Putative ser/thr protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ser/thr protein phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HCK0_LEIBR

TriTrypDb:

LbrM.22.1510 , LBRM2903_220021900

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCK0

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006797	polyphosphate metabolic process	4	1
GO:0006798	polyphosphate catabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8
GO:0000298	endopolyphosphatase activity	6	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	315	319	PF00656	0.480
CLV_NRD_NRD_1	254	256	PF00675	0.712
CLV_NRD_NRD_1	410	412	PF00675	0.340
CLV_NRD_NRD_1	476	478	PF00675	0.398
CLV_NRD_NRD_1	75	77	PF00675	0.776
CLV_NRD_NRD_1	773	775	PF00675	0.433
CLV_PCSK_FUR_1	407	411	PF00082	0.396
CLV_PCSK_KEX2_1	238	240	PF00082	0.509
CLV_PCSK_KEX2_1	409	411	PF00082	0.395
CLV_PCSK_KEX2_1	423	425	PF00082	0.390
CLV_PCSK_KEX2_1	476	478	PF00082	0.398
CLV_PCSK_KEX2_1	75	77	PF00082	0.768
CLV_PCSK_KEX2_1	795	797	PF00082	0.486
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.509
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.373
CLV_PCSK_PC1ET2_1	795	797	PF00082	0.486
CLV_PCSK_PC7_1	419	425	PF00082	0.373
CLV_PCSK_SKI1_1	357	361	PF00082	0.409
CLV_PCSK_SKI1_1	411	415	PF00082	0.373
CLV_PCSK_SKI1_1	489	493	PF00082	0.324
CLV_PCSK_SKI1_1	6	10	PF00082	0.683
CLV_PCSK_SKI1_1	607	611	PF00082	0.648
CLV_PCSK_SKI1_1	735	739	PF00082	0.431
CLV_PCSK_SKI1_1	781	785	PF00082	0.459
CLV_PCSK_SKI1_1	796	800	PF00082	0.331
CLV_Separin_Metazoa	329	333	PF03568	0.524
DEG_APCC_DBOX_1	5	13	PF00400	0.681
DEG_APCC_DBOX_1	683	691	PF00400	0.471
DEG_Nend_UBRbox_2	1	3	PF02207	0.679
DEG_SCF_FBW7_1	649	655	PF00400	0.713
DEG_SPOP_SBC_1	265	269	PF00917	0.679
DOC_CDC14_PxL_1	553	561	PF14671	0.417
DOC_CKS1_1	200	205	PF01111	0.525
DOC_CKS1_1	412	417	PF01111	0.373
DOC_CKS1_1	649	654	PF01111	0.683
DOC_CKS1_1	660	665	PF01111	0.675
DOC_CYCLIN_RxL_1	3	13	PF00134	0.684
DOC_CYCLIN_yClb5_NLxxxL_5	4	12	PF00134	0.647
DOC_CYCLIN_yCln2_LP_2	611	617	PF00134	0.660
DOC_MAPK_gen_1	182	190	PF00069	0.523
DOC_MAPK_gen_1	357	367	PF00069	0.381
DOC_MAPK_gen_1	445	454	PF00069	0.312
DOC_MAPK_gen_1	502	512	PF00069	0.450
DOC_MAPK_gen_1	795	806	PF00069	0.460
DOC_MAPK_MEF2A_6	182	190	PF00069	0.523
DOC_MAPK_MEF2A_6	694	703	PF00069	0.453
DOC_PP2B_LxvP_1	569	572	PF13499	0.601
DOC_PP2B_LxvP_1	611	614	PF13499	0.597
DOC_PP2B_LxvP_1	703	706	PF13499	0.523
DOC_PP2B_PxIxI_1	321	327	PF00149	0.338
DOC_PP4_FxxP_1	554	557	PF00568	0.405
DOC_PP4_FxxP_1	729	732	PF00568	0.359
DOC_PP4_FxxP_1	88	91	PF00568	0.533
DOC_USP7_MATH_1	117	121	PF00917	0.684
DOC_USP7_MATH_1	171	175	PF00917	0.714
DOC_USP7_MATH_1	205	209	PF00917	0.760
DOC_USP7_MATH_1	221	225	PF00917	0.535
