leishmania donovani	75%	100%
A4I020	Leishmania infantum	76%	100%
E9AVZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QBI6	Leishmania major	75%	99%
V5B7G6	Trypanosoma cruzi	25%	100%