DOC_USP7_MATH_1	265	269	PF00917	0.685
DOC_USP7_MATH_1	277	281	PF00917	0.728
DOC_USP7_MATH_1	57	61	PF00917	0.565
DOC_USP7_MATH_1	626	630	PF00917	0.666
DOC_USP7_UBL2_3	489	493	PF12436	0.470
DOC_USP7_UBL2_3	795	799	PF12436	0.419
DOC_WW_Pin1_4	141	146	PF00397	0.665
DOC_WW_Pin1_4	199	204	PF00397	0.682
DOC_WW_Pin1_4	270	275	PF00397	0.676
DOC_WW_Pin1_4	288	293	PF00397	0.635
DOC_WW_Pin1_4	41	46	PF00397	0.723
DOC_WW_Pin1_4	411	416	PF00397	0.373
DOC_WW_Pin1_4	50	55	PF00397	0.676
DOC_WW_Pin1_4	545	550	PF00397	0.476
DOC_WW_Pin1_4	593	598	PF00397	0.663
DOC_WW_Pin1_4	648	653	PF00397	0.658
DOC_WW_Pin1_4	659	664	PF00397	0.676
DOC_WW_Pin1_4	787	792	PF00397	0.528
DOC_WW_Pin1_4	87	92	PF00397	0.684
LIG_14-3-3_CanoR_1	158	162	PF00244	0.588
LIG_14-3-3_CanoR_1	16	23	PF00244	0.562
LIG_14-3-3_CanoR_1	26	34	PF00244	0.483
LIG_14-3-3_CanoR_1	6	15	PF00244	0.698
LIG_14-3-3_CanoR_1	659	663	PF00244	0.560
LIG_14-3-3_CanoR_1	684	688	PF00244	0.480
LIG_BIR_III_4	309	313	PF00653	0.468
LIG_BRCT_BRCA1_1	165	169	PF00533	0.535
LIG_BRCT_BRCA1_1	84	88	PF00533	0.551
LIG_deltaCOP1_diTrp_1	727	733	PF00928	0.476
LIG_FHA_1	142	148	PF00498	0.529
LIG_FHA_1	175	181	PF00498	0.691
LIG_FHA_1	195	201	PF00498	0.512
LIG_FHA_1	30	36	PF00498	0.525
LIG_FHA_1	490	496	PF00498	0.341
LIG_FHA_1	529	535	PF00498	0.352
LIG_FHA_1	538	544	PF00498	0.349
LIG_FHA_1	564	570	PF00498	0.441
LIG_FHA_1	61	67	PF00498	0.679
LIG_FHA_1	638	644	PF00498	0.696
LIG_FHA_1	653	659	PF00498	0.622
LIG_FHA_1	662	668	PF00498	0.772
LIG_FHA_1	672	678	PF00498	0.461
LIG_FHA_1	691	697	PF00498	0.323
LIG_FHA_1	732	738	PF00498	0.374
LIG_FHA_1	756	762	PF00498	0.410
LIG_FHA_1	801	807	PF00498	0.489
LIG_FHA_1	90	96	PF00498	0.665
LIG_FHA_2	412	418	PF00498	0.312
LIG_LIR_Apic_2	552	557	PF02991	0.466
LIG_LIR_Apic_2	727	732	PF02991	0.451
LIG_LIR_Apic_2	85	91	PF02991	0.562
LIG_LIR_Gen_1	333	342	PF02991	0.339
LIG_LIR_Gen_1	398	406	PF02991	0.373
LIG_LIR_Gen_1	731	741	PF02991	0.461
LIG_LIR_LC3C_4	802	806	PF02991	0.315
LIG_LIR_Nem_3	309	314	PF02991	0.461
LIG_LIR_Nem_3	333	339	PF02991	0.339
LIG_LIR_Nem_3	398	402	PF02991	0.373
LIG_LIR_Nem_3	515	520	PF02991	0.518
LIG_LIR_Nem_3	552	556	PF02991	0.457
LIG_LIR_Nem_3	727	733	PF02991	0.444
LIG_MYND_1	145	149	PF01753	0.700
LIG_MYND_3	559	563	PF01753	0.536
LIG_PCNA_PIPBox_1	777	786	PF02747	0.472
LIG_PCNA_yPIPBox_3	210	219	PF02747	0.657
LIG_PCNA_yPIPBox_3	466	477	PF02747	0.475
LIG_PCNA_yPIPBox_3	774	784	PF02747	0.476
LIG_PDZ_Class_2	802	807	PF00595	0.486
LIG_Pex14_2	729	733	PF04695	0.354
LIG_PTB_Apo_2	393	400	PF02174	0.373
LIG_PTB_Phospho_1	393	399	PF10480	0.373
LIG_REV1ctd_RIR_1	214	223	PF16727	0.677
LIG_SH2_CRK	391	395	PF00017	0.373
LIG_SH2_CRK	399	403	PF00017	0.373
LIG_SH2_CRK	449	453	PF00017	0.256
LIG_SH2_GRB2like	371	374	PF00017	0.409
LIG_SH2_PTP2	336	339	PF00017	0.312
LIG_SH2_SRC	336	339	PF00017	0.312
LIG_SH2_STAP1	708	712	PF00017	0.476
LIG_SH2_STAT5	336	339	PF00017	0.312
LIG_SH2_STAT5	358	361	PF00017	0.373
LIG_SH2_STAT5	371	374	PF00017	0.373
LIG_SH2_STAT5	399	402	PF00017	0.373
LIG_SH2_STAT5	436	439	PF00017	0.312
LIG_SH3_1	325	331	PF00018	0.503
LIG_SH3_1	409	415	PF00018	0.373
LIG_SH3_3	165	171	PF00018	0.722
LIG_SH3_3	175	181	PF00018	0.602
LIG_SH3_3	197	203	PF00018	0.521
LIG_SH3_3	220	226	PF00018	0.703
LIG_SH3_3	325	331	PF00018	0.503
LIG_SH3_3	409	415	PF00018	0.373
LIG_SH3_3	441	447	PF00018	0.373
LIG_SH3_3	479	485	PF00018	0.510
LIG_SH3_3	554	560	PF00018	0.511
LIG_Sin3_3	698	705	PF02671	0.496
LIG_SUMO_SIM_anti_2	232	238	PF11976	0.510
LIG_SUMO_SIM_anti_2	363	370	PF11976	0.227
LIG_SUMO_SIM_anti_2	697	703	PF11976	0.451
LIG_SUMO_SIM_anti_2	734	740	PF11976	0.426
LIG_SUMO_SIM_par_1	363	370	PF11976	0.227
LIG_SUMO_SIM_par_1	686	691	PF11976	0.403
LIG_UBA3_1	487	493	PF00899	0.510
LIG_WW_3	570	574	PF00397	0.457
MOD_CDC14_SPxK_1	291	294	PF00782	0.557
MOD_CDK_SPxK_1	288	294	PF00069	0.556
MOD_CDK_SPxxK_3	652	659	PF00069	0.778
MOD_CK1_1	10	16	PF00069	0.639
MOD_CK1_1	109	115	PF00069	0.653
MOD_CK1_1	132	138	PF00069	0.592
MOD_CK1_1	160	166	PF00069	0.641
MOD_CK1_1	174	180	PF00069	0.663
MOD_CK1_1	18	24	PF00069	0.632
MOD_CK1_1	193	199	PF00069	0.566
MOD_CK1_1	267	273	PF00069	0.686
MOD_CK1_1	29	35	PF00069	0.756
MOD_CK1_1	37	43	PF00069	0.782
MOD_CK1_1	53	59	PF00069	0.747
MOD_CK1_1	593	599	PF00069	0.615
MOD_CK1_1	60	66	PF00069	0.588
MOD_CK1_1	603	609	PF00069	0.651
MOD_CK1_1	637	643	PF00069	0.703
MOD_CK1_1	645	651	PF00069	0.648
MOD_CK1_1	661	667	PF00069	0.583
MOD_CK1_1	90	96	PF00069	0.675
MOD_Cter_Amidation	772	775	PF01082	0.421
MOD_DYRK1A_RPxSP_1	411	415	PF00069	0.373
MOD_GlcNHglycan	112	115	PF01048	0.780
MOD_GlcNHglycan	12	15	PF01048	0.648
MOD_GlcNHglycan	121	124	PF01048	0.668
MOD_GlcNHglycan	28	31	PF01048	0.736
MOD_GlcNHglycan	284	287	PF01048	0.691
MOD_GlcNHglycan	517	520	PF01048	0.309
MOD_GlcNHglycan	55	58	PF01048	0.563
MOD_GlcNHglycan	621	625	PF01048	0.607
MOD_GlcNHglycan	66	69	PF01048	0.596
MOD_GlcNHglycan	690	693	PF01048	0.410
MOD_GlcNHglycan	695	699	PF01048	0.374
MOD_GlcNHglycan	719	722	PF01048	0.511
MOD_GlcNHglycan	92	95	PF01048	0.494
MOD_GSK3_1	106	113	PF00069	0.528
MOD_GSK3_1	129	136	PF00069	0.807
MOD_GSK3_1	143	150	PF00069	0.568
MOD_GSK3_1	156	163	PF00069	0.610
MOD_GSK3_1	190	197	PF00069	0.783
MOD_GSK3_1	25	32	PF00069	0.673
MOD_GSK3_1	261	268	PF00069	0.594
MOD_GSK3_1	278	285	PF00069	0.618
MOD_GSK3_1	296	303	PF00069	0.466
MOD_GSK3_1	34	41	PF00069	0.770
MOD_GSK3_1	46	53	PF00069	0.677
MOD_GSK3_1	589	596	PF00069	0.595
MOD_GSK3_1	60	67	PF00069	0.530
MOD_GSK3_1	622	629	PF00069	0.631
MOD_GSK3_1	630	637	PF00069	0.626
MOD_GSK3_1	639	646	PF00069	0.655
MOD_GSK3_1	648	655	PF00069	0.646
MOD_GSK3_1	672	679	PF00069	0.600
MOD_GSK3_1	690	697	PF00069	0.448
MOD_GSK3_1	787	794	PF00069	0.520
MOD_GSK3_1	89	96	PF00069	0.680
MOD_N-GLC_1	37	42	PF02516	0.594
MOD_N-GLC_1	563	568	PF02516	0.440
MOD_N-GLC_1	600	605	PF02516	0.754
MOD_N-GLC_1	637	642	PF02516	0.676
MOD_NEK2_1	110	115	PF00069	0.707
MOD_NEK2_1	230	235	PF00069	0.696
MOD_NEK2_1	671	676	PF00069	0.635
MOD_NEK2_1	688	693	PF00069	0.318
MOD_NEK2_2	164	169	PF00069	0.537
MOD_PIKK_1	7	13	PF00454	0.645
MOD_PIKK_1	722	728	PF00454	0.528
MOD_PK_1	182	188	PF00069	0.704
MOD_PKA_2	118	124	PF00069	0.588
MOD_PKA_2	15	21	PF00069	0.558
MOD_PKA_2	157	163	PF00069	0.531
MOD_PKA_2	25	31	PF00069	0.609
MOD_PKA_2	296	302	PF00069	0.516
MOD_PKA_2	589	595	PF00069	0.592
MOD_PKA_2	658	664	PF00069	0.559
MOD_PKA_2	683	689	PF00069	0.481
MOD_Plk_1	174	180	PF00069	0.525
MOD_Plk_1	397	403	PF00069	0.312
MOD_Plk_1	672	678	PF00069	0.517
MOD_Plk_1	694	700	PF00069	0.296
MOD_Plk_1	755	761	PF00069	0.461
MOD_Plk_4	129	135	PF00069	0.613
MOD_Plk_4	143	149	PF00069	0.605
MOD_Plk_4	164	170	PF00069	0.569
MOD_Plk_4	18	24	PF00069	0.628
MOD_Plk_4	397	403	PF00069	0.312
MOD_Plk_4	506	512	PF00069	0.337
MOD_Plk_4	645	651	PF00069	0.584
MOD_Plk_4	683	689	PF00069	0.421
MOD_Plk_4	800	806	PF00069	0.438
MOD_ProDKin_1	141	147	PF00069	0.670
MOD_ProDKin_1	199	205	PF00069	0.683
MOD_ProDKin_1	270	276	PF00069	0.675
MOD_ProDKin_1	288	294	PF00069	0.636
MOD_ProDKin_1	41	47	PF00069	0.723
MOD_ProDKin_1	411	417	PF00069	0.373
MOD_ProDKin_1	50	56	PF00069	0.678
MOD_ProDKin_1	545	551	PF00069	0.471
MOD_ProDKin_1	593	599	PF00069	0.665
MOD_ProDKin_1	648	654	PF00069	0.661
MOD_ProDKin_1	659	665	PF00069	0.676
MOD_ProDKin_1	787	793	PF00069	0.521
MOD_ProDKin_1	87	93	PF00069	0.676
MOD_SUMO_for_1	560	563	PF00179	0.556
MOD_SUMO_rev_2	563	569	PF00179	0.582
TRG_DiLeu_BaEn_2	778	784	PF01217	0.466
TRG_DiLeu_BaEn_4	470	476	PF01217	0.435
TRG_DiLeu_BaLyEn_6	732	737	PF01217	0.458
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.629
TRG_ENDOCYTIC_2	336	339	PF00928	0.312
TRG_ENDOCYTIC_2	391	394	PF00928	0.373
TRG_ENDOCYTIC_2	399	402	PF00928	0.373
TRG_ENDOCYTIC_2	449	452	PF00928	0.256
TRG_ENDOCYTIC_2	517	520	PF00928	0.499
TRG_ER_diArg_1	407	410	PF00400	0.397
TRG_ER_diArg_1	475	477	PF00400	0.398
TRG_NES_CRM1_1	695	709	PF08389	0.469
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.683
TRG_Pf-PMV_PEXEL_1	774	779	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Q2	Leptomonas seymouri	63%	100%
A0A3Q8IBC4	Leishmania donovani	83%	100%
A0A3R7K273	Trypanosoma rangeli	43%	100%
A4I019	Leishmania infantum	83%	100%
E9AVZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QBI7	Leishmania major	82%	100%